TCM Prescription: Kang Bing Du Ju Jiao Tablets



Prescription Description
Prescription IDTCMF7234
Pinyin NameKang Bing Du Ju Jiao Pian
Chinese Name抗病毒咀嚼片
English NameKang Bing Du Ju Jiao Tablets
Function Description具有清热祛湿, 凉血解毒的功效。用于风热感冒, 上呼吸道感染, 流感。
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1339 Phragmites communis 芦根 TCMH1339 KT695247
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, MAOB, MMP2, MMP9, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 10.6789
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAOB, MET, PPARA, PTAFR, PTGS2, SLC1A1, SRC, XDH 10.2412
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MAOB, MMP2, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 8.87851
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, GSK3B, HCAR2, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 8.60463
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, GSK3B, HCAR2, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 8.60463
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, HMGCR, HSD17B3, IDO1, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, TYR, XDH 8.37252
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MAOB, MMP2, MMP9, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 8.37252
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.17062
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTAFR, PTGES, PTGS2, RELA, SRC, XDH 8.16157
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 7.48731
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, XDH 7.48731
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.40817
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 7.33385
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, MAOB, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 7.26456
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 7.21525
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, PTGES, PTGS2, RELA, SRC 7.18171
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 7.1009
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES, PTGS2 7.05622
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, GRM1, HMGCR, KDR, MAP2K1, MAP3K7, MET, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 7.01023
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 6.85856
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FLT3, GRM1, GSK3B, HMGCR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 6.82189
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MAOB, PTGS2, TYR, XDH 6.80254
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 6.52516
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, MAOB, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 6.45407
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC 6.40498
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC 6.17592
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, HSD17B3 6.12545
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F3, GRIK5, GRM5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MET, MMP12, MMP9, PPARA, PTAFR, PTGS2, PTPN1, SRC 6.0643
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TYR 5.88447
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DHFR, HMGCR, HSD17B3, MAOA, MAOB, PTAFR, TYR 5.88099
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, TYR 5.80081
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 5.7769
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.7769
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.71865
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC 5.51111
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 5.49265
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 5.49265
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, GSK3B, IGF1R, MAOB, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC 5.47062
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, GRIK5, GRM5, GSK3B, IGF1R, MMP2, MMP9, PTAFR, PTGS2, RELA, RORC, SRC 5.47062
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 5.45719
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, F3, HCAR2, HMGCR, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SRC 5.3999
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.3999
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.3999
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PTAFR, PTPN1, RELA, SRC 5.38279
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.34617
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, PTGS2, RELA, SRC 5.13186
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.12648
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, F3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 5.08593
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 5.04309
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 5.0066
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.0066
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, GRM1, HMGCR, KDR, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, XDH 5.0066
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, MMP9, PTAFR, PTGS2, RELA, RORC, SRC 5.00613
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC 4.97858
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.9658
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, PTAFR, PTGS2, RELA, RORC, SRC 4.96445
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 4.93979
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOA, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 4.84384
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 4.7963
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 4.72886
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, F3, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.71654
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 4.70914
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, RELA 4.7038
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.65975
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 4.53707
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.48646
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC, TYR 4.45937
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.39568
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTPN1, RELA, RORC, SRC 4.39568
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 4.35856
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, HSD17B3, IDO1 4.34747
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, F3, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.34399
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SRC, XDH 4.33613
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CACNA1C, CYP1B1, F3, GRM1, GSK3B, HCAR2, HMGCR, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SRC, XDH 4.33033
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TYR, XDH 4.32318
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, GRM1, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, XDH 4.29494
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3 4.25561
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 4.25189
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 4.24166
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, GRIK5, GRM5, GSK3B, HCAR2, HMGCR, MAOB, MAP2K1, MMP12, MMP9, PPARA, PTAFR, PTGS2, PTPN1, SRC 4.1994
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, KDR, MAOB, PTAFR, PTGS2, RELA, SRC 4.19388
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2 4.16427
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.15437
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.11892
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, DHFR, HMGCR, HSD17B3, IDO1, PTAFR, PTGES, PTGS2 4.05259
