GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PPARA, TBXAS1 |
12.6412 |
[BP] GO:0008152 |
metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
10.7946 |
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
9.6087 |
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR |
9.6087 |
[BP] GO:0044281 |
small molecule metabolic process
|
AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR, XDH |
9.24771 |
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 |
8.70608 |
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 |
8.43828 |
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, SRC, TYR |
7.72255 |
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
7.54198 |
[BP] GO:0044237 |
cellular metabolic process
|
ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
7.31014 |
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, TBXAS1 |
6.86046 |
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.82016 |
[BP] GO:0065008 |
regulation of biological quality
|
ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, MIF, POLA1, POLB, PPARA, SRC, TERT, TNKS, TNKS2, XDH |
6.82016 |
[BP] GO:0033993 |
response to lipid
|
ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR |
6.82016 |
[BP] GO:0071704 |
organic substance metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
6.82016 |
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH |
6.71645 |
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, MET, MIF, PPARA, TBXAS1 |
6.7051 |
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, TBXAS1 |
6.6749 |
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, SRC, TERT, TNKS2, TYR |
6.54702 |
[BP] GO:0010033 |
response to organic substance
|
AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, SRC, TYR |
6.54702 |
[BP] GO:0019369 |
arachidonic acid metabolic process
|
CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 |
6.42806 |
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH |
6.42806 |
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
6.41913 |
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
6.06135 |
[BP] GO:0042221 |
response to chemical
|
AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLB, PPARA, SRC, TERT, TYR |
6.06135 |
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
6.04063 |
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA7, CA9 |
5.9603 |
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT |
5.71094 |
[BP] GO:0032787 |
None
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PPARA, TBXAS1 |
5.53328 |
[BP] GO:0048513 |
animal organ development
|
ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, SRC, TYR |
5.46747 |
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
5.46747 |
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR |
5.22435 |
[BP] GO:0009719 |
response to endogenous stimulus
|
AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC |
5.12139 |
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TERT |
4.95172 |
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
4.90576 |
[BP] GO:0009725 |
response to hormone
|
AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC |
4.89766 |
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 |
4.76018 |
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH |
4.74668 |
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.68446 |
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH |
4.6325 |
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
4.62697 |
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT, XDH |
4.60586 |
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT |
4.60176 |
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT |
4.59706 |
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
4.59413 |
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, SRC, TYR |
4.39985 |
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR |
4.38757 |
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT |
4.33639 |
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.33639 |
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT |
4.21457 |
[BP] GO:0050896 |
response to stimulus
|
ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TYR |
4.20789 |
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT |
4.20789 |
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT |
4.18222 |
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
4.07978 |
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
4.078 |
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT, XDH |
4.0566 |
[BP] GO:0043393 |
regulation of protein binding
|
APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT |
3.93442 |
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR |
3.92211 |
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, MIF, SRC, TNKS, TNKS2 |
3.89569 |
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SRC, TERT |
3.85105 |
[BP] GO:0051716 |
cellular response to stimulus
|
AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, POLA1, POLB, PTPN1, SRC, TERT |
3.85105 |
[BP] GO:0006082 |
organic acid metabolic process
|
ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, MIF, PIM1, PPARA, TBXAS1, TYR |
3.84538 |
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT |
3.72473 |
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.63602 |
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.54459 |
[BP] GO:0070887 |
cellular response to chemical stimulus
|
AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT |
3.52989 |
[BP] GO:0009698 |
phenylpropanoid metabolic process
|
CYP1A1, CYP2A13, CYP2A6 |
3.52989 |
[BP] GO:0009804 |
coumarin metabolic process
|
CYP1A1, CYP2A13, CYP2A6 |
3.52989 |
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
3.51055 |
[BP] GO:0034502 |
protein localization to chromosome
|
AURKB, ESR1, TERT, TNKS, TNKS2 |
3.43875 |
[BP] GO:0008283 |
cell proliferation
|
ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, POLA1, SRC, TYR |
3.43828 |
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
3.42073 |
[BP] GO:0042592 |
homeostatic process
