TCM Prescription: Zhi Yan Xiao Capsules



Prescription Description
Prescription IDTCMF6883
Pinyin NameZhi Yan Xiao Jiao Nang
Chinese Name痔炎消胶囊
English NameZhi Yan Xiao Capsules
Function Description清热解毒, 润肠通便, 止血, 止痛, 消肿。用于痔疮发炎肿痛, 肛裂疼痛及痔疮手术后大便困难, 便血等及老年人便秘。
IndicationsConstipation disorder, Fissured anus disorder, Constipation, Hemorrhoids
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
SB7C [Fissured anus disorder (TM1), 肛裂 (TM1) ];
ME05.0 [Constipation, 便秘 ];
DB60 [Haemorrhoids, 痔 ];
Human Tissues Associated with IndicationLarge Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1005 Cannabis sativa 火麻仁 TCMH1005 ITSAJ4165-14
TCMH2732 Callicarpae formosanae folium 紫珠叶 TCMH2732
TCMH938 Sophora japonica 槐花 TCMH938 ITSAN2377-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH462 Sanguisorba officinalis 地榆 TCMH462 GENG545-14, GBVT2403-13
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH1455 Ranunculus japonicus 茅根 TCMH1455 ITSAF2010-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, POLB, PPARA, PPARD, RORC, SRC, TYR 10.4288
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, POLB, PPARA, PPARD, RORC, SRC, TYR 10.4288
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC, SRC 10.4288
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PPARA, PPARD, TBXAS1 10.3028
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR2C, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, POLB, PPARA, PPARD, RORC, SRC, TYR 9.91658
[BP] GO:0033993 response to lipid AKR1C3, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PPARD, RORC, SRC, TYR 9.89014
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC, SRC 9.44716
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, PPARD, RORC, SRC 9.26576
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 8.33941
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HTR2C, PIM1, PPARA, PPARD, TBXAS1, TYR, XDH 8.23984
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR2C, KDR, KIT, MET, POLA1, POLB, PPARA, PPARD, SRC, XDH 8.11274
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, TYR, XDH 7.77029
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2, PPARD 7.73598
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 7.37702
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARD, RORC, SRC, XDH 7.30163
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, KIT, POLB, PPARA, PPARD, SRC, TYR 7.28693
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, POLB, PPARA, PPARD, RORC, SRC, TYR 7.19995
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, PPARD, SRC, XDH 7.18661
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APP, AR, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, RORC, SRC, TYR 7.1866
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, TYR, XDH 7.16606
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AR, AXL, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, FABP4, HSD17B2, HTR2C, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 7.16606
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC 6.90516
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR 6.78235
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 6.61234
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, POLB, PPARA, PPARD, RORC, SRC, TYR 6.60265
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, HTR2C, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TYR 6.45195
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PPARD, SRC, XDH 6.40779
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PPARD, SRC, XDH 6.38197
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 6.33677
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PPARA, PPARD, TBXAS1 6.32286
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARD, RORC, SRC, XDH 6.2913
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, KIT, MMP2, NR3C1, PPARA, SRC 6.20959
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 6.14903
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, POLA1, PPARD, SRC, TYR 6.05269
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 6.03481
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, KIT, NR3C1, PPARA, SRC 6.02452
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, TYR, XDH 6.00104
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PPARD, TBXAS1, TYR, XDH 6.00104
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, TBXAS1 5.97709
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PPARD, RORC, SRC 5.78604
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, PPARD, RORC, SRC 5.6661
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.6661
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HTR2C, PPARD 5.5528
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.53396
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CYP1B1, F10, FLT3, HTR2C, KDR, KIT, MET, PPARD, SRC, XDH 5.49831
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, TYR, XDH 5.23797
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2C, KIT, PPARA, RORC, SRC 5.12992
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PPARD, SRC, XDH 5.11363
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PPARD, SRC, XDH 5.05837
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, FABP4, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARD, SRC, XDH 5.03212
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.98008
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARD, SRC, XDH 4.98008
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, F10, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PPARD, SRC, XDH 4.98008
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.96295
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARD, SRC, XDH 4.96295
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARD, SRC, XDH 4.8758
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.79387
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, POLA1, POLB, PPARD, RORC, SRC 4.79387
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLB, PPARA, PPARD, RORC, SRC 4.7484
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PPARD, RORC, SRC 4.55215
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.55215
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PPARD 4.52813
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CHRM1, CHRM4, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PPARD, SRC 4.49518
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 4.37881
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC 4.33783
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.31147
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 4.28682
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.26126
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARD, RORC, SRC, XDH 4.2474
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PPARD, SRC 4.2055
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, KIT, SRC 4.2055
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PPARD, SRC 4.17612
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PPARD, RORC, SRC, XDH 4.17612
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.14901
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, TBXAS1 4.09755
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HTR2C, KDR, NR3C1, POLB, SRC 3.90619
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARD, SRC 3.8896
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.86586
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, PPARD, TYR 3.76128
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9 3.75348
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARD, SRC, XDH 3.7401
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PPARD, SRC, XDH 3.71485
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PPARD, SRC 3.70349
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69831
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, APP, AR, AXL, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, KIT, MMP2, MMP9, PGR, PPARD, SRC 3.69634
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2C, MET, POLA1, POLB, SRC 3.68246
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PPARD, RORC, SRC, XDH 3.67794
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, PPARD 3.60996
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PPARD, RORC, SRC, XDH 3.59895
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.59359
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.53457
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.49296
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.49296
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.49296
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PPARD, SRC 3.44644
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PPARD, RORC, SRC, XDH 3.44408
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, ESR1, FLT3, NR3C1, PPARD, RORC, SRC 3.42991
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.39462
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.36482
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.3584
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, TYR, XDH 3.3548
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.3548
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2C, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARD, RORC, SRC 3.32962
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, KIT, PPARA, SRC 3.32477
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, PPARD 3.28722
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, TBXAS1, TYR 3.28494
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AR, AXL, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, PPARD, SRC 3.2808
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, KIT, SRC 3.24461
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, KIT, PGR, PPARA, RORC, SRC 3.24018
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 3.23681
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23492
[BP] GO:0071383 None AKR1C3, AR, FLT3, NR3C1, SRC 3.20062
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PPARD, RORC, SRC, XDH 3.16736
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PPARD, SRC 3.1263
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.11226
[BP] GO:0019371 None AKR1C3, CBR1, TBXAS1 3.11226
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, SRC, XDH 3.1008
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2C, KDR, KIT, SRC, XDH 3.09973
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, KIT 3.08928
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, KIT 3.08928
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.08922
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PPARD, RORC, SRC, XDH 2.9914
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 2.96103
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.93369
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.92367
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91127
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2C 2.90435
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, TBXAS1, TYR 2.894
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2C, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PPARD, RORC, SRC 2.89238
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, SRC 2.88516
[BP] GO:0016488 None AKR1B10, AKR1C3 2.88516
[BP] GO:0016487 None AKR1B10, AKR1C3 2.88516
[BP] GO:0016107 None AKR1B10, AKR1C3 2.88516
[BP] GO:0009115 None AOX1, XDH 2.88516
[BP] GO:0006714 None AKR1B10, AKR1C3 2.88516
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, KIT, PGR, SRC 2.88124
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PPARD 2.8652
[BP] GO:0001523 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, PPARD 2.8652
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, SRC 2.84927
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.84927
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, TBXAS1, TYR 2.84927
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARD, RORC, SRC, XDH 2.75464
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, PPARD 2.72461
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARD, RORC, SRC 2.72461
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, SRC, XDH 2.71934
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, KIT, MMP2, POLB, PPARA, PPARD, SRC, TYR 2.69094
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PPARD, SRC 2.69094
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, HTR2C, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARD, SRC, XDH 2.69094
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.69094
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.69094
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2C, IGF1R, KDR, KIT, SRC, XDH 2.67932
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARD, SRC, XDH 2.67751
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARD 2.65758
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, CNR1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.65758
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.64712
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, PPARD 2.63509
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.62314
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.57179
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.57179
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, PPARA, PPARD 2.56023
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.55579
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2 2.51474
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HTR2C, KIT, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, SRC 2.4943
[BP] GO:0060748 None AR, PGR 2.4943
[BP] GO:0046110 None AOX1, XDH 2.4943
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4943
[BP] GO:0016095 None AKR1B10, AKR1C3 2.4943
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.4919
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, SRC 2.4864
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.4823
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.47699
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, PIM1 2.44343
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PPARD 2.44343
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD 2.44322
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.40514
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PPARD 2.39783
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.39306
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PPARD, SRC 2.3816
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, PPARD, SRC 2.37775
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, ESRRB, FABP3, FLT3, HTR2C, KDR, KIT, MMP9, SRC, XDH 2.35368
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, ESRRB, FABP3, FLT3, HTR2C, KDR, KIT, MMP9, SRC, XDH 2.35368
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34173
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, SRC 2.34033
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1 2.32841
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.29919
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, APP, AR, AXL, CBR1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PGR, PPARD, RORC, SRC 2.29919
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.29919
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29919
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.29919
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, SRC, XDH 2.29919
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 2.2964
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, HTR2C, KDR, SRC 2.27946
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARD, RORC, SRC, XDH 2.27891
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.27891
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, KIT 2.27891
