TCM Prescription: Zhi Xue Ling Capsules



Prescription Description
Prescription IDTCMF6719
Pinyin NameZhi Xue Ling Jiao Nang
Chinese Name止血灵胶囊
English NameZhi Xue Ling Capsules
Function Description恶露不绝, 崩漏, 便血, 鼻衄
IndicationsMetrorrhagia disorder, Postpartum lochiorrhea disorder, Abnormal uterine and vaginal bleeding, Epistaxis, Melena
Disease ICD-11 Category SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1) ];
SC13 [Postpartum lochiorrhea disorder (TM1), 恶露不绝 (TM1) ];
GA2Z [Abnormal uterine or vaginal bleeding, unspecified, 异常子宫或阴道出血，未特指的 ];
MD20 [Epistaxis, 鼻衄 ];
ME24.A4 [Melaena, 黑便 ];
Human Tissues Associated with IndicationLarge Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH600 Euonymus fortunei 扶芳藤 TCMH600 GBVF1345-11, GBVF1343-11
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH462 Sanguisorba officinalis 地榆 TCMH462 GENG545-14, GBVT2403-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 7.91516
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, HCAR2, HTR2B, HTR6, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 7.91516
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, HCAR2, HTR2B, HTR6, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 7.91516
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 7.19494
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 7.19494
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC, TERT 7.19494
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.17284
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT, TOP2A, XDH 7.09412
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HTR1A, HTR2B, HTR7, KDR, MET, SRC, TERT, XDH 6.93959
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT, TOP2A, XDH 6.55229
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 6.47574
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, SRC, TERT, TOP2A, XDH 6.42651
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 6.21695
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 6.16347
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.14669
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 6.14669
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HTR5A, IGF1R, MMP2, MMP9, SRC 6.03885
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HTR5A, SRC 6.03822
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 5.80675
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 5.80667
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 5.80047
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, SRC, TERT 5.69656
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B1, MET 5.69656
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HTR2B, PIM1, XDH 5.67244
[BP] GO:0007210 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.46239
[BP] GO:0098664 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.46239
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HTR5A, IGF1R, KDR, MMP2, SRC 5.36371
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HTR5A, IGF1R, MMP2, SRC 5.36371
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, HCAR2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT 5.28747
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR1A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 5.11828
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, F10, F3, FLT3, HTR2B, HTR6, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 5.11454
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HTR2B, MET, SRC, TERT 5.06719
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1 4.90771
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, SRC, TERT, TOP2A 4.89792
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, ESRRA, F10, F3, FABP4, FLT3, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, SRC, TERT, XDH 4.79303
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, ESR1, F10, F3, FLT3, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, SRC, XDH 4.66641
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, F10, F3, FLT3, HTR2B, HTR6, KDR, MET, SRC, XDH 4.6443
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, PIM1, SRC, TERT, TOP2A, XDH 4.57739
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.52085
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT 4.4667
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2B, KDR, SRC 4.37934
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F10, F3, FABP4, HTR1A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC 4.37843
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2B, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, SRC, TERT, TOP2A 4.33378
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD17B1, HTR1A 4.28983
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, TOP2A, XDH 4.22079
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HTR5A, SRC 4.10174
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT 4.04051
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 4.01227
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.00579
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.93696
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT 3.91243
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, TOP2A, XDH 3.82251
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.81761
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MMP9, PIM1, SRC, TERT 3.80166
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.80166
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.80166
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HTR5A, SRC 3.76395
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.73766
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, HCAR2, HTR2B, KDR, SRC 3.70922
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.70575
[BP] GO:0007187 None ADORA1, DRD1, DRD2, HTR1A, HTR5A, HTR6, HTR7 3.7037
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HTR2B, KDR, SRC 3.7037
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.68154
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, SRC, TERT, XDH 3.67229
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.64036
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 3.57289
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.53145
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 3.40039
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.36674
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, F3, MET, SRC, XDH 3.33107
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, HCAR2, HTR2B, MMP12, SRC, TERT 3.31261
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A 3.31261
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR5A, HTR7 3.29197
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3 3.28669
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27904
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIM1, SRC 3.24991
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.23942
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, TERT 3.21007
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 3.20845
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, HCAR2, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT 3.15582
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F10, F3, FLT3, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 3.073
[BP] GO:0097756 None ADORA1, HTR1A, HTR2B, HTR7 3.073
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 3.073
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 3.05302
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT, TOP2A 3.04142
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2B, HTR7, SRC 3.03558
[BP] GO:0007188 None ADORA1, DRD1, DRD2, HTR1A, HTR5A, HTR7 3.02309
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 3.00161
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, SRC 2.95973
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2B, IGF1R, KDR, MET, MMP12, SRC, TERT, TOP2A 2.94419
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2B, SRC 2.94419
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, TOP2A, XDH 2.91077
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, SRC 2.90347
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, HTR2B, MMP12, SRC 2.90133
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8951
[BP] GO:0009115 None AOX1, XDH 2.89143
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.87967
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.87967
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.81137
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.80028
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.79937
[BP] GO:0006939 None DRD1, DRD2, HTR2B, HTR7 2.7961
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, DRD1, DRD2, ESR1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, SRC 2.78168
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.77755
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, HTR2B, MET 2.77507
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, HCAR2, HTR2B, MMP12, SRC 2.76206
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.7591
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, TOP2A, XDH 2.71595
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, TOP2A, XDH 2.71504
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, MET 2.7105
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.7105
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.69657
