TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx4380
Pinyin Name	Huo Xue Jie Tong Gao
Chinese Name	活血解痛膏
English Name	Huo Xue Jie Tong Ointment
Function Description	跌打损伤, 痹病
Indications	Arthritis
Disease ICD-11 Category	FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with Indication	SkeletalMuscle, Blood
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH1228	Capsicum frutescens	辣椒	TCMH1228	ITSAL4555-14
TCMH1059	Glycine max	姜	TCMH1059	ITSAJ4675-14
TCMH296	Radix aconiti	川乌	TCMH296
TCMH517	Angelica pubescens	独活	TCMH517	ITSAF170-14
TCMH658	Nardostachys chinensis	甘松	TCMH658	GBVF2376-11
TCMH2585	Cinnamomum camphora	樟脑	TCMH2585	SDH069-14
TCMH183	Dryobalanops aromatica	冰片	TCMH183	GBVK4926-11
TCMH493	Oleum caryophylli	丁香油	TCMH493

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT139	CA6	Carbonic anhydrase VI	Lyase	P23280
TCMT140	CA5B	Carbonic anhydrase VB	Lyase	Q9Y2D0
TCMT141	CA5A	Carbonic anhydrase VA	Lyase	P35218
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT143	CA3	Carbonic anhydrase III	Lyase	P07451
TCMT154	PRKCD	Protein kinase C delta	Kinase	Q05655
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT189	DUSP3	Dual specificity protein phosphatase 3	Hydrolase	P51452
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT268	CYP2A13	Cytochrome P450 2A13	Oxidoreductase	Q16696
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT287	TAS2R31	Taste receptor type 2 member 31	GPCR	P59538
TCMT327	TRPV1	Vanilloid receptor	Ion channel	Q8NER1
TCMT337	XPO1	Exportin-1	Unclassified	O14980
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT354	AURKA	Serine/threonine-protein kinase Aurora-A	Kinase	O14965
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT377	INSR	Insulin receptor	Kinase	P06213
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT418	EPHB4	Ephrin type-B receptor 4	Kinase	P54760
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT436	NUAK1	NUAK family SNF1-like kinase 1	Kinase	O60285
TCMT45	APP	Beta amyloid A4 protein	Unclassified	P05067
TCMT457	FLT4	Vascular endothelial growth factor receptor 3	Kinase	P35916
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT502	TEK	Tyrosine-protein kinase TIE-2	Kinase	Q02763
TCMT536	PDGFRB	Platelet-derived growth factor receptor beta	Kinase	P09619
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT601	F2	Thrombin	Unclassified	P00734
TCMT626	BRAF	Serine/threonine-protein kinase B-raf	Kinase	P15056
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT689	TGM2	Protein-glutamine gamma-glutamyltransferase	Transferase	P21980
TCMT721	HSPA1A	Heat shock 70 kDa protein 1	Unclassified	P0DMV8
TCMT739	GPR35	G-protein coupled receptor 35	GPCR	Q9HC97
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT753	SMAD3	Mothers against decapentaplegic homolog 3	Unclassified	P84022
TCMT755	PLK4	Serine/threonine-protein kinase PLK4	Kinase	O00444
TCMT756	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Kinase	P41279
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT83	CD38	Lymphocyte differentiation antigen CD38	Unclassified	P28907
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1175	Human immunodeficiency virus
TCMT1178	Actinomyces viscosus
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1218	Staphylococcus aureus
TCMT1221	Human herpesvirus 4
TCMT1223	Staphylococcus epidermidis
TCMT1226	Klebsiella pneumoniae
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1246	Escherichia coli
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1286	Bacillus cereus
TCMT1294	Human parainfluenza virus 3
TCMT1321	Staphylococcus hominis
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Huo Xue Jie Tong Ointment