TCM Prescription: Fu Fang Man Shan Hong Syrup



Prescription Description
Prescription IDTCMF789
Pinyin NameFu Fang Man Shan Hong Tang Jiang 
Chinese Name复方满山红糖浆
English NameFu Fang Man Shan Hong Syrup
Function Description咳嗽, 哮证, 喘病
IndicationsAsthma, Upper respiratory infection(uri)
Disease ICD-11 Category CA23 [Asthma, 哮喘 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1437 Rhododendron dauricum 满山红 TCMH1437 ITSAL1461-14
TCMH46 Stemona tuberosa 百部 TCMH46 GBVC4204-11, GBVC4202-11
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, TYR 10.2074
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK, TYR 9.79734
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, TYR 9.54468
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, PTGS1, SMAD3, SRC, TEK, XDH 8.89462
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, TYR, XDH 8.84954
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRM1, PIM1, PTGS1, SMAD3, SRC, TEK, XDH 8.52419
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 8.4906
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 8.48494
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PDE3A, PPARA, PTGS1 8.00057
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK 7.92222
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TEK, XDH 7.64434
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.24701
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK, TYR 7.11563
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 7.10012
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 7.00754
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SMAD3, SRC, TEK, XDH 7.00754
[BP] GO:0032879 regulation of localization ACHE, ADORA3, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK 7.00754
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SMAD3, SRC, TEK, XDH 6.87948
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.87948
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK, TYR 6.72561
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.67126
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, OPRK1, OPRM1, PDE3A, SRC, TEK, TYR 6.67126
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.64642
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HMGCR, HTR2A, KDR, OPRK1, OPRM1, PDE3A, SRC 6.60826
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PDE3A, PPARA, PTGS1 6.57823
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SMAD3, SRC 6.57823
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.5537
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, INSR, KDR, MET, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 6.52266
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 6.50704
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TEK, XDH 6.50573
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, PTPN1, SMAD3, SRC, TEK 6.50066
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 6.49497
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.42249
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.42195
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HMGCR, HSPA1A, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, TYR 6.42195
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PTGS1, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR 6.39649
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, HMGCR, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, SMAD3, SRC, TEK, TYR 6.33685
[BP] GO:0032502 developmental process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR2A, INSR, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, PPARA, SIGMAR1, SMAD3, SRC, TEK, TOP2A, TYR 6.21235
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.21235
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.20343
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TEK, XDH 6.1994
[BP] GO:0019220 regulation of phosphate metabolic process CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.1994
[BP] GO:0051174 regulation of phosphorus metabolic process CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.13777
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.99893
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SMAD3, SRC, TOP2A 5.96003
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SMAD3, SRC 5.95271
[BP] GO:0003018 None DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR7, PDE3A, SRC, TEK 5.92858
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SMAD3, SRC, TEK 5.88069
[BP] GO:0010562 positive regulation of phosphorus metabolic process CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HMGCR, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 5.87925
[BP] GO:0045937 positive regulation of phosphate metabolic process CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HMGCR, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 5.87925
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 5.71002
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, OPRK1, PDE3B, PPARA, SRC, TEK 5.70266
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, EGFR, FLT3, HMGCR, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 5.69268
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.68614
[BP] GO:0010648 negative regulation of cell communication ACHE, DRD1, DRD2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SMAD3, SRC, XDH 5.61982
[BP] GO:0023057 negative regulation of signaling ACHE, DRD1, DRD2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SMAD3, SRC, XDH 5.60347
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.53915
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, HMGCR, PDE3A 5.44175
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, OPRD1, OPRK1, SRC 5.43497
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, HSD17B2 5.4197
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.3525
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HMGCR, HSD17B1, HSD17B2, HTR1A, HTR2A, OPRK1 5.3042
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.3039
[BP] GO:0043408 regulation of MAPK cascade DRD2, DUSP3, EGFR, FLT3, HMGCR, HTR2A, IGF1R, INSR, KDR, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.3039
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, EGFR, FLT3, HMGCR, HTR2A, INSR, KDR, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.30069
[BP] GO:0042325 regulation of phosphorylation CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TEK, XDH 5.29311
[BP] GO:0001932 regulation of protein phosphorylation CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 5.19262
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 5.17234
[BP] GO:0051049 regulation of transport ACHE, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, INSR, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC 5.13456
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 5.13456
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1 5.11944
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, HMGCR, HTR2A, KDR, OPRM1, PTPN1, SRC, TEK 5.08859
[BP] GO:0003013 None DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR7, PDE3A, SRC, TEK 5.06969
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1 4.98735
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, SMAD3, SRC, TEK 4.9667
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.96532
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, HTR7, OPRK1, OPRM1, PPARA, SRC, TOP2A 4.96532
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, HSD17B2, PTGS1, TYR, XDH 4.94682
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTPN1, SRC 4.88933
[BP] GO:0031399 regulation of protein modification process CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 4.85862
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1 4.80924
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.80924
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.80924
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 4.73607
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.71234
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SRC 4.66305
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SMAD3, SRC, TEK, XDH 4.65982
[BP] GO:0001934 positive regulation of protein phosphorylation CDC25B, DRD2, EGFR, FLT3, HMGCR, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 4.6596
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.65537
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 4.63137
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.59696
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, OPRK1, OPRM1, SRC, TYR 4.55233
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, PTGS1, PTPN1, SMAD3, SRC, TEK, TOP2A 4.47916
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP9, NUAK1, OPRD1, OPRM1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.47802
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, OPRM1, PPARA, SMAD3 4.44824
[BP] GO:0042327 positive regulation of phosphorylation CDC25B, DRD2, EGFR, FLT3, HMGCR, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 4.44371
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SRC 4.37443
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, HSPA1A 4.37443
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 4.35695
[BP] GO:0007193 None DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.35337
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.26058
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, OPRK1, PDE3B, PPARA, SRC, TEK 4.25852
[BP] GO:0080134 regulation of response to stress CYP19A1, DRD2, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, OPRK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.24693
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.23081
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 4.20867
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, HMGCR, HTR2A, KDR, OPRM1, SRC, TEK 4.18848
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.16299
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.1354
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, EGFR, FLT3, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SMAD3, SRC 4.07975
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, OPRM1, SRC 4.07825
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 4.07649
[BP] GO:0007200 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1 4.06816
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, HTR2A, INSR, MET, SMAD3, SRC 4.06285
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.06272
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.05473
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 4.04398
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, HMGCR, HTR2A, KDR, OPRK1, SRC 4.01722
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, INSR, MET, SRC, TEK, XDH 4.01457
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.94633
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 3.93821
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1 3.93821
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, SMAD3, SRC, TEK 3.91643
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.89297
[BP] GO:0042698 ovulation cycle AXL, EGFR, OPRK1, OPRM1 3.89297
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1 3.83014
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.81678
[BP] GO:0007188 None DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.81678
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1 3.76728
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, DRD1, DRD2, GPR35, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 3.76012
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76012
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76012
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76012
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76012
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76012
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, MMP9, NUAK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 3.74496
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, HMGCR, HSPA1A, IGF1R, MET, MMP9, PDE3B, PTPN1, SRC, XDH 3.72238
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, HTR1A, TYR 3.71795
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SENP6, SRC, TEK, TOP2A 3.71795
[BP] GO:0051247 positive regulation of protein metabolic process CDC25B, CSNK2A1, DRD2, EGFR, FLT3, HMGCR, HSPA1A, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 3.70968
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.6876
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PDE3A, PIM1, SENP6, SMAD3, SRC, TOP2A 3.66443
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.61181
[BP] GO:0048585 negative regulation of response to stimulus CYP19A1, DRD1, DRD2, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.60472
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.58469
[BP] GO:0007610 None DRD1, DRD2, EGFR, HMGCR, HTR1A, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PPARA 3.56382
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.55519
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, EGFR, FABP4, HMGCR, KDR, MET, MMP12, OPRM1, PPARA, SMAD3, TEK 3.53363
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HMGCR, HTR2A, IGF1R, INSR, PTPN1, SRC 3.52872
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK 3.51228
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, SRC 3.50391
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.50391
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, SMAD3 3.50391
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 3.50391
[BP] GO:0031401 positive regulation of protein modification process CDC25B, DRD2, EGFR, FLT3, HMGCR, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH 3.5005
[BP] GO:0001666 response to hypoxia CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 3.46005
[BP] GO:0032270 positive regulation of cellular protein metabolic process CDC25B, DRD2, EGFR, FLT3, HMGCR, HSPA1A, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 3.45567
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.45307
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, DRD2, EGFR, HMGCR, HSPA1A, HTR2A, KDR, MET, MMP12, MMP9, OPRM1, PDE3A, PIM1, SMAD3, SRC, TEK 3.4481
[BP] GO:0007187 None DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.44443
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, OPRM1, PDE3A, SRC 3.44443
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.41874
[BP] GO:0003008 None AKR1B1, CYP1B1, DRD1, DRD2, EGFR, HMGCR, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TEK, TYR 3.4133
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, GPR35, HTR2A, INSR, MET, SMAD3 3.41227
