Prescription Description
| Prescription ID | TCMFx3810 |
| Pinyin Name | Cang Er Zi Bi Yan Jiao Nang |
| Chinese Name | 苍耳子鼻炎胶囊 |
| English Name | Cang Er Zi Bi Yan Capsules |
| Function Description | 鼻鼽, 鼻渊, 鼻窒 |
| Indications | Allergic rhinitis disorder, Nasal sinusitis disorder, Allergic rhinitis |
| Disease ICD-11 Category |
SC90 [Allergic rhinitis disorder (TM1), 鼻鼽 (TM1)
]; SC91 [Nasal sinusitis disorder (TM1), 鼻渊 (TM1) ]; CA08.0 [Allergic rhinitis, 变应性鼻炎 ]; |
| Human Tissues Associated with Indication | Nose |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH207 | Fructus xanthii sibirici | 苍耳子浸膏粉 | TCMH207 | KJ496390 |
| TCMH1932 | NA | 石膏浸膏粉 | TCMH1932 | |
| TCMH119 | Angelica dahurica | 白芷浸膏粉 | TCMH119 | ITSAK3312-14 |
| TCMH183 | Dryobalanops aromatica | 冰片 | TCMH183 | GBVK4926-11 |
| TCMH2318 | NA | 辛夷花挥发油 | TCMH2318 | |
| TCMH189 | Mentholum | 薄荷脑 | TCMH189 | |
| TCMH2319 | Magnolia liliflora | 辛夷花浸膏粉 | TCMH2319 | GBVT919-13, GBVT884-13 |
| TCMH990 | Scutellaria baicalensis | 黄芩浸膏粉 | TCMH990 | ITSAP4211-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT232 | ABCB1 | P-glycoprotein 1 | Transporter | P08183 |
| TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
| TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT283 | PTPRS | Receptor-type tyrosine-protein phosphatase S | Hydrolase | Q13332 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
| TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
| TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT594 | PTAFR | Platelet activating factor receptor | GPCR | P25105 |
| TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
| TCMT801 | TUBB3 | Tubulin beta-3 chain | Unclassified | Q13509 |
| TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1191 | Bacillus megaterium |
| TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1214 | Enterococcus faecium |
| TCMT1217 | Bacillus anthracis |
| TCMT1218 | Staphylococcus aureus |
| TCMT1219 | Enterococcus |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1236 | Mycobacterium bovis |
| TCMT1245 | Phytophthora cactorum |
| TCMT1246 | Escherichia coli |
| TCMT1249 | Dengue virus 2 |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1260 | Streptococcus agalactiae |
| TCMT1286 | Bacillus cereus |
| TCMT1319 | Corynebacterium xerosis |
| TCMT1321 | Staphylococcus hominis |
| TCMT1322 | Streptococcus mitis |
| TCMT1323 | Corynebacterium pseudodiphtheriticum |
| TCMT1324 | Corynebacterium diphtheriae |
| TCMT1343 | Staphylococcus simulans |
| TCMT1344 | Staphylococcus sciuri |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1370 | Prevotella melaninogenica |
| TCMT1408 | Colletotrichum gloeosporioides |
| TCMT1410 | Listeria monocytogenes |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1439 | Mycobacterium smegmatis |
| TCMT1442 | Leishmania donovani |
| TCMT1444 | Fusarium oxysporum |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1449 | Influenza A virus |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1464 | Hepatitis B virus |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples