TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx6390
Pinyin Name	Zhi Qi Guan Yan Pian
Chinese Name	支气管炎片
English Name	Zhi Qi Guan Yan Tablets
Function Description	哮喘
Indications	Asthma
Disease ICD-11 Category	CA23 [Asthma, 哮喘 ];
Human Tissues Associated with Indication	Lung
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH8	Rehmannia glutinosa	矮地黄	TCMH8	ITSAH4578-14
TCMH986	Scutellaria baicalensis	黄芩	TCMH986	ITSAP4211-14
TCMH456	Rhizoma dioscoreae nipponicae	地龙	TCMH456
TCMH628	Glycyrrhiza uralensis	甘草	TCMH628	ITSAM892-14
TCMH2394	NA	盐酸麻黄碱	TCMH2394

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT128	TNKS2	Tankyrase-2	Transferase	Q9H2K2
TCMT129	TNKS	Tankyrase-1	Transferase	O95271
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT209	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	Oxidoreductase	P80365
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT231	GBA2	Beta-glucosidase	Hydrolase	Q9HCG7
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT240	AMY1A	Salivary alpha-amylase	Unclassified	P04745
TCMT249	CDK6	Cyclin-dependent kinase 6	Kinase	Q00534
TCMT254	CBR1	Carbonyl reductase [NADPH] 1	Oxidoreductase	P16152
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT283	PTPRS	Receptor-type tyrosine-protein phosphatase S	Hydrolase	Q13332
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT318	HKDC1	Putative hexokinase HKDC1	Transferase	Q2TB90
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT384	GRK6	G protein-coupled receptor kinase 6	Kinase	P43250
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT47	BCL2	Apoptosis regulator Bcl-2	Ion channel	P10415
TCMT506	PTK2B	Protein tyrosine kinase 2 beta	Kinase	Q14289
TCMT563	CDC25B	Dual specificity phosphatase Cdc25B	Hydrolase	P30305
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT614	EGLN1	Egl nine homolog 1	Oxidoreductase	Q9GZT9
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT801	TUBB3	Tubulin beta-3 chain	Unclassified	Q13509
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1170	Enterobacter cloacae
TCMT1175	Human immunodeficiency virus
TCMT1176	Streptococcus pneumoniae
TCMT1178	Actinomyces viscosus
TCMT1179	Escherichia coli ATCC 8739
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1186	Plasmodium yoelii yoelii
TCMT1191	Bacillus megaterium
TCMT1209	Staphylococcus haemolyticus
TCMT1212	Verticillium dahliae
TCMT1214	Enterococcus faecium
TCMT1215	Pseudomonas aeruginosa PAO1
TCMT1217	Bacillus anthracis
TCMT1218	Staphylococcus aureus
TCMT1223	Staphylococcus epidermidis
TCMT1224	Proteus mirabilis
TCMT1226	Klebsiella pneumoniae
TCMT1227	Streptococcus
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1234	Bacillus coagulans
TCMT1235	Clostridium sporogenes
TCMT1236	Mycobacterium bovis
TCMT1237	Mycobacterium kansasii
TCMT1238	Mycobacterium xenopi
TCMT1239	Mycobacterium marinum
TCMT1243	Aspergillus flavus
TCMT1246	Escherichia coli
TCMT1248	Hepatitis C virus
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1260	Streptococcus agalactiae
TCMT1284	Penicillium expansum
TCMT1286	Bacillus cereus
TCMT1294	Human parainfluenza virus 3
TCMT1319	Corynebacterium xerosis
TCMT1322	Streptococcus mitis
TCMT1323	Corynebacterium pseudodiphtheriticum
TCMT1324	Corynebacterium diphtheriae
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1361	Neisseria meningitidis
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410	Listeria monocytogenes
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1457	Leishmania major
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Zhi Qi Guan Yan Tablets