Molecular Weight:   | 346.14 |
Volume:   | 348.433 |
LogP:   | 0.419 |
LogD:   | 1.124 |
LogS:   | -2.432 |
# Rotatable Bonds:   | 4 |
TPSA:   | 93.06 |
# H-Bond Aceptor:   | 6 |
# H-Bond Donor:   | 2 |
# Rings:   | 3 |
# Heavy Atoms:   | 6 |
QED Drug-Likeness Score:   | 0.451 |
Synthetic Accessibility Score:   | 5.02 |
Fsp3:   | 0.474 |
Lipinski Rule-of-5:   | Accepted |
Pfizer Rule:   | Accepted |
GSK Rule:   | Accepted |
BMS Rule:   | 2 |
Golden Triangle Rule:   | Accepted |
Chelating Alert:   | 0 |
PAINS Alert:   | 0 |
Caco-2 Permeability:   | -5.185 |
MDCK Permeability:   | 0.00015472964150831103 |
Pgp-inhibitor:   | 0.011 |
Pgp-substrate:   | 0.0 |
Human Intestinal Absorption (HIA):   | 0.078 |
20% Bioavailability (F20%):   | 0.666 |
30% Bioavailability (F30%):   | 0.645 |
Blood-Brain-Barrier Penetration (BBB):   | 0.062 |
Plasma Protein Binding (PPB):   | 67.15390014648438% |
Volume Distribution (VD):   | 0.848 |
Pgp-substrate:   | 50.1939697265625% |
CYP1A2-inhibitor:   | 0.062 |
CYP1A2-substrate:   | 0.049 |
CYP2C19-inhibitor:   | 0.02 |
CYP2C19-substrate:   | 0.099 |
CYP2C9-inhibitor:   | 0.086 |
CYP2C9-substrate:   | 0.034 |
CYP2D6-inhibitor:   | 0.005 |
CYP2D6-substrate:   | 0.082 |
CYP3A4-inhibitor:   | 0.122 |
CYP3A4-substrate:   | 0.175 |
Clearance (CL):   | 7.043 |
Half-life (T1/2):   | 0.71 |
hERG Blockers:   | 0.105 |
Human Hepatotoxicity (H-HT):   | 0.947 |
Drug-inuced Liver Injury (DILI):   | 0.914 |
AMES Toxicity:   | 0.058 |
Rat Oral Acute Toxicity:   | 0.87 |
Maximum Recommended Daily Dose:   | 0.976 |
Skin Sensitization:   | 0.414 |
Carcinogencity:   | 0.249 |
Eye Corrosion:   | 0.095 |
Eye Irritation:   | 0.128 |
Respiratory Toxicity:   | 0.973 |
Natural Product ID:   | NPC38392 |
Common Name*:   | Cynaropicrin |
IUPAC Name:   | [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate |
Synonyms:   | Cynaropicrin |
Standard InCHIKey:   | KHSCYOFDKADJDJ-NQLMQOPMSA-N |
Standard InCHI:   | InChI=1S/C19H22O6/c1-8-5-14(24-18(22)9(2)7-20)16-11(4)19(23)25-17(16)15-10(3)13(21)6-12(8)15/h12-17,20-21H,1-7H2/t12-,13-,14-,15-,16+,17+/m0/s1 |
SMILES:   | C=C1C[C@@H]([C@H]2C(=C)C(=O)O[C@@H]2[C@H]2C(=C)[C@H](C[C@@H]12)O)OC(=O)C(=C)CO |
Synthetic Gene Cluster:   | n.a. |
ChEMBL Identifier:   | CHEMBL374146 |
PubChem CID:   |
119093 |
Chemical Classification**:   |
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|---|---|---|---|---|---|---|---|
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. | DOI[10.1016/j.phytochem.2005.10.025] |
NPO24419 | Anvillea garcinii | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11087618] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | fruit body | n.a. |
PMID[11520245] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[12045343] |
NPO25119 | Euonymus laxiflorus | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[12713415] |
NPO25119 | Euonymus laxiflorus | Species | Celastraceae | Eukaryota | n.a. | leaf | n.a. |
PMID[12713415] |
NPO25119 | Euonymus laxiflorus | Species | Celastraceae | Eukaryota | n.a. | stem | n.a. |
PMID[12713415] |
NPO19263 | Bulbinella floribunda | Species | Asphodelaceae | Eukaryota | roots | n.a. | n.a. |
PMID[12828488] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[14695801] |
NPO25344 | Caryocar villosum | Species | Caryocaraceae | Eukaryota | Fruits | n.a. | n.a. |
PMID[16792411] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[1791484] |
NPO2291 | Saussurea pulchella | Species | Asteraceae | Eukaryota | aerial parts | n.a. | n.a. |
PMID[18314958] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | Northeastern Regional Plant Introduction Station at Geneva | 1966, 1967, and 1968 crop seasons |
PMID[18460139] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | spore | n.a. |
PMID[18827358] |
NPO10471 | Scorzonera radiata | Species | Asteraceae | Eukaryota | n.a. | Mongolian | n.a. |
PMID[19271716] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | fruiting bodies | Nagano, Japan | 2008-MAY |
PMID[20039640] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[20384295] |
NPO23525 | Physalis sordida | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[20575572] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | fruiting bodies | n.a. | n.a. |
PMID[20702092] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | fruiting bodies | n.a. | n.a. |
PMID[21924611] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[22014750] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | fruit body | n.a. |
PMID[22044278] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | fruiting body | n.a. | n.a. |
PMID[22047696] |
NPO25727 | Tabernaemontana divaricata | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[23944995] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26222905] |
NPO25727 | Tabernaemontana divaricata | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26231157] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26477735] |
NPO25377 | Ocimum gratissimum | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[29192771] |
NPO25727 | Tabernaemontana divaricata | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[30169038] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | The ‘Dolina Mogilnicy’ Organic Farming Products Cooperative (Wolkowo, Poland) | 2016-Oct |
PMID[31416184] |
NPO25377 | Ocimum gratissimum | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[6114991] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[6821187] |
NPO24419 | Anvillea garcinii | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[8699183] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | fruit body | n.a. |
PMID[9635497] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO23343 | Cynara cardunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO16242 | Phlojodicarpus sibiricus | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO2291 | Saussurea pulchella | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO14834 | Trachelospermum asiaticum | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO23343 | Cynara cardunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO30574 | Cynara scolymus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO24574 | Berberis orthobotrys | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO1663 | Amberboa muricata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO9427 | Lemna minor | Species | Araceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO9427 | Lemna minor | Species | Araceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO23343 | Cynara cardunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO24574 | Berberis orthobotrys | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21021 | Hemisteptia lyrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO16242 | Phlojodicarpus sibiricus | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25608 | Zanthoxylum acutifolium | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25428 | Ceriops decandra | Species | Rhizophoraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25727 | Tabernaemontana divaricata | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO14834 | Trachelospermum asiaticum | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25377 | Ocimum gratissimum | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO14387 | Dalbergia ecastaphyllum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO1663 | Amberboa muricata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2749 | Baccharis dracunculifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2291 | Saussurea pulchella | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO30115 | Aucklandia lappa | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO30574 | Cynara scolymus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO2291 | Saussurea pulchella | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO23343 | Cynara cardunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO1663 | Amberboa muricata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO16242 | Phlojodicarpus sibiricus | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO14834 | Trachelospermum asiaticum | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO25656 | Rhizoctonia repens | Species | Ceratobasidiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25401 | Glochidion philippicum | Species | Phyllanthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20636 | Myoporum platycarpum | Species | Scrophulariaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24419 | Anvillea garcinii | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19263 | Bulbinella floribunda | Species | Asphodelaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14834 | Trachelospermum asiaticum | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25453 | Solidago petiolaris | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17104 | Pithecellobium racemosum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25632 | Sarcophyton buitendijki | Species | Alcyoniidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25727 | Tabernaemontana divaricata | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9427 | Lemna minor | Species | Araceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22056 | Streptomyces roseoverticillatus | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16242 | Phlojodicarpus sibiricus | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24483 | Acrisione denticulata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25269 | Ganoderma lucidum | Species | Ganodermataceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25344 | Caryocar villosum | Species | Caryocaraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25064 | Streptomyces purpurogeneiscleroticus | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24442 | Calycotome villosa | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25687 | Archidendron ellipticum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24710 | Achillea biebersteinii | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11134 | Himalaiella deltoidea | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25206 | Cucurbita moschata | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23583 | Taonia australasica | Species | Dictyotaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18861 | Pyxine coccifera | Species | Caliciaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11433 | Candelaria concolor | Species | Candelariaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2291 | Saussurea pulchella | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23456 | Palaquium canaliculatum | Species | Sapotaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25063 | Ongokea gore | Species | Aptandraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO750 | Emericellopsis salmosynnemata | Species | n.a. | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23725 | Dytiscus marginalis | Species | Dytiscidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23525 | Physalis sordida | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6394 | Shorea robusta | Species | Dipterocarpaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23336 | Cladonia impexa | Species | Cladoniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22012 | Cipadessa fruticosa | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24534 | Senecio heliopsis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4480 | Phlojodicarpus villosus | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5721 | Psorothamnus spinosus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16819 | Preussia aemulans | Species | Sporormiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24251 | Taxus drupacea | Species | Taxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2749 | Baccharis dracunculifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21021 | Hemisteptia lyrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25517 | Colladonia triquetra | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24574 | Berberis orthobotrys | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10193 | Agave tequilana | Species | Asparagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24666 | Codium dwarkense | Species | Codiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10471 | Scorzonera radiata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25067 | Sanicula epipactis | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1663 | Amberboa muricata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18273 | Merendera sobolifera | Species | Colchicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25428 | Ceriops decandra | Species | Rhizophoraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22536 | Cladosporium cucumerinum | Species | Cladosporiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25157 | Cymbastela coralliophila | Species | Axinellidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12790 | Lachnosiphonium niloticum | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11001 | Ceanothus papillosus | Species | Rhamnaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24860 | Euphorbia formosana | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25119 | Euonymus laxiflorus | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11464 | Centaurea kotschyi | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24903 | Diplazium esculentum | Species | Athyriaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5142 | Garcinia pedunculata | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24325 | Ilex brevicuspis | Species | Aquifoliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25244 | Scopolia atropoides | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24149 | Paracoccus denitrificans | Species | Rhodobacteraceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21570 | Blumea eriantha | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23219 | Lactarius sanguifluus | Species | Russulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25608 | Zanthoxylum acutifolium | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25486 | Zaluzania grayana | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22863 | Littorina littorea | Species | Littorinidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14387 | Dalbergia ecastaphyllum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25578 | Chiton tuberculatus | Species | Chitonidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25377 | Ocimum gratissimum | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT2716 | Individual Protein | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Escherichia coli K-12 | IC50 | = | 19500.0 | nM | PMID[507033] |
NPT2717 | Individual Protein | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | IC50 | = | 12100.0 | nM | PMID[507033] |
NPT81 | Cell Line | A549 | Homo sapiens | ED50 | = | 24.51 | uM | PMID[507034] |
NPT146 | Cell Line | SK-OV-3 | Homo sapiens | ED50 | = | 7.42 | uM | PMID[507034] |
NPT147 | Cell Line | SK-MEL-2 | Homo sapiens | ED50 | = | 4.07 | uM | PMID[507034] |
NPT148 | Cell Line | HCT-15 | Homo sapiens | ED50 | = | 12.13 | uM | PMID[507034] |
NPT91 | Cell Line | KB | Homo sapiens | IC50 | = | 15900.0 | nM | PMID[507035] |
NPT81 | Cell Line | A549 | Homo sapiens | IC50 | = | 16500.0 | nM | PMID[507035] |
NPT83 | Cell Line | MCF7 | Homo sapiens | IC50 | = | 3200.0 | nM | PMID[507035] |
NPT147 | Cell Line | SK-MEL-2 | Homo sapiens | IC50 | = | 5800.0 | nM | PMID[507035] |
NPT839 | Cell Line | L6 | Rattus norvegicus | IC50 | = | 2190.0 | nM | PMID[507039] |
NPT2718 | Organism | Trogoderma granarium | Trogoderma granarium | Activity | = | 49.5 | n.a. | PMID[507036] |
NPT777 | Organism | Tribolium confusum | Tribolium confusum | Activity | = | 98.8 | n.a. | PMID[507036] |
NPT733 | Organism | Sitophilus granarius | Sitophilus granarius | Activity | = | 51.6 | n.a. | PMID[507036] |
NPT32 | Organism | Mus musculus | Mus musculus | FC | = | 4.3 | n.a. | PMID[507037] |
NPT32 | Organism | Mus musculus | Mus musculus | FC | = | 1.7 | n.a. | PMID[507037] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 37.1 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 33.3 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 35.8 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 39.6 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 49.0 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 42.0 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 23.0 | uM | PMID[507038] |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | Activity | = | 34.9 | uM | PMID[507038] |
NPT2 | Others | Unspecified | Inhibition | = | 51.0 | % | PMID[507038] | |
NPT2 | Others | Unspecified | INH | = | 50.0 | uM | PMID[507038] | |
NPT2 | Others | Unspecified | Ratio IC50 | = | 7.8 | n.a. | PMID[507039] | |
NPT844 | Organism | Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | IC50 | = | 280.0 | nM | PMID[507039] |
NPT2 | Others | Unspecified | Activity | = | 72.85 | RLU | PMID[507041] | |
NPT2 | Others | Unspecified | Activity | = | 5.67 | RLU | PMID[507041] | |
NPT2 | Others | Unspecified | Activity | = | 134.36 | RLU | PMID[507041] |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC38392 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
0.9881 | High Similarity | NPC19087 |
0.9765 | High Similarity | NPC184063 |
0.9643 | High Similarity | NPC217983 |
0.9643 | High Similarity | NPC207114 |
0.9639 | High Similarity | NPC187661 |
0.9398 | High Similarity | NPC194859 |
0.9398 | High Similarity | NPC224386 |
0.9222 | High Similarity | NPC474313 |
0.9195 | High Similarity | NPC297474 |
0.9195 | High Similarity | NPC54065 |
0.9176 | High Similarity | NPC304558 |
0.9111 | High Similarity | NPC142529 |
0.9111 | High Similarity | NPC91771 |
0.9091 | High Similarity | NPC29821 |
0.9091 | High Similarity | NPC171360 |
0.9091 | High Similarity | NPC133888 |
0.9091 | High Similarity | NPC57304 |
0.9091 | High Similarity | NPC475925 |
0.9091 | High Similarity | NPC293001 |
0.9091 | High Similarity | NPC35959 |
0.9091 | High Similarity | NPC63193 |
0.908 | High Similarity | NPC155935 |
0.908 | High Similarity | NPC215556 |
0.9048 | High Similarity | NPC128246 |
0.8977 | High Similarity | NPC35809 |
0.8977 | High Similarity | NPC216284 |
0.8966 | High Similarity | NPC79549 |
0.8929 | High Similarity | NPC246076 |
0.8889 | High Similarity | NPC473331 |
0.881 | High Similarity | NPC126248 |
0.8804 | High Similarity | NPC311904 |
0.8791 | High Similarity | NPC476053 |
0.8791 | High Similarity | NPC472873 |
0.8778 | High Similarity | NPC475788 |
0.8778 | High Similarity | NPC200237 |
0.8778 | High Similarity | NPC473273 |
0.8778 | High Similarity | NPC473234 |
0.8778 | High Similarity | NPC473263 |
0.8778 | High Similarity | NPC308656 |
0.8778 | High Similarity | NPC60386 |
0.8778 | High Similarity | NPC258216 |
0.8736 | High Similarity | NPC56593 |
0.8723 | High Similarity | NPC171759 |
0.8696 | High Similarity | NPC18019 |
0.8696 | High Similarity | NPC24956 |
0.8681 | High Similarity | NPC198853 |
0.8667 | High Similarity | NPC155215 |
0.8667 | High Similarity | NPC286341 |
0.8667 | High Similarity | NPC191339 |
0.8652 | High Similarity | NPC168679 |
0.8652 | High Similarity | NPC12872 |
0.8636 | High Similarity | NPC118601 |
0.8636 | High Similarity | NPC24728 |
0.8621 | High Similarity | NPC284534 |
0.8621 | High Similarity | NPC300082 |
0.8621 | High Similarity | NPC204105 |
0.8605 | High Similarity | NPC111409 |
0.8602 | High Similarity | NPC471150 |
0.8587 | High Similarity | NPC170120 |
0.8587 | High Similarity | NPC213698 |
0.8587 | High Similarity | NPC163228 |
0.8571 | High Similarity | NPC153590 |
0.8539 | High Similarity | NPC178875 |
0.8539 | High Similarity | NPC471149 |
0.8523 | High Similarity | NPC309757 |
0.8523 | High Similarity | NPC64153 |
0.8523 | High Similarity | NPC236692 |
0.8511 | High Similarity | NPC49833 |
0.8511 | High Similarity | NPC249171 |
0.8478 | Intermediate Similarity | NPC470010 |
0.8478 | Intermediate Similarity | NPC470013 |
0.8478 | Intermediate Similarity | NPC262133 |
0.8478 | Intermediate Similarity | NPC127019 |
0.8478 | Intermediate Similarity | NPC323008 |
0.8462 | Intermediate Similarity | NPC133698 |
0.8462 | Intermediate Similarity | NPC131209 |
0.8444 | Intermediate Similarity | NPC283409 |
0.8444 | Intermediate Similarity | NPC472872 |
0.8438 | Intermediate Similarity | NPC80144 |
0.8427 | Intermediate Similarity | NPC201658 |
0.8404 | Intermediate Similarity | NPC213947 |
0.8404 | Intermediate Similarity | NPC108475 |
0.8404 | Intermediate Similarity | NPC161493 |
0.8404 | Intermediate Similarity | NPC170143 |
0.8391 | Intermediate Similarity | NPC245665 |
0.8387 | Intermediate Similarity | NPC52044 |
0.8387 | Intermediate Similarity | NPC304886 |
0.8387 | Intermediate Similarity | NPC67584 |
0.8367 | Intermediate Similarity | NPC44004 |
0.8333 | Intermediate Similarity | NPC150923 |
0.8315 | Intermediate Similarity | NPC238593 |
0.8315 | Intermediate Similarity | NPC470242 |
0.8298 | Intermediate Similarity | NPC213078 |
0.8298 | Intermediate Similarity | NPC476009 |
0.8298 | Intermediate Similarity | NPC126156 |
0.828 | Intermediate Similarity | NPC477131 |
0.8229 | Intermediate Similarity | NPC186861 |
0.8229 | Intermediate Similarity | NPC471381 |
0.8211 | Intermediate Similarity | NPC181151 |
0.8211 | Intermediate Similarity | NPC304445 |
0.8211 | Intermediate Similarity | NPC236580 |
0.8193 | Intermediate Similarity | NPC320537 |
0.8193 | Intermediate Similarity | NPC143979 |
0.8191 | Intermediate Similarity | NPC475900 |
0.8163 | Intermediate Similarity | NPC473148 |
0.8144 | Intermediate Similarity | NPC67296 |
0.814 | Intermediate Similarity | NPC19841 |
0.8132 | Intermediate Similarity | NPC91248 |
0.8125 | Intermediate Similarity | NPC45125 |
0.8125 | Intermediate Similarity | NPC221615 |
0.8111 | Intermediate Similarity | NPC162071 |
0.8111 | Intermediate Similarity | NPC67493 |
0.8105 | Intermediate Similarity | NPC474297 |
0.8061 | Intermediate Similarity | NPC86077 |
0.8046 | Intermediate Similarity | NPC51507 |
0.8046 | Intermediate Similarity | NPC258965 |
0.8046 | Intermediate Similarity | NPC6823 |
0.8046 | Intermediate Similarity | NPC156658 |
0.8022 | Intermediate Similarity | NPC190753 |
0.8022 | Intermediate Similarity | NPC186148 |
0.8022 | Intermediate Similarity | NPC270270 |
0.8021 | Intermediate Similarity | NPC169205 |
0.8 | Intermediate Similarity | NPC235792 |
0.8 | Intermediate Similarity | NPC54737 |
