TCM Prescription: Shi Liu Bu Xue Syrup



Prescription Description
Prescription IDTCMF7139
Pinyin NameShi Liu Bu Xue Tang Jiang
Chinese Name石榴补血糖浆
English NameShi Liu Bu Xue Syrup
Function Description补气血。用于气血虚引起的气短, 头晕, 心悸, 健忘等。
IndicationsForgetfulness disorder, Blood deficiency pattern
Disease ICD-11 Category SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SF00 [Blood deficiency pattern (TM1), 血虚证 (TM1) ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1943 Punica granatum 石榴 TCMH1943 ITSAJ1428-14
TCMH2050 Punica granatum 酸石榴 TCMH2050 ITSAJ1428-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT393 MERTK Proto-oncogene tyrosine-protein kinase MER Kinase Q12866
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1316 Leishmania sp.
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SMAD3, SRC, TEK, TYR 6.59888
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SRC, TEK, TYR 6.38928
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.11535
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.11535
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.11535
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.11471
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.11471
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.11471
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.11471
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.70224
[BP] GO:0042127 regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 5.58966
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SLCO1B1, SMAD3, SRC, TEK, XDH 5.56322
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.56322
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.56322
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 5.56035
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.56035
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.4924
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.48271
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.41413
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.41413
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 5.35715
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.33343
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.29558
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.29558
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.09913
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, SRC, TEK 5.08735
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 5.0714
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.05494
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.97906
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 4.97793
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.97793
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC5A1, SMAD3, SRC, TEK, TYR 4.90035
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 4.7183
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 4.71776
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.70969
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.70969
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC, TEK, TYR 4.70793
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.70724
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.70724
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.70724
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.70724
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 4.52709
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 4.51702
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 4.47854
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.45742
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.38232
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 4.34884
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 4.32486
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.30816
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 4.2903
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.25794
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.0913
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.04769
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.00456
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, F10, F2, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.97694
[BP] GO:0080134 regulation of response to stress CYP19A1, DUSP3, EGFR, ESR1, F2, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.97694
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.9653
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.87767
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.84637
[BP] GO:0032879 regulation of localization ACHE, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 3.79475
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.77996
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.755
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.74735
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLCO1B1, SLCO1B3 3.74634
[BP] GO:0030334 regulation of cell migration APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.74634
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.74634
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.6705
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.64645
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.61972
[BP] GO:0030335 positive regulation of cell migration EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.56812
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.56605
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.53873
[BP] GO:2000145 regulation of cell motility APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.49207
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC 3.47658
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.46561
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F2, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.46561
[BP] GO:2000147 positive regulation of cell motility EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.46561
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 3.40901
[BP] GO:0051272 positive regulation of cellular component movement EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.36528
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.35081
[BP] GO:0048585 negative regulation of response to stimulus CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.32502
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.30506
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC, TEK 3.30041
[BP] GO:0040017 positive regulation of locomotion EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.26089
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 3.23115
[BP] GO:0040012 regulation of locomotion APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.17965
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.17528
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.17528
[BP] GO:0051270 regulation of cellular component movement APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.17528
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17376
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.14288
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B1, HSD17B2, SLCO1B1 3.1292
[BP] GO:0019220 regulation of phosphate metabolic process CDC25B, DUSP3, EGFR, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.10457
[BP] GO:0051174 regulation of phosphorus metabolic process CDC25B, DUSP3, EGFR, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.05916
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.99302
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.98231
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.96885
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.94652
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLCO1B1, SLCO1B3 2.89665
[BP] GO:0010648 negative regulation of cell communication ACHE, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.86242
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA 2.86242
[BP] GO:0023057 negative regulation of signaling ACHE, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.85526
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85526
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 2.85526
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, SMAD3, XDH 2.80789
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.7868
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.7686
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.7529
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.73233
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.71119
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.71119
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.69621
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.68948
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.66849
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, INSR, SMAD3, XDH 2.65049
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63007
[BP] GO:0031348 negative regulation of defense response CYP19A1, F2, MMP12, PPARA, SMAD3, TEK 2.63007
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.63007
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.63007
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.63007
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.63007
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, F2, FABP3, FLT3, PPARA, RORC, SRC, TEK 2.61041
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.5928
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 2.56316
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.55064
[BP] GO:0065009 regulation of molecular function AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.54823
[BP] GO:0009611 response to wounding ACHE, CYP1A1, EGFR, F2, PPARA, SMAD3 2.54809
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.53935
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.53572
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.5188
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48435
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48435
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, CDC25B, EGFR, ESR1, ESR2, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.46229
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, SMAD3, TEK 2.43781
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.43469
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.43469
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43469
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.43091
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, F2, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.42776
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, F2, PPARA, SMAD3, TEK 2.41839
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41839
[BP] GO:0010562 positive regulation of phosphorus metabolic process CDC25B, EGFR, F2, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.40268
[BP] GO:0045937 positive regulation of phosphate metabolic process CDC25B, EGFR, F2, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.40268
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.40268
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.36265
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35251
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.35251
[BP] GO:0009893 positive regulation of metabolic process AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.33425
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.33425
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.33425
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.31313
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.31313
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.31313
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.31313
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.29648
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.29648
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26424
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.26272
[BP] GO:0042325 regulation of phosphorylation CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 2.25949
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.25569
[BP] GO:0050790 regulation of catalytic activity AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.24983
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.24859
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.24257
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.24257
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.2423
[BP] GO:0051894 None KDR, SMAD3, TEK 2.2423
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2423
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2423
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2423
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.23922
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.23922
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.23922
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 2.23309
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.2269
[BP] GO:0043549 regulation of kinase activity CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.22128
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, TOP2A 2.21911
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.20127
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, SRC, TOP2A 2.19953
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.19953
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.19676
[BP] GO:0009968 negative regulation of signal transduction DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.19187
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17006
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, F2, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.17006
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.17006
[BP] GO:0044093 positive regulation of molecular function AURKB, CDC25B, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.17006
[BP] GO:0043408 regulation of MAPK cascade DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.15773
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.15256
[BP] GO:0001932 regulation of protein phosphorylation CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.1444
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13265
[BP] GO:0031399 regulation of protein modification process CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 2.1043
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR 2.09585
[BP] GO:0034219 None SLC5A1, SLC5A2, SLC5A4 2.0907
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.08241
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.07786
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.07786
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.05946
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.05814
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, SRC 2.05814
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TOP2A 2.0424
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.02812
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.02812
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.02812
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.02812
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.02812
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, F2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.02812
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, F2, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC 2.02812
[BP] GO:0051247 positive regulation of protein metabolic process CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.0151
[CC] GO:0005886 plasma membrane ACHE, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CSNK2A1, EGFR, ESR1, F10, F2, FLT3, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC5A1, SLC5A2, SLCO1B1, SLCO1B3, SMAD3, SRC, TEK 2.85526
[CC] GO:0031226 intrinsic component of plasma membrane AXL, BACE1, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, TEK 2.83141
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, EGFR, SLCO1B1, SLCO1B3, TEK 2.46985
[CC] GO:0044459 plasma membrane part AXL, BACE1, CA2, CA4, DUSP3, EGFR, F10, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SRC, TEK 2.3441
[CC] GO:0005887 integral component of plasma membrane AXL, BACE1, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, TEK 2.07501
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 10.0007
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F2, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP2A, TUBB3, TYR, XDH 9.82773
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TUBB3, TYR, XDH 9.3588
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.68759
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.1014
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.38928
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 5.56035
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.4924
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.40808
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.97793
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 4.79734
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 4.74979
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 4.47854
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.43133
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.39328
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.01621
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.99695
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.77996
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.70954
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.68405
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.64346
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.52887
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.33267
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.30041
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.30041
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.89927
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79748
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.75246
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.72282
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.71846
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.69621
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.65049
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.62378
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.62378
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, MMP1, MMP12, MMP2, MMP9 2.43091
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.38996
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.37088
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.35251
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.33425
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.31313
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.29648
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, F10, F2, FABP3, FABP4, HSD17B1, PPARA, RORC 2.29599
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.25813
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.25258
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.24257
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.24257
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.24232
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.2423
[MF] GO:0015145 None SLC5A1, SLC5A2, SLC5A4 2.2423
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2423
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.19187
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.17006
[MF] GO:0038023 signaling receptor activity AXL, EGFR, ESR1, ESR2, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.15938
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07786
[MF] GO:0043559 insulin binding IGF1R, INSR 2.07786
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.05814
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3 2.02793


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.5032
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.5567
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2808
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.2061
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.4414
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2061
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4482
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2105
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6799
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.4357
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1514
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1514
Bile secretion_Homo sapiens_hsa04976 SLCO1B1, CA2, SLCO1B3, SLC5A1 3.1514
Metabolic pathways_Homo sapiens_hsa01100 FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, AKR1B1, TYR, CYP19A1, XDH 2.6189
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.6323
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6323
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.385
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5605
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6419
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3174
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2059
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1674
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1307
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1672
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1301
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9876
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8145
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1292
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9292
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.9566
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5544
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7595
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5082
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4559
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 1.1235
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3031
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3667
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3267
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3625
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1007
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1106
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.048
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0732
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2997
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1726
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3442
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3031
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9326
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0999
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9326
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2 1.1711
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9326
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9087
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8517
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.862
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3031
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9087
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8486
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8456
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8456
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8413
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8486
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8216
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8035
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6745
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, F2 0.5541
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2615
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3274
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.364
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3571
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3507
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3563
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3764
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3567
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3817
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3571
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3337
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.364
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.364
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3817
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3504
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.423
Platelet activation_Homo sapiens_hsa04611 SRC 0.4464
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4464
Axon guidance_Homo sapiens_hsa04360 MET 0.4385
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4731
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8125
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4731
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4965
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4965
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4965
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4893
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4731
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4965
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5002
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5002
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5043
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5173
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5268
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5173
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.517
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5599
Peroxisome_Homo sapiens_hsa04146 XDH 0.5272
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5588
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6934
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5519
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5719
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.586
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7698
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5732
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6055
Shigellosis_Homo sapiens_hsa05131 SRC 0.5877
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6017
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6284
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6017
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6438
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.631
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9876
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.631
Malaria_Homo sapiens_hsa05144 MET 0.658
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.6467
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6613
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6647
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 SLC5A1 0.6722
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6684
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7147
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7537
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7097
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8216
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7537
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7873
Base excision repair_Homo sapiens_hsa03410 APEX1 0.767
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8035
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8216
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7951
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8216
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0442
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.991


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)