TCM Prescription: Xin Shen Ning Tablets



Prescription Description
Prescription IDTCMF6991
Pinyin NameXin Shen Ning Pian
Chinese Name心神宁片
English NameXin Shen Ning Tablets
Function Description养血除烦, 宁心安神。用于心肝血虚所致的失眠多梦, 烦躁而惊, 疲倦食少。
IndicationsHeart and liver blood deficiency pattern, Liver blood deficiency pattern, Blood deficiency pattern, Insomnia
Disease ICD-11 Category SF6G [Heart and liver blood deficiency pattern (TM1), 心肝血虚证 (TM1) ];
SF54 [Liver blood deficiency pattern (TM1), 肝血虚证 (TM1) ];
SF00 [Blood deficiency pattern (TM1), 血虚证 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.4101
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.2038
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 9.49937
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA 9.15517
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, SRC, TERT, TYR 9.15517
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, SRC, TYR 8.96725
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 8.41008
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 7.36054
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 7.31707
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, PPARA, SRC 7.12951
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.05819
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 6.95205
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.89786
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.79656
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 6.79656
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, SRC, TERT, TNKS2, TYR 6.79656
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.76311
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.76311
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.71402
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HMGCR, PIM1, PPARA, TYR, XDH 6.53049
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, SRC 6.17824
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.09314
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.09314
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PPARA, SRC, TYR 6.09314
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.09031
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 6.08251
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 5.71503
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT 5.4744
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 5.44438
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 5.41156
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.39911
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.2605
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 5.1881
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 5.10106
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.93103
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.84997
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.82906
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.80798
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.7995
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, PPARA, SRC, TYR 4.7995
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.6588
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.61781
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.61781
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 4.52321
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.46589
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.45289
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.42679
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42483
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.42483
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.42483
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PPARA 4.32801
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.32286
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.24178
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 4.23396
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.21545
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 4.187
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.15319
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.15058
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, SRC 4.12206
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.12206
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, SRC, TERT 4.12003
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.11722
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.06733
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.06447
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.03809
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, TYR 3.93142
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TYR 3.92773
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.91037
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 3.91037
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.89869
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.88588
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.73379
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.72601
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.68563
[BP] GO:2000145 regulation of cell motility APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.67695
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.66785
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.65811
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 3.64714
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CDK6, CYP19A1, DYRK1A, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP2, PPARA, PTPN1, SRC, TERT, XDH 3.6408
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.62972
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH 3.61438
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.54386
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.54386
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, KIT, MMP2, PPARA, SRC, TERT, TYR 3.54386
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, HMGCR, KDR, SRC, TNKS, TNKS2 3.51518
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.51517
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.49591
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.42898
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, SRC 3.42732
[BP] GO:0040012 regulation of locomotion APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.38282
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, SRC 3.3811
[BP] GO:0051270 regulation of cellular component movement APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.37398
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.36063
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.30732
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.26248
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.25738
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25738
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.24365
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.24365
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 3.22859
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.13692
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.13002
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.11676
[BP] GO:0032879 regulation of localization ABCB1, ACHE, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT 3.11186
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, KDR, KIT, MET, MMP2, MMP9, SRC, TERT 3.10962
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.0992
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.07461
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.02518
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.93187
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.87284
[BP] GO:0009115 None AOX1, XDH 2.87276
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.85496
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.79951
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS 2.79516
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.78986
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.78986
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.7843
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, SRC 2.77396
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.7377
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.70318
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.70194
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, SRC 2.6938
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.66301
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.66177
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.63956
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.63956
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.63818
[BP] GO:0051247 positive regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.60782
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.60782
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.60782
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.59826
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.59214
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.57757
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.55888
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.55888
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.51122
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.50894
[BP] GO:0009892 negative regulation of metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.50336
[BP] GO:0046110 None AOX1, XDH 2.48813
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48813
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.47279
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CYP19A1, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.46122
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.41453
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.41453
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.41453
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.41453
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH 2.41453
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41052
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.38752
[BP] GO:0042327 positive regulation of phosphorylation APP, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.379
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.35885
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.35885
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.35885
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.34232
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2 2.33712
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 2.33682
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.33104
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC, XDH 2.32847
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.32847
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.31831
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31831
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.31785
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 2.3152
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, SRC, TYR 2.3079
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.28676
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27361
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.26556
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, SRC 2.26556
[BP] GO:0070213 None TNKS, TNKS2 2.26556
[BP] GO:0006145 None AOX1, XDH 2.26556
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26556
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.2411
[BP] GO:0031401 positive regulation of protein modification process APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.23935
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.19043
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.18008
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.14633
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, KDR, KIT, PIM1, PPARA, SRC, TERT, TNKS2, XDH 2.14633
[BP] GO:0032845 None BCL2, HMGCR, SRC, TNKS, TNKS2 2.13476
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.11985
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.11523
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.10312
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.08775
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, SRC 2.08775
[BP] GO:0043696 None CDK6, ESRRB 2.08775
[BP] GO:0043697 None CDK6, ESRRB 2.08775
[BP] GO:0010641 None F3, SRC 2.08775
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.08775
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, KDR, KIT, PIM1, SRC, TERT 2.08534
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, SRC 2.08103
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, TNKS 2.07884
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.07884
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.06813
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.06251
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.06251
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC 2.05987
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.05137
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.05137
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.05137
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, TERT, XDH 2.03227
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, SRC 2.03015
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, TERT, XDH 2.02377
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.01945
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HMGCR, KIT, PPARA, SRC 2.01776
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.85313
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.50336
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.21594
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.18384
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 2.11523
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 13.7729
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 12.9617
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 11.3968
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3262
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 6.76311
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.58444
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.58444
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TERT, TNKS, TNKS2, TYR, XDH 5.79989
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.74365
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.70271
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TERT, TNKS, TNKS2, TYR, XDH 5.44438
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.82489
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.54233
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.54233
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.32286
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.14492
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.99601
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.99601
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 3.92605
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.88811
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.87963
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80734
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, TERT, TYR, XDH 3.66795
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.66785
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63141
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.57511
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.54386
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.477
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, SRC, XDH 3.46532
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.21427
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 3.08889
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.06767
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.87284
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.87284
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.87276
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 2.87276
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87276
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87276
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.85313
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.8255
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.82215
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.60782
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.46114
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.46114
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.32847
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC 2.31785
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26556
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, ESR1, ESR2, ESRRB, F3, HMGCR, KIT, MET, PPARA, PTPN1, SRC, TNKS2 2.24188
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.21102
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.1089
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08775
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.03015
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.01825


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4751
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.4067
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2743
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.7031
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 5.2721
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.3724
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3724
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3724
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0783
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8877
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0783
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.1914
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.734
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2529
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.6057
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 2.4669
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.5438
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0562
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.2541
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.2537
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3796
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.2537
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2541
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.2154
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2142
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0368
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.7333
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR 2.2154
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.5375
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3828
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2752
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3162
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0916
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0832
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2584
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3323
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0422
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0999
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.035
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1687
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0916
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9872
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2584
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0202
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9923
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0749
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9872
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9694
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9694
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9694
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8891
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9531
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9531
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8768
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8864
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6751
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7894
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7533
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6751
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8122
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7217
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2712
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2711
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3208
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3572
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3703
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3803
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3405
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4235
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3571
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4235
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.415
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4116
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4222
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3996
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4209
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4343
Platelet activation_Homo sapiens_hsa04611 SRC 0.4509
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.452
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4343
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.452
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.476
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4509
Axon guidance_Homo sapiens_hsa04360 MET 0.4432
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7711
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7106
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5036
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5265
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5109
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5146
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5146
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5146
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5265
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5265
Gap junction_Homo sapiens_hsa04540 SRC 0.5265
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5265
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.572
Peroxisome_Homo sapiens_hsa04146 XDH 0.5358
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5712
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5504
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5837
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5976
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5976
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5976
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6059
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5847
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6284
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6029
Shigellosis_Homo sapiens_hsa05131 SRC 0.5976
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6284
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6029
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0271
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6556
Malaria_Homo sapiens_hsa05144 MET 0.6666
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6726
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6694
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7089
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6726
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6751
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6726
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6737
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7894
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8069
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8069
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8333
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8239
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8864
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9531
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0991
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9923
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2584


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)