CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; ALOX12; ALOX15; HSD17B10; IDH1; USP2;
Hydrolase	GAA;
Oxidoreductase	PTGS2; PTGS1; MAOA;
Transcription Factor	NFKB1; RELA;
Unclassified	MAPT; XBP1; LMNA;
Transferase	FASN;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	O75874	CHEMBL2007625
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608

Showing 1 to 10 of 19 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.536E-12	7.700E-08	ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9, FASN, GAA, HSD17B10, IDH1, MAOA, PTGS1, PTGS2
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	4.482E-07	3.486E-04	ALOX12, ALOX15, PTGS2
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	9.167E-07	5.871E-04	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	9.151E-06	4.151E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:2000630; positive regulation of miRNA metabolic process	9.151E-06	4.151E-03	NFKB1, RELA
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.372E-05	5.857E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0046890; regulation of lipid biosynthetic process	1.888E-05	7.463E-03	FASN, IDH1, NFKB1, PTGS2
BP	GO:0032501; multicellular organismal process	GO:0045075; regulation of interleukin-12 biosynthetic process	1.919E-05	7.463E-03	NFKB1, RELA
BP	GO:0050896; response to stimulus	GO:0009750; response to fructose	2.558E-05	9.440E-03	PTGS2, XBP1
BP	GO:0009987; cellular process	GO:0071316; cellular response to nicotine	2.558E-05	9.440E-03	NFKB1, RELA

Showing 1 to 10 of 21 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.820E-11	5.946E-10	CYP2C9, ALOX15, ALOX12, CYP2C19, PTGS2, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.615E-06	6.406E-05	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.660E-05	5.979E-04	CYP2C9, MAOA, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.471E-04	1.311E-03	PTGS2, RELA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	8.936E-05	8.757E-04	PTGS2, RELA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.706E-03	7.051E-03	MAPT, RELA, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.996E-04	2.447E-03	LMNA, RELA, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.808E-12	3.336E-10	CYP2C9, MAOA, ALOX15, ALOX12, CYP2C19, PTGS2, PTGS1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.019E-03	7.051E-03	PTGS2, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.277E-03	7.051E-03	PTGS2, PTGS1

Showing 1 to 10 of 33 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Nicotiana sylvestris

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities