TCM Prescription: Huo Long Bu Shen Oral Liquid



Prescription Description
Prescription IDTCMF6975
Pinyin NameHuo Long Bu Shen Kou Fu Ye
Chinese Name藿龙补肾口服液
English NameHuo Long Bu Shen Oral Liquid
Function Description补肾助阳。用于肾阳不足引起的腰膝冷痛, 肢体酸软, 尿频。
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationKidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH784 Syngnathus sp. 海龙 TCMH784 FBERM005-06
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH625 Gecko 蛤蚧 TCMH625
TCMH1346 Cornu cervi degelatinatum 鹿角霜 TCMH1346
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH2059 Radix pseudostellariae 太子参 TCMH2059
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FDPS, HSD11B1, HSD17B1, MET, PPARA, PPARG, TRPV1 10.4934
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, KDR, MAOB, MET, PPARA, PPARG, SRC, TRPV1, XDH 10.4934
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MMP2, NR3C1, PPARA, PPARG, SRC, TRPV1 8.66333
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, HSP90AB1, IGF1R, MAOB, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TRPV1 8.25886
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 7.78924
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 7.73842
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 7.73842
[BP] GO:0014070 response to organic cyclic compound BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSP90AB1, MAOB, NR3C1, PPARG, SRC, TRPV1 7.73842
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FDPS, PDE5A, PIM1, PPARA, PPARG, XDH 7.72884
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TRPV1 7.60037
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MAOB, MMP9, SRC 7.33476
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.32627
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, FDPS, HSD11B1, HSD17B1 6.97393
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FDPS, MET, PPARA, PPARG 6.95721
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.95431
[BP] GO:0009719 response to endogenous stimulus AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, FLT3, IGF1R, MAOB, MMP2, NR3C1, PPARA, PPARG, SRC, TRPV1 6.85605
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HSP90AB1, KDR, MAOB, NR3C1, PPARG, SRC, TRPV1 6.84187
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.82376
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 6.65368
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.65368
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.62159
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, MAOB, NR3C1, PPARA, PPARG, SRC, TRPV1 6.59826
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, SRC, TRPV1, XDH 6.45294
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.41627
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 6.35273
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.31602
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.26592
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, XDH 6.24397
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, MAOB 5.99361
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, PPARG, TRPV1 5.96722
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, HSP90AB1, KDR, MET, MMP9, PDE5A, SRC, XDH 5.93789
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, HSP90AB1, KDR, MET, MMP9, PDE5A, SRC, XDH 5.91515
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 5.91515
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.87644
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, MAOB, PPARG, XDH 5.86355
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARG, SRC, TRPV1, XDH 5.85116
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.85116
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, MET, PPARG, SRC, TRPV1 5.77802
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARG, SRC, TRPV1 5.7198
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1 5.65402
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, MAOB, NR3C1, PPARG, SRC 5.33929
[BP] GO:0042127 regulation of cell proliferation AKR1B1, ALOX12, BCL2, CHRM1, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PDE5A, PIM1, PPARG, SRC, XDH 5.32065
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.28016
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.27312
[BP] GO:0032879 regulation of localization ACHE, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HCAR2, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, PPARA, PPARG, SRC, TRPV1 5.24672
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, HSP90AA1, KDR, MAOB, SRC 5.21815
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.0615
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, PPARG, TRPV1 4.88545
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSD11B1, HSP90AB1, KDR, MAOB, MMP9, PIM1, PPARA, PPARG, SRC 4.86255
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, DRD1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1 4.76371
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.57268
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 4.51838
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, HSP90AB1, KDR, NR3C1, SRC, TRPV1 4.5062
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.50361
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PDE5A, PPARG, SRC, XDH 4.46977
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC, TRPV1 4.41197
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSP90AB1, KDR, PPARA, PPARG, SRC 4.38391
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CHRM1, CSNK2A1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 4.38011
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PDE5A, PPARG, SRC, XDH 4.38011
[BP] GO:0040012 regulation of locomotion ALOX12, BCL2, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 4.35562
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HSD11B1, HSD17B1 4.31716
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX12, ALOX15, ALOX5, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, SRC, TRPV1 4.30359
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 4.27032
[BP] GO:0030334 regulation of cell migration ALOX12, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 4.24427
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 4.24138
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 4.16166
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC 4.16166
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 4.14904
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, MET, PPARG, TRPV1 4.09775
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA9, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP4, FLT3, HSD11B1, HSP90AB1, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, PPARG, SRC 4.09565
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 4.0723
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 4.0723
[BP] GO:0007165 signal transduction AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1 4.06676
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HSD11B1, HSD17B1 4.02297
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.01327
[BP] GO:0009056 catabolic process ACHE, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, HSP90AA1, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 4.00237
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 3.99474
[BP] GO:2000145 regulation of cell motility ALOX12, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.99474
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.96438
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.96438
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, PPARG, SRC, TRPV1, XDH 3.90332
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.90193
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, HSP90AA1, HSP90AB1, MAOB, TRPV1 3.88306
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, PPARG, SRC 3.86839
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, SRC, TRPV1 3.85955
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, NR3C1, PPARG, SRC 3.84108
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.84108
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.84108
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.79919
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.79698
[BP] GO:0019216 regulation of lipid metabolic process CHRM5, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, PPARG, SRC 3.79483
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, F3, HCAR2, KDR, MET, MMP9, PDE5A, PIM1, PPARG, SRC, TRPV1 3.79327
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1 3.79116
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD1, DRD2, HCAR2, KDR, SRC, TRPV1 3.79116
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.75488
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.75421
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, ALOX12, DRD1, DRD2, MET, TRPV1 3.72245
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.7142
[BP] GO:0051270 regulation of cellular component movement ALOX12, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.69623
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, PPARG, SRC, TRPV1, XDH 3.69179
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.69179
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, PPARG, SRC, TRPV1, XDH 3.67889
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 3.67889
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TRPV1 3.64012
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PDE5A, PPARA, PPARG, SRC, XDH 3.63539
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.63412
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, PPARG, SRC 3.63412
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HSD11B1, HSD17B1 3.59014
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, SRC 3.52486
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC 3.52486
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, SRC, XDH 3.52375
[BP] GO:0065007 biological regulation ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 3.4811
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, MAOB 3.45564
[BP] GO:0007193 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.41901
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.41619
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, HCAR2, HSP90AB1, MAOB, MMP9, PPARA, PPARG, SRC, TRPV1 3.40873
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, HCAR2, HSP90AB1, PPARG, SRC, TRPV1 3.39943
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOB 3.37413
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TRPV1 3.354
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, KDR, MET, PDE5A, SRC, XDH 3.35188
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TRPV1 3.30659
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, HSP90AB1, KDR, MET, MMP9, PDE5A, SRC, XDH 3.28055
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, HCAR2, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 3.26464
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.22171
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, SRC 3.19994
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.19994
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 3.19548
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 3.18664
[BP] GO:0007188 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 3.13701
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HSP90AA1, IGF1R, KDR, MET, PDE5A, PIM1, SRC, XDH 3.12894
[BP] GO:0051098 regulation of binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC 3.12198
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.12198
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, KDR, MET, MMP2, MMP9, PDE5A, SRC, XDH 3.11933
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, HSP90AA1, HSP90AB1, MMP9, TRPV1, XDH 3.08147
[BP] GO:0051239 regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, ESR1, F3, HCAR2, HSP90AB1, KDR, MET, MMP9, PDE5A, PIM1, PPARG, SRC, TRPV1, XDH 3.08053
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 3.06795
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 3.06795
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, FDPS 3.06465
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.04089
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.03086
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.03086
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.03086
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.03086
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, SRC 3.01202
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, HSP90AA1, HSP90AB1, TRPV1, XDH 2.98469
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.94258
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.91684
[BP] GO:0006939 None CHRM3, DRD1, DRD2, TRPV1 2.90909
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HSP90AA1, IGF1R, KDR, MET, PDE5A, PIM1, SRC, XDH 2.90436
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.88057
[BP] GO:0080134 regulation of response to stress ALOX12, CYP19A1, DRD2, ESR1, F3, FABP4, HSP90AA1, HSP90AB1, IGF1R, MET, MMP2, PPARA, PPARG, SRC, XDH 2.88028
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSP90AB1, PPARG, SRC 2.88028
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.88028
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.88028
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.88028
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, DRD2, PPARA 2.87245
[BP] GO:0032101 regulation of response to external stimulus ALOX12, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, PPARA, PPARG 2.87006
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.86525
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, MAOB 2.83801
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.83801
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.83153
[BP] GO:0007187 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 2.8302
[BP] GO:0048585 negative regulation of response to stimulus ALOX12, ALOX15, BCL2, CYP19A1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PPARG, SRC, XDH 2.82192
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.82192
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.82192
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD1, DRD2, FABP3, PPARA, PPARG, TRPV1 2.81831
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.77917
[BP] GO:0050878 regulation of body fluid levels AKR1B1, ALOX12, CHRM1, CHRM3, DRD2, F3, MET, XDH 2.73661
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MAOB 2.71981
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PPARG, SRC 2.71061
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PDE5A, PPARA, PPARG, SRC, XDH 2.70553
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.6847
[BP] GO:0044248 cellular catabolic process ACHE, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, HSP90AA1, MAOB, PDE5A, SRC, XDH 2.67593
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CHRM5, DRD1, DRD2, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.67172
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, SRC 2.67172
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PPARG, SRC, TRPV1 2.65594
