Prescription Description
| Prescription ID | TCMFx293 |
| Pinyin Name | Xiao Huo Luo Wan |
| Chinese Name | å°æ´»ç»œä¸¸ |
| English Name | Xiao Huo Luo Pills |
| Function Description | 风寒湿邪é—阻, 痰瘀阻络所致的痹病, ç—‡è§è‚¢ä½“关节疼痛, 或冷痛, 或刺痛 |
| Indications | Arthritis, Rheumatoid arthritis |
| Disease ICD-11 Category |
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的
]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
| Human Tissues Associated with Indication | Blood, SkeletaMuscle |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH404 | Rhizoma arisaema cum bile | 胆å—星 | TCMH404 | |
| TCMH296 | Radix aconiti | å·ä¹Œ | TCMH296 | |
| TCMH222 | Aconitum carmichaelii | è‰ä¹Œ | TCMH222 | ITSAH2410-14 |
| TCMH456 | Rhizoma dioscoreae nipponicae | 地龙 | TCMH456 | |
| TCMH1508 | Commiphora myrrha | æ²¡è¯ | TCMH1508 | MH522406 |
| TCMH1753 | Boswellia carterii | 乳香 | TCMH1753 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT17 | POLB | DNA polymerase beta | Transferase | P06746 |
| TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
| TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT289 | TBXAS1 | Thromboxane-A synthase | Isomerase | P24557 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT318 | HKDC1 | Putative hexokinase HKDC1 | Transferase | Q2TB90 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
| TCMT636 | POLA1 | DNA polymerase alpha subunit | Transferase | P09884 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT783 | NR3C2 | Mineralocorticoid receptor | Nuclear receptor | P08235 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT904 | PGR | Progesterone receptor | Nuclear receptor | P06401 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1212 | Verticillium dahliae |
| TCMT1218 | Staphylococcus aureus |
| TCMT1219 | Enterococcus |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1245 | Phytophthora cactorum |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1408 | Colletotrichum gloeosporioides |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1442 | Leishmania donovani |
| TCMT1449 | Influenza A virus |
| TCMT1454 | Bacillus subtilis |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples