TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx5030
Pinyin Name	Niu Huang Qin Hua Wan
Chinese Name	牛黄噙化丸
English Name	Niu Huang Qin Hua Pills
Function Description	喉喑
Indications	Hoarseness disorder
Disease ICD-11 Category	SC92 [Hoarseness disorder (TM1), 喉喑 (TM1) ];
Human Tissues Associated with Indication	Lung
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH1952	NA	柿霜	TCMH1952
TCMH1613	Sal sedatirum	硼砂	TCMH1613
TCMH972	Coptis chinensis	黄连	TCMH972	ITSAO4469-14
TCMH2329	Realgar	雄黄	TCMH2329
TCMH1102	Tinospora capillipes	金果榄	TCMH1102	ITSAP1073-14
TCMH183	Dryobalanops aromatica	冰片	TCMH183	GBVK4926-11
TCMH1573	Bovis calculus	牛黄	TCMH1573
TCMH1880	Moschus moschiferus	麝香	TCMH1880	GBMA2112-09
TCMH1383	Onobrychis viciifolia	绿豆	TCMH1383	ITSAJ2861-14

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT187	AR	Androgen Receptor	Nuclear receptor	P10275
TCMT203	G6PD	Glucose-6-phosphate 1-dehydrogenase	Oxidoreductase	P11413
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT230	HSD17B3	Estradiol 17-beta-dehydrogenase 3	Oxidoreductase	P37058
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT27	DRD1	Dopamine D1 receptor	GPCR	P21728
TCMT322	MMP13	Matrix metalloproteinase 13	Hydrolase	P45452
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT784	AVPR2	Vasopressin V2 receptor	GPCR	P30518
TCMT785	CXCR1	Interleukin-8 receptor A	GPCR	P25024
TCMT786	CCR4	C-C chemokine receptor type 4	GPCR	P51679
TCMT791	PKN1	Protein kinase N1	Kinase	Q16512
TCMT793	PYGL	Liver glycogen phosphorylase	Transferase	P06737
TCMT807	SLC22A12	Solute carrier family 22 member 12	Transporter	Q96S37
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718
TCMT974	GPER1	G-protein coupled estrogen receptor 1	GPCR	Q99527
TCMT99	SHBG	Testis-specific androgen-binding protein	Unclassified	P04278

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1178	Actinomyces viscosus
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1208	Escherichia coli K12
TCMT1209	Staphylococcus haemolyticus
TCMT1212	Verticillium dahliae
TCMT1218	Staphylococcus aureus
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1226	Klebsiella pneumoniae
TCMT1229	Enterococcus faecalis
TCMT1230	Human herpesvirus 5
TCMT1232	Pseudomonas aeruginosa
TCMT1236	Mycobacterium bovis
TCMT1246	Escherichia coli
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1286	Bacillus cereus
TCMT1289	Shigella dysenteriae
TCMT1305	Salmonella enteritidis
TCMT1318	Human T-lymphotropic virus 1
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1353	Plasmodium yoelii
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385	Candida shehatae
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1458	Filobasidiella neoformans
TCMT1460	Mycobacterium intracellulare
TCMT1462	Streptococcus mutans
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Niu Huang Qin Hua Pills