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, DRD2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PPARG, SRC 2.65594
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.64557
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CHRM5, DRD1, DRD2, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.64367
[BP] GO:0065009 regulation of molecular function AURKB, BCL2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, MET, MMP9, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 2.61649
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC 2.59299
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, SRC, XDH 2.59299
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.56333
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, HSP90AA1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PPARG, SRC, XDH 2.56333
[BP] GO:0019222 regulation of metabolic process ACHE, ALOX15, AURKB, BCL2, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 2.56268
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, MET, SRC, XDH 2.54515
[BP] GO:0007154 None AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, PPARG, TRPV1 2.52802
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.52792
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.51484
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS 2.50318
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, SRC, TRPV1 2.49907
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.49581
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.47668
[BP] GO:0048545 response to steroid hormone BCL2, CA2, FLT3, MAOB, NR3C1, SRC 2.46848
[BP] GO:0080090 regulation of primary metabolic process ALOX15, AURKB, BCL2, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 2.4663
[BP] GO:0015908 None DRD2, FABP3, PPARA, PPARG 2.45141
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.4313
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.4313
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, FLT3, PPARG 2.42074
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, MAOB, PDE5A, XDH 2.42016
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2 2.40726
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.40174
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.40174
[BP] GO:0051094 positive regulation of developmental process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD2, F3, HSP90AB1, KDR, PDE5A, PIM1, PPARG, SRC 2.38511
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.35094
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.35094
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.34685
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, MMP9, PPARG, SRC, TRPV1, XDH 2.34586
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, SRC, XDH 2.32666
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, DRD1, DRD2, FABP3, FLT3, HSP90AB1, KDR, MMP9, PDE5A, SRC, XDH 2.32073
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, DRD1, DRD2, FABP3, FLT3, HSP90AB1, KDR, MMP9, PDE5A, SRC, XDH 2.32073
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, MMP9, PPARG, SRC, TRPV1, XDH 2.32072
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, PPARA, PPARG, SRC, TRPV1 2.3135
[BP] GO:0009410 None DRD1, DRD2, HSP90AB1, NR3C1, PPARG 2.31327
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, HSP90AB1, SRC, TRPV1 2.3022
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.28822
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, FLT3, PPARG 2.28483
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.2756
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.2756
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.2756
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.26798
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, DRD1, DRD2, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.25818
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.25096
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, HSP90AB1, IGF1R, KDR, MET, MMP9, PDE5A, PPARG, SRC, XDH 2.23909
[BP] GO:0021853 None DRD1, DRD2 2.23909
[BP] GO:0046541 None CHRM1, CHRM3 2.23909
[BP] GO:0010641 None F3, SRC 2.23909
[BP] GO:1904936 None DRD1, DRD2 2.23909
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.23909
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.23909
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.23909
[BP] GO:0010891 None PPARA, PPARG 2.23909
[BP] GO:0031960 response to corticosteroid BCL2, FLT3, MAOB, NR3C1, SRC 2.22206
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.21131
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.21131
[BP] GO:0002682 regulation of immune system process ALOX15, AXL, BCL2, CA2, CYP19A1, DRD2, ESR1, HCAR2, HSP90AA1, HSP90AB1, MMP2, PDE5A, PPARG, SRC 2.21094
[BP] GO:1901655 None AKR1B1, NR3C1, PPARG, SRC 2.21094
[BP] GO:0006810 None ACHE, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, FABP3, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SRC, TRPV1, XDH 2.19584
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.18348
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, DRD2, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, MET, MMP9, PDE5A, PPARG, SRC, XDH 2.18314
[BP] GO:0001659 None DRD1, DRD2, TRPV1 2.17893
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.17893
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.17893
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, NR3C1, PPARA, PPARG 2.17344
[BP] GO:0050789 regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 2.17258
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.16719
[BP] GO:0051179 None ACHE, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, ESR1, FABP3, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SRC, TRPV1, XDH 2.15377
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.15338
[BP] GO:1901575 None ACHE, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, HSP90AA1, MAOB, PDE5A, XDH 2.14887
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.14846
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, HCAR2, MMP9, PPARG, SRC, TRPV1, XDH 2.13882
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MET, MMP9, SRC, XDH 2.12556
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.11214
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, MET, NR3C1, PPARA, PPARG, SRC, TRPV1 2.11214
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, TRPV1 2.11214
[BP] GO:0010887 None PPARA, PPARG 2.11214
[BP] GO:0010871 None PPARA, PPARG 2.11214
[BP] GO:0021843 None DRD1, DRD2 2.11214
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.11214
[BP] GO:0021830 None DRD1, DRD2 2.11214
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.11214
[BP] GO:0021826 None DRD1, DRD2 2.11214
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.11214
[BP] GO:0051234 None ACHE, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, FABP3, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SRC, TRPV1, XDH 2.11214
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, DRD1, DRD2, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP9, PDE5A, SRC, XDH 2.1018
[BP] GO:0016042 lipid catabolic process CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.1018
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.10031
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process HSP90AA1, HSP90AB1, TRPV1, XDH 2.08108
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, IGF1R, MMP2, PPARG, SRC, TRPV1 2.06887
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.06739
[BP] GO:0043279 None DRD2, HSP90AB1, PPARG, TRPV1 2.06739
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2 2.06534
[BP] GO:0032102 negative regulation of response to external stimulus ALOX12, CYP19A1, DRD1, DRD2, PPARA, PPARG 2.03403
[BP] GO:0051973 positive regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1 2.03087
[BP] GO:0009987 cellular process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 2.02454
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, MET 2.01948
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, ESR1, MET, SRC 2.0148
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CSNK2A1, DRD2, ESR1, F3, FLT3, HSP90AB1, KDR, MMP9, PDE5A, PPARG, SRC, XDH 2.00665
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5 2.00222
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, HSP90AA1, HSP90AB1, MET, SRC, TRPV1 3.96361
[CC] GO:0016020 membrane ACHE, ALOX12, ALOX15, ALOX5, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP2, PIM1, SRC, TRPV1 3.354
[CC] GO:0031253 None CA4, CA9, DRD1, DRD2, HSP90AA1, HSP90AB1, SRC, TRPV1 3.354
[CC] GO:0005886 plasma membrane ACHE, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, HCAR2, HSP90AA1, IGF1R, KDR, MET, MMP2, PIM1, SRC, TRPV1 3.03086
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.72548
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, BCL2, CA1, CA2, CA4, CA7, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, KDR, MAOB, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARG, SRC, TRPV1, XDH 2.67172
[CC] GO:0044425 membrane part ACHE, ALOX15, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, HCAR2, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, SRC, TRPV1 2.61649
[CC] GO:0044459 plasma membrane part ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, SRC, TRPV1 2.54515
[CC] GO:0044463 None AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, HSP90AA1, HSP90AB1, SRC, TRPV1 2.46305
[CC] GO:0120038 None AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, HSP90AA1, HSP90AB1, SRC, TRPV1 2.46305
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.39432
[CC] GO:0031226 intrinsic component of plasma membrane AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET, TRPV1 2.34663
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, XDH 13.3221
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 13.1711
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4934
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SRC, TRPV1 9.09957
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.66333
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.63333
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F3, FDPS, FLT3, HSD11B1, HSD17B1, HSP90AA1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 7.73842
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.32175
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, TRPV1, XDH 7.19975
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.78139
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.65368
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, MAOB, XDH 6.08071
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.98642
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.85116
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.85116
[MF] GO:0038023 signaling receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 5.7198
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.64796
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.40028
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PPARG, TRPV1, XDH 5.0615
[MF] GO:0004872 receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 4.95309
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.85857
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PPARG, TRPV1 4.80927
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PPARA, PPARG 4.78055
[MF] GO:0060089 molecular transducer activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 4.77018
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, MAOB, SRC, XDH 4.49882
[MF] GO:0004871 signal transducer activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 4.38011
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.32726
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.14904
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.90332
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 3.86206
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, PPARG 3.85048
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.84108
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.79939
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.78431
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.77906
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 3.5596
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 3.5596
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.54719
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, PPARG, TRPV1, XDH 3.52241
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.354
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.24674
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 3.21866
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1 3.19994
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.03086
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.03086
[MF] GO:0008389 None CYP2A13, CYP2A6 3.03086
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, F3, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, PPARG, SRC, TRPV1, XDH 2.88921
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG 2.88172
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG 2.88172
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.82192
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.79925
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.64557
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.64557
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.64557
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, PPARG, SRC, TRPV1, XDH 2.56129
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.40174
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.40174
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.40174
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.34685
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2 2.33523
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.3135
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.3135
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.3135
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.25224
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.23909
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.23909
[MF] GO:0004629 None CHRM1, CHRM3, CHRM5 2.21131
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.14846
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARA, SRC 2.14846
[MF] GO:0050543 None FABP3, PPARG 2.11214
[MF] GO:0004064 arylesterase activity CA1, CA2 2.11214
[MF] GO:0035258 None ESR1, FLT3, PPARG, SRC 2.11214
[MF] GO:0097159 organic cyclic compound binding AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FDPS, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIM1, PPARA, PPARG, SRC, TRPV1, XDH 2.1018
[MF] GO:0008081 None CHRM1, CHRM3, CHRM5, PDE5A 2.06739
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.01948


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.6388
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.7889
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.245
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.8554
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, ESR2 6.6096
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.0105
