ICD10 Disease Category |
Disease Name |
ICD10 Code |
Associated Disease Targets (Association Ref: TTD database) |
E00-E89: Endocrine, nutritional and metabolic diseases |
Hyperprolactinemia |
E22.1 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Opiate dependence |
F11 |
OPRM1; |
H00-H59: Diseases of the eye and adnexa |
Open-angle glaucoma |
H40-H42 |
CA2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Huntington's disease |
F02.2, G10 |
DRD2; PDE10A; |
NA: NA |
Hyperaemia |
NA |
DRD2; |
K00-K95: Diseases of the digestive system |
Diarrhea-predominant IBS |
K58.0 |
OPRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Major depressive disorder |
F32, F33, M32 |
OPRM1; HTR7; DRD2; OPRD1; HTR1A; |
I00-I99: Diseases of the circulatory system |
Maintain blood pressure in hypotensive states |
I10 |
DRD2; |
A00-B99: Certain infectious and parasitic diseases |
Malaria |
B54 |
CYP2D6; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Narcotic depression |
F19.20, F32 |
OPRM1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Dementia |
F01-F07 |
DRD1; |
NA: NA |
Malignant phaeochromocytoma |
NA |
DRD2; |
NA: NA |
Malignant essential hypertension |
NA |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Depression |
F30-F39 |
HTR2A; HTR1A; |
K00-K95: Diseases of the digestive system |
Dermal necrosis |
K05 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Substance dependence |
F10-F19 |
DRD1; DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Systemic pain |
R52, G89 |
OPRM1; |
G00-G99: Diseases of the nervous system G00-G99 |
Migraine headaches |
G43 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Premature ejaculation |
F52.4 |
OPRD1; HTR1A; |
NA: NA |
False perceptions |
NA |
DRD2; |
H00-H59: Diseases of the eye and adnexa |
Ophthalmic disease |
H00-H59 |
DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Mild pain |
R52, G89 |
OPRM1; |
G00-G99: Diseases of the nervous system G00-G99 |
Migraine |
G43 |
CYP2D6; OPRM1; HTR2A; HTR1A; |
M00-M99: Diseases of the musculoskeletal system and connective tissue |
Fibromyalgia |
M79.7 |
HTR2A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Female sexual dysfunction |
F52 |
HTR1A; |
L00-L99: Diseases of the skin and subcutaneous tissue |
Fibrosis |
L90.5 |
DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Moderate-to-severe acute pain |
R52, G89 |
OPRM1; |
J00-J99: Diseases of the respiratory system |
Asthma |
J45 |
OPRM1; DRD2; |
I00-I99: Diseases of the circulatory system |
Coronary artery disease |
I20-I25 |
HTR1A; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Movement disorder |
R25 |
OPRM1; |
I00-I99: Diseases of the circulatory system |
Cerebrovascular ischaemia |
I61-I63 |
DRD2; |
A00-B99: Certain infectious and parasitic diseases |
Bacterial infections |
A00-B99 |
DRD2; |
NA: NA |
Corneal vascularity |
NA |
DRD2; |
NA: NA |
Peripheral sensory neuropathies |
NA |
HTR1A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Insomnia |
F51.0, G47.0 |
CYP2D6; CA2; DRD2; |
K00-K95: Diseases of the digestive system |
Constipation |
K59.0 |
OPRM1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Alcohol use disorders |
F10.2 |
DRD2; OPRD1; HTR2A; |
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism |
Idiopathic thrombocytopenic purpura |
D69.3 |
DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Anesthesia |
R20.0 |
OPRM1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Analgesia |
R52, G89 |
OPRM1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Cocaine addiction |
F14.2 |
DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Cognitive disorders |
F01-F07, F04, F05, R41.3 |
DRD1; HTR1A; |
I00-I99: Diseases of the circulatory system |
Hypotension |
I95 |
DRD2; |
J00-J99: Diseases of the respiratory system |
Chronic obstructive pulmonary disease |
J40-J44, J47 |
DRD2; |
I00-I99: Diseases of the circulatory system |
Pulmonary hypertension |
I27.0, I27.2 |
DRD2; |
N00-N99: Diseases of the genitourinary system |
Urinary incontinence |
N39.3, N39.4, R32 |
OPRM1; OPRD1; HTR1A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Anxiety disorder |
F32, F40-F42 |
DRD2; OPRD1; HTR2A; HTR1A; |
O00-O9A: Pregnancy, childbirth and the puerperium |
Excessive bleeding following childbirth and spontaneous or elective abortion |
O04 |
DRD1; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Type 2 diabetes |
E11 |
DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Hypoactive sexual desire disorder |
F52.0 |
HTR1A; |
G00-G99: Diseases of the nervous system G00-G99 |
Alzheimer disease |
G30 |
DRD2; HTR1A; |
S00-T88: Injury, poisoning and certain other consequences of external causes |
Allergy |
T78.4 |
DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Chronic pain |
R52.1-R52.2, G89 |
OPRM1; |
C00-D49: Neoplasms |
Breast cancer |
C50 |
DRD2; |
O00-O9A: Pregnancy, childbirth and the puerperium |
Postpartum haemorrhage |
O72 |
DRD2; |
NA: NA |
Cervical dystonia |
NA |
HTR1A; |
G00-G99: Diseases of the nervous system G00-G99 |
Central nervous system disease |
G00-G99 |
HTR2A; |
NA: NA |
Vomiting |
NA |
DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Moderate-to-severe pain |
R52, G89 |
OPRD1; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Erythropoietic porphyria |
E80.0 |
HTR2A; |
NA: NA |
Episode |
NA |
HTR1A; |
NA: NA |
Addiction |
NA |
HTR2A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Mood disorder |
F30-F39 |
HTR2A; HTR1A; |
I00-I99: Diseases of the circulatory system |
Cardiac failure |
I50 |
DRD2; |
I00-I99: Diseases of the circulatory system |
Cardiovascular disorder |
I00-I99 |
HTR2A; |
I00-I99: Diseases of the circulatory system |
Cardiotonic |
I50 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Psychotic disorders |
F20-F29 |
DRD1; DRD2; HTR1A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Psychosis |
F20-F29 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Psychiatric disorder |
F01-F99 |
DRD1; HTR2A; HTR1A; |
NA: NA |
Chronic diarrhea associated with inflammatory bowel disease |
NA |
OPRD1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Cancer pain |
R52, G89 |
OPRM1; |
J00-J99: Diseases of the respiratory system |
Bronchitis |
J20-J21, J42 |
DRD2; |
NA: NA |
Bulimia nervosa |
NA |
HTR1A; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Carcinoid syndrome |
E34.0 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Sleep maintenance insomnia |
F51.0, G47.0 |
HTR2A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Sexual dysfunction |
F52 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Severe mood disorders |
F30-F39 |
HTR1A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Sleep disorders |
F51, G47 |
HTR7; HTR2A; |
K00-K95: Diseases of the digestive system |
Duodenal ulcers |
K25-K27 |
CA2; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Eating disorder |
E66, F50, I10-I16, I50 |
HTR1A; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Spasm |
R25.2 |
HTR1A; |
NA: NA |
Social phobia |
NA |
HTR1A; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Emesis |
R11 |
DRD2; |
I00-I99: Diseases of the circulatory system |
