Prescription Description
| Prescription ID | TCMFx6817 |
| Pinyin Name | He Shou Wu Ke Li |
| Chinese Name | 何首乌颗粒 |
| English Name | He Shou Wu Granules |
| Function Description | 血劳, 眩晕, 耳鸣, 白å‘ç—‡, å´©æ¼ |
| Indications | Metrorrhagia disorder, Tinnitus disorder, Vertigo disorder, Abnormal uterine and vaginal bleeding, Tinnitus, Dizziness, Anemia |
| Disease ICD-11 Category |
SB93 [Metrorrhagia disorder (TM1), å´©æ¼ (TM1)
]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; GA2Z [Abnormal uterine or vaginal bleeding, unspecified, 异常å宫或阴é“出血，未特指的 ]; MC41 [Tinnitus, 耳鸣 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; MB21.1 [Amnesia, å¥å¿˜ç—‡ ]; |
| Human Tissues Associated with Indication | Brain |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
| TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
| TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
| TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
| TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1218 | Staphylococcus aureus |
| TCMT1229 | Enterococcus faecalis |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1438 | Plasmodium falciparum |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1464 | Hepatitis B virus |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples