TCM Prescription: Xiao Chuan Tablets



Prescription Description
Prescription IDTCMF6644
Pinyin NameXiao Chuan Pian
Chinese Name哮喘片
English NameXiao Chuan Tablets
Function Description咳嗽, 哮病, 喘病
IndicationsWheezing disorder, Dyspnea
Disease ICD-11 Category SA81 [Wheezing disorder (TM1), 哮病 (TM1) ];
MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 8.94982
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.21285
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 8.21285
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, OPRK1, OPRM1, PDE3A, SRC, TYR 8.21285
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.78426
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, KDR, MET, MIF, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TNKS, TNKS2, XDH 7.75194
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 7.57692
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HSD17B2, OPRK1, OPRM1, SRC, TYR 7.42
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PDE3A 7.22054
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 7.09032
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 7.09032
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.75918
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 6.60793
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, OPRM1, PIM1, SRC, XDH 6.45489
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FLT3, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC 6.33929
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 6.2695
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, HTR2A, KDR, MIF, OPRK1, SRC, TNKS, TNKS2 6.2695
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC, TNKS2, TYR 6.2695
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 6.2695
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.23258
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FUT7, GBA2, MIF, PDE10A, PDE3A, PDE3B, PIM1, TYR, XDH 6.18055
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, OPRK1 5.95164
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 5.93345
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.8669
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 5.82959
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.82959
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.82522
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, HSD11B2, HTR2A, KDR, OPRK1, OPRM1, PDE3A, SRC 5.80062
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, KDR, MET, MIF, MMP2, MMP9, PDE3A, PDE3B, PIM1, SIGMAR1, SRC, TNKS2, TYR 5.68826
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.30675
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 5.27406
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, SRC 5.27406
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 5.13433
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP2, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 5.11787
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 5.11787
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, OPRD1, OPRK1, OPRM1 5.07674
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SIGMAR1, SRC, TNKS, TNKS2 4.99468
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, OPRK1, PDE3B, SRC 4.79143
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SRC 4.76846
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 4.73549
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.62889
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 4.57175
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP4, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 4.52871
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.5194
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 4.51329
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, HTR2A, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 4.51329
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.49633
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SRC, TYR 4.46817
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, HTR2A, KDR, MET, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 4.36325
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, GBA2, HTR1A, TYR 4.33243
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31894
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 4.2593
[BP] GO:0032879 regulation of localization ACHE, ADORA3, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC 4.24809
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 4.24809
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 4.2339
[BP] GO:0007193 None DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.17793
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, OPRK1, SRC 4.15093
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.12728
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, TYR 4.12728
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TNKS, XDH 4.11291
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 4.07451
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.07438
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, SRC, TYR 4.05135
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 4.01486
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.98995
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, XDH 3.98995
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC 3.96924
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, HTR7, OPRK1, OPRM1, SRC 3.91469
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC 3.89579
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.86395
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.86025
[BP] GO:0032845 None BCL2, DRD2, HTR2A, MIF, SRC, TNKS, TNKS2 3.85978
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TNKS, XDH 3.85001
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, DRD1, DRD2, ESRRB, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.82664
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, DRD1, DRD2, ESRRB, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.82664
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP4, FUT7, GBA2, MET, MIF, PDE3A 3.8257
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.78643
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, DRD1, DRD2, HTR1A, HTR2A, MIF, MMP9, OPRD1, OPRK1, OPRM1 3.71659
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, DRD2, ESRRB, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.70335
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.69827
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, TNKS2, XDH 3.69732
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 3.69732
[BP] GO:0007188 None DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.68164
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HSD11B2, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, SRC, TYR 3.64879
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 3.64879
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 3.64879
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60887
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MET, MIF, MMP9, PDE3B, PTPN1, SRC, XDH 3.60096
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 3.58455
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, OPRM1, PIM1, PTPN1, SRC, TNKS 3.56452
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP4, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.55862
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 3.55831
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, FLT3, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 3.5551
[BP] GO:0051270 regulation of cellular component movement ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.53787
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 3.50058
[BP] GO:0030334 regulation of cell migration ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.49443
[BP] GO:0042325 regulation of phosphorylation BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.46772
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIM1, SRC, TYR 3.46772
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, SIGMAR1, SRC, TYR 3.35482
[BP] GO:0001932 regulation of protein phosphorylation BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.34002
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.33809
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.32257
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, OPRM1, PDE3A, SRC 3.32026
[BP] GO:0007187 None DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.31337
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, CDC25B, DRD2, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.30417
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.29205
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 3.28731
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, FLT3, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 3.26122
[BP] GO:0009893 positive regulation of metabolic process AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.20955
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 3.18334
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16934
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.16934
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.15697
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, DRD1, DRD2, ESR1, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 3.12293
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, OPRM1, SRC 3.12293
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 3.10573
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1 2.9402
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, FLT3, HTR2A, KDR, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 2.92955
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.83947
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRM1, PDE3A, PIM1, SRC 2.82411
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2 2.82411
[BP] GO:0031635 None OPRK1, OPRM1 2.82411
[BP] GO:0009115 None AOX1, XDH 2.82411
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, TNKS, TNKS2 2.81354
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.76721
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76721
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.76721
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.7578
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.74515
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 2.73978
[BP] GO:0003018 None DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.73978
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.70995
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF 2.68858
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.66338
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.66338
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.61154
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.59709
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.58264
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, IGF1R, MET, MIF, MMP9, OPRD1, OPRM1, PIM1, PTPN1, SRC, TNKS, XDH 2.57452
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.54676
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.54676
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.49483
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, SRC 2.49483
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.49155
[BP] GO:0043408 regulation of MAPK cascade DRD2, FLT3, HTR2A, IGF1R, KDR, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 2.48842
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.48823
[BP] GO:0010564 regulation of cell cycle process AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, MIF, PDE3A, SENP6, TNKS 2.48745
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.48637
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CYP19A1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PDE3B, PTPN1, SRC, XDH 2.47831
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.47803
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.46313
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, OPRM1 2.45115
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.45115
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.45115
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PDE3A, SRC 2.45115
[BP] GO:0046110 None AOX1, XDH 2.45115
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45115
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.45115
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, SRC 2.45115
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, HTR1A, HTR2A, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC 2.44605
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.44605
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MIF, MMP2, MMP9, PDE3A, SRC 2.42473
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, SENP6, SRC, TNKS 2.42452
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, OPRK1, SRC 2.39885
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, HTR2A, KDR, MIF, OPRM1, PTPN1, SRC 2.39377
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.38977
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.36967
[BP] GO:0032270 positive regulation of cellular protein metabolic process BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.36813
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.35877
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP4, GBA2, PDE10A, PDE3A, PDE3B, SRC, XDH 2.35491
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.33941
[BP] GO:0032094 None CYP1A1, HSD11B2, OPRM1 2.33781
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.33781
[BP] GO:0031401 positive regulation of protein modification process BCL2, CDC25B, DRD2, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.33781
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.33627
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, MET 2.31456
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31115
[BP] GO:1901575 None ACHE, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP4, FUT7, GBA2, PDE10A, PDE3A, PDE3B, XDH 2.31098
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, HTR2A, IGF1R, MIF, MMP9, OPRM1, PTPN1, SRC, TNKS, XDH 2.30421
[BP] GO:0003008 None AKR1B1, BCL2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TYR 2.30238
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.29437
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.29437
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, OPRD1 2.29437
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, HTR2A, KDR, MIF, OPRM1, SRC 2.29019
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, MET, MIF, MMP9, OPRD1, PTPN1, SRC, TNKS, XDH 2.28546
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.28546
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, SRC 2.27708
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.27122
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.27122
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.2563
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2538
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, OPRM1 2.25162
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.24275
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, DRD1, DRD2, HTR2A 2.24181
[BP] GO:0051881 regulation of mitochondrial membrane potential BCL2, KDR, OPRD1, SRC 2.24181
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.24181
[BP] GO:0007198 None HTR1A, HTR7 2.24181
[BP] GO:0070213 None TNKS, TNKS2 2.24181
[BP] GO:0006145 None AOX1, XDH 2.24181
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24181
[BP] GO:0031399 regulation of protein modification process BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.23767
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.23545
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.23545
[BP] GO:0003013 None DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.23545
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.23335
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.23335
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.23335
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.23335
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 2.21601
[BP] GO:0009892 negative regulation of metabolic process AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRM1, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 2.20455
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.18957
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, MET, SRC, XDH 2.18701
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2 2.17369
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.15198
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.15001
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.14234
[BP] GO:0080134 regulation of response to stress CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, OPRK1, PTPN1, SRC, XDH 2.12173
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, HTR1A, HTR2A, MIF, MMP12, OPRK1, OPRM1, SRC 2.1161
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.11493
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, ESR1, FLT3, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.11493
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.11493
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.10435
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.102
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, OPRM1, SRC, TYR 2.0943
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.0814
[BP] GO:0021853 None DRD1, DRD2 2.0814
[BP] GO:0043696 None CDK6, ESRRB 2.0814
[BP] GO:0043697 None CDK6, ESRRB 2.0814
[BP] GO:0010641 None F3, SRC 2.0814
[BP] GO:1904936 None DRD1, DRD2 2.0814
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC 2.08075
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.07517
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.07517
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.04323
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HTR2A, KDR, MIF, OPRM1, PDE3A, PDE3B, PIM1, SRC, TNKS2, XDH 2.04062
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.03308
[BP] GO:0051952 None DRD1, DRD2, HTR2A, OPRK1 2.02816
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, MIF, PDE3A, PIM1, SENP6, SRC, TNKS 2.00689
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, TYR 3.50442
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, DRD1, DRD2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.05949
[CC] GO:0044425 membrane part ACHE, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SIGMAR1, SRC, TYR 2.60624
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, KDR, MIF, MMP2, MMP9, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.45115
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, SIGMAR1 2.28371
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 2.25648
[CC] GO:0005783 None BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 2.22952
[CC] GO:0031253 None CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC 2.1244
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, SIGMAR1 2.1244
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, TNKS, TYR, XDH 11.1585
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.57092
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 9.38352
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.94982
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, TNKS, TNKS2, TYR, XDH 7.09032
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.23258
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.40679
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.30675
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PTPN1, TNKS 5.27406
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.17791
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 5.09197
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.08571
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.05131
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.97454
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CDK6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 4.76846
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.57175
[MF] GO:0004872 receptor activity ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 4.36664
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FLT3, HTR2A, IGF1R, KDR, MET, PDE10A, PIM1, SIGMAR1, SRC 4.3224
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.2593
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, TNKS, TNKS2, TYR, XDH 4.01486
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.96429
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.93127
