TCM Prescription: Zhi Dai Tablets



Prescription Description
Prescription IDTCMF6829
Pinyin NameZhi Dai Pian
Chinese Name治带片
English NameZhi Dai Tablets
Function Description带下病
IndicationsLeukorrhea disorder
Disease ICD-11 Category SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1532 Patrinia rupestris 墓头回 TCMH1532 GBVF2379-11
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, NUAK1, PDE5A, PIM1, SMAD3, SRC, TEK, XDH 8.63297
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 8.63297
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 8.63297
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 8.48863
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, MAOB, PPARA, SRC, TEK 8.18155
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, PPARA, RORC, SMAD3, SRC, TEK 7.85942
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, MIF, PPARA 7.83105
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.71535
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.71535
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MAOB, PPARA, SMAD3, SRC, TEK 7.61339
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSPA1A, INSR, KDR, MAOB, MET, MIF, PPARA, SMAD3, SRC, TEK, XDH 7.52033
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 7.44105
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 7.34034
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.34034
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.34034
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 7.31405
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, INSR, KDR, PPARA, SMAD3, SRC, TEK 7.31042
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 7.17715
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, MIF, PDE5A, PIM1, PPARA, XDH 7.04124
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, MAOB, RORC, SRC 6.97997
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.97997
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, MAOB, RORC, SRC, TEK 6.97077
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PDE5A, PTPN1, SRC, TEK, XDH 6.97077
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, IGF1R, INSR, MAOB, PPARA, RORC, SRC, TEK 6.85641
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.82825
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MIF, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 6.51868
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 6.48432
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MAOB, MET, MIF, MMP12, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.37891
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, PPARA, RORC, SMAD3, SRC, TEK 6.31602
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.31602
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.31144
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SMAD3, SRC, TEK 5.96523
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD17B1 5.95859
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MAOB, MET, MIF, MMP12, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.93242
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, INSR, KDR, MAOB, MET, MIF, PIM1, PPARA, RORC, SMAD3, SRC, TEK 5.89565
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1 5.85756
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.84652
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.79481
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MAOB, SRC 5.55234
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 5.51234
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, INSR, KDR, MAOB, PIM1, PPARA, RORC, SMAD3, SRC, TEK 5.44181
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.35328
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.28607
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MIF, PIM1, PTPN1, SMAD3, SRC, TEK 5.28607
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.24926
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 5.21081
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.18394
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1 5.1706
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.1706
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 5.04678
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.99703
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.92823
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.92205
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.88259
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC 4.8754
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, XDH 4.81108
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA 4.70715
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 4.62726
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, PTPN1, RORC, SMAD3, SRC 4.62663
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.62663
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MAOB, MMP12, PDE5A, SRC, XDH 4.59958
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.58785
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, PDE5A, PTPN1, SRC, TEK, XDH 4.55705
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, RORC, SMAD3, SRC 4.5518
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.53533
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, XDH 4.52926
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.43638
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MIF, MMP12, PIM1, TEK 4.40025
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, INSR, MET, SRC, TEK, XDH 4.40025
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, MIF, PDE5A, PTPN1, SRC, TEK, XDH 4.32413
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, RORC, SMAD3, SRC 4.29587
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.2938
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 4.27132
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.27132
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.26882
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALPL, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MIF, MMP12, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 4.26589
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, INSR, MET, SRC, TEK 4.22571
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOB 4.21815
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.17419
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.17419
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.17419
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.1449
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 4.13881
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 4.13867
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 4.13867
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, PTPN1, SMAD3, SRC, XDH 4.06573
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, PTPN1, SMAD3, SRC, XDH 4.05141
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 4.03389
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.01675
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 3.99742
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.96494
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.93549
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 3.93521
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, SRC 3.91841
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC 3.91745
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC, TEK 3.91745
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MIF, PDE5A, PPARA, PTPN1, SRC, TEK, XDH 3.91635
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.88688
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC, TEK 3.85081
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, FABP4, IGF1R, INSR, MET, MMP12, PDE5A, PIM1, PPARA, RORC, SMAD3, SRC, TEK 3.84823
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, MIF, PDE5A, PTPN1, SRC 3.84035
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD17B1 3.83664
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.80525
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.78304
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MAOB, PDE5A, XDH 3.75775
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 3.7283
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 3.72138
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, MAOB, XDH 3.72138
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.72138
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.72138
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.72138
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.72138
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MIF, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.72138
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, SRC 3.68154
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 3.66396
