TCM Prescription: Jin Lian Qing Re Granules



Prescription Description
Prescription IDTCMF709
Pinyin NameJin Lian Qing Re Ke Li 
Chinese Name金莲清热颗粒
English NameJin Lian Qing Re Granules
Function Description感冒, 喉痹
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1105 Trollius chinensis 金莲花 TCMH1105 GBVJ1059-11
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, IDO1, PDE5A, PIM1, PPARA, PTGS2, TBXAS1, XDH 8.25035
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 8.25035
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MAOB, PPARA, PTGS2, RORC, SRC 8.056
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.74029
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, KIT, MET, PPARA, PTGS2, TBXAS1 7.14271
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GSK3B, IDO1, IGF1R, MAOB, PPARA, PTGS2, RORC, SRC 6.85558
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MAOB, PPARA, PTGS2, RORC, SRC 6.41511
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MAOB, PTGS2, SRC 6.39906
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, IDO1, MAOB, PTGS2, RORC, SRC 6.39018
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSD17B1, KDR, KIT, MAOB, MET, PPARA, PTGS2, SRC, XDH 6.39018
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 6.34185
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MET, PIM1, PPARA, PTGS2, SRC, XDH 6.3032
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, KDR, KIT, MET, MMP12, PDE5A, PTGS2, SRC, XDH 6.293
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, KDR, KIT, MET, MMP12, PDE5A, PTGS2, SRC, XDH 6.28196
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, PIM1, PPARA, PTGS2, SRC 6.06948
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, MAOB, PPARA, PTGS2, SRC 6.02074
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MET, PIM1, PTGS2, SRC, XDH 6.01795
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GSK3B, IGF1R, KIT, MAOB, PPARA, PTGS2, SRC 5.92385
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, PIM1, PTGS2, SRC 5.63302
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 5.613
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, MAOB, PTGS2, RORC, SRC 5.59246
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD17B1, IDO1, MAOB, PTGS2, TBXAS1, XDH 5.52109
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PTGS2, RORC, SRC 5.46408
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, XDH 5.35033
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 5.2285
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGS2, TBXAS1 5.18616
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, XDH 5.15057
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOB, MMP12, PDE5A, SRC, XDH 4.92853
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CSNK2A1, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP12, PDE5A, PIM1, PTGS2, SRC, XDH 4.8416
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, XDH 4.57348
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, PIM1, PTGS2, SRC, XDH 4.52281
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.46772
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, XDH 4.37143
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.30494
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.25386
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GSK3B, KDR, KIT, MAOB, MET, PIM1, PPARA, PTGS2, RORC, SRC 4.21733
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, PTGS2, SRC 4.21733
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.19317
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.1611
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GSK3B, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP12, PPARA, PTGS2, SRC 4.14713
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, KDR, KIT, MAOB, PIM1, PPARA, PTGS2, RORC, SRC 4.13149
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, PTGS2, RORC, SRC 4.13149
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 4.11408
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, PIM1, PTGS2, SRC 4.09639
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 4.07631
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, PTGS2, SRC 4.07631
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 4.03992
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 4.02508
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MAOB, MMP12, PPARA, PTGS2, RORC, SRC 3.98156
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, PTGS2, RORC, SRC 3.96243
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PDE5A, PIM1, PTGS2, SRC, XDH 3.93129
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, KDR, MAOB, PTGS2, SRC 3.89162
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, PDE5A, PTGS2, SRC, XDH 3.87221
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MET, MMP12, PDE5A, PTGS2, SRC, XDH 3.84878
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.7919
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MET, MMP12, PDE5A, PTGS2, SRC, XDH 3.76662
[BP] GO:1901575 None ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOB, PDE5A, XDH 3.74983
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PDE5A, PIM1, PTGS2, SRC, XDH 3.6875
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2, TBXAS1 3.63824
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, KDR, KIT, MET, PDE5A, PTGS2, SRC, XDH 3.60491
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, PTGS2, RORC, SRC 3.57819
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.53864
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.52025
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 3.43656
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP12, PDE5A, PTGS2, SRC, XDH 3.38299
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1 3.32284
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.24316
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, MAOB, SRC 3.23904
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.23904
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.20653
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, GSK3B, KIT, PPARA, RORC, SRC 3.2021
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 3.15256
[BP] GO:0044248 cellular catabolic process ACHE, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GSK3B, IDO1, MAOB, PDE5A, SRC, XDH 3.13406
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 3.06362
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, PDE5A, PTGS2, SRC, XDH 3.01267
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.01267
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1 2.99042
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1 2.96815
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, PTGS2, SRC 2.93556
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, FABP4, KIT, MAOB, PTGS2 2.9205
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, GSK3B, IGF1R, MET, PIM1, PPARA, PTGS2, SRC 2.9205
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1 2.91859
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, KIT, PPARA, SRC 2.85299
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, CYP19A1, CYP1A2, GSK3B, IDO1, MAOB, XDH 2.79673
[BP] GO:0048545 response to steroid hormone ALPL, CA2, FLT3, MAOB, PTGS2, SRC 2.79673
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PTGS2, SRC 2.79673
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, PTGS2, SRC 2.73033
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.70379
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DHFR, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, PPARA, PTGS2, SRC, XDH 2.69901
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, FLT3, PTGS2, RORC, SRC 2.69488
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, PDE5A, PPARA, PTGS2, SRC, XDH 2.66197
