Prescription Description
| Prescription ID | TCMFx2233 |
| Pinyin Name | Niu Huang Bao Long Wan |
| Chinese Name | 牛黄抱龙丸 |
| English Name | Niuhuang Baolong Pills |
| Function Description | 急惊风 |
| Indications | Acute convulsion disorder, Convulsions |
| Disease ICD-11 Category |
SE33 [Acute convulsion disorder (TM1), 急惊风 (TM1)
]; 8A68.Z [Type of seizure, unspecified, 癫痫发作类型，未特指的 ]; |
| Human Tissues Associated with Indication | Heart, Brain |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1573 | Bovis calculus | 牛黄 | TCMH1573 | |
| TCMH404 | Rhizoma arisaema cum bile | 胆南星 | TCMH404 | |
| TCMH2102 | Concretio silicea bambusae | 天竺黄 | TCMH2102 | |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH916 | Succinus | 琥珀 | TCMH916 | |
| TCMH1880 | Moschus moschiferus | 麝香 | TCMH1880 | GBMA2112-09 |
| TCMH1709 | Buthus martensi | 全蝎 | TCMH1709 | |
| TCMH1060 | Bombyx batryticatus | 僵蚕 | TCMH1060 | |
| TCMH2329 | Realgar | 雄黄 | TCMH2329 | |
| TCMH2682 | Cinnabaris | 朱砂 | TCMH2682 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
| TCMT203 | G6PD | Glucose-6-phosphate 1-dehydrogenase | Oxidoreductase | P11413 |
| TCMT230 | HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | Oxidoreductase | P37058 |
| TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
| TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
| TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
| TCMT807 | SLC22A12 | Solute carrier family 22 member 12 | Transporter | Q96S37 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
| TCMT974 | GPER1 | G-protein coupled estrogen receptor 1 | GPCR | Q99527 |
| TCMT99 | SHBG | Testis-specific androgen-binding protein | Unclassified | P04278 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1212 | Verticillium dahliae |
| TCMT1218 | Staphylococcus aureus |
| TCMT1245 | Phytophthora cactorum |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1408 | Colletotrichum gloeosporioides |
| TCMT1442 | Leishmania donovani |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples