TCM Prescription: Wei Ling Granules



Prescription Description
Prescription IDTCMF7040
Pinyin NameWei Ling Ke Li
Chinese Name胃灵颗粒
English NameWei Ling Granules
Function Description健胃和中, 制酸, 止痛。用于慢性浅表性胃炎引起的胃脘痛, 泛酸。
IndicationsStomach ache disorder, Gastritis, Peptic ulcer
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
DA42 [Gastritis, 胃炎 ];
DA61 [Peptic ulcer, site unspecified, 消化性溃疡，部位未特指 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH789 Lonicera japonica 海螵蛸 TCMH789 ITSAI3881-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.4363
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.4363
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.4363
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 10.2792
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 10.2592
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 9.89795
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.69316
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, INSR, PPARA, SRC, TEK, TYR 9.61579
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.61579
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.60576
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 9.52467
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, SRC, TEK, TYR 9.33636
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, INSR, PPARA, SRC, TEK 9.15511
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.78652
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 8.78652
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 8.74222
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, XDH 8.66613
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 8.54342
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 8.22614
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, PIM1, PPARA, SIGMAR1, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 8.20942
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 8.20942
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.04253
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 7.94476
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.85385
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, SRC, TYR 7.71441
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 7.67907
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.6578
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 7.64466
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HSD11B2, HTR2A, HTR2B, KDR, SRC 7.64447
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 7.64447
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.38105
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A 7.29144
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, PIM1, TEK 7.21702
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 7.17427
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 7.14489
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 7.10727
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3, SRC 7.06592
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.91901
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 6.91901
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.86081
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.86081
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.86081
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 6.76149
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR 6.75673
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 6.75075
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.69123
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.6585
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 6.59228
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 6.44524
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.42711
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 6.2605
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, INSR, KDR, PIM1, PPARA, SIGMAR1, SMAD3, SRC, TEK, TYR 6.21451
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 6.13825
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH 6.13648
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.11081
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3 6.09431
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.04724
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.02796
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GBA2, GLO1, HSPA1A, HTR2B, PIM1, PPARA, TYR, XDH 5.97102
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2 5.91885
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.90055
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.87812
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK 5.87812
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.87566
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.87538
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.8227
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.78471
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH 5.77568
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 5.75553
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HSPA1A, HTR2A, HTR2B, PPARA, SMAD3, SRC, TEK, TYR 5.74052
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.69348
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.68419
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.6308
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, SRC, TOP2A 5.51001
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 5.5087
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 5.4895
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.45794
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.45794
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.42288
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, TNKS, TNKS2 5.4045
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.32489
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, SRC 5.26048
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, PIM1, PTPN1, SMAD3, SRC, TEK 5.25986
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.23327
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.23327
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.20111
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 5.17593
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.17593
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 5.17593
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 5.17593
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.11773
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, SMAD3 5.10582
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.08747
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.07519
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.07471
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.06846
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.05043
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 5.05043
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.0354
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 4.93431
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.93116
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.85855
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SRC, TEK, XDH 4.85533
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.84908
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 4.82684
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 4.77911
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, PTPN1, SRC, TEK 4.75127
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.70951
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP12, PIM1, SMAD3, SRC, TEK, TNKS2, XDH 4.68614
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.67731
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.66926
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.66926
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.65369
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, SRC, TEK 4.60903
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.59226
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.59226
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3 4.58921
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.57395
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.55973
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, PPARA, PTPN1, SRC, TEK, XDH 4.52875
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.52875
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.52167
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 4.51386
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.51128
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.51128
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.49431
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 4.48764
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2, TOP2A 4.48267
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.44535
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.44535
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.44359
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.43552
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, PIM1, SMAD3, SRC, TEK 4.42577
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.38724
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 4.37966
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 4.32351
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.31418
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.30879
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP12, PPARA, PTPN1, SMAD3, SRC 4.30781
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 4.30757
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.29843
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 4.2898
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TNKS, TOP2A 4.26695
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 4.26695
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A 4.26656
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.24973
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.22881
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.21379
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 4.20821
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.18186
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.18186
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 4.16411
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.15572
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3 4.11624
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.11624
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, SMAD3 4.11535
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, PTPN1, SRC, XDH 4.06977
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, PPARA, SMAD3, SRC, TEK 4.06336
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC 4.0622
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.05894
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2, TOP2A 4.05728
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, SMAD3, SRC 4.04296
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 4.04296
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, MMP12, SMAD3, SRC 4.03875
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA 4.03493
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3 4.00509
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.97676
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, PPARA, SMAD3, SRC, TEK 3.97676
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 3.96593
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.96593
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.94819
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.9338
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 3.92275
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SRC, TEK, XDH 3.91165
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 3.9101
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.8722
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 3.83928
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, SRC 3.80829
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.803
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 3.78241
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.74749
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, HSD11B2, PPARA, SMAD3 3.72601
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.71786
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, PPARA, SMAD3, SRC, TEK 3.71119
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.70382
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.68961
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.68961
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.66099
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.65626
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 3.65448
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK, TNKS 3.64749
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.62496
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.59473
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.59473
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.59473
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.59473
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 3.59459
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.5739
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, NUAK1, PTPN1, SRC, TEK, XDH 3.5739
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.56425
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.55571
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.55571
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.55571
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.52751
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.52751
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.52751
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SRC, TEK, XDH 3.51992
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.48133
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.47617
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TNKS 3.45766
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.45766
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, SRC 3.45766
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC, TOP2A 3.44995
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.43542
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.40909
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.40749
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.40227
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 3.39486
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.37812
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.36816
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, INSR, SRC, TEK, TYR 3.36734
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, SRC 3.36047
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.35706
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.34879
[BP] GO:0050678 None CDK6, EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 3.34611
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.30301
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27585
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.26682
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 3.26629
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 3.26207
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.25549
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.20369
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.18172
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 3.1786
[BP] GO:0055065 metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.1786
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 3.17467
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK 3.17179
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 3.16562
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 3.16212
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.15975
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, SRC 3.15779
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.14526
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.12686
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.1093
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.10486
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.0999
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.0999
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 3.0999
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, SRC 3.09828
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 3.09828
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.08799
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 3.06884
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.0666
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.0666
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 3.0666
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.06512
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.04112
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 3.03303
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 3.02551
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.99333
[BP] GO:0009115 None AOX1, XDH 2.98718
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.96707
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96707
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.96707
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.96707
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.94538
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, GPR35, HTR2A 2.89496
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.89363
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.88751
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.87855
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.87855
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.87855
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.87855
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.87146
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.87146
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.86119
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.85722
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.8565
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.81933
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.81913
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.81913
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC 2.81447
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 2.80948
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.79917
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.78825
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 2.78485
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.76838
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.75096
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.74763
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.72159
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72159
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.72159
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.72159
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.71471
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.70259
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.68847
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, SMAD3 2.68386
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.67424
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.65718
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.65106
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.64774
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.63398
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HTR2A, INSR, KDR, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, XDH 2.61487
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, TOP2A 2.61487
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.58911
[BP] GO:0046110 None AOX1, XDH 2.58911
[BP] GO:0060160 None DRD2, DRD3 2.58911
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58911
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.58911
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.58911
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.58911
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.58408
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.58394
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SMAD3, TNKS2 2.57418
[BP] GO:0007610 None BCL2, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, INSR, PPARA 2.56509
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.55116
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.54842
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.54226
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.52897
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.52897
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.52897
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.52897
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B 2.52881
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.51789
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.51789
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HTR2B, KDR, MET, SMAD3, SRC, TEK, TOP2A 2.49357
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, SRC 2.49357
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, PPARA, SMAD3, SRC, TNKS 2.49357
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.49357
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.49357
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.49357
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.4746
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.4746
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SRC, TEK, XDH 2.47308
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, SRC, TOP2A 2.47308
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR2B, IGF1R, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 2.47285
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.47238
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.47152
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, TEK 2.46711
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP12, SRC, XDH 2.45941
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.45941
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.44916
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.44051
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.42336
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.42336
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.4216
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTPN1, SMAD3, SRC 2.42058
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.41331
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.40581
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.40294
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.39363
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.38436
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.37267
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.37267
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.37267
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.37267
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.34989
[BP] GO:0070213 None TNKS, TNKS2 2.34989
[BP] GO:0006145 None AOX1, XDH 2.34989
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34989
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.34989
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, SMAD3, XDH 2.34697
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.34646
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, DRD3, EGFR, HSD11B2, HTR2A, MMP12, SMAD3, SRC, TYR 2.34364
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR 2.32904
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.32904
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.32904
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP12, SRC, TEK 2.32904
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.32904
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32904
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 2.32117
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.31532
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, GLO1, PPARA 2.29179
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.28023
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, SRC, TEK 2.27904
[BP] GO:0051894 None KDR, SMAD3, TEK 2.2789
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2789
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.27251
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.26348
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.26014
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.26014
[BP] GO:0050927 None F3, KDR, SMAD3 2.22929
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A 2.22157
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, TYR 2.22053
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A 2.21372
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.19734
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, TNKS2 2.1928
[BP] GO:0006110 None ESRRB, HTR2A, INSR, PPARA 2.1928
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.1928
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.1928
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK 2.1928
[BP] GO:0050926 None F3, KDR, SMAD3 2.1928
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.1928
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1928
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.1928
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 2.17864
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.17854
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.17854
[BP] GO:0021853 None DRD1, DRD2 2.17854
[BP] GO:0043696 None CDK6, ESRRB 2.17854
[BP] GO:0043697 None CDK6, ESRRB 2.17854
[BP] GO:0010641 None F3, SRC 2.17854
[BP] GO:0090325 None DRD2, DRD3 2.17854
[BP] GO:0007598 None F10, F3 2.17854
[BP] GO:1904936 None DRD1, DRD2 2.17854
[BP] GO:0042321 None ADORA1, DRD2 2.17854
[BP] GO:0010513 None HTR2A, HTR2B 2.17854
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.16345
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.15787
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.15124
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 2.15124
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK 2.142
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP12, SRC, TEK 2.13917
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, SRC 2.13648
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.11931
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.11931
[BP] GO:0001936 None F3, HTR2B, KDR, TEK, XDH 2.11879
[BP] GO:0051254 None DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TOP2A 2.1157
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.10633
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.10544
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.08103
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.08052
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.08031
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA 2.08031
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, NUAK1, PTPN1, SMAD3, SRC, XDH 2.07491
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.07374
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.04441
[BP] GO:0043470 None ESRRB, HTR2A, INSR, PPARA 2.04441
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.04441
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2 2.04441
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.04441
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.04441
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.04441
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.04441
[BP] GO:0021843 None DRD1, DRD2 2.03953
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.03953
[BP] GO:0046113 None AOX1, XDH 2.03953
[BP] GO:0021830 None DRD1, DRD2 2.03953
[BP] GO:0021826 None DRD1, DRD2 2.03953
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.03953
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.03924
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.03924
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.03924
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP12, SRC, TEK 2.02725
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1 2.02306
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.02291
[BP] GO:1901890 None KDR, SMAD3, TEK 2.0222
[BP] GO:0045777 None ADORA1, ADRA1A, HSD11B2 2.0222
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.0222
[BP] GO:0045744 None DRD2, DRD3, MET 2.0222
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.0222
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.00523
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MMP12, PTPN1, SMAD3, SRC 2.00099
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 6.53595
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK 5.02859
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 5.00313
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 4.95661
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SRC, TEK 4.75442
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPN1, SIGMAR1, SRC, TEK, TYR 4.33148
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSPA1A, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.96707
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.94538
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, SIGMAR1, SRC, TEK 2.80958
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, SIGMAR1 2.68163
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR5A, INSR, KDR, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.61295
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, SIGMAR1 2.51382
[CC] GO:0031233 None CA4, F10, F3 2.4746
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TYR 2.43683
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR2A, HTR5A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.42223
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.34793
[CC] GO:0031965 None ADRA1A, ALOX5, BCL2, EGFR, SIGMAR1, SMAD3, TNKS 2.19703
[CC] GO:0045121 membrane raft ADRA1A, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.17327
[CC] GO:0098857 membrane microdomain ADRA1A, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.15769
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, SRC 2.12389
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.03953
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC 2.02306
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 11.8747
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 10.2792
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 10.2678
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.8232
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CDK6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 9.75708
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 9.4348
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, SMAD3, TEK 9.24275
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 8.54342
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP2A 8.48113
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.11222
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 7.67537
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 7.67537
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 7.64447
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.55985
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.28437
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.86081
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.86081
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.86081
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.86081
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.8196
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.75075
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.59228
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.25387
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.75553
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.4045
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.27607
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.15526
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.10455
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.05589
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.04417
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.99432
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP12, PPARA, PTPN1, SMAD3, TNKS 4.86891
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.52603
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 4.52167
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.52167
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 4.31708
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.02998
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.94819
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.89766
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.8722
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.8722
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.72386
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.72386
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 3.59459
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.52751
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.51598
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.40749
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.40523
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.35706
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 3.27904
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25178
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.09828
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.06577
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.06297
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.98718
[MF] GO:0003845 None HSD11B1, HSD11B2 2.98718
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.96707
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 2.94538
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, SRC, XDH 2.90642
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.87146
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.78644
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 2.70259
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.6744
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.64559
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.58911
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 2.53353
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.4746
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45941
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.34989
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.21429
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.21329
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRA1A, AXL, BCL2, DRD2, EGFR, SMAD3, TOP2A, TYR 2.1928
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.17854
[MF] GO:0043559 insulin binding IGF1R, INSR 2.17854
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.15658
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.14011
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.08031
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.0444
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03953
[MF] GO:0043546 None AOX1, XDH 2.03953
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.03924
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.03924
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.02466
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0222


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.9682
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6041
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 8.7296
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.7272
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9496
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 6.5797
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 5.0452
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.6328
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2, EGFR 4.7003
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.8303
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.5334
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.8851
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.3622
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.3869
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.3108
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.6942
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3108
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.3622
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.0265
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.0265
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, EGFR, CDC25B 3.0071
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.9889
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, BCL2, MET, EGFR, IGF1R 2.3404
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1, F3 2.4389
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.7657
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0434
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.0178
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1447
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2 2.0167
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0178
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.0167
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A 1.8407
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0167
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0178
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0167
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9792
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.7525
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.0167
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.657
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0167
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.5685
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4928
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3621
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4904
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.4688
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.4307
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.3854
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3221
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.4688
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.351
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2743
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.0464
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.1498
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8993
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.0186
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7752
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9838
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0419
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7642
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7683
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8586
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0048
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2021
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0186
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7683
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7642
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.1498
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.7642
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.7515
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.045
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7462
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6842
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0074
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1034
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7228
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2891
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6572
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3014
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6572
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2888
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3014
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0996
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5812
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6019
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3394
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2743
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3653
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.377
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.3096
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3023
Platelet activation_Homo sapiens_hsa04611 SRC 0.3998
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4022
Axon guidance_Homo sapiens_hsa04360 MET 0.392
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3998
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4022
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2682
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2812
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.446
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4533
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4533
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4533
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4627
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4621
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.479
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4799
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4799
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4889
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.3854
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4799
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4878
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4799
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.4904
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.5124
Peroxisome_Homo sapiens_hsa04146 XDH 0.4889
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5099
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5214
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5355
Bile secretion_Homo sapiens_hsa04976 CA2 0.5336
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5471
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5373
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.545
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5493
Shigellosis_Homo sapiens_hsa05131 SRC 0.5493
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5653
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5493
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6761
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5754
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5564
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5916
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6057
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5685
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6096
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6415
Malaria_Homo sapiens_hsa05144 MET 0.6214
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6258
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6254
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6254
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.626
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6258
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8719
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7144
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6692
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7683
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7462
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7296
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7642
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7683
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7642
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7683
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8993
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9923
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0071
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2743


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)