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, CYP1A1, CYP1A2, GSK3B, IDO1, MAOB, MMP12, PTGS2, SRC 2.6575
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.63889
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.63889
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1 2.61452
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.60784
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, IDO1, IGF1R, KIT, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC 2.59251
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1 2.54871
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.53277
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC 2.53178
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1, MAOB 2.51985
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, HCAR2, IDO1, KDR, KIT, MET, MMP12, PDE5A, PIM1, PTGS2, SRC 2.51951
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.49973
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.49372
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, PTGS2, SRC 2.49372
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DHFR, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, SRC, XDH 2.49372
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, PTGS2, SRC 2.48669
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.44947
[BP] GO:0031960 response to corticosteroid ALPL, FLT3, MAOB, PTGS2, SRC 2.44377
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.40918
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.37831
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.37417
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3734
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3734
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CSNK2A1, DHFR, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PPARA, PTGS2, RORC, SRC, XDH 2.37028
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.32777
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.32777
[BP] GO:0001816 cytokine production FABP4, IDO1, KIT, PTGS2 2.30987
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTGS2, SRC 2.2987
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DHFR, FABP3, FLT3, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.28117
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, GSK3B, HCAR2, MMP12, PTGS2, SRC 2.25857
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.25857
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.25857
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 2.23206
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, DHFR, MAOB 2.23206
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, SRC 2.21335
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 2.21335
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DHFR, PPARA 2.20769
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2 2.20769
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, PTGS2 2.20609
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.2017
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.20166
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, KIT, PTGS2 2.18639
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, KIT, PTGS2 2.18639
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.16911
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, IDO1, MAOB, PDE5A, XDH 2.13192
[BP] GO:0030098 lymphocyte differentiation AXL, FLT3, FUT7, KIT, RORC 2.13139
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, MMP12, PTGS2, SRC 2.12771
[BP] GO:0010906 None GSK3B, PPARA, RORC, SRC 2.12266
[BP] GO:0032091 negative regulation of protein binding AURKB, GSK3B, MET, PPARA 2.09258
[BP] GO:1901698 response to nitrogen compound AKR1B1, DHFR, FABP3, FLT3, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.08415
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CYP1B1, GSK3B, HCAR2, IDO1, KDR, KIT, MET, MMP12, PDE5A, PIM1, PTGS2, SRC, XDH 2.08087
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, XDH 2.05584
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, KDR, PTGS2, SRC 2.05371
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.04755
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, MAOB 2.04157
[BP] GO:0051188 None CYP1A1, CYP1A2, DHFR, MAOB, PTGS2 2.0229
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, FLT3, KIT, MET, PIM1, SRC 2.00469
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GSK3B, HCAR2, IGF1R, KDR, KIT, MAOB, MET, PIM1, PTGS2, SRC, TBXAS1 1.46628
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MET, PIM1, SRC 1.33299
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9 1.30668
[CC] GO:0042629 None AKR1B1, KIT 1.19166
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HCAR2, IGF1R, KDR, KIT, MAOB, MET, PTGS2, SRC, TBXAS1 1.0159
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.6495
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 9.72837
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PTGS2, SRC, TBXAS1, XDH 9.28631
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.13333
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, PIM1, PPARA, RORC, TBXAS1, XDH 7.04114
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.39018
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC, TBXAS1 6.34185
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, MAOB, PTGS2, SRC, TBXAS1, XDH 6.34185
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC, TBXAS1 6.21101
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, MAOB, PTGS2, TBXAS1, XDH 5.58519
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.5046
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 5.2854
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.945
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.53586
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 4.24165
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 4.24165
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.24165
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.21733
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.1611
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, KIT, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, TBXAS1, XDH 4.07631
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, PDE5A, PIM1, SRC, XDH 4.02508
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.01992
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, KIT, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, TBXAS1, XDH 3.66564
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.65991
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.53864
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.3279
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.29842
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.18525
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, PDE5A, PIM1, SRC, XDH 2.95524
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, PDE5A, PIM1, SRC, XDH 2.95524
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, PDE5A, PIM1, SRC, XDH 2.80078
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.74981
[MF] GO:1901363 heterocyclic compound binding ADORA1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 2.44751
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.40913
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.3734
[MF] GO:0097159 organic cyclic compound binding ADORA1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, XDH 2.23206
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, PIM1, PPARA, SRC 2.20166
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP12, PPARA, RORC 2.12023
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06118


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.487
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.1
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1, IDO1 5.9983
