TCM Prescription: Yi Shen Syrup



Prescription Description
Prescription IDTCMF6645
Pinyin NameYi Shen Tang Jiang
Chinese Name益肾糖浆
English NameYi Shen Syrup
Function Description阳痿, 遗精, 遗精
IndicationsInvoluntary ejaculation disorder, Impotence disorder, Sexual dysfunction
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
Human Tissues Associated with IndicationKidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 8.78126
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, SMAD3, SRC, TEK, TRPV1, XDH 8.55385
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 8.45007
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 7.57464
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TRPV1, TYR 7.26348
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.87157
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.87157
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.87157
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 6.63614
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, HSPA1A, PIM1, PPARA, TYR, XDH 6.63614
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH 6.48045
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.40638
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 6.40584
[BP] GO:0042127 regulation of cell proliferation AKR1B1, ALOX12, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 6.37887
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.37887
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.37887
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 6.29741
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.29741
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.24025
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 6.1216
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 6.0624
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.01
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.99258
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SLC5A1, SMAD3, SRC, TEK, TRPV1, TYR 5.94495
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.90848
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 5.73435
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 5.68548
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.65358
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 5.56608
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR 5.53047
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TEK, TRPV1, TYR 5.48001
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK, XDH 5.4611
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.46076
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.44964
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 5.44652
[BP] GO:0032879 regulation of localization ACHE, ALOX12, ALOX15, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.42366
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.42366
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 5.42366
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 5.26467
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.26467
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.23502
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 5.20927
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 5.14929
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.14929
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 5.14929
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 5.12271
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 5.06374
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.05068
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 5.04254
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.03391
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 5.02951
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.99334
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 4.91536
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 4.91536
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.91536
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.91536
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, MET, PPARA 4.90547
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.85114
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 4.84538
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.82502
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.80785
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA 4.76263
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 4.67974
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, TEK 4.61215
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.58958
[BP] GO:0040012 regulation of locomotion ALOX12, APP, CHRM1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 4.58438
[BP] GO:0030334 regulation of cell migration ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 4.52074
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH 4.51548
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 4.50862
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.49739
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.39035
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 4.37707
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 4.30379
[BP] GO:2000145 regulation of cell motility ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 4.22671
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.1003
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.06466
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 4.05683
[BP] GO:0080134 regulation of response to stress ALOX12, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.01345
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.00172
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.00172
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, EGFR, FLT3, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.92208
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.9121
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 3.9121
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.9121
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.90109
[BP] GO:0051270 regulation of cellular component movement ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 3.87933
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.87933
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.87104
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.87056
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, PPARA, PRKCA, PTPN1, SMAD3, SRC, TRPV1 3.86702
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.84141
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.84141
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.84141
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.84141
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TRPV1 3.82244
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CHRM3, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, PRKCA, SMAD3, SRC, TEK, TRPV1 3.79192
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.77941
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.73041
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.70387
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.6834
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.67571
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 3.66397
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.6159
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.6159
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.6016
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.59969
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.59021
[BP] GO:0071407 cellular response to organic cyclic compound APP, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 3.58542
[BP] GO:0019216 regulation of lipid metabolic process CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 3.47728
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR 3.46235
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, SRC 3.41182
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 3.40115
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.38874
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.37885
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.37885
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC, TEK 3.37885
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC 3.36706
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.36706
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, PRKCA, SRC, TEK 3.36416
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 3.36209
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, TEK, XDH 3.33917
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 3.33917
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.30649
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.18358
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 3.17297
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.11942
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 3.08267
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 3.06624
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3 3.04665
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 3.04561
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.01471
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.01471
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 3.01471
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, SMAD3, SRC, TEK 3.00232
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.98959
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97512
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.97444
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.97444
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.96337
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 2.93489
[BP] GO:0007165 signal transduction AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 2.93489
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.93489
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.93489
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.93489
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.93241
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.91376
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 2.85254
[BP] GO:0051239 regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIM1, PRKCA, SMAD3, SRC, TEK, TRPV1, XDH 2.84033
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.84033
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.83921
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.83241
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.75933
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.74798
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.74348
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.73136
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.73136
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.73136
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.73136
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.73136
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.72131
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 2.7167
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.7167
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK 2.70759
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.70526
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.70524
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 2.70524
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.69075
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.65706
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.64891
[BP] GO:0009611 response to wounding ACHE, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 2.64891
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK 2.64891
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.63097
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.63024
[BP] GO:0065009 regulation of molecular function APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 2.63024
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.59459
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.59459
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.56183
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.55938
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55831
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.53294
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.53294
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.52492
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.52492
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 2.48648
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.47465
[BP] GO:0044057 None CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, PRKCA, SMAD3, TRPV1 2.46444
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45586
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 2.40481
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.40348
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.40348
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.40348
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.40334
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, HSPA1A, MMP9, PRKCA, RORC, SMAD3, SRC, TRPV1 2.40334
[BP] GO:0051050 positive regulation of transport ACHE, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 2.38755
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.38161
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.38161
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, FABP3, PPARA, SLC5A1, SLC5A2, SLC5A4, TRPV1 2.36013
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35549
[BP] GO:0048585 negative regulation of response to stimulus ALOX12, ALOX15, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.34256
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, SLC5A1 2.33673
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.32046
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32046
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32046
[BP] GO:0051894 None KDR, SMAD3, TEK 2.32046
[BP] GO:0061900 None APP, EGFR, TRPV1 2.32046
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32046
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 2.2973
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC, TEK 2.2973
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.2973
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.28769
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.27196
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, SRC 2.26311
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.25192
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.24572
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.23715
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.23715
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23715
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.22207
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.21703
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.16511
[BP] GO:0034219 None SLC5A1, SLC5A2, SLC5A4 2.14905
[BP] GO:0046541 None CHRM1, CHRM3 2.14313
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.14313
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.14313
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 2.14061
[BP] GO:0065007 biological regulation ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.13752
[BP] GO:0007193 None CHRM1, CHRM2, CHRM3, CHRM5 2.13706
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.13706
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.13706
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSPA1A, MMP9, TRPV1, XDH 2.13584
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.13312
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.12188
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC 2.11496
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.08598
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.08598
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.07271
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05125
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05125
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.05125
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, KDR, SRC, TRPV1 2.05125
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.05125
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, KDR, PRKCA, TEK 2.04488
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.03568
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.03568
[BP] GO:0003018 None CHRM1, CHRM3, EGFR, SRC, TEK 2.03568
[BP] GO:0009894 regulation of catabolic process CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PTPN1, SMAD3 2.02749
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.01796
[BP] GO:1990535 None APP, INSR 2.01512
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01512
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01512
[CC] GO:0005886 plasma membrane ACHE, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 4.19379
[CC] GO:0031226 intrinsic component of plasma membrane APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 4.00172
[CC] GO:0044459 plasma membrane part ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 3.7579
[CC] GO:0005887 integral component of plasma membrane APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 3.66397
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, INSR, MET, SRC, TEK, TRPV1 2.89756
[CC] GO:0016020 membrane ACHE, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR 2.84033
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 2.71056
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, CA9, CHRM3, EGFR, TEK 2.56858
[CC] GO:0044425 membrane part ACHE, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1, TYR 2.25974
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HCAR2, HSPA1A, KDR, TEK, TRPV1 2.14313
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01512
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH 13.0809
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.76993
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, TYR, XDH 9.51149
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH 8.39533
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, SRC, TEK, TRPV1 7.95615
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.34351
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.6506
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.37887
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.37887
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.22508
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.90848
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.64682
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.51452
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.40953
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.38424
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.24391
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.17646
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3 5.02827
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH 4.78129
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.45862
[MF] GO:0038023 signaling receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 4.36868
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.22671
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.19452
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.15266
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.04881
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.92208
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.9121
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH 3.80693
[MF] GO:0004871 signal transducer activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 3.77941
[MF] GO:0004872 receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 3.73613
[MF] GO:0060089 molecular transducer activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 3.57899
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.51791
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.47728
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.41874
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.41874
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.3752
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.33917
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.1624
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.07664
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 3.04059
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 3.04059
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.93489
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.93241
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.88057
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.85968
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.77068
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.74348
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH 2.69356
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK 2.57027
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.55831
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.55831
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.55831
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.52492
[MF] GO:0032403 protein complex binding ACHE, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.45586
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.45586
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH 2.41235
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.40348
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 2.34953
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.32046
[MF] GO:0051425 None APP, INSR 2.32046
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.32046
[MF] GO:0015145 None SLC5A1, SLC5A2, SLC5A4 2.32046
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.32046
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH 2.26311
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH 2.26193
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.23715
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.19436
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.19436
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.19436
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.14313
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14313
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.12388
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12388
[MF] GO:0004629 None CHRM1, CHRM3, CHRM5 2.08598
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05125
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 2.02913
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.01966
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.01512
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01512


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.6977
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2438
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.3295
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.5756
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, EGFR, IGF1R 5.3959
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.5074
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.3188
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3959
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 4.808
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, PRKCA 4.7655
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3959
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PRKCA, MMP9, MET, EGFR, IGF1R 4.3448
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 4.3097
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 4.1495
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8351
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8431
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, PRKCA, EGFR 3.7685
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, CHRM5, TRPV1, NR3C1 3.7219
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, PRKCA, TEK, EGFR, IGF1R 3.8139
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 3.5741
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PRKCA, ALOX12 3.7082
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, PRKCA, MET, EGFR, IGF1R 3.5741
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 3.4722
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.5605
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, EGFR 2.9948
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA, ALOX12, TRPV1 2.8861
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, PRKCA 2.8649
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4135
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4263
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 2.3288
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, PRKCA, MMP9 2.3386
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.3386
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.3748
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3386
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0905
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PPARA 1.9706
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3288
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.3386
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 2.2466
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2882
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3212
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA, EGFR 2.0747
Bile secretion_Homo sapiens_hsa04976 CA2, SLC5A1, CYP3A4 2.2882
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.852
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8748
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA, EGFR 2.07
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6087
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.9722
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.7729
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.5909
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.5817
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, EGFR 1.4925
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.6087
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2504
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1261
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9154
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8582
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1853
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 1.0031
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.1158
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.927
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9755
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6807
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8928
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9041
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 1.1135
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1534
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 1.0031
Influenza A_Homo sapiens_hsa05164 PRKCA, HSPA1A 0.7744
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA 1.2041
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9755
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.1853
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA 1.1853
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2569
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1822
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.267
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3227
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3496
Purine metabolism_Homo sapiens_hsa00230 XDH 0.36
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3705
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3592
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.349
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3705
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3842
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3705
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3921
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.4004
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4293
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3903
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4293
Platelet activation_Homo sapiens_hsa04611 SRC 0.4499
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCA 0.4525
Axon guidance_Homo sapiens_hsa04360 MET 0.4417
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4499
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.4393
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4744
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.4925
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4646
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4525
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA, EGFR 1.4925
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3603
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4917
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4992
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.4557
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.5099
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4992
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.5005
Morphine addiction_Homo sapiens_hsa05032 PRKCA 0.511
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4847
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.5088
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5088
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3964
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA 0.4992
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5099
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5167
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5317
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5308
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.516
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5337
Peroxisome_Homo sapiens_hsa04146 XDH 0.5317
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4629
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5664
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.568
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5494
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5787
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5712
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5825
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5825
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5696
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.5807
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.604
Shigellosis_Homo sapiens_hsa05131 SRC 0.5825
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5952
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6087
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6345
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6486
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6345
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, PRKCA 1.7366
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6521
Malaria_Homo sapiens_hsa05144 MET 0.6596
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.6521
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6635
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.6676
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 SLC5A1 0.6807
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9187
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7744
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7744
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7883
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8719
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7744
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8582
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0925
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8193
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8582
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2516


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)