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, BCL2, PPARG, MMP9, MET, IGF1R 5.5979
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 5.0136
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, CHRM5, TRPV1, DRD1, NR3C1, DRD2 4.8894
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.776
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, KDR, BCL2, MET, IGF1R 4.356
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOB, ALOX15, AKR1B1, ALOX12, CYP3A4, CYP19A1, HSD11B1, CYP2A6, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH 4.33
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.776
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, DRD1, DRD2, PPARA 3.8239
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 4.356
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3423
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.618
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2, CYP3A4 3.539
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1 3.0919
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, BCL2, IGF1R 3.1697
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.4415
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 3.0127
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.8938
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 3.0919
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.8539
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.8404
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12 2.8739
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET 2.2537
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.3639
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.0409
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, IGF1R 2.0409
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7066
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.5399
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 2.1506
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 1.7174
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.5911
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.8645
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.8271
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.3434
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.4495
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.402
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2092
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4662
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4296
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0837
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.3801
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1979
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3801
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3334
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3588
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 1.1872
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.129
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3769
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1882
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.4662
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0498
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0498
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3068
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0498
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3588
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.1777
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9393
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8735
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, IGF1R 1.0245
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.3092
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9431
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8202
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7474
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8173
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2863
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3544
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.378
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.3707
Influenza A_Homo sapiens_hsa05164 FDPS 0.3932
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4481
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3778
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.437
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4526
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PDE5A 0.4056
Platelet activation_Homo sapiens_hsa04611 SRC 0.4703
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4334
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4481
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4716
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4212
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.4569
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4569
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4481
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4959
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4716
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4959
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4569
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4703
Axon guidance_Homo sapiens_hsa04360 MET 0.4624
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5198
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5514
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5514
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5514
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.539
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.5513
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5514
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5514
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5514
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5514
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5514
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5514
Peroxisome_Homo sapiens_hsa04146 XDH 0.5514
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5581
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.601
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6196
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6209
Glioma_Homo sapiens_hsa05214 IGF1R 0.6209
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6334
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6511
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6253
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4664
Shigellosis_Homo sapiens_hsa05131 SRC 0.6209
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6353
Malaria_Homo sapiens_hsa05144 MET 0.6895
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6836
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6866
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7011
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7565
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1506
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.8499
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8416
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB 0.8005
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8204
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7943
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8735
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9108
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.9393
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.0245


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)