[BP] GO:0006145 None AOX1, XDH 2.26892
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.26892
[BP] GO:0038171 None CNR1, CNR2 2.26892
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26892
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.26764
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, PPARD 2.26764
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.26764
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26764
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.2651
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 2.26463
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, CA9, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARD, RORC, SRC, XDH 2.2516
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, XDH 2.24795
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PPARD, SRC 2.21491
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, ESRRB, FLT3, HTR2C, KDR, KIT, MMP9, SRC, XDH 2.21491
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.20742
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, ESRRB, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PPARA, SRC, XDH 2.20021
[BP] GO:0048545 response to steroid hormone AKR1C3, AR, CA2, FLT3, NR3C1, SRC 2.19461
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, SRC 2.17271
[BP] GO:0030335 positive regulation of cell migration APP, F10, IGF1R, KDR, KIT, MET, MMP9, SRC 2.1401
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.1401
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.12765
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PPARD, RORC, SRC 2.1174
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.09822
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, KDR, KIT, MET, MMP1, MMP12, MMP9, PPARD, SRC 2.09665
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.09665
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.09665
[BP] GO:0007154 None ADORA1, AKR1C3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR2C, PGR 2.09178
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PPARA, SRC, XDH 2.08343
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4 2.07789
[BP] GO:0022602 ovulation cycle process ESR1, KIT, PGR, SRC 2.07789
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, PPARD, XDH 2.07479
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, XDH 2.06772
[BP] GO:2000147 positive regulation of cell motility APP, F10, IGF1R, KDR, KIT, MET, MMP9, SRC 2.06473
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PPARD 2.06473
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.06473
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PPARA, SRC, XDH 2.05593
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, CYP1B1, MMP9, SRC 2.04346
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, ESR1, FLT3, KIT, NR3C1, SRC 2.04346
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.03857
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.03857
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.03857
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.03452
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.03452
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CSNK2A1, FLT3, HTR2C, IGF1R, KDR, KIT, MET, PIM1, POLB, PPARD, SRC, XDH 2.0282
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.00256
[BP] GO:0009889 regulation of biosynthetic process ADORA3, AKR1C3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2C, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, POLA1, PPARA, PPARD, RORC, SRC 2.0009
[BP] GO:0051272 positive regulation of cellular component movement APP, F10, IGF1R, KDR, KIT, MET, MMP9, SRC 2.00088
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.00088
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.00088
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, FLT3, HTR2C, IGF1R, KDR, MET 2.77952
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, F10, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC 2.29919
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, FLT3, HTR2C, IGF1R, KDR, KIT, MET, SRC 2.24889
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR2C, IGF1R, KDR, MET 1.99916
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, SRC, TBXAS1, TYR 1.8198
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARD, RORC, TBXAS1, TYR, XDH 18.8105
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 12.3209
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, TYR, XDH 10.4288
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARD, RORC 9.98592
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARD, RORC 9.98592
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC 9.46652
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 9.33307
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 9.09561
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, HTR2C, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, TBXAS1, TYR, XDH 8.79822
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 8.29924
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.29924
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 8.07304
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, TBXAS1, TYR, XDH 7.73598
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 7.5683
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 7.53151
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, SRC, TBXAS1, TYR, XDH 6.32286
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.32286
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 6.02068
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 5.7658
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD17B1, HSD17B2, XDH 5.33748
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.11363
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 5.11363
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.85824
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR2C, IGF1R, KDR, KIT, MET, PIM1, PPARA, PPARD, SRC 4.79387
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.28682
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.16756
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.14901
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.83609
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75678
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57827
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.45629
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.42247
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD17B1, HSD17B2 3.38891
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.28049
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.24292
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.08928
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR2C 3.01697
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.94324
[MF] GO:0045550 None AKR1B10, AKR1C3 2.88516
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88516
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.78078
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.55579
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.54187
[MF] GO:0047718 None AKR1B10, AKR1C3 2.4943
[MF] GO:0004949 None CNR1, CNR2 2.4943
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR2C 2.44845
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.40215
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR2C, IGF1R, KDR, KIT, MET 2.40091
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR2C, IGF1R, KDR, KIT, MET 2.40091
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.35405
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.29919
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26892
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.22001
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.18071
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.1401