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, SRC 2.69484
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, TOP2A, XDH 2.69484
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, ESR1, HTR7, SRC, TOP2A 2.68121
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.67085
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.65853
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2 2.65726
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.65726
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSD17B1, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.65569
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.64427
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.62686
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, SRC 2.62686
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HCAR2, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, XDH 2.6246
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, MET, MMP2, MMP9, SRC, TERT, TOP2A 2.59931
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, HTR2B, MMP2, SRC, TERT 2.58883
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3 2.57678
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.57678
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, SRC 2.56532
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2 2.56532
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2 2.56532
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GLO1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TOP2A, XDH 2.56532
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.55376
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.55254
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2B, IGF1R, MET, MMP12, SRC, TERT, TOP2A 2.55194
[BP] GO:0046110 None AOX1, XDH 2.55194
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55194
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2B, HTR7, SRC 2.53881
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, SRC, TERT 2.53881
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.52714
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.52043
[BP] GO:0097746 None ADORA1, DRD1, HTR1A, HTR2B, HTR7 2.51313
[BP] GO:0035296 None ADORA1, DRD1, HTR1A, HTR2B, HTR7 2.51313
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.51283
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.50243
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.47247
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, SRC, TOP2A 2.45845
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.45069
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.45069
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, HTR5A, KDR, MMP9, PIM1, SRC 2.45021
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.4499
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2B 2.4499
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.43868
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.42963
[BP] GO:0050880 None ADORA1, DRD1, HTR1A, HTR2B, HTR7 2.41325
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40799
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.40382
[BP] GO:0035150 None ADORA1, DRD1, HTR1A, HTR2B, HTR7 2.40382
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, HCAR2, HTR1A, HTR2B, MMP12, MMP9, SRC, TERT 2.38089
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.36328
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36328
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2 2.35778
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.35159
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.34984
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, SRC, TERT, XDH 2.34897
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.33478
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.33478
[BP] GO:0006145 None AOX1, XDH 2.33478
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33478
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33478
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, SRC, TERT, XDH 2.31523
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, SRC 2.31452
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, SRC 2.31085
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2B, KDR, MMP9, SRC, XDH 2.31085
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2B, KDR, MMP9, SRC, XDH 2.31085
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, SRC, TERT, XDH 2.31085
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2B, SRC 2.30619
[BP] GO:0050714 None ACHE, DRD2, HCAR2, HTR2B, MMP12, SRC 2.29848
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.28637
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, MMP12 2.22692
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, HCAR2, HTR2B, MMP12, SRC 2.22692
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.22692
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.18816
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A 2.18816
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2B, SRC 2.1844
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.17189
[BP] GO:0042310 None HTR1A, HTR2B, HTR7 2.17189
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, XDH 2.16832
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.16832
[BP] GO:0021853 None DRD1, DRD2 2.16832
[BP] GO:0010641 None F3, SRC 2.16832
[BP] GO:0007598 None F10, F3 2.16832
[BP] GO:1904936 None DRD1, DRD2 2.16832
[BP] GO:0042321 None ADORA1, DRD2 2.16832
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.16829
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.15029
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CYP1A1, DRD2, SRC, TERT 2.1495
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC 2.12903
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, HCAR2, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, SRC, TERT, XDH 2.11807
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, SRC, TERT 2.11631
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, HTR2B, KDR, SRC, XDH 2.11447
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.11447
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, SRC 2.10369
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.10369
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.1014
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.07915
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2 2.07322
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, HTR2B 2.07201
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.07201
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MMP2, MMP9, SRC, TERT, TOP2A 2.06895
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.06535
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, SRC, TERT 2.06336
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2B 2.05888
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.0537
[BP] GO:0021843 None DRD1, DRD2 2.03689
[BP] GO:0046113 None AOX1, XDH 2.03689
[BP] GO:0021830 None DRD1, DRD2 2.03689
[BP] GO:0021826 None DRD1, DRD2 2.03689
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2B, MMP12, SRC 2.02786
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, TOP2A, XDH 2.02612
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, ESR1, FLT3, IGF1R, MMP2, SRC 2.02612
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, IGF1R, MMP2, SRC 2.0251
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CYP1A1, DRD2, TERT 2.02211
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, DRD2, F10, F3, FLT3, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.62331
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, ESR1, F10, F3, FLT3, GLO1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, SRC, TERT 4.57739
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD1, DRD2, FLT3, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 2.97653
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, F10, F3, FLT3, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SRC 2.96324
[CC] GO:0031233 None CA4, F10, F3 2.55021
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GLO1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, SRC, TERT 2.16832
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 12.4275
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, XDH 11.5406
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3294
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, TERT, TOP2A, XDH 8.47415
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.17284
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.56737
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.2845
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TERT, TOP2A, XDH 6.06333
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2B, HTR5A, HTR7 5.93501
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.78895
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.62987
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9 5.51939
[MF] GO:0004993 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.46239
[MF] GO:0099589 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.46239
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.46239
[MF] GO:0008227 None DRD2, HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.19931
[MF] GO:0043176 None HTR1A, HTR2B, HTR5A, HTR7 5.07065
[MF] GO:0051378 None HTR1A, HTR2B, HTR5A, HTR7 5.07065
