TCM Prescription: Bai Hua Cao Capsules



Prescription Description
Prescription IDTCMF7227
Pinyin NameBai Hua Cao Jiao Nang
Chinese Name柏花草胶囊
English NameBai Hua Cao Capsules
Function Description具有清热利湿, 活血消肿止痛的功效。用于Ⅰ, Ⅱ期内痔湿热下注证, 症见便血, 肛门肿痛, 肛门潮湿, 坠胀, 舌红苔黄, 脉弦细数。
IndicationsInterior haemorroid disorder
Disease ICD-11 Category SB7B [Interior haemorroid disorder (TM1), 内痔 (TM1) ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1299 Ganoderma lucidum 灵芝 TCMH1299 MGEN736-15
TCMH2252 Agrimonia pilosa var. japonica 仙鹤草 TCMH2252
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 8.11991
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.0243
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.0243
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, SMAD3, SRC, TEK, TYR 8.0243
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.0243
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.90034
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, XDH 7.71912
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TYR 7.6252
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.46373
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 7.46373
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 7.4495
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 7.37242
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.36492
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 7.3263
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.21951
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 7.21951
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TYR 7.17211
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.93778
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.90808
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.85368
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.80457
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.80068
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.792
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 6.56537
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 6.50339
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 6.34053
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.25326
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 6.24902
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 6.23788
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.23788
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.20388
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TYR 6.17244
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 6.01578
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.94423
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.92924
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.92836
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.8764
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.86125
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.82176
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.75395
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR 5.62184
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.57708
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F3, INSR, MET, SRC, TEK, XDH 5.51686
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, SRC, TEK, TYR 5.39629
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.3676
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 5.34951
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.34729
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.20914
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 5.17543
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 5.16326
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.11635
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 5.11635
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.07541
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 5.06927
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.04076
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 5.04076
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.04076
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.9904
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.94882
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.94882
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.93348
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.85644
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.85644
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA 4.85644
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC, TOP2A 4.83588
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.82846
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.79625
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.74905
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.73128
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.73128
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.71901
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 4.67814
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.59552
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.58189
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 4.52707
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 4.52465
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HSD17B1, HSD17B2 4.43045
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 4.42052
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 4.40809
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 4.37317
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.32001
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.31063
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, HSPA1A 4.30668
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 4.29368
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, DRD2, FABP3, PPARA 4.28456
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.23614
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.23614
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.20392
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 4.17419
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.0077
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.99397
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.95682
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.95483
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.95483
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.95483
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.92775
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.92372
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 3.91581
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.88996
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.84576
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.84576
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.84174
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.81237
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.81208
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.80248
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 3.80215
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 3.76835
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.76547
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.74421
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR 3.70877
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 3.69672
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.63564
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 3.61312
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.60419
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, EGFR, F3, FABP4, KDR, MET, PPARA, SMAD3, TEK 3.59415
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.5773
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.55502
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.53268
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC 3.53268
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.53268
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.52386
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.52113
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.51357
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, TYR 3.47742
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.4666
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.43868
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, DRD2, FABP3, PPARA 3.41597
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.39789
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.36864
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 3.32383
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 3.29192
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 3.25977
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 3.18082
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.15802
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, KDR, SRC 3.11598
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.11063
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.11063
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, SRC 3.09741
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.07753
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.06032
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, EGFR, KDR, SRC 3.05638
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.0506
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.0506
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, SRC 3.03906
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, INSR, SMAD3 3.03603
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.00455
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.97633
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HSPA1A, INSR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.95058
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.93846
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.93846
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.93846
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.93846
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.88488
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.87901
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.86333
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.84491
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.827
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, DRD1, DRD2, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.82545
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, PPARA, SMAD3, TEK 2.8214
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 2.81902
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.81902
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.81762
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.80367
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.79641
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, PPARA, SRC, TOP2A 2.79096
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.76499
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.75853
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.75853
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.75754
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.73557
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.73254
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.7235
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.71825
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, DRD2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.70923
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, INSR, MMP2, MMP9, SRC, TOP2A 2.70903
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, SRC, TEK 2.70529
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TOP2A 2.70423
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, EGFR, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.70151
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK 2.6926
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.69091
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.68205
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK 2.66874
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, EGFR 2.66874
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, EGFR 2.66874
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.65451
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.64838
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.64838
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.64838
[BP] GO:0051246 regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.62931
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP9, SRC, TEK 2.62931
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.62198
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.61784
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.60977
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.60203
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.59163
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.59163
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.5802
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 2.54078
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.5376
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.53548
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.52196
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.48822
[BP] GO:0051894 None KDR, SMAD3, TEK 2.4363
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.4363
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR 2.43049
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.42022
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.40941
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, SRC, TEK 2.40449
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.40449
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.40449
[BP] GO:0050927 None F3, KDR, SMAD3 2.40186
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.40008
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.37786
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.36909
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.36386
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.36086
[BP] GO:0050926 None F3, KDR, SMAD3 2.36086
[BP] GO:1903393 None KDR, SMAD3, TEK 2.36086
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.35733
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.35661
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR 2.35661
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.30632
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.30632
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.2975
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.2975
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.29126
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.29126
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.26099
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 2.26099
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, TYR 2.26099
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, SRC, TEK 2.25653
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, INSR, SMAD3, SRC 2.25653
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, DRD2, EGFR, F3, HSPA1A, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 2.2448
[BP] GO:0003018 None ADORA1, DRD1, EGFR, SRC, TEK 2.23477
[BP] GO:0021853 None DRD1, DRD2 2.23477
[BP] GO:0010641 None F3, SRC 2.23477
[BP] GO:1904936 None DRD1, DRD2 2.23477
[BP] GO:0042321 None ADORA1, DRD2 2.23477
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.21542
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.21351
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.21351
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, XDH 2.20192
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.20126
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.20126
[BP] GO:1901890 None KDR, SMAD3, TEK 2.18023
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.18023
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.18023
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC 2.16455
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.15095
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PTPN1, SRC 2.14417
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.14417
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2 2.13924
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, GPR35, SMAD3 2.13642
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.11532
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.11181
[BP] GO:0010907 None INSR, PPARA, SRC 2.11181
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.1014
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, XDH 2.1014
[BP] GO:0021843 None DRD1, DRD2 2.1014
[BP] GO:0021830 None DRD1, DRD2 2.1014
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.1014
[BP] GO:0021826 None DRD1, DRD2 2.1014
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.1014
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 2.09139
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.09139
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.08688
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, INSR 2.08688
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, XDH 2.08639
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.07796
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, SRC, TEK 2.05646
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, SMAD3 2.04925
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2 2.04208
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.0387
[BP] GO:0045124 None CA2, EGFR, SRC 2.02812
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTPN1, SRC 2.00579
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 2.59163
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD1, DRD2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.40451
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, CA1, CA2, CA4, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TOP2A, TYR, XDH 2.31874
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.1014
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, PIM1, PTPN1, SMAD3, SRC, TOP2A, TYR, XDH 2.09168
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP2A, TYR, XDH 11.9726
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 10.5527
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 10.3294
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 9.63845
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.8209
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 7.75523
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7 7.37242
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.25054
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.85368
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.99395
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, GLO1 5.94423
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.67671
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.42059
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, GLO1, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TOP2A, TYR, XDH 5.07541
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.06927
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.74905
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.62664
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.40809
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.31063
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 4.27173
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.23614
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, GLO1, MMP1, MMP2, MMP9, PPARA, PTPN1, SMAD3 4.18085
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.17473
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.94367
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TOP2A, TYR, XDH 3.70331
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.58792
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.56204
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.56204
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.43868
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.30092
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.27581
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.24474
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 3.22243
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.17911
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 3.12059
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.03052
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.03052
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.91415
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.81668
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 2.80418
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.79107
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.70529
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.64838
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.58846
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.54078
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.52388
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.4363
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.40449
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.40449
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.40449
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.40449
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.30659
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.24362
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.23477
[MF] GO:0043559 insulin binding IGF1R, INSR 2.23477
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.18023
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PTPN1, SMAD3 2.14417
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.1014
[MF] GO:0004064 arylesterase activity CA1, CA2 2.1014
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.09139
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.01455