Edema associated with congestive heart failure |
I50, R60.9 |
CA2; |
NA: NA |
Edema |
NA |
CA2; |
G00-G99: Diseases of the nervous system G00-G99 |
Acute migraine |
G43 |
OPRD1; |
NA: NA |
Acute nonspecific diarrhea |
NA |
OPRD1; |
NA: NA |
Benign prostatic hypertrophy |
NA |
DRD2; |
N00-N99: Diseases of the genitourinary system |
Bladder disease |
N30-N32 |
OPRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Bipolar disorder |
F31, F40-F42 |
DRD2; |
I00-I99: Diseases of the circulatory system |
Hypertension |
I10-I16 |
DRD1; DRD2; HTR1A; |
M00-M99: Diseases of the musculoskeletal system and connective tissue |
Rheumatoid arthritis |
M05-M06 |
OPRD1; |
NA: NA |
Schizoaffective disorder |
NA |
PDE10A; HTR1A; |
NA: NA |
Schizoaffective disorders |
NA |
DRD2; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Obesity |
E66 |
OPRM1; |
C00-D49: Neoplasms |
Non-small cell lung cancer |
C33-C34 |
OPRM1; DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Advanced stage Parkinson's disease |
F02.3, G20 |
DRD2; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Acromegaly |
E22.0 |
DRD2; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetic neuropathy |
E11.40 |
OPRM1; |
H00-H59: Diseases of the eye and adnexa |
Glaucoma |
H40-H42 |
DRD2; HTR2A; |
I00-I99: Diseases of the circulatory system |
Hemorrhoids |
I84 |
HTR2A; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Schizophrenia |
F20 |
HTR7; DRD1; DRD2; HTR2A; PDE10A; HTR1A; |
A00-B99: Certain infectious and parasitic diseases |
Diarrhea |
A09, K59.1 |
OPRM1; |
K00-K95: Diseases of the digestive system |
Gastrointestinal disease |
K00-K93 |
OPRM1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
General anesthesia |
R20.0 |
OPRM1; |
K00-K95: Diseases of the digestive system |
Gastrointestinal problems |
K30-K31, Q40-Q41 |
DRD2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Generalized anxiety disorder |
F32, F40-F42, F41.1 |
HTR1A; |
J00-J99: Diseases of the respiratory system |
Nasal congestion |
J34.89 |
DRD2; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Cough |
R05 |
OPRD1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Nausea |
R11 |
DRD2; |
G00-G99: Diseases of the nervous system G00-G99 |
Headache |
G43-G44, R51 |
OPRM1; |
E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetes |
E23.2, N25.1 |
HTR2A; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Depressive fatigue |
R53.82 |
DRD2; |
NA: NA |
Peripheral vasoconstriction |
NA |
DRD2; |
NA: NA |
Inflammatory diseases |
NA |
DRD2; |
C00-D49: Neoplasms |
Inflammatory disease |
C11, C44, K75.9, M00-M25 |
OPRM1; DRD2; |
K00-K95: Diseases of the digestive system |
Inflammatory bowel disease |
K50, K51 |
DRD2; |
K00-K95: Diseases of the digestive system |
Pancreatitis |
K85, K86.0K86.1 |
HTR2A; |
G00-G99: Diseases of the nervous system G00-G99 |
Parkinson's disease |
G20 |
DRD1; DRD2; HTR1A; |
G00-G99: Diseases of the nervous system G00-G99 |
Pain |
G64, G90.0, R52, G89 |
OPRM1; DRD1; DRD2; OPRD1; HTR1A; |
I00-I99: Diseases of the circulatory system |
High blood pressure |
I10-I16 |
CA2; |
NA: NA |
Itching |
NA |
DRD2; |
I00-I99: Diseases of the circulatory system |
Ischemic heart diseases |
I20-I25 |
OPRD1; |
C00-D49: Neoplasms |
Overactive bladder disorder |
C67, N32.81 |
OPRD1; |
I00-I99: Diseases of the circulatory system |
Angina pectoris |
I20 |
DRD2; |
G00-G99: Diseases of the nervous system G00-G99 |
Lateral sclerosis |
G12.2 |
HTR1A; |
K00-K95: Diseases of the digestive system |
Opioid-induced constipation |
K59.0 |
OPRM1; |
NA: NA |
Anxiety disorders |
NA |
HTR1A; |