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Graphics
of DNA, proteins, and drug-bound systems:
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need to have CHIME plug-in installed in order for you to view,
rotate and play with the graphics on the left-hand side. CHIME plug-in
is free and can be downloaded from this
site. Otherwise only the GIF version on the right-hand side
is viewable.
CHIME
plug-in is "live"; you can use the left mouse button to move
and rotate the molecule, and the right button (click and hold down the mouse
button on the Macintosh) to modify properties of the plug-in. Try it!
Also Click Here For More Graphics.
A short DNA
chain bound by two anticancer drugs
daunomycin.
DNA is composed of two chains winding
into a double helix. The bulk of daunomycin
is inserted into the space between base pairs.
The protein HIV-1
protease bound by an inhibitor.
Such an inhibitor has been designed
as anti-HIV drugs. A few of them are now in
the market. This protein is used by HIV-1 virus to cut a bundle of proteins
into functional individuals.
A short DNA
chain bound by an antibiotic drug
netropsin.
DNA is composed of two chains winding
into a double helix. Netropsin is bound
to the minor groove of DNA.
A protein calmodulin
in open (upper graph) and closed (lower graph) form. The open form is unligated
and the closed form is induced by the binding of a peptide (not shown here).
This protein mediates many Ca2+ regulated processes.
Click
Here For More Graphics.
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