TCM Prescription: Zhi Kang Granules



Prescription Description
Prescription IDTCMF918
Pinyin NameZhi Kang Ke Li 
Chinese Name脂康颗粒
English NameZhi Kang Granules
Function Description脂血症
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationBrain, Blood, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.14203
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.76441
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.34118
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 6.24455
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.16575
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.00315
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 5.96468
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FUT7, PIM1, PPARA, TYR, XDH 5.73364
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.73254
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 5.47255
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 5.36461
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 5.12017
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, XDH 5.06614
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.86228
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 4.8354
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, EPHX2, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.82624
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 4.81616
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.57796
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 4.56463
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.43177
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, FLT3, MET, PIM1, SRC, TYR 4.43177
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36473
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.36282
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.34374
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.18847
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.09335
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 4.06016
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 4.06016
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 4.05179
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 4.02869
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.99521
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.98545
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 3.97075
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 3.95453
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.87622
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.87622
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.87622
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.81856
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.81856
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.81047
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, MET, PPARA 3.74387
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 3.7412
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 3.72713
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.7135
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.70262
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EPHX2, KDR, SRC 3.70149
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.69554
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.6085
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.5814
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.53486
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.39539
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27486
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.25915
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TYR 3.17396
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.03488
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 2.97585
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96334
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.95744
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.94334
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.94334
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.87074
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 2.84601
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.84424
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.80679
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.79695
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.78585
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.78585
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.78585
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC 2.76381
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 2.76348
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA 2.74863
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 2.72218
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.69978
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2, RORC 2.69978
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 2.68472
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2 2.68442
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.62824
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.6175
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.6047
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56288
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.53696
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 2.53696
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.50916
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.50083
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.46854
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46854
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, EPHX2, FABP3, FABP4, FLT3, MET, SRC 2.44759
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, KDR, SRC 2.43183
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.42948
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.42427
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.42296
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.42144
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PTPN1, SRC, XDH 2.42144
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.3778
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32395
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.32313
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.29833
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22766
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.22766
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.19837
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EPHX2, SRC 2.19837
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.19434
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC 2.19434
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.17875
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC 2.12981
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.07698
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.07236
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP9, PTPN1, SRC, XDH 2.06809
[BP] GO:0046541 None CHRM1, CHRM3 2.06203
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 2.06203
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.05903
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5 2.04476
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC 2.02743
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.02743
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.02743
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, PPARA, RORC, SRC 2.01832
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, SRC 2.00914
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 2.21613
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TYR 1.94729
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.94087
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3 1.92021
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, MET, SRC 1.83465
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2914
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 9.17196
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 8.75834
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.6031
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.34118
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.96468
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 5.82975
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 4.34374
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.18847
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.87622
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.81856
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.7412
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.72713
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC 3.72713
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.53194
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 3.49344
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.37671
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.32425
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1 3.25915
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.16428
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.1047
[MF] GO:0042578 None ADORA1, ALPL, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1 3.06615
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.98032
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.96796
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.92498
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.86001
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 2.65468
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.60692
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.50834
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.50834
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.42144
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.3991
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.39783
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.38828
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.32313
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.19837
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.19837
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET 2.19434
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET 2.19434
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.14295
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R 2.06809
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05903


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.1663
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7825
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.6803
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 5.099
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.6478
Metabolic pathways_Homo sapiens_hsa01100 EPHX2, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.0859
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.8719
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2457
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.2864
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1 3.2495
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5119
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.1544
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 3.0335
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, BCL2, MET, IGF1R 2.9674
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 3.0335
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.9674
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.275
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0335
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.275
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0783
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.3332
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 2.0618
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0697
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.25
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8674
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8965
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.7005
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.329
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5256
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5237
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4917
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5074
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3983
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.422
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4484
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2863
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2166
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2775
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4471
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2 1.4901
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4623
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.2443
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.365
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.2166
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.184
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2691
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.329
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.2522
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.1386
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9314
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1386
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9038
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0231
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8765
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8085
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9702
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8674
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9303
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1314
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.337
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5845
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4048
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5845
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5387
Platelet activation_Homo sapiens_hsa04611 SRC 0.5232
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4571
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4465
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4327
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5232
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5047
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5845
Measles_Homo sapiens_hsa05162 CSNK2A1 0.505
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5232
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5232
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5092
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5047
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5232
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4934
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5669
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5696
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5047
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4899
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4326
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5092
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5363
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4773
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5845
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5047
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5845
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5669
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5771
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5232
Axon guidance_Homo sapiens_hsa04360 MET 0.5184
Gap junction_Homo sapiens_hsa04540 SRC 0.5845
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5845
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5845
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5845
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5845
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5771
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5845
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6358
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6221
Glioma_Homo sapiens_hsa05214 IGF1R 0.6358
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6358
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6227
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6358
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6358
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6353
Bile secretion_Homo sapiens_hsa04976 CA2 0.6223
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6229
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6358
Shigellosis_Homo sapiens_hsa05131 SRC 0.6358
Malaria_Homo sapiens_hsa05144 MET 0.7029
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6927
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7224
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8228
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8668
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8765
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9038
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8735
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8972
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.24
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1386


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)