TCM Prescription: Gua Zi Ding



Prescription Description
Prescription IDTCMFx3662
Pinyin NameGua Zi Ding
Chinese Name瓜子锭
English NameGua Zi Ding
Function Description哮喘, 喘病, 急惊风
IndicationsAcute convulsion disorder, Dyspnea, Convulsions, Asthma
Disease ICD-11 Category SE33 [Acute convulsion disorder (TM1), 急惊风 (TM1) ];
MD11.5 [Dyspnoea, 呼吸困难 ];
8A68.Z [Type of seizure, unspecified, 癫痫发作类型,未特指的 ];
CA23 [Asthma, 哮喘 ];
Human Tissues Associated with IndicationHeart, Brain, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1871 NA 蛇含石 TCMH1871
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH1692 Lapis chloriti 青礞石 TCMH1692
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH1060 Bombyx batryticatus 僵蚕 TCMH1060
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1462 Streptococcus mutans
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway