TCM Prescription: Geng Mei Ning Capsules



Prescription Description
Prescription IDTCMF6905
Pinyin NameGeng Mei Ning Jiao Nang
Chinese Name更美宁胶囊
English NameGeng Mei Ning Capsules
Function Description滋肾平肝, 清心安神。用于更年期综合征肝肾阴虚, 心肝火旺证。表现为烘热汗出, 烦躁易怒, 失眠, 头晕耳鸣, 五心烦热, 腰膝酸软, 心悸, 胸闷, 胁痛, 多梦易惊, 口干口苦等。
IndicationsHypochondrium pain disorder, Tinnitus disorder, Kidney yin deficiency pattern, Liver and kidney yin deficiency pattern, Climacteric states
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SF93 [Kidney yin deficiency pattern (TM1), 肾阴虚证 (TM1) ];
SF5H [Liver and kidney yin deficiency pattern (TM1), 肝肾阴虚证 (TM1) ];
GA30.00 [Menopausal or female climacteric states, 更年期或女性更年期状态 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH848 Sesamum indicum 黑芝麻 TCMH848 GENG619-14, GBVT1400-13
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH815 Flos albiziae 合欢花 TCMH815
TCMH1797 Morus alba 桑叶 TCMH1797 ITSAL1073-14
TCMH2605 Margarita 珍珠 TCMH2605
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT244 HRH1 Histamine H1 receptor GPCR P35367
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT596 SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 Transporter Q9H2J7
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 12.8659
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.8195
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 12.7312
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FDPS, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 12.3269
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HRH1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 12.1047
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0998
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HRH1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 12.0785
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, FABP3, GBA, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 11.8065
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FDPS, FUCA1, FUT7, GBA, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.6143
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.4194
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.3911
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 10.7274
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT 10.1812
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.87658
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, EGFR, ESR1, FABP3, FLT3, GBA, HRH1, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 9.35065
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, FLT3, GBA, HRH1, PTGS2, RORC, SRC, TEK, TYR 9.34594
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.19335
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, EGFR, ESR1, FABP3, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 9.19335
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, HIF1A, KDR, MMP9, PTGS2, SRC, TERT 8.9616
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FLT3, GBA, GPR35, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.94921
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 8.92474
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.91487
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 8.85612
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.85612
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 8.74901
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.68695
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.64466
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.53081
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 8.48438
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GBA, HIF1A, HRH1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.42678
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HRH1, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 8.42119
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 8.28673
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 8.08517
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.07926
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FDPS, FUCA1, FUT7, GBA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.07174
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GBA, GPR35, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.0678
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F10, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.91793
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.91793
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.89888
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, FABP4, GAA, GBA, HIF1A, HRH1, HSD17B2, IGF1R, INSR, KCNH2, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 7.8291
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.62217
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.4814
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.47516
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.4347
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.272
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.22709
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 7.14101
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.11671
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GBA, HIF1A, HRH1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.05875
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GBA, HIF1A, HRH1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.05875
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, GBA, HIF1A, HRH1, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 7.03977
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.92761
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 6.89273
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.88424
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, INSR, PPARA, PTGS2, SRC, TEK 6.82326
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.80071
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 6.7506
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HRH1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.71318
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HRH1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.64004
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FDPS, HSD17B1, HSD17B2 6.59326
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DAO, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.55569
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.53871
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 6.37655
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, HSD17B2, PTGS2, RORC, SRC, TYR 6.26494
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 6.24386
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.22887
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 6.2133
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, GBA, KCNH2, KDR, PTGS2, SRC 6.15203
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 6.08518
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 6.0686
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, DRD1, DRD2, FDPS, GBA, HIF1A, TYR 6.06719
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, HRH1, PTGS2, RORC, SRC 5.95864
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, DRD2, EGFR, FABP3, FLT3, HRH1, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.95107
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.93971
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.91907
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F10, FABP4, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.91605
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, EGFR, HCAR2, HIF1A, INSR, KCNH2, MMP12, PTGS2, SMAD3, SRC, TERT 5.91605
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.88982
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.793
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, HIF1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.75742
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.74288
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, GBA, HIF1A, HRH1, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 5.72544
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.69414
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.65815
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.63642
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 5.56694
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 5.55093
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.53175
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, DRD2, EGFR, FABP3, FLT3, HRH1, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.5108
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.50861
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, HIF1A, MMP9, PTGS2, TERT 5.50716
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.46137
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.44887
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.44655
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.43237
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, EGFR, HCAR2, HIF1A, KDR, PIK3CB, PTGS2, SRC 5.43237
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.43164
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.37907
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.36938
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.34269
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.32826
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.3268
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.3268
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HIF1A, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.24412
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.20244
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.18778
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 5.09095
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, GAA, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.02061
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2, HIF1A, PIK3CB, PTGS2 5.00768
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.98823
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.93904
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GAA, HIF1A, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.91154
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.90246
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, EGFR, ESR1, FLT3, GBA, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.90246
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HRH1, PTGS2 4.86469
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HRH1, PTGS2 4.86469
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.85524
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GBA, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.72543
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, ESR1, FLT3, GBA, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.72543
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, FDPS, GBA, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.71821
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 4.69243
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, HRH1, IGF1R, INSR, MMP2, PTGS2, SRC 4.62639
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 4.5533
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC 4.52641
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, GPR35, HIF1A, KCNH2, PIK3CB, SMAD3 4.52099
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, FLT3, GBA, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.50575
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.48544
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 4.47573
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HIF1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.45616
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, ESR1, FLT3, HRH1, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 4.42046
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.38634
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 4.34217
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.34217
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HIF1A, HSD17B1, HSD17B2 4.33989
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, HRH1, IGF1R, INSR, MMP2, PTGS2, SRC 4.30192
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 4.29588
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, GBA, HCAR2, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 4.25723
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KCNH2, KDR, PTGS2, SRC 4.22607
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FDPS 4.22213
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.1998
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.1998
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, EGFR, HIF1A, HRH1, PTGS2, TYR 4.19446
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.18824
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, EGFR, GBA, HCAR2, HIF1A, HRH1, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 4.1574
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 4.1574
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, DRD2, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 4.1028
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HIF1A, HRH1, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 4.09492
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.07807
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC, TERT 4.07417
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, DRD2, EGFR, ESR1, GAA, GBA, GPR35, HCAR2, HIF1A, HRH1, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 4.07218
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC 4.06527
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DUSP3, DYRK1A, EGFR, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.04544
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, HIF1A, KCNH2, PIK3CB, SMAD3 4.03176
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH 4.01992
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.01935
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 4.01577
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, GBA, MMP12, PPARA, SMAD3, TEK 3.98844
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, GBA, MET, PIK3CA 3.9806
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.95079
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.94076
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA 3.92784
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.92329
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 3.92329
[BP] GO:0018958 None AKR1B1, BCL2, DAO, DRD1, DRD2, TYR 3.86227
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, FLT3, HIF1A, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.86227
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.86175
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.85832
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FDPS 3.8391
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 3.8391
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1, DRD2, GBA 3.81859
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, EGFR, ESR1, FABP4, GBA, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.78173
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.77183
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.74729
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.72607
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.68528
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HIF1A, HRH1, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.68046
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.66938
[BP] GO:0008542 None APP, DRD1, DRD2, HIF1A, HRH1 3.6474
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HIF1A, HRH1, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.64164
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.63862
[BP] GO:0007612 None APP, DRD1, DRD2, HIF1A, HRH1, INSR, PTGS2 3.62757
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.61886
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.60678
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.57478
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TOP2A 3.57364
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, FLT3, HIF1A, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.56602
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, EGFR, GAA, GBA, GPR35, HCAR2, HRH1, KCNH2, PTGS2, SMAD3 3.5594
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.55644
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA 3.5413
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, GPR35, KCNH2, MMP9, PTGS2 3.54108
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.52164
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, EGFR, HIF1A, HRH1, INSR, PTGS2 3.52157
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FDPS, FLT3, GBA, GLO1, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.51722
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DRD1, DRD2, EGFR, HSPA1A 3.49834
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.49383
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.49383
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48162
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, HIF1A, KCNH2, PIK3CB, SMAD3 3.47859
[BP] GO:0007632 None APP, DRD1, DRD2, HIF1A, HRH1 3.4741
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.45499
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FDPS, FLT3, GBA, GLO1, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.44646
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.41644
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 3.41644
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HIF1A, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 3.33662
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 3.32605
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 3.32435
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, HIF1A, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 3.31176
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTGS2, SRC 3.31176
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2, SRC 3.31176
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 3.31176
[BP] GO:0003018 None ADORA1, DRD1, EGFR, HRH1, PTGS2, SRC, TEK 3.31176
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, PTGS2 3.27048
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 3.26922
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.26922
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.26922
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.26922
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PTGS2, SMAD3, TEK 3.17961
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.17961
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, HIF1A, PPARA, PTGS1, PTGS2 3.17388
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, HRH1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.1726
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.17224
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GAA, GPR35, HIF1A, PIK3CA, PIK3CB, SMAD3 3.17224
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, FABP3, GBA, HIF1A, HRH1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A 3.17156
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DUSP3, DYRK1A, ESR1, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.15833
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 3.12909
[BP] GO:0007611 None APP, DRD1, DRD2, EGFR, HIF1A, HRH1, INSR, PTGS2 3.12836
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10882
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10882