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC 3.63569
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 3.63098
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.6287
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP12, PDE5A, PIM1, SMAD3, SRC, TEK, XDH 3.60894
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.5702
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.55564
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 3.55539
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 3.54347
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 3.53797
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PDE5A, PTPN1, SRC 3.52929
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK 3.50223
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.48508
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 3.46749
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.44071
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MAOB, MIF, MMP12, PPARA, PTPN1, SMAD3, SRC 3.43309
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.4137
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 3.39231
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, CA2, EGFR, FLT3, MAOB, SRC 3.38679
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, MIF, PDE5A, PTPN1, SRC, TEK 3.35768
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, MIF, PDE5A, PTPN1, SRC, TEK 3.33522
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.32344
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, MIF, PDE5A, PTPN1, SRC, TEK, XDH 3.3199
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PTPN1, SRC 3.26772
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, EGFR, ESRRB, HCAR2, HSPA1A, KDR, MET, MIF, MMP12, PDE5A, PIM1, SMAD3, SRC, TEK 3.24015
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, HSPA1A, MAOB, PDE5A, SRC, XDH 3.23531
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MIF, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.18783
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, EGFR, FLT3, MAOB, SRC 3.1725
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 3.1725
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, PDE5A, PTPN1, SRC, TEK, XDH 3.14077
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, SMAD3, XDH 3.13566
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 3.11341
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.10263
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.07965
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.07802
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, MIF, PDE5A, PTPN1, SRC 3.07802
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.06643
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, INSR, SRC 3.06343
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.04958
[BP] GO:0016488 None AKR1B10, AKR1C3 3.04958
[BP] GO:0016487 None AKR1B10, AKR1C3 3.04958
[BP] GO:0016107 None AKR1B10, AKR1C3 3.04958
[BP] GO:0009115 None AOX1, XDH 3.04958
[BP] GO:0006714 None AKR1B10, AKR1C3 3.04958
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, MIF, SRC 3.04958
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 3.03846
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MIF, MMP12, SRC 3.0373
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, MIF, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.03239
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 3.0249
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, EGFR, INSR, SMAD3, XDH 3.01272
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MIF, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.01121
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.9927
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.9918
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 2.96083
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.96083
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.96083
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.96083
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.96083
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, SRC 2.96083
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 2.94275
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.9131
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, SRC 2.9125
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.91052
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.90255
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.88451
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.88206
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 2.88105
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, EGFR, FLT3, INSR, KDR, MIF, PDE5A, PTPN1, SRC, TEK, XDH 2.87671
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, MAOB 2.87111
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.84521
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.83634
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, MIF, PDE5A, PTPN1, SRC 2.83632
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, PTPN1, SRC, XDH 2.82001
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.81539
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, EGFR, HCAR2, INSR, MIF, MMP12, SMAD3, SRC 2.81468
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC 2.79929
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.78731
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.78731
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.78731
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.78252
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.77847
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.75837
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC 2.74567
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.73844
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MIF, MMP12, PDE5A, PTPN1, SMAD3, SRC 2.73376
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MIF, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.72547
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.70952
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.67553
[BP] GO:0046110 None AOX1, XDH 2.67553
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.67553
[BP] GO:0016095 None AKR1B10, AKR1C3 2.67553
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.65089
[BP] GO:0009968 negative regulation of signal transduction DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, PTPN1, SMAD3, SRC, XDH 2.64641
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, MIF 2.63256
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.63256
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.62333
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.60766
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD17B1 2.57799
[BP] GO:0050793 regulation of developmental process AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, MIF, NUAK1, PDE5A, PIM1, PPARA, RORC, SMAD3, SRC, TEK, XDH 2.5601
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.55149
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.53233
[BP] GO:0010038 response to metal ion AKR1C3, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MAOB 2.53128
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.52587
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.52384
[BP] GO:0030335 positive regulation of cell migration EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.51527
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.50619
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.46674
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, MAOB, SRC 2.45539
[BP] GO:0051894 None KDR, SMAD3, TEK 2.45539
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.45539
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.45498
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, HSPA1A, MAOB, PDE5A, XDH 2.44407
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.43308
[BP] GO:2000147 positive regulation of cell motility EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.42665
[BP] GO:0006145 None AOX1, XDH 2.42665
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.42665
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.42665
[BP] GO:0050730 None ADORA1, EGFR, FLT3, MIF, PTPN1, SRC 2.38894
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, RORC, SRC 2.38492
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.38313
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.3755
[BP] GO:1903393 None KDR, SMAD3, TEK 2.37123
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.37055
[BP] GO:0050714 None ACHE, EGFR, HCAR2, MIF, MMP12, SRC 2.358
[BP] GO:0051272 positive regulation of cellular component movement EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.35608
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.33909
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.33123
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 2.31202
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4 2.30434
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.30089
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.29124
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.28643
[BP] GO:0071396 cellular response to lipid AKR1C3, AXL, EGFR, ESR1, FLT3, RORC, SRC 2.28643
[BP] GO:0040017 positive regulation of locomotion EGFR, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.26416
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.24328
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, PTPN1, SMAD3, SRC, TEK 2.21714
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.21681
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.21681
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOB, SMAD3 2.19832
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.19832
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.19832
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.19832
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, AXL, CDC25B, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MIF, RORC, SMAD3, SRC, TEK 2.19285
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTPN1, XDH 2.18858
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR 2.18562
[BP] GO:1901890 None KDR, SMAD3, TEK 2.18562
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, PPARA, SMAD3, SRC, TEK 2.17251
[BP] GO:0090087 None ACHE, ADORA1, CA2, EGFR, HCAR2, MIF, MMP12, PTPN1, SMAD3, SRC 2.17058
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, AURKB, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.16326
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC 2.15246
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.15166
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.1514
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PPARA, SMAD3 2.14389
[BP] GO:0051246 regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.1239
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.11763
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, PPARA, SMAD3, SRC, TEK 2.11403
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.11403
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 2.11403
[BP] GO:0010605 negative regulation of macromolecule metabolic process AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.11403
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.11403
[BP] GO:0046113 None AOX1, XDH 2.11403
[BP] GO:0016115 None AKR1B10, AKR1C3 2.11403
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, PPARA, SMAD3, SRC, TEK 2.11103
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, CYP19A1, ESR1, INSR, SRC 2.1018
[BP] GO:0001523 None AKR1B10, AKR1C3, CYP1A1, CYP1B1 2.07985
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4 2.06448
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MAOB, MIF, MMP12, SRC 2.06418
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, EGFR, ESR1, FLT3, IGF1R, INSR, SMAD3, SRC 2.06062
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, MIF, PTPN1, SRC 2.05759
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4 2.05759
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, MAOB, SRC 2.04981
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, INSR, PPARA, RORC, SRC 2.04831
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, EGFR, FLT3, INSR, KDR, MIF, PDE5A, PTPN1, SRC, TEK, XDH 2.04291
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, MIF, PPARA, SMAD3, TEK 2.03764
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, MIF, SMAD3 2.03764
[BP] GO:0045124 None CA2, EGFR, SRC 2.03456
[BP] GO:0051172 None AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MIF, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.03456
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.02932
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, SRC 2.01718
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CYP19A1, DUSP3, MIF, MMP12, PDE5A 2.01105
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, PTPN1, SRC 2.00833
[BP] GO:0055118 None ADORA1, PDE5A 2.00001
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.82505
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.11403
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK 1.78462
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 1.75662
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MAOB, MIF, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 1.70864
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 10.0954
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0954
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MIF, MMP12, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, XDH 8.85573
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 8.63297
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.79282
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.20432
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82825
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.96523
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.92135
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.59448
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.59448
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, RORC, SMAD3 5.55234
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.18394
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.97449
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 4.96564
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.95982
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 4.59958
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, MAOB, XDH 4.50195
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD17B1, XDH 4.48507
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 4.40008
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.38589
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.37241
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.32413
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.21739
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.17419
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 4.17419
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.12364
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, XDH 4.07776
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.00284
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.91841
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.88189
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 3.86452
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.83664
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.80184
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.5702
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 3.36051
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, XDH 3.333
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, XDH 3.33245
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.24015
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.22806
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.04958
[MF] GO:0045550 None AKR1B10, AKR1C3 3.04958
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.04958
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.0373
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, MAOB, SRC, XDH 3.00832
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, XDH 2.9306
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.72022
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD17B1 2.67553
[MF] GO:0047718 None AKR1B10, AKR1C3 2.67553
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.58232
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.55007
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.54672
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.52587
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.42665
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.42665
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.37123
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.35608
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD17B1 2.33123
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.26153
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD17B1 2.25061
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.25061
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.24328
[MF] GO:0043559 insulin binding IGF1R, INSR 2.24328
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.239
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.22761
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.18562
[MF] GO:0019899 enzyme binding AURKB, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, MET, MIF, PPARA, PTPN1, SMAD3, SRC, TEK 2.18094