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 10.1798
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 11.6712
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.9296
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.1214
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.6029
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.6029
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.5706
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.9292
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.7711
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.923
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.5258
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.3796
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.3152
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.909
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3796
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.909
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 3.0819
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.6876
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.1752
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.833
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.909
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.5599
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, DRD1, DRD2 2.3516
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.909
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.4066
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.5599
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3807
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1791
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, DRD2, PPARA 2.059
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3773
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.3516
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4034
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0811
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.7433
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.9069
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6953
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.6178
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4877
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.2047
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2153
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1574
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4122
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1835
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4877
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4559
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2021
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4082
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 1.0316
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.2035
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2959
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0316
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0253
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.013
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9606
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.9889
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9718
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.013
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9582
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9582
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.38
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4747
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9582
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9582
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9582
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9226
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3647
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9531
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.9014
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR 0.8348
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8348
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7757
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7392
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.6019
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2917
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3604
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6353
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.4056
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3983
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3879
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3976
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3983
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4255
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3874
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4334
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4773
Platelet activation_Homo sapiens_hsa04611 SRC 0.5016
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5258
Axon guidance_Homo sapiens_hsa04360 MET 0.4934
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5016
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.51
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5258
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5505
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5505
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.543
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.551
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5258
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5505
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5553
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.555
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5597
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5733
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5733
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5835
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5727
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6182
Peroxisome_Homo sapiens_hsa04146 XDH 0.5842
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6194
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9344
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6169
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5993
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6054
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6264
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6413
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6394
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6529
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.643
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6488
Shigellosis_Homo sapiens_hsa05131 SRC 0.643
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.9516
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.643
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8119
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6759
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6488
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6966
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6786
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9017
Malaria_Homo sapiens_hsa05144 MET 0.716
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7196
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1146
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7852
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8248
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7796
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8492
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9014
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8248
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8348
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9014
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9014
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1752
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0613


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)