Metabolic pathways_Homo sapiens_hsa01100 MAOB, AKR1B1, PTGS2, CYP19A1, DHFR, FUT7, ALOX5, HSD17B1, TBXAS1, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.3584
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.3584
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.37
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.9792
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.9355
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.2604
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, KIT, PTGS2, MET, IGF1R 2.6287
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.6214
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.6214
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.6214
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.5712
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.5712
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KIT, KDR, MET, IGF1R 2.2967
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.5216
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, IGF1R 2.2455
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.104
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.4592
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.5088
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, PTGS2 2.0174
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.8938
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MET 1.7326
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.5777
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.413
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.5032
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3961
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.406
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.3961
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4145
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.2678
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.2678
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2 1.406
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT 1.1942
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3419
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2678
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA 1.1347
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.074
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2428
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.081
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0775
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOB 1.0483
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 1.0245
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.0514
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 1.0332
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.9884
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 1.0244
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 1.0244
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0245
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9646
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.9038
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8827
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.8539
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.7042
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1893
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.3684
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4278
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4394
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4721
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4804
Alcoholism_Homo sapiens_hsa05034 MAOB 0.4804
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4819
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.512
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.4931
Hepatitis B_Homo sapiens_hsa05161 SRC 0.5342
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.5204
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5358
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B 0.5455
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1 0.6264
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5583
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.6264
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.6304
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.6052
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.6264
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1231
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5827
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.6264
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5812
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5812
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC 0.6264
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6304
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.6227
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.6052
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.5812
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6264
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6264
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6308
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5854
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6264
Gap junction_Homo sapiens_hsa04540 SRC 0.6308
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.6227
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.631
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6306
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.6264
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6828
Peroxisome_Homo sapiens_hsa04146 XDH 0.6405
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.7009
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6819
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6828
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6855
Glioma_Homo sapiens_hsa05214 IGF1R 0.7009
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7029
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6996
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7009
Bile secretion_Homo sapiens_hsa04976 CA2 0.6847
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.7009
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6983
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.7009
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7042
Shigellosis_Homo sapiens_hsa05131 SRC 0.7009
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.7397
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.7222
Malaria_Homo sapiens_hsa05144 MET 0.7501
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7501
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7501
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7501
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7615
Bladder cancer_Homo sapiens_hsa05219 SRC 0.8033
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.5216
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8508
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.8074
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8827
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8827
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8755
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB 0.8508
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.869
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8453
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9038
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8827
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8989
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9266
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.0245
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9884


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)