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PTPN1, SMAD3 2.1401
[MF] GO:0004064 arylesterase activity CA1, CA2 2.11403
[MF] GO:0043546 None AOX1, XDH 2.11403
[MF] GO:0035258 None ESR1, FLT3, SMAD3, SRC 2.11398
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.00001
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1 2.00001
[MF] GO:0001758 None AKR1B10, AKR1C3 2.00001
[MF] GO:0004032 None AKR1B1, AKR1C3 2.00001
[MF] GO:0001609 None ADORA1, ADORA3 2.00001


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 10.1075
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.6071
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.8576
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 8.0582
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.6045
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3313
Metabolic pathways_Homo sapiens_hsa01100 MAOB, AKR1C3, AKR1B1, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.9393
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8781
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.8781
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.513
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2822
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2112
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.5321
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.6776
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.7545
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0802
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4284
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, MIF 2.9176
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4284
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2853
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A 2.2355
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2823
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET, EGFR, CDC25B 2.1818
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2823
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2853
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2784
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1 2.2823
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2761
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2823
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MET, EGFR, IGF1R 1.7165
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8333
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6761
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6402
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.5924
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3734
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.2933
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3881
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4242
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3734
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1 1.1055
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 1.0181
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1785
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1763
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1221
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1662
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1479
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4058
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3698
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1774
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2587
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5 1.0382
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3 1.3844
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3734
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0181
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 1.0181
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0117
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9408
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9991
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9516
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9263
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9363
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC 0.9169
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9991
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9215
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9363
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9027
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8931
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8931
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6688
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7615
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8419
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7282
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2863
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3546
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.863
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3965
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3821
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3881
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3881
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3881
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3881
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3815
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4276
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4712
Platelet activation_Homo sapiens_hsa04611 SRC 0.4923
Axon guidance_Homo sapiens_hsa04360 MET 0.484
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4923
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4816
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5232
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7447
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5441
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5516
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5516
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.556
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5607
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5602
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5698
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5704
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5651
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5715
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5715
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5819
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5709
Peroxisome_Homo sapiens_hsa04146 XDH 0.5827
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6211
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8333
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6196
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.608
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6295
Bile secretion_Homo sapiens_hsa04976 CA2 0.628
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6445
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6428
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6486
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6657
Shigellosis_Homo sapiens_hsa05131 SRC 0.6465
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.657
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6891
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6921
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.7104
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0796
Malaria_Homo sapiens_hsa05144 MET 0.7256
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7256
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7217
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7256
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7256
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7256
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7282
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7765
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MIF 2.2784
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8162
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7711
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8931
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8564
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8739
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8739
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8931
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8649
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8931
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0802
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.909
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0403
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3243


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)