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, HIF1A 3.09349
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 3.08276
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, XDH 3.08276
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.05626
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.05626
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.04937
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.04937
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.04803
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GBA, PPARA, SMAD3, TEK 3.04138
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, PTGS2, SRC 3.02994
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.02994
[BP] GO:0045913 None HIF1A, HRH1, INSR, PPARA, SRC 3.02299
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 3.00111
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, DRD1, DRD2, GPR35, KCNH2, MMP9, PTGS2 2.97108
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, DRD2, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, SMAD3, SRC, TEK 2.95163
[BP] GO:0008306 None APP, DRD1, DRD2, HIF1A, HRH1 2.93703
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.92597
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, EGFR, HIF1A, HRH1, PTGS2, TYR 2.91272
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.9118
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.90851
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, INSR, PTGS2, SMAD3 2.90851
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HIF1A, MMP12, SRC 2.90851
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.89775
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.89724
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HIF1A, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.88429
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.88188
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.88188
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.88188
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.83185
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.82953
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.81483
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.80727
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, FABP3, GBA, HIF1A, HRH1, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A 2.80727
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.79298
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.78233
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, EGFR, GAA, HIF1A, HRH1, INSR, PPARA, PTGS2 2.76941
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.74043
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, EGFR, ESR1, GPR35, HIF1A, KCNH2, PIK3CB, SMAD3 2.73687
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HIF1A, HRH1, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.72422
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.72179
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, INSR, TERT 2.72179
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.72179
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, EGFR, GAA, HIF1A, HRH1, INSR, KCNH2, PIK3CA, PTGS2, SRC, TEK, TYR 2.71879
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HIF1A, PIK3CA, PIK3CB, SMAD3 2.71879
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.71027
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71027
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD2, DUSP3, ESR1, HCAR2, HIF1A, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.707
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, HIF1A, PIK3CB 2.69034
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.69034
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.68461
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.68461
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MGAM, PIK3CB, SRC, XDH 2.68326
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, GBA, PPARA, SMAD3, TEK 2.68326
[BP] GO:0003013 None ADORA1, DRD1, EGFR, HRH1, PTGS2, SRC, TEK 2.65754
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2 2.65072
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.6489
[BP] GO:0016311 None ALPI, ALPL, APEX1, BCL2, CA3, CDC25B, DUSP3, PTPN1 2.63368
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.62794
[BP] GO:1903522 None ADORA1, ADORA3, DRD2, EGFR, GAA, HRH1, KCNH2, PTGS2 2.62673
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.62445
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HIF1A, PIK3CB, SMAD3 2.62101
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.62101
[BP] GO:0006584 None AKR1B1, DAO, DRD1, DRD2 2.62101
[BP] GO:0009712 None AKR1B1, DAO, DRD1, DRD2 2.62101
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.62101
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.61362
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.57486
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.56329
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56329
[BP] GO:0070920 None EGFR, ESR1, TERT 2.56329
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.56329
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.56329
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.5596
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.55871
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DRD1, DRD2, EGFR, ESR1, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 2.55871
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.55871
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.55871
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, KCNH2, PPARA 2.55607
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HIF1A, MMP12, SRC 2.55461
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HIF1A, PIK3CB, SMAD3 2.54732
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.54064
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.53664
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.53273
[BP] GO:0008217 None ADORA1, DRD2, PPARA, PTGS1, PTGS2, SMAD3 2.52269
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.49761
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.49616
[BP] GO:0000023 None GAA, MGAM 2.47599
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47599
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, PTGS2, SMAD3, TERT, XDH 2.47517
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.45453
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, HRH1, PTGS2 2.45453
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, EGFR, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.44371
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.4322
[BP] GO:0042391 None ADORA1, APP, BCL2, DRD1, GBA, GPR35, KCNH2, KDR, SRC 2.42747
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR, TERT 2.39388
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.39388
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.39028
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.38953
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37263
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.37263
[BP] GO:0006644 phospholipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, FDPS, MET, PIK3CA, PIK3CB 2.3614
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.35995
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HIF1A, MMP12, SRC 2.35468
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, DAO, FDPS, GBA, TYR 2.35296
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.35296
[BP] GO:0010676 None HRH1, INSR, PPARA, SRC 2.35296
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.34232
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.34232
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.34232
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.34232
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.33269
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.32523
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.30792
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.30792
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.30348
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.30348
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, HIF1A, KDR, TEK, TYR 2.29731
[BP] GO:0071456 cellular response to hypoxia BCL2, HIF1A, PTGS2, SRC, TERT 2.29483
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A 2.28519
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.28489
[BP] GO:0007613 None DRD1, DRD2, HRH1, INSR, PTGS2 2.27934
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.26917
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.26917
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.26917
[BP] GO:0044236 multicellular organism metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.26401
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.25294
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.23836
[BP] GO:0098908 None GBA, GPR35 2.23391
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.23391
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23391
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.23301
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.23301
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.23301
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.23233
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, PTGS2, SRC, TYR 2.22545
[BP] GO:0006109 regulation of carbohydrate metabolic process HIF1A, HRH1, INSR, PPARA, RORC, SRC 2.2242
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.2242
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.2242
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.2124
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.18776
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.18339
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, DRD1, DRD2, GPR35, KCNH2, MMP9 2.18082
