Prescription ID | TCMF6749 |
Pinyin Name | Yang Chun Kou Fu Ye |
Chinese Name | 阳春口服液 |
English Name | Yang Chun Oral Liquid |
Function Description | 阳痿, 遗精, 早泄, 不寐, 健忘, 腰痛 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Lumbago disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Sexual dysfunction, Lumbago, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Heart, Brain, Kidney |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
TCMH1349 | Cervus elaphus | 鹿茸 | TCMH1349 | ABMC060-05 |
TCMH2507 | Epimedium brevicornum | 淫羊藿 | TCMH2507 | AY362429 |
TCMH1862 | Cornus officinalis | 山茱萸 | TCMH1862 | ITSAO2979-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH2437 | Actinolitum | 阳起石 | TCMH2437 | |
TCMH2183 | Gallus domesticus | 乌鸡 | TCMH2183 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT302 | HMGCR | HMG-CoA reductase | Oxidoreductase | P04035 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1292 | Japanese encephalitis virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1336 | Yellow fever virus |
TCMT1337 | Dengue virus type 4 |
TCMT1338 | Rift Valley fever virus |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 11.9669 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SRC, XDH | 9.61176 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 8.52925 |
[BP] GO:0007215 | None | APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.44198 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR | 8.26266 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HMGCR, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 8.26266 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 6.93467 |
[BP] GO:0010033 | response to organic substance | AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR | 6.93467 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.92287 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 6.6019 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 6.53446 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH | 6.41135 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.41135 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.41135 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.40697 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 6.31172 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.18894 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 5.96313 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.93266 |
[BP] GO:0042221 | response to chemical | AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR | 5.92948 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.76378 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.76378 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 5.68998 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.68998 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.58625 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AXL, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.45772 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 | 5.40661 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH | 5.2345 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.21464 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 5.21368 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 5.14708 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.14682 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 5.06203 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SRC, XDH | 5.0493 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.91443 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 4.91443 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 4.91443 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 4.91087 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 | 4.91026 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, APP, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 4.85196 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR | 4.80705 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, APP, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 4.80705 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.74639 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 4.70803 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.67631 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.62486 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH | 4.62053 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC | 4.62053 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 4.62053 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 4.56127 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.53719 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR | 4.46608 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.45492 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC | 4.42646 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC | 4.38286 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.28862 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC | 4.2715 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, APP, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.23512 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, APP, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.23512 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TYR | 4.13951 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC | 4.1137 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.09042 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.07081 |
[BP] GO:0014070 | response to organic cyclic compound | APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TYR | 4.06734 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR | 4.06387 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.00569 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH | 3.91485 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.8898 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC | 3.88464 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR | 3.88464 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC | 3.88464 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 | 3.81105 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.74618 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.72412 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.7148 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH | 3.67108 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB | 3.6429 |
[BP] GO:0035235 | None | APP, GRIA2, GRIA4, GRIK5 | 3.58105 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 | 3.55554 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.5118 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.42166 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH | 3.40291 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC | 3.39256 |
[BP] GO:0032787 | None | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 3.36374 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.32381 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR | 3.30597 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.30489 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 3.29308 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.2486 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.20997 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.20997 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH | 3.20872 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.18447 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.18302 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, APP, FLT3, GRM1, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH | 3.163 |
[BP] GO:0007193 | None | ADORA1, GRM1, GRM3, GRM5, GRM8 | 3.163 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, HMGCR, MMP2, MMP9, PTGS2 | 3.163 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5 | 3.13819 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, F10, MET, PIK3CA, PIK3CB, SRC, XDH | 3.13797 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.13604 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 3.10928 |
[BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC | 3.02862 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, APP, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.95546 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 | 2.95203 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 2.94544 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, F10, MET, PIK3CA, PIK3CB, SRC | 2.90018 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.90018 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.89467 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.81403 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, FLT3, GRM1, HMGCR, IGF1R, PIK3CB, PTPN1, SRC | 2.80023 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 2.77684 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTGS2, SRC, TYR | 2.76485 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.73408 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, PTGS2, SRC | 2.73122 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, APP, FLT3, GRM1, HMGCR, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH | 2.73122 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC | 2.71832 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, APP, CDC25B, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.68236 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.65675 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 | 2.62265 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC | 2.62265 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.59792 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.58612 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR | 2.57897 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 2.54308 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.54308 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 2.5385 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.5385 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR | 2.5385 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.5385 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.48748 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.45574 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.45421 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.45421 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, XDH | 2.45091 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.43512 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC | 2.43185 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.41907 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.40086 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 2.40086 |
[BP] GO:0042391 | None | ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC | 2.40086 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.37938 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.37938 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, PTGS2 | 2.36427 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 2.34644 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.34644 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC | 2.34084 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TYR, XDH | 2.34084 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC | 2.34084 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, MET, MMP9, PPARA, SRC | 2.32326 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, HMGCR, TYR | 2.32326 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.31487 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR | 2.31487 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AURKB, CSNK2A1, CYP2D6, ESR1, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, XDH | 2.30832 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH | 2.29654 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.28512 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC | 2.2781 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, HMGCR, MMP2, MMP9, PTGS2 | 2.2781 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC | 2.2781 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.2781 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH | 2.27735 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.2423 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.2423 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.2423 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.2423 |
[BP] GO:0010038 | response to metal ion | APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.20796 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, HMGCR | 2.19177 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5 | 2.19177 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.1882 |
[BP] GO:0030335 | positive regulation of cell migration | APP, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.16563 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 | 2.13219 |
[BP] GO:1904646 | cellular response to amyloid-beta | APP, GRM5, IGF1R | 2.10823 |
[BP] GO:0061097 | None | ADORA1, APP, GRM5, PTPN1 | 2.08732 |
[BP] GO:0050730 | None | ADORA1, APP, FLT3, GRM5, PTPN1, SRC | 2.08732 |
[BP] GO:2000147 | positive regulation of cell motility | APP, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.07126 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, PTGS2, SRC | 2.05794 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC | 2.03912 |
[BP] GO:0071248 | cellular response to metal ion | CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.02728 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AURKB, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH | 2.02481 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR | 4.39969 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR | 4.20612 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC | 4.13668 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC | 3.88464 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.52804 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.89485 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, APP, AXL, CA4, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 | 2.88109 |
[CC] GO:0044456 | None | ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC | 2.84086 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTGS2, SLC1A1, SRC | 2.80023 |
[CC] GO:0097060 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 2.42006 |
[CC] GO:0005783 | None | ADORA1, APP, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, KDR, PTGS2, PTPN1, XDH | 2.41951 |
[CC] GO:0043005 | None | ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC | 2.40823 |
[CC] GO:0043197 | None | ADORA1, APP, GRIA2, GRIA4, GRM3 | 2.40086 |
[CC] GO:0014069 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.38407 |
[CC] GO:0099572 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.38407 |
[CC] GO:0044309 | None | ADORA1, APP, GRIA2, GRIA4, GRM3 | 2.37938 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 2.07419 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 | 2.04505 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH | 10.3017 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.99789 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.26266 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 7.94921 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 7.94405 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TYR, XDH | 6.60113 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.40697 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 5.6006 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC | 5.40266 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 5.29791 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH | 5.22948 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC | 5.21173 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 5.09495 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR | 4.91087 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 4.91087 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 | 4.51777 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC | 4.38271 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC | 4.28878 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 4.11187 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 3.8898 |
[MF] GO:0005506 | iron ion binding | ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH | 3.80183 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC | 3.73739 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC | 3.73739 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TYR, XDH | 3.72412 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC | 3.56711 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.52804 |
[MF] GO:0046872 | metal ion binding | ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TYR, XDH | 3.46631 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.46118 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC | 3.21511 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.10928 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.09927 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET | 3.0342 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET | 3.0342 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.84356 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.5385 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.5385 |
[MF] GO:0030594 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 2.52239 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.46514 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.46514 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.45421 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.43954 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.40086 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.2423 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.18287 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.10823 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.02826 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 9.7513 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.2901 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 7.1073 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 7.6202 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.481 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.3355 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1 | 6.3355 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 | 5.5759 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 | 5.7488 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 5.0599 |