0.8 | Intermediate Similarity | NPC167893 |
0.7979 | Intermediate Similarity | NPC472874 |
0.7979 | Intermediate Similarity | NPC135776 |
0.7978 | Intermediate Similarity | NPC54468 |
0.7957 | Intermediate Similarity | NPC301969 |
0.7957 | Intermediate Similarity | NPC474323 |
0.7957 | Intermediate Similarity | NPC37607 |
0.7957 | Intermediate Similarity | NPC206614 |
0.7938 | Intermediate Similarity | NPC141191 |
0.7935 | Intermediate Similarity | NPC224652 |
0.7935 | Intermediate Similarity | NPC58219 |
0.7935 | Intermediate Similarity | NPC177629 |
0.7921 | Intermediate Similarity | NPC26617 |
0.7917 | Intermediate Similarity | NPC185553 |
0.7917 | Intermediate Similarity | NPC230800 |
0.7907 | Intermediate Similarity | NPC208223 |
0.79 | Intermediate Similarity | NPC100487 |
0.79 | Intermediate Similarity | NPC203659 |
0.7889 | Intermediate Similarity | NPC156485 |
0.7879 | Intermediate Similarity | NPC474747 |
0.7879 | Intermediate Similarity | NPC225353 |
0.7857 | Intermediate Similarity | NPC70865 |
0.7849 | Intermediate Similarity | NPC295312 |
0.7849 | Intermediate Similarity | NPC4986 |
0.7849 | Intermediate Similarity | NPC92974 |
0.7843 | Intermediate Similarity | NPC68248 |
0.7835 | Intermediate Similarity | NPC477949 |
0.7822 | Intermediate Similarity | NPC243998 |
0.7822 | Intermediate Similarity | NPC166115 |
0.7812 | Intermediate Similarity | NPC193645 |
0.7812 | Intermediate Similarity | NPC469873 |
0.7812 | Intermediate Similarity | NPC48803 |
0.7812 | Intermediate Similarity | NPC275960 |
0.7812 | Intermediate Similarity | NPC90121 |
0.7802 | Intermediate Similarity | NPC255307 |
0.7802 | Intermediate Similarity | NPC165162 |
0.78 | Intermediate Similarity | NPC475871 |
0.78 | Intermediate Similarity | NPC110989 |
0.78 | Intermediate Similarity | NPC475945 |
0.7789 | Intermediate Similarity | NPC125674 |
0.7789 | Intermediate Similarity | NPC475912 |
0.7789 | Intermediate Similarity | NPC228451 |
0.7789 | Intermediate Similarity | NPC475838 |
0.7778 | Intermediate Similarity | NPC308824 |
0.7778 | Intermediate Similarity | NPC242666 |
0.7767 | Intermediate Similarity | NPC59489 |
0.7767 | Intermediate Similarity | NPC139838 |
0.7766 | Intermediate Similarity | NPC71533 |
0.7766 | Intermediate Similarity | NPC129419 |
0.7766 | Intermediate Similarity | NPC475855 |
0.7766 | Intermediate Similarity | NPC246173 |
0.7766 | Intermediate Similarity | NPC106510 |
0.7765 | Intermediate Similarity | NPC48641 |
0.7753 | Intermediate Similarity | NPC47635 |
0.7742 | Intermediate Similarity | NPC476803 |
0.7742 | Intermediate Similarity | NPC202672 |
0.7742 | Intermediate Similarity | NPC476805 |
0.7732 | Intermediate Similarity | NPC39859 |
0.7732 | Intermediate Similarity | NPC158416 |
0.7732 | Intermediate Similarity | NPC284518 |
0.7732 | Intermediate Similarity | NPC470883 |
0.7732 | Intermediate Similarity | NPC76862 |
0.7717 | Intermediate Similarity | NPC475461 |
0.7717 | Intermediate Similarity | NPC474949 |
0.7717 | Intermediate Similarity | NPC475019 |
0.7717 | Intermediate Similarity | NPC305475 |
0.7708 | Intermediate Similarity | NPC474338 |
0.7708 | Intermediate Similarity | NPC474247 |
0.7708 | Intermediate Similarity | NPC167219 |
0.77 | Intermediate Similarity | NPC164551 |
0.7692 | Intermediate Similarity | NPC158756 |
0.7692 | Intermediate Similarity | NPC474780 |
0.7692 | Intermediate Similarity | NPC212363 |
0.7692 | Intermediate Similarity | NPC114979 |
0.7692 | Intermediate Similarity | NPC476804 |
0.7692 | Intermediate Similarity | NPC191476 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC38392 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.7921 | Intermediate Similarity | NPD7899 | Clinical (unspecified phase) |
0.7849 | Intermediate Similarity | NPD1695 | Approved |
0.7812 | Intermediate Similarity | NPD1698 | Clinical (unspecified phase) |
0.7524 | Intermediate Similarity | NPD6371 | Approved |
0.7396 | Intermediate Similarity | NPD5785 | Approved |
0.734 | Intermediate Similarity | NPD4249 | Approved |
0.7263 | Intermediate Similarity | NPD4251 | Approved |
0.7263 | Intermediate Similarity | NPD4250 | Approved |
0.7234 | Intermediate Similarity | NPD5363 | Approved |
0.7097 | Intermediate Similarity | NPD4269 | Approved |
0.7097 | Intermediate Similarity | NPD4270 | Approved |
0.7021 | Intermediate Similarity | NPD5362 | Discontinued |
0.6989 | Remote Similarity | NPD5369 | Approved |
0.6979 | Remote Similarity | NPD5786 | Approved |
0.6909 | Remote Similarity | NPD6053 | Discontinued |
0.6882 | Remote Similarity | NPD5790 | Clinical (unspecified phase) |
0.6882 | Remote Similarity | NPD4252 | Approved |
0.6875 | Remote Similarity | NPD6082 | Clinical (unspecified phase) |
0.6869 | Remote Similarity | NPD6698 | Approved |
0.6869 | Remote Similarity | NPD46 | Approved |
0.6842 | Remote Similarity | NPD7154 | Phase 3 |
0.6832 | Remote Similarity | NPD5282 | Discontinued |
0.68 | Remote Similarity | NPD7983 | Approved |
0.6737 | Remote Similarity | NPD6435 | Approved |
0.6733 | Remote Similarity | NPD5778 | Approved |
0.6733 | Remote Similarity | NPD5779 | Approved |
0.6731 | Remote Similarity | NPD4225 | Approved |
0.6702 | Remote Similarity | NPD4820 | Approved |
0.6702 | Remote Similarity | NPD4821 | Approved |
0.6702 | Remote Similarity | NPD4822 | Approved |
0.6702 | Remote Similarity | NPD4819 | Approved |
0.6701 | Remote Similarity | NPD1733 | Clinical (unspecified phase) |
0.6667 | Remote Similarity | NPD7639 | Approved |
0.6667 | Remote Similarity | NPD4271 | Approved |
0.6667 | Remote Similarity | NPD4268 | Approved |
0.6667 | Remote Similarity | NPD7640 | Approved |
0.6632 | Remote Similarity | NPD4790 | Discontinued |
0.6571 | Remote Similarity | NPD7638 | Approved |
0.6535 | Remote Similarity | NPD7838 | Discovery |
0.6526 | Remote Similarity | NPD5368 | Approved |
0.6495 | Remote Similarity | NPD5331 | Approved |
0.6495 | Remote Similarity | NPD5332 | Approved |
0.6471 | Remote Similarity | NPD7637 | Suspended |
0.6396 | Remote Similarity | NPD6686 | Approved |
0.6379 | Remote Similarity | NPD7115 | Discovery |
0.6372 | Remote Similarity | NPD8413 | Clinical (unspecified phase) |
0.6316 | Remote Similarity | NPD4238 | Approved |
0.6316 | Remote Similarity | NPD4802 | Phase 2 |
0.6316 | Remote Similarity | NPD5784 | Clinical (unspecified phase) |
0.6275 | Remote Similarity | NPD6101 | Approved |
0.6275 | Remote Similarity | NPD5764 | Clinical (unspecified phase) |
0.6262 | Remote Similarity | NPD8029 | Clinical (unspecified phase) |
0.625 | Remote Similarity | NPD6399 | Phase 3 |
0.6239 | Remote Similarity | NPD7632 | Discontinued |
0.6226 | Remote Similarity | NPD7839 | Suspended |
0.6216 | Remote Similarity | NPD6008 | Approved |
0.6167 | Remote Similarity | NPD8513 | Phase 3 |
0.6167 | Remote Similarity | NPD8516 | Approved |
0.6167 | Remote Similarity | NPD8517 | Approved |
0.6167 | Remote Similarity | NPD8515 | Approved |
0.6154 | Remote Similarity | NPD8034 | Phase 2 |
0.6154 | Remote Similarity | NPD6411 | Approved |
0.6154 | Remote Similarity | NPD8035 | Phase 2 |
0.6148 | Remote Similarity | NPD7492 | Approved |
0.6147 | Remote Similarity | NPD5344 | Discontinued |
0.6121 | Remote Similarity | NPD8133 | Approved |
0.6106 | Remote Similarity | NPD5345 | Clinical (unspecified phase) |
0.6098 | Remote Similarity | NPD6616 | Approved |
0.6083 | Remote Similarity | NPD6319 | Approved |
0.6083 | Remote Similarity | NPD6054 | Approved |
0.608 | Remote Similarity | NPD7319 | Approved |
0.6061 | Remote Similarity | NPD4752 | Clinical (unspecified phase) |
0.6048 | Remote Similarity | NPD7078 | Approved |
0.6047 | Remote Similarity | NPD3198 | Approved |
0.604 | Remote Similarity | NPD1694 | Approved |
0.6033 | Remote Similarity | NPD6016 | Approved |
0.6033 | Remote Similarity | NPD8268 | Approved |
0.6033 | Remote Similarity | NPD8269 | Approved |
0.6033 | Remote Similarity | NPD6015 | Approved |
0.6033 | Remote Similarity | NPD8266 | Approved |
0.6033 | Remote Similarity | NPD8267 | Approved |
0.6019 | Remote Similarity | NPD6084 | Phase 2 |
0.6019 | Remote Similarity | NPD6083 | Phase 2 |
0.6018 | Remote Similarity | NPD5697 | Approved |
0.6018 | Remote Similarity | NPD6412 | Phase 2 |
0.6 | Remote Similarity | NPD7736 | Approved |
0.5984 | Remote Similarity | NPD5988 | Approved |
0.5984 | Remote Similarity | NPD6370 | Approved |
0.5981 | Remote Similarity | NPD5695 | Phase 3 |
0.5968 | Remote Similarity | NPD7507 | Approved |
0.5965 | Remote Similarity | NPD6899 | Approved |
0.5965 | Remote Similarity | NPD7320 | Approved |
0.5965 | Remote Similarity | NPD6881 | Approved |
0.5963 | Remote Similarity | NPD5696 | Approved |
0.5962 | Remote Similarity | NPD5370 | Suspended |
0.595 | Remote Similarity | NPD6059 | Approved |
0.5948 | Remote Similarity | NPD6649 | Approved |
0.5948 | Remote Similarity | NPD6650 | Approved |
0.5941 | Remote Similarity | NPD7338 | Clinical (unspecified phase) |
0.5929 | Remote Similarity | NPD6675 | Approved |
0.5929 | Remote Similarity | NPD5739 | Approved |
0.5929 | Remote Similarity | NPD7128 | Approved |
0.5929 | Remote Similarity | NPD6402 | Approved |
0.592 | Remote Similarity | NPD8293 | Discontinued |
0.592 | Remote Similarity | NPD8074 | Phase 3 |
0.5913 | Remote Similarity | NPD4061 | Clinical (unspecified phase) |
0.5913 | Remote Similarity | NPD6014 | Approved |
0.5913 | Remote Similarity | NPD6373 | Approved |
0.5913 | Remote Similarity | NPD6372 | Approved |
0.5913 | Remote Similarity | NPD6013 | Approved |
0.5913 | Remote Similarity | NPD6012 | Approved |
0.5909 | Remote Similarity | NPD6648 | Approved |
0.5906 | Remote Similarity | NPD6007 | Clinical (unspecified phase) |
0.59 | Remote Similarity | NPD5209 | Approved |
0.5889 | Remote Similarity | NPD9496 | Clinical (unspecified phase) |
0.5882 | Remote Similarity | NPD7520 | Clinical (unspecified phase) |
0.5877 | Remote Similarity | NPD5701 | Approved |
0.5865 | Remote Similarity | NPD6903 | Approved |
0.5862 | Remote Similarity | NPD5955 | Clinical (unspecified phase) |
0.5862 | Remote Similarity | NPD6883 | Approved |
0.5862 | Remote Similarity | NPD7290 | Approved |
0.5862 | Remote Similarity | NPD7102 | Approved |
0.5849 | Remote Similarity | NPD4810 | Clinical (unspecified phase) |
0.5847 | Remote Similarity | NPD4632 | Approved |
0.5842 | Remote Similarity | NPD4788 | Approved |
0.5842 | Remote Similarity | NPD6695 | Phase 3 |
0.5841 | Remote Similarity | NPD4056 | Clinical (unspecified phase) |
0.5841 | Remote Similarity | NPD4057 | Clinical (unspecified phase) |
0.584 | Remote Similarity | NPD8273 | Phase 1 |
0.5826 | Remote Similarity | NPD6011 | Approved |
0.5825 | Remote Similarity | NPD7146 | Approved |
0.5825 | Remote Similarity | NPD6409 | Approved |
0.5825 | Remote Similarity | NPD7521 | Approved |
0.5825 | Remote Similarity | NPD6684 | Approved |
0.5825 | Remote Similarity | NPD5330 | Approved |
0.5825 | Remote Similarity | NPD7334 | Approved |
0.5812 | Remote Similarity | NPD6847 | Approved |
0.5812 | Remote Similarity | NPD8130 | Phase 1 |
0.5812 | Remote Similarity | NPD6869 | Approved |
0.5812 | Remote Similarity | NPD6617 | Approved |
0.5804 | Remote Similarity | NPD5211 | Phase 2 |
0.5784 | Remote Similarity | NPD3665 | Phase 1 |
0.5784 | Remote Similarity | NPD3133 | Approved |
0.5784 | Remote Similarity | NPD3666 | Approved |
0.5763 | Remote Similarity | NPD8297 | Approved |
0.5763 | Remote Similarity | NPD6882 | Approved |
0.5743 | Remote Similarity | NPD3667 | Approved |
0.5739 | Remote Similarity | NPD6685 | Approved |
0.5726 | Remote Similarity | NPD4634 | Approved |
0.5714 | Remote Similarity | NPD7513 | Clinical (unspecified phase) |
0.5714 | Remote Similarity | NPD1700 | Approved |
0.5702 | Remote Similarity | NPD6009 | Approved |
0.5702 | Remote Similarity | NPD5141 | Approved |
0.5701 | Remote Similarity | NPD5281 | Approved |
0.5701 | Remote Similarity | NPD5284 | Approved |
0.5701 | Remote Similarity | NPD5693 | Phase 1 |
0.5699 | Remote Similarity | NPD229 | Approved |
0.5692 | Remote Similarity | NPD6845 | Suspended |
0.5688 | Remote Similarity | NPD6356 | Clinical (unspecified phase) |
0.5688 | Remote Similarity | NPD4629 | Approved |
0.5688 | Remote Similarity | NPD5210 | Approved |
0.5673 | Remote Similarity | NPD3618 | Phase 1 |
0.566 | Remote Similarity | NPD4753 | Phase 2 |
0.5659 | Remote Similarity | NPD5956 | Approved |
0.5656 | Remote Similarity | NPD7328 | Approved |
0.5656 | Remote Similarity | NPD7327 | Approved |
0.5645 | Remote Similarity | NPD6291 | Clinical (unspecified phase) |
0.5645 | Remote Similarity | NPD5983 | Phase 2 |
0.5645 | Remote Similarity | NPD8033 | Approved |
0.5639 | Remote Similarity | NPD7966 | Clinical (unspecified phase) |
0.5631 | Remote Similarity | NPD4786 | Approved |
0.5631 | Remote Similarity | NPD6400 | Clinical (unspecified phase) |
0.5625 | Remote Similarity | NPD4696 | Approved |
0.5625 | Remote Similarity | NPD5285 | Approved |
0.5625 | Remote Similarity | NPD5286 | Approved |
0.562 | Remote Similarity | NPD6274 | Approved |
0.5619 | Remote Similarity | NPD7524 | Approved |
0.5619 | Remote Similarity | NPD7750 | Discontinued |
0.5615 | Remote Similarity | NPD7260 | Phase 2 |
0.5614 | Remote Similarity | NPD5765 | Approved |
0.561 | Remote Similarity | NPD7516 | Approved |
0.5607 | Remote Similarity | NPD5207 | Approved |
0.5603 | Remote Similarity | NPD5954 | Clinical (unspecified phase) |
0.56 | Remote Similarity | NPD6929 | Approved |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.