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.1401
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, POLA1, POLB, SRC 2.1401
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HTR2C, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, XDH 2.1174
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09665
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HTR2C, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, POLA1, POLB, PPARA, PPARD, RORC, SRC, TBXAS1, XDH 2.08343
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.0686
[MF] GO:0043565 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 2.03591


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 9.4425
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 7.6284
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.2501
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1C3, AKR1B1, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 5.3057
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, CNR1, ADORA3, CHRM4, ADORA1, HTR2C, NR3C1 5.3057
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, AKR1C3 4.5196
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, KIT, MMP9, MET, IGF1R, PPARD 4.2645
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2824
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.3541
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8159
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0384
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0363
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KIT, KDR, MET, IGF1R 3.3365
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1, PPARD 3.534
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1773
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1773
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.5809
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KIT, KDR, MET, IGF1R 2.3875
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0548
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, HTR2C 2.5809
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.1682
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.1834
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1292
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2022
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, ADORA1, PPARA 1.8133
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9473
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8133
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.766
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.7109
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.6436
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.505
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.3604
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, HTR2C 1.2775
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.375
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3366
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2C 1.0633
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.1149
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0554
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1056
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2613
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.0633
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0554
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3536
Gap junction_Homo sapiens_hsa04540 SRC, HTR2C 1.1153
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2775
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1153
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1943
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9385
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2752
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9496
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9496
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8306
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9442
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8447
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.8447
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8468
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7983
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7765
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7515
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6659
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8016
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2524
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8133
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3216
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3424
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7109
Tuberculosis_Homo sapiens_hsa05152 SRC 0.351
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3424
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3661
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3945
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3829
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4069
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4229
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4268
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4268
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4397
Axon guidance_Homo sapiens_hsa04360 MET 0.4352
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4748
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4748
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4896
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5024
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4865
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4535
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4999
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5024
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4896
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5024
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4836
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4999
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5024
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4999
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5024
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4999
Peroxisome_Homo sapiens_hsa04146 XDH 0.5141
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5487
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.766
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5283
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9543
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5605
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5794
Glioma_Homo sapiens_hsa05214 IGF1R 0.5794
Bile secretion_Homo sapiens_hsa04976 CA2 0.5599
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5784
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5849
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5794
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7109
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5794
Shigellosis_Homo sapiens_hsa05131 SRC 0.5794
Malaria_Homo sapiens_hsa05144 MET 0.6602
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6659
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6629
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6659
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7247
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7891
DNA replication_Homo sapiens_hsa03030 POLA1 0.7515
Base excision repair_Homo sapiens_hsa03410 POLB 0.7755
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7983
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.83
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7964
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.821
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.157
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2775


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)