TCM Prescription: Xiao Er Qing Yan Granules



Prescription Description
Prescription IDTCMF7122
Pinyin NameXiao Er Qing Yan Ke Li
Chinese Name小儿清咽颗粒
English NameXiao Er Qing Yan Granules
Function Description清热解表, 解毒利咽。用于小儿外感风热引起的发热头痛, 咳嗽音哑, 咽喉肿痛。
IndicationsCommon cold
Disease ICD-11 Category CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH1678 Indigo naturalis 青黛 TCMH1678
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FUT7, GLO1, HMGCR, IDO1, PIM1, PPARA, PTGS2, XDH 9.31189
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.78391
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.50034
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 8.16635
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 8.12944
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CYP1B1, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 7.76642
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 7.76642
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.72164
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 7.56132
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 7.4764
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 7.34101
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, GSK3B, HMGCR, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC 7.25355
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 7.23997
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 7.05438
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SRC 6.64383
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TERT 6.51898
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CYP1B1, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 6.48638
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 6.4486
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 6.43373
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, KDR, MET, PPARA, PTGS2, SRC, TERT, XDH 6.26916
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 6.24056
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 6.18362
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGS2 5.99664
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 5.69263
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 5.65819
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 5.38625
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 5.15744
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 5.05412
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, GSK3B, HMGCR, IDO1, PTGS2, XDH 5.05412
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.01913
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.90207
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 4.84812
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.82453
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC, TERT 4.81599
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 4.73021
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 4.72004
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CYP1B1, FABP4, FLT3, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 4.67512
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 4.66211
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.65901
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CYP1B1, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.61289
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 4.38231
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR 4.29376
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.29376
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, KDR, PTGS2, SRC 4.29376
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.29376
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 4.29376
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 4.20254
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 4.17069
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC 4.17069
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.16504
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 4.10076
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 3.99475
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGS2 3.98365
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, GSK3B, IDO1, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A 3.98348
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, FLT3, HMGCR, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.93485
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.91162
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.89562
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 3.89562
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, HMGCR 3.78525
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 3.76155
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.76155
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.75432
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.68949
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2 3.60456
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.60456
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 3.60221
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CYP1A1, CYP1B1, DHFR, FLT3, PTGS2, RORC, SRC 3.58922
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CYP1A1, CYP3A4, DHFR, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 3.56691
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.56691
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CDC25B, CYP1A1, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 3.54662
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.51757
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 3.4308
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.4308
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 3.36755
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, FLT3, PTGS2, RORC, SRC 3.36551
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, DHFR, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.30656
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.24256
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC, TERT 3.22939
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.22861
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.21009
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, GSK3B, HMGCR, IGF1R, MET, PTGS2, PTPN1, TERT, XDH 3.20539
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.16888
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.13974
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, HMGCR, MMP2, PPARA, PTGS2, SRC, TERT 3.13292
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 3.11595
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.10725
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, GSK3B, HMGCR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 3.07323
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, DHFR, HMGCR 3.06907
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC 3.06199
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 3.02204
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CYP19A1, CYP1B1, FABP4, HMGCR, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC 3.02204
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.02117
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.98908
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.98908
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.98262
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, DHFR, FABP4, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.96494
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.9583
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.9583
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.95728
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.95728
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.95728
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1B1 2.91302
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.90601
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CYP1A1, FABP3, FLT3, IDO1, PTGS2, RORC, SRC 2.90044
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.89727
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.87486
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.87486
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.86566
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.85047
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.8392
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.83327
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.83061
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.83061
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.83061
[BP] GO:0030335 positive regulation of cell migration APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.80363
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.80363
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, CA2, CA9, CYP1B1, DHFR, GSK3B, MMP9, PTGS2, PTPN1, SRC, TERT, TOP2A 2.80363
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.78919
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, SRC 2.78683