|
ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC, TERT |
3.41028 |
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC |
3.36815 |
[BP] GO:0051098 |
regulation of binding
|
APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS |
3.3513 |
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR |
3.34816 |
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS |
3.33256 |
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT |
3.29886 |
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT |
3.20901 |
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 |
3.17711 |
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, MIF, PTPN1, SRC, XDH |
3.14175 |
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
3.09628 |
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.09628 |
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC |
3.09108 |
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
3.09013 |
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, APP, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH |
3.05768 |
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC |
3.04057 |
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SRC, TERT, TYR |
3.04057 |
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH |
3.0201 |
[BP] GO:0042493 |
response to drug
|
AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, POLB, SRC |
3.01052 |
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS |
2.985 |
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.92088 |
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC |
2.87907 |
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.85966 |
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT |
2.85966 |
[BP] GO:0032845 |
None
|
ADORA1, BCL2, MIF, SRC, TNKS, TNKS2 |
2.826 |
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.826 |
[BP] GO:0048583 |
regulation of response to stimulus
|
ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.82256 |
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR |
2.79993 |
[BP] GO:0071310 |
cellular response to organic substance
|
AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC |
2.79993 |
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.78249 |
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA |
2.77647 |
[BP] GO:0009115 |
None
|
AOX1, XDH |
2.76089 |
[BP] GO:0010038 |
response to metal ion
|
APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT |
2.75854 |
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.70399 |
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF |
2.6525 |
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.65053 |
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH |
2.63404 |
[BP] GO:0070198 |
None
|
TERT, TNKS, TNKS2 |
2.6261 |
[BP] GO:0030335 |
positive regulation of cell migration
|
APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT |
2.62329 |
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, MIF, MMP9, PTPN1, SRC |
2.60955 |
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH |
2.58277 |
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.54855 |
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC |
2.53126 |
[BP] GO:2000147 |
positive regulation of cell motility
|
APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT |
2.5185 |
[BP] GO:1904355 |
positive regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.47663 |
[BP] GO:0016310 |
phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS |
2.47663 |
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH |
2.46241 |
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC |
2.44732 |
[BP] GO:0051272 |
positive regulation of cellular component movement
|
APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT |
2.43681 |
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, GBA2 |
2.41707 |
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MIF, MMP2, MMP9, SRC, TERT |
2.41707 |
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH |
2.40084 |
[BP] GO:0032210 |
regulation of telomere maintenance via telomerase
|
AURKB, SRC, TNKS, TNKS2 |
2.39939 |
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, AXL, BCL2, CYP1B1, SRC |
2.38919 |
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, AXL, CYP1B1, MMP9, SRC |
2.38919 |
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MET, MIF, MMP12, MMP9, PIM1, SRC, TERT, TNKS2, XDH |
2.38424 |
[BP] GO:0046110 |
None
|
AOX1, XDH |
2.37411 |
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.37411 |
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.36975 |
[BP] GO:0022414 |
reproductive process
|
AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC |
2.36013 |
[BP] GO:0040017 |
positive regulation of locomotion
|
APP, BCL2, F3, IGF1R, KDR, MET, MMP9, SRC, TERT |
2.35542 |
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, FLT3, IGF1R, KDR, MET, SRC |
2.32883 |
[BP] GO:0006805 |
xenobiotic metabolic process
|
CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
2.30145 |
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, FLT3, IGF1R, KDR, MET, SRC |
2.29732 |
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC |
2.29241 |
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.2568 |
[BP] GO:0044093 |
positive regulation of molecular function
|
ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MET, MIF, MMP9, PTPN1, SRC, TERT, TNKS, XDH |
2.25137 |
[BP] GO:1904356 |
regulation of telomere maintenance via telomere lengthening
|
AURKB, SRC, TNKS, TNKS2 |
2.23053 |
[BP] GO:0090344 |
None
|
CDK6, MIF, TERT |
2.20548 |
[BP] GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation
|
MMP2, MMP9, TERT |
2.20548 |
[BP] GO:0030520 |
intracellular estrogen receptor signaling pathway
|
ESR1, ESR2, SRC |
2.20548 |
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, ESR1, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH |
2.19229 |
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.1534 |
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 |
2.1534 |
[BP] GO:2000573 |