Pathways in cancer_Homo sapiens_hsa05200 | PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R | 4.4944 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 | 5.5418 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.817 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 | 4.5369 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 | 4.3066 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.4944 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, PTGS2, GRM1, GRIA4 | 3.909 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, CYP2D6, ALOX5, PTGS2, PTGS1 | 3.7149 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 3.6131 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.6091 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.5411 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.6672 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.1719 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, PTGS2, PTGS1 | 3.583 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.4861 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, IGF1R | 3.4204 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.4125 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, PIM1, PIK3CB | 2.9136 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 2.937 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.4528 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.3064 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.7978 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 2.8002 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.611 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.6743 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.7062 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.7062 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.6902 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, HMGCR, IGF1R | 2.6588 |
FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, GRM1, IGF1R | 2.5656 |
Hepatitis B_Homo sapiens_hsa05161 | PIK3CA, SRC, PIK3CB, MMP9 | 2.4537 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.3548 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.2752 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.1735 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.0046 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.454 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, IGF1R | 2.4537 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1, IGF1R | 2.5258 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, PIK3CB | 2.0435 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.159 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, PIK3CB, IGF1R | 2.1467 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 2.453 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.9179 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PIK3CB, IGF1R | 2.0871 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.453 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.1652 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, PIK3CB | 1.9278 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.7373 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, PIK3CB, IGF1R | 2.0046 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, GRM1 | 2.1529 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB | 1.8674 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.7438 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB | 1.7349 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.6988 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.7162 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.648 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.6007 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2649 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB | 1.4007 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.465 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.3887 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB | 1.3452 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5 | 0.3469 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3577 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3684 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.3675 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.381 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4353 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.1596 |
HTLV-I infection_Homo sapiens_hsa05166 | PIK3CA, PIK3CB | 0.6521 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.4774 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4719 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4774 |
Calcium signaling pathway_Homo sapiens_hsa04020 | GRM5, GRM1 | 0.8748 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 1.0277 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 0.9897 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 1.0437 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 1.0293 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB | 0.8881 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 1.0569 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, GRIA4 | 1.0704 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 1.122 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5471 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5465 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.2104 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5604 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.2841 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5594 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.2926 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.236 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.2213 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.2396 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.5735 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.2213 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5746 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5746 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 1.2716 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.2513 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5746 |
Taste transduction_Homo sapiens_hsa04742 | GRM1 | 0.5899 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5746 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.2841 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.5746 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5899 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10 | 0.6024 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.4807 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.6265 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6245 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.4517 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | PIK3CA, PIK3CB | 1.4517 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6396 |
Pancreatic cancer_Homo sapiens_hsa05212 | PIK3CA, PIK3CB | 1.4899 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.4827 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.5525 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.465 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.4807 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1 | 1.4972 |
Bile secretion_Homo sapiens_hsa04976 | CA2, HMGCR | 1.465 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6619 |
Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, PIK3CB | 1.5308 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2 | 1.4737 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6619 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.6619 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB | 1.5986 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.648 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.561 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2 | 1.6874 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.6988 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.7484 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.7349 |
Malaria_Homo sapiens_hsa05144 | MET | 0.761 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.8239 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7742 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.8091 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.7796 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 2.0046 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8784 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.965 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8841 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.927 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1735 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.9473 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.9855 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.937 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9735 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | HMGCR | 1.0402 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.3076 |