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, OPRD1 3.40404
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.39961
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 3.39057
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.36909
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.35678
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, PPARA, SRC, TEK 3.35232
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HMGCR, HTR2A, PDE3B, PPARA, SRC, TEK 3.34956
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.34176
[BP] GO:0097746 None DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR7 3.34015
[BP] GO:0035296 None DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR7 3.34015
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32201
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.31277
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.30905
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, CA2, CYP1B1, DRD2, EGFR, GPR35, HMGCR, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SMAD3, SRC, TEK, XDH 3.30217
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 3.2998
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 3.29298
[BP] GO:0043434 None APEX1, FABP3, INSR, OPRK1, PDE3B, PPARA, SRC, TEK 3.29188
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, OPRD1, OPRM1, PDE3A, SMAD3, SRC 3.28238
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PPARA, PTGS1 3.26609
[BP] GO:0032268 regulation of cellular protein metabolic process CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 3.24961
[BP] GO:0043549 regulation of kinase activity CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, PTPN1, SRC, TEK 3.2401
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.21784
[BP] GO:0050880 None DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR7 3.21784
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 3.21064
[BP] GO:0035150 None DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR7 3.20515
[BP] GO:0043269 regulation of ion transport CA2, CA7, DRD1, DRD2, GPR35, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 3.17575
[BP] GO:0070482 response to oxygen levels CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 3.17489
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, TYR 3.16425
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.16386
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC 3.16044
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HMGCR, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 3.14867
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, PTPN1, SRC, TEK 3.12939
[BP] GO:0032868 None FABP3, INSR, OPRK1, PDE3B, PPARA, SRC 3.11315
[BP] GO:0009893 positive regulation of metabolic process AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.09117
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, HMGCR, IGF1R, OPRK1, PTPN1, XDH 3.07985
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, HMGCR, IGF1R, OPRK1, PTPN1, XDH 3.06847
[BP] GO:0097756 None HMGCR, HTR1A, HTR2A, HTR7 3.06334
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.01703
[BP] GO:0031635 None OPRK1, OPRM1 2.99478
[BP] GO:0022414 reproductive process AKR1B1, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC, TOP2A 2.98773
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, HTR2A, IGF1R, INSR, KDR, MET, NUAK1, OPRM1, PDE3A, PTPN1, SRC, TEK 2.96086
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.93358
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.93114
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 2.93114
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.92869
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.92185
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.91429
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.90689
[BP] GO:0045859 regulation of protein kinase activity CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, IGF1R, INSR, PTPN1, SRC 2.90656
[BP] GO:0080090 regulation of primary metabolic process ADORA3, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.87309
[BP] GO:0007611 None DRD1, DRD2, EGFR, HMGCR, HTR2A, INSR, OPRK1 2.87112
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.86394
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.8374
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.81608
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, EGFR, HMGCR, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 2.78642
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR, PDE3A 2.776
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, OPRD1, PDE3A, SMAD3, SRC 2.7718
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.75799
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.7032
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.69309
[BP] GO:0072523 None PDE10A, PDE3A, PDE3B, XDH 2.69309
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.67809
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR, PDE3A, SENP6 2.59872
[BP] GO:0046883 regulation of hormone secretion CYP19A1, DRD2, EGFR, HMGCR, HTR1A, HTR2A, OPRK1 2.5944
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58638
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, TYR 2.58638
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.57749
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.57749
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.57749
[BP] GO:0051246 regulation of protein metabolic process CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PTPN1, SMAD3, SRC, TEK, XDH 2.53944
[BP] GO:0051046 None ACHE, CYP19A1, DRD2, EGFR, HMGCR, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 2.53021
[BP] GO:0050890 None DRD1, DRD2, EGFR, HMGCR, HTR2A, INSR, OPRK1 2.51454
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.50766
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, SIGMAR1, SMAD3, SRC, TEK, TYR 2.5055
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.49566
[BP] GO:0009968 negative regulation of signal transduction DRD2, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PTPN1, SMAD3, SRC, XDH 2.48697
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1 2.48136
[BP] GO:0048869 cellular developmental process ACHE, AXL, CBR1, CDC25B, CYP1A1, DRD1, DRD2, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PDE3A, SMAD3, SRC, TEK, TOP2A 2.47041
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, HMGCR, PPARA, SMAD3, TEK 2.45592
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45509
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD1, DRD2, EGFR, HTR2A 2.4461
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.4461
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.42051
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, MET 2.42047
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, HSPA1A, PDE10A, PDE3A, PDE3B, SRC, XDH 2.42047
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HMGCR, HTR2A, IGF1R, INSR, PTPN1, SRC 2.41043
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.39843
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.39843
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD1, DRD2, EGFR 2.3782
[BP] GO:1901575 None ACHE, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.3707
[BP] GO:0009894 regulation of catabolic process APEX1, CSNK2A1, EGFR, HSPA1A, HTR2A, INSR, KDR, MET, PDE3B, PPARA, PTPN1, SMAD3 2.36317
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35741
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.35741
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.35741
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.35741
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.35741
[BP] GO:0007198 None HTR1A, HTR7 2.34095
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34095
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34095
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, DRD1, DRD2, HTR2A 2.33599
[BP] GO:0044057 None ADORA3, DRD2, EGFR, GPR35, HTR2A, OPRD1, OPRK1, OPRM1, SMAD3 2.331
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.32924
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.32296
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.32296
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, OPRK1, PTPN1, XDH 2.32296
[BP] GO:0051894 None KDR, SMAD3, TEK 2.32296
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.32296
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.32296
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32296
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.31772
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.31772
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, CSNK2A1, DRD2, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, OPRD1, PDE3A, PTPN1, SENP6, SMAD3, SRC, TEK, TOP2A 2.30328
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD1, DRD2, EGFR, HTR2A 2.30328
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD1, DRD2, EGFR, HTR2A 2.30328
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.30029
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, IGF1R, INSR, PDE3B, SRC 2.29273
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.26002
[BP] GO:0051094 positive regulation of developmental process AXL, CA2, CYP1B1, DRD2, HMGCR, HTR2A, INSR, KDR, OPRM1, PDE3A, PIM1, SMAD3, SRC, TEK 2.25615
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, TYR 2.25615
[BP] GO:0009892 negative regulation of metabolic process APEX1, AURKB, CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRM1, PDE3B, PPARA, PTPN1, SMAD3, SRC, XDH 2.24792
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.24237
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23746
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, GPR35, HTR2A, SMAD3 2.23746
[BP] GO:0031644 None GPR35, OPRD1, OPRK1, OPRM1 2.22148
[BP] GO:0009314 response to radiation AURKB, DRD1, DRD2, EGFR, HMGCR, OPRK1, OPRM1, TYR 2.22022
[BP] GO:0051050 positive regulation of transport ACHE, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, INSR, MMP12, OPRK1, SMAD3, SRC 2.20119
[BP] GO:0008306 None DRD1, DRD2, HMGCR, OPRK1 2.20094
[BP] GO:0007612 None DRD1, DRD2, HMGCR, INSR, OPRK1 2.19619
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, TYR 2.19619
[BP] GO:0033674 positive regulation of kinase activity CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, PTPN1, SRC, TEK 2.19496
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.17394
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 2.17344
[BP] GO:0021853 None DRD1, DRD2 2.17322
[BP] GO:1904936 None DRD1, DRD2 2.17322
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, PTGS1 2.17313
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, INSR, PTPN1, SRC, TEK 2.17052
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.16765
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.16054
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.16054
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.15846
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR 2.13223
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.11977
[BP] GO:0051952 None DRD1, DRD2, HTR2A, OPRK1 2.11186
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.11186
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR 2.10533
[BP] GO:0042060 None EGFR, OPRM1, PPARA, SMAD3 2.09201
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.0871
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.0871
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.0871
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.0871
[BP] GO:0009410 None DRD1, DRD2, EGFR, OPRK1, OPRM1 2.08486
[BP] GO:1900542 None DRD1, DRD2, HTR2A, INSR, OPRM1, PPARA 2.06636
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.06057
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.06057
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, EGFR, KDR, OPRM1, PDE3A 2.06057
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05777
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05777
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.05777
[BP] GO:0001659 None DRD1, DRD2, HTR2A 2.05777
[BP] GO:0043114 None PDE3A, SRC, TEK 2.05777
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.05291
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, DRD2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.05052
[BP] GO:0021843 None DRD1, DRD2 2.04341
[BP] GO:0021830 None DRD1, DRD2 2.04341
[BP] GO:0021826 None DRD1, DRD2 2.04341
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.04341
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.03533
[BP] GO:0051098 regulation of binding AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC 2.03047
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.03047
[BP] GO:0043278 None DRD2, OPRK1, OPRM1 2.03047
[BP] GO:0014072 None DRD2, OPRK1, OPRM1 2.03047
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.03047
[BP] GO:0006140 None DRD1, DRD2, HTR2A, INSR, OPRM1, PPARA 2.02397
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.02183
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, OPRD1, OPRM1, PTPN1, SRC, TOP2A 2.01849
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.01825
[BP] GO:0045936 None DRD2, DUSP3, FABP4, HMGCR, IGF1R, OPRM1, PPARA, PTPN1, XDH 2.00296
[BP] GO:0010563 None DRD2, DUSP3, FABP4, HMGCR, IGF1R, OPRM1, PPARA, PTPN1, XDH 2.00112
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.00112
[BP] GO:0010907 None INSR, PPARA, SRC 2.00112
[BP] GO:0046058 None PDE10A, PDE3A, PDE3B 2.00112
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 4.23081
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 3.89297
[CC] GO:0044459 plasma membrane part ADORA3, AXL, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TEK 3.29298
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, OPRD1, OPRM1, SIGMAR1, SRC, TEK 3.27614
[CC] GO:0045121 membrane raft EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.16044
[CC] GO:0098857 membrane microdomain EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.14248
[CC] GO:0031253 None CA4, CA9, DRD1, DRD2, INSR, OPRD1, OPRM1, SRC 2.96162
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, FLT3, FUT7, GLO1, GPR35, HMGCR, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTGS1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TYR 2.93677
[CC] GO:0032590 None INSR, OPRD1, OPRM1 2.93358
[CC] GO:0005783 None APEX1, CA4, CYP19A1, CYP2D6, FLT3, HMGCR, HSPA1A, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 2.84338
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, INSR, KDR, MMP2, MMP9, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PTGS1, PTPN1, SENP6, SIGMAR1, SMAD3, SRC, TOP2A, TYR, XDH 2.776
[CC] GO:0005886 plasma membrane ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, FLT3, GLO1, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SMAD3, SRC, TEK 2.7201
[CC] GO:0044425 membrane part ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, FLT3, FUT7, GPR35, HMGCR, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTGS1, PTPN1, SIGMAR1, SRC, TEK, TYR 2.68653
[CC] GO:0098589 membrane region EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 2.65469
[CC] GO:0044463 None AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PTGS1, SIGMAR1, SRC 2.39687
[CC] GO:0120038 None AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PTGS1, SIGMAR1, SRC 2.39687
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04341
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 10.4795
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PTGS1, PTPN1, SENP6, SRC, TEK, TOP2A, TYR, XDH 10.4795
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82419
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 8.84954
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP2A 8.08498
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.29402
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.79583
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.67126
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, GLO1, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SMAD3, TOP2A, TYR, XDH 6.50704
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.42195
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, HSD17B2, PTGS1, TYR, XDH 5.96569
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.53915
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.43202
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.39055
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.38758
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, TEK 5.21896
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.1631
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 5.13703
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 5.13703
[MF] GO:0004872 receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, TEK 4.4829
[MF] GO:0004871 signal transducer activity ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, SMAD3, TEK 4.47916
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.44824
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.44371
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, TEK 4.30458
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, SRC 4.28566
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.25852
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 4.13991
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.1354
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.12675
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, SRC 4.10957
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, SMAD3 4.05056
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.88509
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, TYR 3.83014
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 3.76012
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGS1, PTPN1, SMAD3, TOP2A, TYR, XDH 3.7328
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.59322
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.52989
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.44443
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.41874
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, PTGS1, SRC, XDH 3.2401
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.21784
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.21784
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.20916
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 3.1022
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A 3.01844
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.00753
[MF] GO:0004119 None PDE3A, PDE3B 2.99478
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A 2.98938
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A, XDH 2.9393
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.93358
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.85547
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A, XDH 2.84175
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A, XDH 2.84027
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.76991
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SENP6, SRC, TEK 2.65545
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.63255
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.55914
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.49566
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.40204
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.35741
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.32296
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.32296
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.32296
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.27831
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.27204
[MF] GO:0008528 None GPR35, OPRD1, OPRK1, OPRM1, SIGMAR1 2.25871
[MF] GO:0001653 None GPR35, OPRD1, OPRK1, OPRM1, SIGMAR1 2.24787
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A, XDH 2.17344
[MF] GO:0043559 insulin binding IGF1R, INSR 2.17322
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.14025
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.11977
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.11186
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.11186
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A 2.09027
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A 2.06378
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PIM1, SRC, TEK, TOP2A 2.05957
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05777
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04341
[MF] GO:0004930 None ADORA3, DRD1, DRD2, GPR35, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 2.01849
[MF] GO:0097159 organic cyclic compound binding APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PDE10A, PDE3A, PIM1, PPARA, PTGS1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.00874


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.4607
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0414
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2159
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR7, GPR35, ADORA3, HTR1A, OPRK1, OPRM1, HTR2A, DRD1, DRD2 6.0193
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9543
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.988
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2386
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, EGFR, HSPA1A 4.7627
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, CYP2D6, ALOX5, HTR1A, HTR2A, PTGS1 4.4992
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.1795
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.9087
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.1944
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6276
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, PDE3A, OPRM1, DRD1 3.87
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2, EGFR 3.9087
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.3985
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, HMGCR, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 3.3985
cAMP signaling pathway_Homo sapiens_hsa04024 PDE3B, PDE3A, HTR1A, DRD1, DRD2, PPARA 3.3985
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, PDE3B, PTGS1 3.4892
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, INSR, PDE3B, PDE3A 2.8297
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2285
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.5914
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3104
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5209
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6536
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.978
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3009
Calcium signaling pathway_Homo sapiens_hsa04020 HTR7, HTR2A, DRD1, EGFR 1.9385
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2334
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.95
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7224
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1897
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1435
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS1 2.2592
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9385
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1845
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8013
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8962
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.817
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5022
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7296
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4726
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.595
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4479
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR, PDE3B 1.4789
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2A 1.0423
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0979
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.109
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 1.0253
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0683
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.9048
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9179
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9179
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3 0.9112
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.307
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3355
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8745
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8523
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0959
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8633
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8986
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8428
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3748
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8428
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8428
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.189
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8428
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3022
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8428
Renin secretion_Homo sapiens_hsa04924 PDE3B, PDE3A 1.307
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8236
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8033
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3547
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6688
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.2734
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7349
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2576
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2354
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.307
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.647
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2987
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.324
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3433
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3331
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3353
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3239
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.362
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3695
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4111
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4742
Axon guidance_Homo sapiens_hsa04360 MET 0.4264
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4343
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4639
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4455
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4639
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4806
Melanogenesis_Homo sapiens_hsa04916 TYR 0.488
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4878
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4996
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4994
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5039
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.528
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5173
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5173
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5272
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5167
Peroxisome_Homo sapiens_hsa04146 XDH 0.528
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5615
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5629
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5602
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5488
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5698
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5845
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5827
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6052
Shigellosis_Homo sapiens_hsa05131 SRC 0.5864
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5864
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5965
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8108
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6282
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.647
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.631
Malaria_Homo sapiens_hsa05144 MET 0.6639
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6962
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6678
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7765
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6757
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.971
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7333
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.768
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7277
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8401
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.768
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8033
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7825
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8207
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8428
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8401
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8706
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1353


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)