positive regulation of DNA biosynthetic process
|
AURKB, SRC, TNKS, TNKS2 |
2.14308 |
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 |
2.13953 |
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PTPN1, SRC, XDH |
2.13953 |
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PTPN1, SRC, XDH |
2.13953 |
[BP] GO:0070213 |
None
|
TNKS, TNKS2 |
2.13953 |
[BP] GO:0006145 |
None
|
AOX1, XDH |
2.13953 |
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.13953 |
[BP] GO:0030574 |
collagen catabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.13423 |
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.12287 |
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, KDR, SRC |
2.12286 |
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2 |
2.09597 |
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
BCL2, MIF, MMP9, PTPN1, SRC, TERT |
2.09484 |
[BP] GO:0030198 |
extracellular matrix organization
|
APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 |
2.0924 |
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH |
2.09125 |
[BP] GO:0043062 |
extracellular structure organization
|
APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 |
2.08775 |
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH |
2.08091 |
[BP] GO:0006820 |
anion transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA |
2.06881 |
[BP] GO:1904353 |
regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.03875 |
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH |
2.03827 |
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, BCL2, CA2, FLT3, HSD11B2, SRC |
2.02228 |
[CC] GO:0044432 |
endoplasmic reticulum part
|
APP, BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 |
3.09108 |
[CC] GO:0044444 |
cytoplasmic part
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, PIM1, POLA1, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
3.06525 |
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2, TBXAS1 |
2.2275 |
[CC] GO:0097443 |
sorting endosome
|
KDR, PTPN1 |
1.83515 |
[CC] GO:0043227 |
membrane-bounded organelle
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH |
1.69915 |
[MF] GO:0046914 |
transition metal ion binding
|
ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH |
15.851 |
[MF] GO:0003824 |
catalytic activity
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
13.4819 |
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
10.0174 |
[MF] GO:0043167 |
ion binding
|
ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
9.6087 |
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH |
7.53112 |
[MF] GO:0005506 |
iron ion binding
|
ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH |
6.82016 |
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB |
6.82016 |
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
6.82016 |
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
6.67849 |
[MF] GO:0046872 |
metal ion binding
|
ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH |
6.5275 |
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.39684 |
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH |
6.33379 |
[MF] GO:0008270 |
zinc ion binding
|
CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS |
6.23273 |
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR |
6.22294 |
[MF] GO:0048037 |
cofactor binding
|
AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH |
5.50013 |
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 |
5.29406 |
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
5.26978 |
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 |
5.07245 |
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR |
4.72656 |
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.33639 |
[MF] GO:0016829 |
lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB |
4.24031 |
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
3.94537 |
[MF] GO:0005496 |
steroid binding
|
ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 |
3.92482 |
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
ESR1, ESR2, ESRRA, ESRRB, PPARA |
3.80395 |
[MF] GO:0004879 |
nuclear receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA |
3.80395 |
[MF] GO:0003707 |
steroid hormone receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA |
3.43875 |
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.37573 |
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, FLT3, IGF1R, KDR, MET |
3.357 |
[MF] GO:0016229 |
steroid dehydrogenase activity
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.2759 |
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2A13, CYP2A6 |
3.04057 |
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, FLT3, IGF1R, KDR, MET |
2.92088 |
[MF] GO:0008144 |
drug binding
|
ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC |
2.77675 |
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.76089 |
[MF] GO:0003845 |
None
|
HSD11B1, HSD11B2 |
2.76089 |
[MF] GO:0008389 |
None
|
CYP2A13, CYP2A6 |
2.76089 |
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AOX1, XDH |
2.66124 |
[MF] GO:0008289 |
lipid binding
|
AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA |
2.66096 |
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC |
2.52098 |
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, SRC, TERT |
2.4312 |
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, AOX1, CYP19A1, CYP1A2, XDH |
2.38919 |
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, FLT3, IGF1R, KDR, MET, SRC |
2.38008 |
[MF] GO:0001223 |
transcription coactivator binding
|
ESR1, PPARA, TERT |
2.31014 |
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC |
2.1534 |
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC |
2.14719 |
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.13953 |
[MF] GO:0019899 |
enzyme binding
|
APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, ESR1, ESR2, ESRRB, F3, MET, MIF, POLA1, POLB, PPARA, PTPN1, SRC, TNKS2 |
2.12287 |
[MF] GO:0042802 |
identical protein binding
|
ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, TERT, TYR, XDH |
2.10294 |