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.06719
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.99156
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, TERT, TOP2A, XDH 4.5932
[MF] GO:0099528 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.57924
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.12678
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, F3, FLT3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.12678
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.00579
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2B, HTR5A, HTR7 3.98656
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.86589
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TOP2A 3.74788
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7037
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.6864
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.22865
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 3.073
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 3.01129
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.91045
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89143
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.89053
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.77507
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.77507
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.74681
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.7105
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.68838
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, SRC 2.64273
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1 2.62686
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.55194
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.45798
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, TERT, TOP2A, XDH 2.43747
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, XDH 2.36328
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.34546
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.33478
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, PIM1, SRC, TERT, TOP2A, XDH 2.25055
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH 2.23675
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, SRC 2.18816
[MF] GO:0004252 None F10, F3, MMP1, MMP12, MMP2, MMP9 2.18732
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.16832
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.13241
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03689
[MF] GO:0043546 None AOX1, XDH 2.03689


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7528
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.5619
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, ALOX5, HTR2B, HTR1A, HTR5A 6.0465
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, DRD1, HTR5A, DRD2 5.7595
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.5852
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9059
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1569
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.0048
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1569
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2 3.6953
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.269
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, DRD1, HTR5A 2.9516
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, DRD1, DRD2 3.0471
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.6607
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.2841
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.208
Metabolic pathways_Homo sapiens_hsa01100 FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, AKR1B1, CYP19A1, XDH 2.055
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2841
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.208
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0981
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2333
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.971
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.9176
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.8533
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.0981
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6799
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.501
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.45
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4479
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4157
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3496
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0554
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3443
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1831
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B 1.133
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4314
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3487
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5355
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1831
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3477
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2787
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0129
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.863
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2783
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.9606
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0129
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0083
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8976
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9108
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9108
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9112
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8601
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8471
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8791
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8159
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7685
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8533
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.055
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2917
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3569
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3459
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3872
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.356
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3785
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3872
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3989
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.416
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3785
Platelet activation_Homo sapiens_hsa04611 SRC 0.4817
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4495
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4608
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5051
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5474
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4647
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5051
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4817
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5487
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4817
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5385
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5242
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5474
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4869
Axon guidance_Homo sapiens_hsa04360 MET 0.4773
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5417
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5474
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5474
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5474
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5417
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5417
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5474
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5417
Peroxisome_Homo sapiens_hsa04146 XDH 0.5487
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.583
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6124
Glioma_Homo sapiens_hsa05214 IGF1R 0.6124
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6156
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6119
Bile secretion_Homo sapiens_hsa04976 CA2 0.594
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6114
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6124
Shigellosis_Homo sapiens_hsa05131 SRC 0.6124
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6124
Malaria_Homo sapiens_hsa05144 MET 0.6912
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6959
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6936
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6985
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7493
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.7981
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8286
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8471
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8159
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8471
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8601
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8582
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1463
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3443


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)