[MF] GO:0004871 signal transducer activity ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.85001
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.72978
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.46772
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.4459
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.41562
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.33376
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.30417
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.28868
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, DRD1, DRD2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.26092
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, DRD1, DRD2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.26092
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.13574
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, SRC, XDH 3.11876
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.05949
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.05949
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.98307
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 2.9733
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 2.93604
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82411
[MF] GO:0003845 None HSD11B1, HSD11B2 2.82411
[MF] GO:0004119 None PDE3A, PDE3B 2.82411
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.76721
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 2.73978
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.72989
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.69111
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.57046
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.57046
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.48745
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45115
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.44605
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.37644
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.33627
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.29437
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24181
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.23545
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.23335
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.23335
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.23335
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.18701
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0814
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.07552


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1081
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.9905
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9119
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR7, ADORA3, HTR1A, OPRK1, OPRM1, HTR2A, DRD1, DRD2 4.9897
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, ESR2 4.6165
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1044
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.9147
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.1044
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1044
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9147
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.3451
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, PDE3A, OPRM1, DRD1 3.8542
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9147
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, CYP2D6, ALOX5, HTR1A, HTR2A 3.4519
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.3117
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.6332
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2 2.833
cAMP signaling pathway_Homo sapiens_hsa04024 PDE3B, PDE3A, HTR1A, DRD1, DRD2 2.4904
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9104
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.4811
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.4147
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.1301
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, PDE3A 1.9813
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.833
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0812
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0795
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1407
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.1005
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.9278
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.7011
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9066
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.7708
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6251
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4508
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, BCL2 1.5993
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3289
Calcium signaling pathway_Homo sapiens_hsa04020 HTR7, HTR2A, DRD1 1.2581
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B 1.3289
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3289
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2699
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2971
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0777
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.942
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2A 1.0244
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0678
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9488
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2581
Renin secretion_Homo sapiens_hsa04924 PDE3B, PDE3A 1.2699
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0971
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.315
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0582
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1672
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2581
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.942
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8533
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.942
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.942
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4282
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8867
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PDE3B 0.8489
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8447
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9104
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8447
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8489
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.2581
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6552
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7147
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7147
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6552
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2427
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2901
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3284
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.354
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3283
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3727
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4033
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3913
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4019
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4176
Platelet activation_Homo sapiens_hsa04611 SRC 0.435
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4359
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.435
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.435
Axon guidance_Homo sapiens_hsa04360 MET 0.4302
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4634
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4634
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7615
Melanogenesis_Homo sapiens_hsa04916 TYR 0.487
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B 0.487
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4985
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5114
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4984
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4983
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5214
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5107
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5114
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5114
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.511
Peroxisome_Homo sapiens_hsa04146 XDH 0.5214
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5538
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5319
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5528
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6428
Bile secretion_Homo sapiens_hsa04976 CA2 0.5604
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5756
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5756
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5756
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5741
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7187
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.567
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5857
Shigellosis_Homo sapiens_hsa05131 SRC 0.5756
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5822
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6084
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5822
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9359
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6407
Malaria_Homo sapiens_hsa05144 MET 0.6519
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6552
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6552
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6552
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6552
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7091
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.787
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8094
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8094
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8377
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8277
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.942
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.942
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0494
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2699


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)