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 2.78683
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.78073
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.78041
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, FABP4, MMP9, PTGS2, TERT 2.78041
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.76371
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, KDR, MMP2, PTGS2, SRC 2.76371
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.76371
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.76371
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.74904
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.74728
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1B1, CYP3A4, HMGCR 2.74564
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.74564
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.74564
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.74564
[BP] GO:2000147 positive regulation of cell motility APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.74537
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.74002
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.71011
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.71011
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, DHFR, FABP4, FLT3, GSK3B, HMGCR, IGF1R, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.69948
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 2.69399
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, GSK3B, MMP12, PTGS2, SRC, TERT 2.69399
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.67895
[BP] GO:0051272 positive regulation of cellular component movement APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.67895
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HMGCR, KDR, PTGS2, SRC 2.6567
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.6567
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.6567
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.6567
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1B1, FABP3, GLO1, IDO1, PPARA, PTGS2 2.64164
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.63118
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.62287
[BP] GO:0007568 aging APEX1, AURKB, CYP1A1, HMGCR, PTGS2, TERT 2.61692
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.61692
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.60866
[BP] GO:0040017 positive regulation of locomotion APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.59839
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, GSK3B, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.59588
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.57292
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, DHFR, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.52996
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, HMGCR, IGF1R, PTPN1, SRC 2.52996
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.52996
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.52786
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, FABP3, FLT3, PPARA, PTGS2, SRC 2.52786
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, TERT 2.52786
[BP] GO:0010942 positive regulation of cell death CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.51994
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR 2.49344
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, HMGCR, KDR, PTPN1, SRC, XDH 2.48358
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, DHFR, FABP4, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.48178
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, SRC, TERT 2.47842
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.47842
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.46723
[BP] GO:1902532 negative regulation of intracellular signal transduction HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.4587
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, FLT3, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.43087
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2 2.43087
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.42323
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1B1, CYP3A4, DHFR, IDO1 2.40568
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.39297
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, MMP9, RORC 2.38523
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.36911
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, FABP3, IDO1, PTGS2, TERT, XDH 2.35053
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.33058
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DHFR, HMGCR 2.32883
[BP] GO:0051099 positive regulation of binding APP, GSK3B, MET, MMP9, TERT 2.31816
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTGS2 2.29517
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 2.28979
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, TERT 2.28429
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.27616
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.27616
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.27616
[BP] GO:0032092 positive regulation of protein binding APP, GSK3B, MMP9, TERT 2.2668
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CYP1B1, DHFR, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.2668
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.25282
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.25282
[BP] GO:0048511 rhythmic process AXL, GSK3B, PPARA, RORC, SRC, TOP2A 2.21788
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.20794
[BP] GO:0046165 None AKR1B1, CYP3A4, DHFR, HMGCR 2.20428
[BP] GO:0030154 cell differentiation AXL, CYP1A1, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, KDR, MMP2, MMP9, PTGS2, RORC, TOP2A 2.19571
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, XDH 2.17692
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DHFR, PPARA 2.16071
[BP] GO:0022414 reproductive process AKR1B1, APP, AXL, CDC25B, CYP19A1, CYP1A1, IDO1, MMP2, MMP9, PTGS2, SRC, TOP2A 2.15756
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1B1, FABP3, PPARA, PTGS2 2.13391
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2 2.13363
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.1283
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, AXL, CDC25B, CYP1A1, CYP1B1, CYP3A4, DHFR, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.11456
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MMP9, PTGS2, PTPN1, SRC 2.11441
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, PTGS2 2.10762
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, PTGS2 2.10762
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.10762
[BP] GO:0010906 None GSK3B, PPARA, RORC, SRC 2.1076
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1B1, PTGS2 2.09188
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2 2.09161
[BP] GO:1900087 None APEX1, CYP1A1, TERT 2.09161
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CYP19A1, CYP1A1, CYP1B1, DHFR, FLT3, GSK3B, KDR, MMP9, PIM1, PPARA, PTGS2, RORC, SRC 2.0834
[BP] GO:0042752 None ADORA1, PPARA, RORC, TOP2A 2.0834
[BP] GO:0032091 negative regulation of protein binding AURKB, GSK3B, MET, PPARA 2.0834
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.06391
[BP] GO:0009968 negative regulation of signal transduction GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.05435
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, PTPN1, SRC 2.04638
[BP] GO:0007566 embryo implantation MMP2, MMP9, PTGS2 2.0346
[BP] GO:0097756 None ADORA1, HMGCR, PTGS2 2.0074
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.0074
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1B1, PTGS2 2.0004
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, FLT3, HMGCR, KDR, PTGS2, PTPN1, XDH 2.7521
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.10762
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, KDR, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 2.0074
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.0074
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, CA4, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP2, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 1.92021
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, XDH 10.9265
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 10.9265
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.8368
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 10.6427
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.75004
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.17122
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 6.35311
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, TOP2A, XDH 6.26916
[MF] GO:0046872 metal ion binding ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, TOP2A, XDH 5.78746
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 5.54434
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2, XDH 5.14928
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.9051
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.73021
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2, SRC, XDH 4.16759
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP3A4 4.06112
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.035
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.91767
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.89562
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.48603
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP3A4, XDH 3.26843
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 3.26843
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.1924
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.07323
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 3.02819
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.6567
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.5451
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.43087
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1B1, CYP3A4, PTGS2 2.40568
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.39297
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.24606
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.24606
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.13939
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.11441
[MF] GO:0004064 arylesterase activity CA1, CA2 2.10762
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.06391


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.2139
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 6.9404
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 3.9367
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.961
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7014
Metabolic pathways_Homo sapiens_hsa01100 DHFR, FUT7, AKR1B10, ALOX5, CYP1A1, AKR1B1, HMGCR, PTGS2, CYP3A4, CYP19A1, XDH, IDO1 3.473
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1A1, CYP1B1, CYP3A4, CYP19A1 3.6527
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.4075
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.473
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.1138
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.95
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A1, CYP1B1, PTGS2, CYP3A4 3.2774
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1, IDO1 2.95
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.5456
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.4658
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0127
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2221
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A1, CYP1B1, CYP3A4 2.2912
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.3001
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9996
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.9048
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8108
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.9048
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.4517
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4517
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2816
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4517
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3859
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2 1.424
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3742
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.3742
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3859
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1, CYP3A4 1.3979
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1706
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1665
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.2434
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.2514
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2355
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1852
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6174
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3194
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.1207
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9048
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.0863
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0863
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0863
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0459
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0774
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 1.0381
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 1.0774
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9957
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.0666
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 1.0023
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 1.0113
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.9767
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8108
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9559
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9289
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8784
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.9289
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8804
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.852
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.6972
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6765
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3436
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B 0.4103
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3976
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4087
Purine metabolism_Homo sapiens_hsa00230 XDH 0.451
Influenza A_Homo sapiens_hsa05164 GSK3B 0.451
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4505
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4824
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4904
Measles_Homo sapiens_hsa05162 GSK3B 0.5226
Tight junction_Homo sapiens_hsa04530 SRC 0.5181
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B 0.514
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5271
Platelet activation_Homo sapiens_hsa04611 SRC 0.5488
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5505
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5488
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.5348
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5722
Melanogenesis_Homo sapiens_hsa04916 GSK3B 0.5965
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5965
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5933
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5965
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5998
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.553
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6036
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6078
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6036
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5998
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5933
NF-kappa B signaling pathway_Homo sapiens_hsa04064 PTGS2 0.5998
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6078
Gap junction_Homo sapiens_hsa04540 SRC 0.6078
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.6078
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5998
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5965
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6544
Peroxisome_Homo sapiens_hsa04146 XDH 0.6128
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6536
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6544
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6765
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6765
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6615
Glioma_Homo sapiens_hsa05214 IGF1R 0.6765
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6765
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6753
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6765
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP3A4 0.6625
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6765
Shigellosis_Homo sapiens_hsa05131 SRC 0.6765
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.714
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6972
Malaria_Homo sapiens_hsa05144 MET 0.727
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7245
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.852
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8049
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8807
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP3A4 0.8959
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8671
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9289
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8881
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9194
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9957
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9718
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0863
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.3777


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)