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, SRC 2.17697
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, DRD2, EGFR, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 2.1768
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.17377
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17377
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.1518
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.1434
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.13665
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.13665
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CSNK2A1, DRD2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.13245
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.13245
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12588
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12588
[BP] GO:0050900 leukocyte migration FUT7, HRH1, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.1247
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.11355
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.10669
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, F10, FABP3, FUCA1, GAA, HIF1A, HSPA1A, KCNH2, MGAM, MMP12, MMP9, PPARA, SRC, TERT, XDH 2.10621
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.10158
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.10039
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HIF1A, MMP12, SRC 2.09129
[BP] GO:0060249 None AKR1B1, APEX1, BCL2, GAA, HIF1A, SRC, TERT 2.08409
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.07167
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, ESR1, F10, FABP3, FUCA1, GAA, HIF1A, HSPA1A, KCNH2, MGAM, MMP12, MMP9, PPARA, SRC, TERT, XDH 2.06083
[BP] GO:0009888 tissue development ALPL, CYP1B1, GAA, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.06083
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.06083
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.06083
[BP] GO:0021853 None DRD1, DRD2 2.06059
[BP] GO:1904936 None DRD1, DRD2 2.06059
[BP] GO:0042321 None ADORA1, DRD2 2.06059
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.05566
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.05566
[BP] GO:0010675 None HRH1, INSR, PPARA, RORC, SRC 2.05099
[BP] GO:0046466 None CYP1B1, FUCA1, GBA 2.04682
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04682
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.0419
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HIF1A, HRH1, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 2.01656
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.01458
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA 2.01458
[BP] GO:0097746 None ADORA1, DRD1, EGFR, HRH1, PTGS2 2.01216
[BP] GO:0035296 None ADORA1, DRD1, EGFR, HRH1, PTGS2 2.01216
[BP] GO:0010575 positive regulation of vascular endothelial growth factor production CYP1B1, HIF1A, PTGS2 2.00597
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.00403
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.00403
[BP] GO:0046887 positive regulation of hormone secretion CYP19A1, DRD2, EGFR, HCAR2, HIF1A 2.00033
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F10, FLT3, GAA, GLO1, GPR35, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 4.35147
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MGAM, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.9439
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.68528
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DRD1, DRD2, EGFR, ESR1, F10, FLT3, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HRH1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TYR 3.26026
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.56055
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.54944
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, HRH1, IGF1R, INSR, KCNH2, KDR, MET, MGAM, PTGS2, SRC, TEK 2.48581
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.44581
[CC] GO:0031974 None ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MMP9, PTGS2 2.4322
[CC] GO:0043233 None ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MMP9, PTGS2 2.4322
[CC] GO:0070013 None ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MMP9, PTGS2 2.4322
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, DRD1, DRD2, EGFR, INSR, MET, MGAM, PTGS2, SRC, TEK 2.31247
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, KCNH2, MET, TEK 2.18339
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, F10, FLT3, HSD17B2, PTGS1, PTGS2, PTPN1 2.15019
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.10327
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.09314
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, DRD1, DRD2, F10, FLT3, GPR35, HRH1, IGF1R, INSR, KDR, MET, TEK 2.04864
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HRH1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MGAM, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR 2.0089
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.7466
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, F10, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH 18.061
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 15.4032
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 13.6605
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.05
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.979
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 9.33613
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.94921
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, ESR1, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TOP2A, TYR, XDH 8.07174
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A 7.39374
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.00748
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TOP2A, TYR, XDH 6.71624
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.24386
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.7895
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.4919
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.37092
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.09095
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.09095
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.8433
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 4.82742
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.75057
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.60348
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 4.59898
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 4.33547
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR 4.25972
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.83891
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.77183
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.67456
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 3.52157
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.44479
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 3.30628
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.30262
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.25211
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 3.23847
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.23752
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 3.17224
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 3.17224
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.13365
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.88604
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 2.86965
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85872
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, FDPS, FLT3, HIF1A, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.84005
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.76697
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.73141
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CSNK2A1, DAO, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 2.72098
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, AXL, BCL2, DAO, DRD2, EGFR, FLT3, HIF1A, KCNH2, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.70822
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.63228
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 2.58078
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, FLT3, GPR35, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.48581
[MF] GO:0032450 None GAA, MGAM 2.47599
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.33108
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.31887
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DYRK1A, EGFR, ESR1, FDPS, FLT3, HIF1A, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.30792
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HIF1A, HSPA1A, KDR 2.27934
[MF] GO:0051425 None APP, INSR 2.23391
[MF] GO:0004558 None GAA, MGAM 2.23391
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.23384
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.09356
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, DRD2, FLT3, KCNH2, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.07201
[MF] GO:0019899 enzyme binding ALPI, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, HIF1A, HSPA1A, KCNH2, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 2.07158
[MF] GO:0043559 insulin binding IGF1R, INSR 2.06059
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.04682
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.03629
[MF] GO:0042578 None ADORA1, ALPI, ALPL, APEX1, CA3, CDC25B, DUSP3, PTPN1 2.02966


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.0632
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.2643
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 7.3714
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3714
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, PIK3CA, BCL2, MET 6.5552
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.8844
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 6.5669
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.3851
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MGAM, DNMT1, GAA, GBA, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 6.2268
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 6.5552
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 6.094
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR 5.2793
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.6232
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.5754
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.3157
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.2548
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0004
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 3.9496
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.2387
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.1811
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA 3.7997
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.9801
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.7997
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.5953
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.5953
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1735
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.2069
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, PTGS2, PTGS1 3.1735
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.1158
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1, HIF1A 3.1158
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2069
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.0945
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1158
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.1811
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.0936
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.0936
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.6836
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 2.9698
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 3.0936
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.6101
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.7066
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.716
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8573
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 2.9574
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HRH1, PIK3CA, SRC, PIK3CB 2.5829
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0301
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HRH1, GPR35, ADORA3, ADORA1, DRD1, DRD2 2.4542
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6254
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.6975
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5829
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.7846
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.542
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4279
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.3344
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4351
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.319
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3516
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2998
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.2085
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1859
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1578
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.1204
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.1364
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0583
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, PIK3CA, TERT, PIK3CB 1.9821
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.9996
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB, HSPA1A 1.8548
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.828
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.5926
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3664
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2621
Purine metabolism_Homo sapiens_hsa00230 XDH 0.274
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3913
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3312
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3135
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3428
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5532
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.5294
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3529
Calcium signaling pathway_Homo sapiens_hsa04020 HRH1, DRD1, EGFR 1.1711
Axon guidance_Homo sapiens_hsa04360 MET 0.3677
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.0501
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8435
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7053
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3757
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1344
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6923
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7867
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7916
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.817
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6668
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8055
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6661
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6931
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8219
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4401
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4401
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8453
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7867
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.0774
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.828
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4401
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4509
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4499
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9535
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9642
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4726
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 2.265
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4726
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.484
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9901
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3963
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4713
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0014
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0373
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0506
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0501
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.3312
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5035
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.51
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1471
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5242
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.522
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6655
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5369
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.4675
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1091
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1972
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5505
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2364
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.2305
Shigellosis_Homo sapiens_hsa05131 SRC 0.5589
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5619
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.5417
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.215
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.215
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5835
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6421
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.2291
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.268
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.268
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.614
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3324
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6404
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6451
Malaria_Homo sapiens_hsa05144 MET 0.6499
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.3654
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6631
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6655
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4602
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.6631
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6706
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6668
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6988
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7459
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6988
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.817
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7459
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7849
Base excision repair_Homo sapiens_hsa03410 APEX1 0.763
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7951
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8219
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7881
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6962
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7852
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.817
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0295
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8798
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.195
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.3561
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0936


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)