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, CDC25B, DHFR, F3, FLT3, GRM1, GRM5, GSK3B, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTAFR, PTPN1, RELA, SRC, XDH 4.05211
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.04516
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, GSK3B, IGF1R, PPARA, PTGS2, RELA, SRC 4.04516
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MAOB, MAP2K1, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.02915
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.01048
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, MAOB, PPARA, PTAFR, PTGS2, RELA, SRC 3.98727
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.98149
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, XDH 3.98149
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B2, HSD17B3, KDR, MAOB, MAP2K1, MMP9, PIM1, PPARA, PTGS2, RELA, RORC, SRC, TYR 3.96034
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, MAOB, PTGES, PTGS2, RELA, SRC 3.93566
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC 3.93286
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 3.92504
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTAFR, PTGS2, PTPN1, SRC, XDH 3.90477
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.86707
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, F3, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 3.86707
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 3.80755
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B2, HSD17B3, KDR, MAOB, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RELA, RORC, SRC, TYR 3.74524
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, F3, FLT3, FUT7, GSK3B, HMGCR, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TYR, XDH 3.73763
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, IDO1, MAOB, PTGES, PTGS2, RELA, SRC 3.73621
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, MAOB, PTAFR, PTGS2, RELA, SRC 3.71397
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TYR, XDH 3.67798
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGES, PTGS2 3.67085
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.6675
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GRM5, GSK3B, IGF1R, MMP2, PTAFR, PTGS2, RELA, SRC 3.65374
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GRM3, GRM8, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAOB, MAP2K1, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.65258
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.64635
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTAFR, PTGS2, PTPN1, SRC, XDH 3.62929
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.62687
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.62687
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 3.62687
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, DHFR, HMGCR, HSD17B3, PTAFR, TYR 3.55908
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.53143
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, PTGES, PTGS2 3.52987
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 3.51148
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.50405
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 3.46536
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.45865
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.45865
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, GSK3B, IGF1R 3.45308
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.43894
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GRM5, GSK3B, IGF1R, MMP2, PTAFR, PTGS2, RELA, SRC 3.4152
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.41483
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DHFR, F3, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 3.38952
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.38819
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.3874
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, MAOB, PTAFR, RELA, SRC 3.3474
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, GRIK5, MAOA, MAOB, PTGS2, SLC1A1 3.33652
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, F3, FABP4, HMGCR, IDO1, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA 3.33104
[BP] GO:1904645 response to amyloid-beta APP, GRM5, GSK3B, IGF1R 3.3013
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, HSD17B3, PTGES, PTGS2 3.29502
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, PTAFR, PTGS2, RORC, SRC 3.26336
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 3.25803
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 3.24727
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.24727
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.22414
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, FLT3, GRM5, GSK3B, IGF1R, MMP2, PTAFR, PTGS2, RELA, SRC 3.21305
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.20901
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19844
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.14495
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.13441
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2 3.11036
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, IDO1, MAP2K1, PDE5A, PTGES, PTGS2, XDH 3.10296
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, HCAR2, HMGCR, KDR, PTGS2, SRC 3.0951
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTAFR, PTGS2, RELA, SRC 3.07257
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.05194
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, DHFR, F3, FLT3, GRM1, GRM5, GSK3B, MAP2K1, MAP3K7, PDE5A, PTAFR, PTPN1, SRC, XDH 3.04819
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, TYR, XDH 3.03265
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.0309
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 3.01565
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, GSK3B, IGF1R, RELA, SRC 2.98126
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.97227
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS2 2.94204
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.9367
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.91461
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.9099
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.90096
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTAFR, PTGS2 2.8974
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.89434
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.88882
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88882
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, MAOB, RELA, SRC 2.87572
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DHFR, F3, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 2.86921
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.85179
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GRM3, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.85179
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.83737
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, DHFR, MAOA, MAOB 2.79437
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TYR, XDH 2.77958
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GRM1, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 2.77319
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1, MAOA, MAOB 2.76384
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1 2.76384
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, GSK3B, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, XDH 2.75012
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, HSD17B2, HSD17B3, IDO1, MAP2K1, MMP2, MMP9, PTAFR, PTGS2, SRC 2.74527
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 2.72442
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, IDO1, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 2.69998
[BP] GO:0010942 positive regulation of cell death CYP1B1, F3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.69039
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.64859
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 2.63329
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOA, MAOB, PDE5A, XDH 2.63136
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.61189
[BP] GO:0030335 positive regulation of cell migration APP, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.6057
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, GSK3B, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.58741
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, GRIK5, HCAR2, HMGCR, MAOB, MMP12, PTAFR, SRC 2.58639
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 2.5745
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.57444
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS2, RELA, SRC 2.5698
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, CA2, CYP1B1, F3, HMGCR, IDO1, KDR, MAP2K1, PDE5A, PIM1, PTGS2, RELA, SRC 2.53716
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 2.52909
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 2.50585
[BP] GO:2000147 positive regulation of cell motility APP, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.505
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.48801
[BP] GO:0099566 None GRM1, GRM5 2.48258
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48258
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.48097
[BP] GO:0009607 response to biotic stimulus AXL, CYP1A1, CYP1A2, GSK3B, IDO1, MAOB, MMP12, PTAFR, PTGES, PTGS2, RELA, SRC 2.45755
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.4468
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.4468
[BP] GO:0051272 positive regulation of cellular component movement APP, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.43302
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, MAOA, MAOB 2.40626
[BP] GO:2000243 None AR, PDE5A, PTAFR, SRC 2.40592
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.40592
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 2.40215
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.39894
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, HSD17B3, MAP2K1, SRC 2.39456
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.39456
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGES, PTGS2 2.39456
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, GRIK5, HCAR2, HMGCR, MAOB, MMP12, PTAFR, SRC 2.35679
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.35623
[BP] GO:0042135 None ACHE, MAOA, MAOB 2.35623
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35623
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, DHFR, HMGCR, PTAFR 2.34495
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CACNA1C, GRM5, MAOB, MMP9, PTAFR, PTGS2 2.34495
[BP] GO:0040017 positive regulation of locomotion APP, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.34495
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, SRC 2.31304
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.28482
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.28258
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.27835
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.27281
[BP] GO:1903522 None ADORA1, ADORA3, CACNA1C, PDE5A, PTAFR, PTGS2, SLC1A1 2.27281
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.26003
[BP] GO:0010675 None GSK3B, PPARA, PTAFR, RORC, SRC 2.26003
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25724
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25322
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25322
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.23668
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, IDO1, MAP3K7, MMP12, PTAFR, PTGS2, RELA, SRC 2.22793
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GSK3B, IDO1, MAOA, MAOB, PDE5A, SRC, XDH 2.22153
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.20934
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.20934
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.20493
[BP] GO:1902532 negative regulation of intracellular signal transduction HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.18766
[BP] GO:0044057 None ADORA1, ADORA3, CACNA1C, GRM1, HCAR2, PDE5A, PTAFR, PTGS2, SLC1A1 2.17635
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.17004
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.16793
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.15127
[BP] GO:0046683 response to organophosphorus APP, PTAFR, PTGS2, RELA, TYR 2.14312
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 2.13097
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, MMP9, PTGS2, PTPN1, RELA, SRC 2.1256
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.12193
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.10736
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.1
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, XDH 2.09172
[BP] GO:0031349 positive regulation of defense response FABP4, IDO1, MAP3K7, MMP12, MMP2, PTGS2, RELA, SRC 2.09172
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 2.07606
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.07606
[BP] GO:0010641 None F3, SRC 2.07606
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.06136
[BP] GO:0043207 response to external biotic stimulus AXL, CYP1A1, CYP1A2, IDO1, MAOB, MMP12, PTAFR, PTGES, PTGS2, RELA, SRC 2.06136
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1 2.05168
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.05117
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, SRC 2.05117
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.05101
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.05101
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.03187
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.03048
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, GSK3B, HCAR2, MMP12, PTAFR, PTGS2, SRC 2.02829
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.00459
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTAFR, PTGES, PTGS2, PTPN1, SLC1A1, SRC, TYR 4.08834
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SRC 4.07644
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, SRC 3.77719
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 3.62687
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.45865
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.41483
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.09812
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.09812
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, APP, AXL, CA2, CA4, CACNA1C, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTGS2, SLC1A1, SRC 2.98172
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 2.8974
[CC] GO:0098794 None ADORA1, APP, GRIA2, GRIA4, GRM3, GSK3B 2.76384
[CC] GO:0005783 None ADORA1, APP, CA4, CYP19A1, FLT3, GRIK5, HMGCR, HSD17B3, KDR, MAP2K1, PTGS2, PTPN1, XDH 2.62443
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MMP2, MMP9, PDE5A, PIM1, PTAFR, PTGES, PTGS2, PTPN1, RELA, SRC, TYR, XDH 2.5745
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAOB, MET, PTAFR, PTGES, PTGS2, PTPN1, SLC1A1, SRC, TYR 2.52736
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.29961
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.27281
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.25831
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 2.12092
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 2.11799
[CC] GO:0043235 receptor complex ABCG2, APP, GRIA2, GRIA4, GRIK5, GRM1, IGF1R 2.01595
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, TYR, XDH 8.54744
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.04498
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTGES, PTGS2, PTPN1, SRC, TYR, XDH 7.95367
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.86662
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 7.85075
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MAOB, PTGS2, TYR, XDH 7.21525
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HMGCR, HSD17B1, IDO1, MAOB, PTGES, PTGS2, SRC, XDH 5.24048
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 4.87793
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.85801
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, PPARA, PTAFR, RORC 4.71651
[MF] GO:0043168 anion binding ABCG2, APP, AURKB, AXL, CSNK2A1, DHFR, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTAFR, PTGES, RELA, SLC1A1, SRC, XDH 4.20637
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.18953
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 4.17474
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.09111
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 4.01048
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, HSD17B3, XDH 3.96634
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 3.93498
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.67085
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR 3.64635
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR 3.64635
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC 3.61752
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50405
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 3.45865
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.41483
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.37876
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.30735
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.26342
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 3.19844
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SLC1A1, SRC, XDH 3.10055
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.98172
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.85963
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.72442
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.71244
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.71167
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.66056
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.65804
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, TYR, XDH 2.64262
[MF] GO:0099583 None GRM1, GRM5 2.48258
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.45691
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.45691
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, TYR, XDH 2.45072
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 2.45072
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.4323
[MF] GO:0042802 identical protein binding ABCG2, ACHE, APP, CSNK2A1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MAOB, MAP3K7, MET, MMP9, PTGS2, RELA, TYR, XDH 2.4323
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.40626
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.39287
[MF] GO:0004971 None GRIA2, GRIA4 2.25322
[MF] GO:0005497 None AR, SHBG 2.25322
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.16793
[MF] GO:0000166 nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, XDH 2.14831
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, XDH 2.14695
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.1256
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SRC 2.11799
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.08938
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.08938
[MF] GO:0008289 lipid binding AR, AXL, F3, FABP3, FABP4, HSD17B1, PPARA, PTAFR, RORC, SHBG 2.04462
[MF] GO:0016229 steroid dehydrogenase activity HSD17B1, HSD17B2, HSD17B3 2.01595


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9442
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.9289
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.8359
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 7.3002
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, MAOA, CYP1A2, CYP1A1, CYP1B1, IDO1 6.7693
Metabolic pathways_Homo sapiens_hsa01100 MAOB, MAOA, HSD17B3, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES, IDO1 6.1591
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, MAP2K1, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, RELA, IGF1R 5.6353
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, PTAFR, GRM8, ADORA1, GRM1, GRIA4 6.0267
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOB, MAOA, ALOX5, CACNA1C, PTGS2 5.6353
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA, GRIA4 5.2058
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.4265
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 4.7693
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.3282
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, MAOA, RELA 5.0044
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, IGF1R 4.198
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, MAOA, CACNA1C, GRIA4 4.4108
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GSK3B, MAOB, MAOA, CACNA1C, GRIA4 4.2343
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 4.4153
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, RELA, IGF1R 3.8778
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, GRM1 3.6753
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PTGS2, MMP9, MAP3K7, RELA 3.4759
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, SRC, KDR, MET, IGF1R 3.3001
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.2972
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.4374
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR, PTGS2 3.3587
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 3.3686
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, GRM8, GRM1 3.0756
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, SRC, RELA 3.1433
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, PDE5A, CACNA1C 2.8431
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.8431
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3, RELA 2.71
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1997
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, GRM1 2.8771
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.7174
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.9682
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.4595
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, MAP3K7, RELA 2.6728
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, KDR, MET, RELA, IGF1R 2.3401
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2, MAP3K7, RELA 2.823
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA, RELA 2.6068
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.3401
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.4605
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, MAP3K7, RELA 2.3085
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, MMP9, RELA 2.2313
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.2065
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, PTGS2 2.178
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, CACNA1C, GRM1 2.0026
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.3978
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, SRC, RELA 1.9504
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.2313
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, MAP3K7, RELA 1.8645
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, RELA 2.195
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.2065
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.2276
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.8901
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, SRC 2.0074
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGES 2.3079
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.9205
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, MAOA, CYP1A2 2.2178
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1, TYR 1.8778
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.195
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.783
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.8601
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.2065
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.8324
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MAOA, TYR 2.8771
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5884
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.195
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, SRC 1.7277
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, RELA 1.7176
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.7277
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.7007
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.6299
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, GRM1, IGF1R 1.6299
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, MAP3K7, IGF1R 1.6966
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, RELA 1.6299
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1 1.5884
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, IGF1R 1.5786
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA, RELA 1.517
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1, MAP3K7 1.5786
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3112
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP, CACNA1C 1.4181
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3804
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3722
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.389
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0051
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOB, MAOA 1.3833
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, RELA 1.4027
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4176
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, RELA 0.5724
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.3575
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.6702
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.777
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6902
Platelet activation_Homo sapiens_hsa04611 SRC 0.4501
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.909
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9108
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.7724
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0081
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.9855
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.971
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5045
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.0028
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5126
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5126
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5126
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5222
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.516
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.521
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5275
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5328
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5343
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5343
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5343
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5379
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5396
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5343
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5343
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.1763
Peroxisome_Homo sapiens_hsa04146 XDH 0.5458
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5494
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5458
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5581
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5561
Pertussis_Homo sapiens_hsa05133 RELA 0.5701
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5724
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.2628
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2243
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5724
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5962
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2, RELA 1.2386
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3084
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.3575
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6167
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6167
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.4181
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.3833
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.4181
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.4142
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.4142
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1 1.4297
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.3833
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4181
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.4181
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6631
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.4181
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.6631
Legionellosis_Homo sapiens_hsa05134 RELA 0.6643
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4656
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4892
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6643
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1 1.5553
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6851
Malaria_Homo sapiens_hsa05144 MET 0.6916
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6897
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6966
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB, MAOA 1.5786
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7106
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.7251
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7176
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8901
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.8083
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8083
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB, MAOA 1.7176
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8722
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8514
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8948
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8601
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7781
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8722
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0708
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9038
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8617
Histidine metabolism_Homo sapiens_hsa00340 MAOB, MAOA 2.0411
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8948
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MAOA 2.2376
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9918
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9626
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.1273
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1407


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)