Prescription Description
| Prescription ID | TCMFx4073 |
| Pinyin Name | Li Te Min Pian |
| Chinese Name | 痢特æ•ç‰‡ |
| English Name | Li Te Min Tablets |
| Function Description | 痢疾, 腹泻 |
| Indications | Dysentery disorder, Diarrhea, Dysentery |
| Disease ICD-11 Category |
SA56 [Dysentery disorder (TM1), 痢疾 (TM1)
]; ME05.1 [Diarrhoea, 腹泻 ]; 1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, æœªç‰¹æŒ‡æ„ŸæŸ“æ€§ç—…åŽŸä½“çš„æ„ŸæŸ“æ€§èƒƒè‚ ç‚Žæˆ–ç»“è‚ ç‚Ž ]; |
| Human Tissues Associated with Indication | Intestine, Stomach |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
| TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT337 | XPO1 | Exportin-1 | Unclassified | O14980 |
| TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
| TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
| TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
| TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
| TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
| TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
| TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
| TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
| TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
| TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
| TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
| TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
| TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
| TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
| TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
| TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
| TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
| TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
| TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1212 | Verticillium dahliae |
| TCMT1246 | Escherichia coli |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples