Macromolecular Structures:

• GeneCards. A database of human genes, their products and their involvement in diseases. It offers concise information about the functions of all human genes that have an approved symbol, as well as selected others [gene listing].
  
  

• PROSITE. Protein families and domains. It consists of biologically significant sites, patterns and profiles that help to reliably identify to which known protein family (if any) a new sequence belongs. Mirror sites in Australia, Canada, China, Taiwan.
  
  

• PRINTS. Protein fingerprint database. A fingerprint is a group of conserved motifs used to characterise a protein family.
  
  

• PROCAT. A database of 3D enzyme active site templates.  It can be thought of as the 3D equivalent of the 1D templates found in sequence motif databases such as PROSITE and PRINTS.
  
  

• KEGG: Kyoto Encyclopedia of Genes and Genomes. Site contains  Pathway Info, Disease Catalogs, Cell Catalogs, Molecule Catalog, and Genomic Info. It also provides Links to Pathway and Other Databases.
  
  

• SPAD: Signaling Pathway Database. An integrated database for genetic information and signal transduction systems. Divided into four categories based on extracellular signal molecules (Growth factor, Cytokine, and Hormone) and stress, that initiate the intracellular signaling pathway.
  
  

• CSNDB: Cell Signaling Networks Database. It compiles the information on biological molecules, sequences, structures, functions, and biological reactions which transfer the cellular signals in human cells.
  
  

• PFBP: Protein Function and Biochemical Pathways. Site contains info about Biochemical Pathways, Pathway Analysis, and Links to Biochemical Networks Internet resources.
  
  

• Boehringer Mannheim Biochemical Pathways at ExPASy. Site gives access to the digitized version of the Boehringer Mannheim "Biochemical Pathways" wall chart.
  
  

• Database of Interacting Proteins. Database contains 9746 interactions among 5703 proteins.
  
  

• Protein Motions Database.  This database lists protein motions in a multi-level classification scheme.
  
  

• CLiBE: Computed Ligand Binding Energy Database. Database provides info about ligand-receptor interacion energy, ligand classification, function, structure and other properties.  It currently contains 11,635 entries (2,532 distinctive ligands and 1,997 distinctive receptors).
  
  

• The NCI Drug Information System 3D Database.  A collection of 3D structures for over 400,000 drugs which was built and is maintained by the Developmental Therapuetics Program Division of Cancer Treatment, National Cancer Institute. The database is an extension of the NCI Drug Information System.
  
  

• Molecular Models from Chemistry at Okanagan University College. Database of over 1250 PDB files of nicely categorized compounds. Compounds can be accessed by type of function, molecular origin, functional group, formula index, and alphabetic index etc.
  
  

• Chemicals with Pharmaceutical Activity - A 3D Structural Database. Database contains 400 compounds in alphabetical order. Located at Oxford University UK. This site also hosts Molecules of the Month web-page.
  
  

• 3D Pharmaceutical Structures at Tokyo University. This site (3D Molecular Modeling Homepage of Tokyo University of Pharmacy and Life Science) contains 3D structure of a number of pharmaceutical compounds. It also provides animation of motions, links to pharmaceutical companies and other databases.
  
  

• Klotho: Biochemical Compounds Declarative Database. Database of over 400 biochemical compounds and computational mechanics at Washington University in St. Louis.
  
  

• AntiCancer Agent Mechanism Database.  Structural and biological info for a set of 122 compounds with anticancer activity and reasonablly well known mechanism of action.
  
  

• AntiCancer Standard Agent Database.  Structural and biological info for a set of 175 compounds with anticancer activity.
  
  

• Molecules of the Month. This Oxford University web-site posts every month's high-impact molecules since January 1996.
  
  

• Hetero-compound Information Centre - Uppsala. Information about hetero-compounds (small molecules) found in PDB files.
  
  

• Smells. Database of odorous micromolecules from UC Berkeley.
  
  

• CLiBE: Computed Ligand Binding Energy Database. Database provides info about ligand-receptor interacion energy, ligand classification, function, structure and other properties.  It currently contains 11,635 entries (2,532 distinctive ligands and 1,997 distinctive receptors).
  
  

• TTD: Therapeutic Target Database. A database to provide information about the known and newly proposed therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs/ligands directed at each of these targets. Links to relevant databases also provided.
  
  

• MedChem/Biobyte QSAR Database.   A collection of 10,000 of  QSAR datasets that covers both biological and physical-organic chemistry.
  
  

• RELIBase: Receptor/Ligand Complex Database.     An object oriented comprehensive receptor-ligand database.
  
  

• AntiCancer Agent Mechanism Database.  Structural and biological info for a set of 122 compounds with anticancer activity and reasonablly well known mechanism of action.
  
  

• AntiCancer Standard Agent Database.  Structural and biological info for a set of 175 compounds with anticancer activity.
  
  

• Drug Discovery Databases Compiled by The Biophysical Pharmacology Group at NCI. Site has links to several therapeutics program databases and tools, and a 2D-Gel protein expression database.
  
  

• Drug ADME Associated Protein Database. A database for facilitating the search for drug Absorption, Distribution, Metabolism, Excretion associated proteins. It contains information about known drug ADME associated proteins, functions, similarities, substrates / ligands, tissue distributions, and other properties of the targets. Associated references are also included. Currently this database contains 321 protein entries.
  
  

• Drug Adverse Reaction Target (DART). A database for facilitating the search for drug adverse reaction target. It contains information about known drug adverse rection targets, functions and properties. Associated references are also included.
  
  

• Virtual Drug Store Search Database. Site contains information on useage, function, side effect, drug interactions, and literature of clinically used drugs.
  
  

• Pharmaceutical Information Network . A comprehensive information database about drugs and diseases.
  
  

• U. S. Food and Drug Administration Center for Drug Evaluation and Research.
  
  

• Side Effect Registry for Antidepressant Drugs. Site provides side effect data on a number of antidepressant drugs.
  
  

• Internet Mental Health . Site contains information on 67 most common psychiatric drugs as well as that for most common mental disorders and internet links.
  
  

• Internet Drug Index. Comprehensive information about prescription and over the counter drugs. Site also gives list of top 200 drugs in each year since 1996.
  
  

• Health Answers. Site contains information on symptoms and iseases (definition, what is going on, symptom, diagnostics and treatment etc.) and drugs (their uses, side effects, and generic and brand names etc.). A convenient keyword search facility.
  
  

• TOXNET. A cluster of databases on toxicology, hazardous chemicals, and related areas.
  
  

• CenterWatch.  A general database of clinical trials divided into four main sections: listings for more than 7,500 clinical trials, searchable by therapeutic area and geographic region; newly approved drug therapies; and research center and industry provider profiles.
  
  

• OncoLink. Comprehensive listing of Internet clinical trial resources, as well as a searchable database of all open UPCC clinical trials, frequently asked questions, and news.
  
  

• CancerNet. Containing information on over 1,600 open clinical trials, including all NCI funded studies, this is the most comprehensive resource for locating clinical trials in the US.
  
  

• HerbNET. For everything herbal.
  
  

• HerbMe. An interactive, electronic herbal database - provides hyperlinked access to the cientific data underlying the use of herbs for health.
  
  

• The Vaults of Erowid. A collection of information and links about ethnobotany, and the medicinal use of plants.
  
  

• EthnoMedicinals Home Page.  Dedicated to the transfer of information on the use of herbs and other natural products in biochemistry, pharmacology, and traditional medicine.
  
  

• Medicinal and Poisonous Plant Databases. Info and internet links about specific plants, medical resources, pharmacognosy, herbalism, chemistry and molecular modeling.
  
  

• PDD - NIMH-NCI Protein-Disease Database. A relational database designed to answer questions regarding protein patterns found in common body fluids with respect to disease conditions discussed in the literature.
  
  

• Karolinska disease database. A catalog of Web resources for lay persons, health care professionals and scientists. Also features an alphabetical list of diseases.
  
  

• CancerNet. Oncology - for researchers, physicians, patients.
  
  

• The Chinese Medicine Sampler. General info about acupuncture, diagnostic methods of oriental medicine, herbal medicine, principles of and pathology guide to oriental medicine, and discussion about capability of oriental medicine. Site also provide links to other sites.
  
  

• Traditional Chinese Medicine. Information about chinese medicine, related resources and programmes.
  
  

• Native American Ethnobotany Database. It includs foods, drugs, dyes, fibers and other uses of plants (a total of over 44,000 items). This represents uses by 291 Native American groups of 4,029 species from 243 different plant families.
  
  

• The National Center for Complementary and Alternative Medicine.
  
  

• The Delphion Intellectual Property Network. Web site for searching, viewing, and analyzing patent documents. Database  include US patents, European patents and patent applications, PCT application data from the World Intellectual Property Office, Patent Abstracts of Japan, INPADOC family and legal status data, and IBM Technical Disclosure Bulletins.
  
  

• US Patent and Trademark Office USPTO Web Patent Databases. It offers access to separate bibliographic and full-text patent databases that cover the period from 1 January 1976 to the most recent weekly issue date.
  
  

• Federal Bio-Technology Transfer Directory. Database covers federal laboratory (e.g., NIH) inventions, licenses granted and Collaborative Research and Development Agreements (CRADAs) in the biomedical, biotechnology and pharmaceutical areas.
  
  

• Numerical Recipes Books On Line.  Provides the complete numerical recipes books in C, Fortran 77, and Fortran 90, in both Acrobat and PostScript format.