TCM Prescription: Jin Fo Zhi Tong Pills



Prescription Description
Prescription IDTCMF650
Pinyin NameJin Fo Zhi Tong Wan 
Chinese Name金佛止痛丸
English NameJin Fo Zhi Tong Pills
Function Description胃脘痛, 痛经
IndicationsStomach ache disorder, Dysmenorrhea disorder, Gastritis
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
DA42 [Gastritis, 胃炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT962 ENPP2 Autotaxin Hydrolase Q13822
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 11.5959
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PPARA, PTGES 10.3846
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TYR 9.33658
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR7, MAOA, PPARA, TNKS, TNKS2, XDH 8.50662
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, HSD11B2, HTR5A, PTGES, RELA, TYR 8.21998
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 7.98597
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HSD17B3, HTR1A, MAOA, TYR 7.98597
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 7.98597
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A 7.84967
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, PPARA, PTGES, RELA, TYR 7.7895
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.47173
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, HSD17B3, HTR2B, PPARA, PTGES, TYR, XDH 6.99154
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.87458
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.87458
[BP] GO:0033993 response to lipid ALPL, AR, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, PTGES, RELA, TYR 6.86872
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 6.79864
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, HTR1A, HTR2A, HTR2B, MAP2K1, PTGES, RELA, XDH 6.79864
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HTR5A, PPARA, PTGES, RELA, TYR 6.57598
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.44142
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, HSD17B3, MAP2K1, PPARA, RELA, TYR 6.18636
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.0961
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, PPARA, PTGES, RELA, TYR 6.03848
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B 5.98543
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 5.96751
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CYP1B1, DRD2, F10, F3, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, XDH 5.92817
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.82157
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.77036
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HTR5A, PPARA, RELA 5.75106
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CACNA1C, CDK6, DRD1, DRD2, DRD3, HTR2A, HTR2B, TNKS, TNKS2 5.6061
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR5A, MAP2K1, PPARA, RELA, SIGMAR1, TYR 5.54577
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.47867
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 5.36334
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.35135
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.28036
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, MAOA, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, TYR, XDH 5.27869
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, HSD11B2, HTR5A, PPARA, RELA 5.1783
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, MAOA 5.16831
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR1A, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 5.13186
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES 5.03787
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR1A, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 5.02508
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES 4.94901
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, PPARA, RELA, TNKS2, TYR 4.94901
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B 4.92901
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.90494
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, MAP2K1, PPARA, RELA, SIGMAR1, TNKS2, TYR 4.9024
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1, ESR1 4.84461
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.82978
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES 4.78798
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.77382
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.77382
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 4.77141
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B 4.75557
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.74071
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.7183
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, PPARA, PTGES 4.64637
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, RELA 4.51217
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PPARA, RELA 4.50805
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, MAOA, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, TYR, XDH 4.50805
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.50805
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.46603
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46603
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2 4.42557
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, SIGMAR1, TNKS, TNKS2 4.41324
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 4.38765
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, HTR1A, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 4.37925
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.37925
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.37925
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.35151
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.3402
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F3, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, XDH 4.25002
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.21878
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.20048
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.19596
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.19596
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 4.1607
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, PTGES, RELA 4.15428
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 4.06329
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.06002
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, MAP2K1, PTGES, XDH 4.0243
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, TNKS, TNKS2 4.01693
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 4.01693
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 4.01693
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 4.01693
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.01693
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PPARA, PTGES 3.96511
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.93673
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, HSD11B2, PPARA 3.93622
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.91411
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.86763
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, MAOA, MAP3K7, PPARA, RELA, TYR, XDH 3.85552
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.85552
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES 3.84392
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.84392
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, PPARA, RELA, TYR 3.83581
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, TYR 3.83581
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 3.80669
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.77662
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES 3.77662
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, HTR1A, HTR2A, HTR2B, RELA 3.74878
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.73956
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.72278
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, FABP3, PPARA 3.72278
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A6, CYP2D6 3.72278
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A6, CYP2D6 3.72278
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HTR1A, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 3.67465
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.62573
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B 3.58491
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.53731
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.53731
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 3.51838
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, MAP2K1, PPARA, PTPN1 3.5074
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.4974
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, MAOA, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, TYR, XDH 3.47531
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.47531
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.47531
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, XDH 3.42977
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.39012
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 3.38963
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, XDH 3.38898
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.35453
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.34405
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 3.26905
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, DRD1, DRD2, DRD3, ESR1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.26552
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGES 3.26194
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, ESRRB, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 3.26194
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25989
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.24765
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.22654
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 3.21157
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR1A, HTR2A 3.1831
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.1662
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.1662
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.1662
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.15463
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.15463
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.12454
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, XDH 3.09349
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, MAP2K1, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, XDH 3.09349
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 3.05727
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, RELA 3.05516
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 3.03408
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 2.99536
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F3, FABP4, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 2.99085
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95205
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.95205
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.95205
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, DRD2, DRD3, TNKS, TNKS2 2.93147
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.93146
[BP] GO:0009115 None AOX1, XDH 2.92226
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, PTGES 2.91895
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, TNKS, XDH 2.90138
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.90138
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, XDH 2.89702
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.87392
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.87392
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, FABP3, PPARA 2.87216
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.87216
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 2.85609
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.85506
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CACNA1C, DRD1, DRD2, DRD3, HTR2B, HTR5A 2.85506
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, XDH 2.82264
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.79429
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.79238
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.78267
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, RELA, XDH 2.74948
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, XDH 2.74712
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CACNA1C, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.72199
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.72197
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.72081
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.72081
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.70996
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.70451
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.68674
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 2.68674
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.68166
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA 2.65957
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 2.62803
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, TYR, XDH 2.61834
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.5782
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.5782
[BP] GO:0007154 None ADORA1, ADRA1A, AR, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.57426
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.57426
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1 2.56609
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.56392
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.56392
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.56053
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CA2, CACNA1C, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, RELA, TNKS2, XDH 2.54374
[BP] GO:0046110 None AOX1, XDH 2.53128
[BP] GO:0060160 None DRD2, DRD3 2.53128
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53128
[BP] GO:0048608 reproductive structure development AR, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1 2.52989
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.5279
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, MAP2K1 2.51755
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.51755
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, MAP2K1, PTPN1 2.49793
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3 2.4977
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3 2.48521
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.47762
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.47547
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.46767
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 2.45362
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, MAOA, XDH 2.44754
[BP] GO:0007267 None ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.44754
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, TYR 2.43329
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, RELA 2.42904
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR2A, HTR2B, HTR6, MAP2K1, MAP3K7, PTPN1, RELA, TNKS, TNKS2, XDH 2.42904
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.42904
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.42904
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.42904
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA 2.42904
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.42258
[BP] GO:0009416 response to light stimulus APP, BCL2, DRD1, DRD2, DRD3, RELA, TYR 2.42258
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A 2.41705
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, MAP2K1 2.38343
[BP] GO:0048589 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, TNKS2 2.36078
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, MAP2K1, PPARA, RELA 2.3559
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.3559
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD2, ESR1, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, TNKS, XDH 2.33486
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, MAP2K1, PPARA, RELA, TNKS, TNKS2 2.33288
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.32731
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32731
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FUT7, GBA2, HTR1A, HTR2B, MAOA, MAP2K1, MAP3K7, PPARA, PTPN1, RELA, TNKS, TNKS2, TYR, XDH 2.32445
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.31627
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.30603
[BP] GO:0070213 None TNKS, TNKS2 2.30388
[BP] GO:0006145 None AOX1, XDH 2.30388
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30388
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.28539
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.28539
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, MAP2K1, PPARA, RELA, TNKS, TNKS2 2.26464
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.25063
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA 2.24579
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, PTPN1, RELA, XDH 2.24532
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, PTPN1, RELA, XDH 2.2323
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.22217
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HSD17B3 2.20783
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, MAOA, XDH 2.20144
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3 2.20144
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.19467
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, MAP2K1, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, XDH 2.19358
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.19194
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, HSD11B2, RELA 2.17839
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.17067
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, PPARA, PTPN1, RELA, XDH 2.15795
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.14974
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MAP2K1, PPARA, PTPN1 2.14497
[BP] GO:0021853 None DRD1, DRD2 2.12545
[BP] GO:0043696 None CDK6, ESRRB 2.12545
[BP] GO:0043697 None CDK6, ESRRB 2.12545
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.12545
[BP] GO:0090325 None DRD2, DRD3 2.12545
[BP] GO:0007598 None F10, F3 2.12545
[BP] GO:1904936 None DRD1, DRD2 2.12545
[BP] GO:0042321 None ADORA1, DRD2 2.12545
[BP] GO:0010513 None HTR2A, HTR2B 2.12545
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, HTR2A 2.12397
[BP] GO:0008209 androgen metabolic process CYP19A1, ESR1, HSD17B3 2.12397
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.12397
[BP] GO:0051302 None CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.0967
[BP] GO:0007568 aging ADRA1A, BCL2, CYP1A1, HTR2A, MAP2K1, RELA 2.07743
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGES, TYR 2.07163
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, MAP2K1, MAP3K7, PTPN1, RELA 2.05188
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.05118
[BP] GO:0040007 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, TNKS2 2.05118
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, ESR1, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, XDH 2.04603
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, MAP2K1, TNKS 2.04603
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.04603
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.04603
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AR, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, HTR2A, HTR2B, MAP2K1, MAP3K7, RELA 2.03899
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, MAP2K1, PPARA, PTPN1, RELA, TNKS, TNKS2 2.0287
[BP] GO:0045777 None ADORA1, ADRA1A, HSD11B2 2.00803
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.00803
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, APP, AR, BCL2, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MAOA, MAP2K1, MAP3K7, PTGES, PTPN1, SIGMAR1, TNKS, TNKS2, TYR 4.76511
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, F10, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1, SIGMAR1 4.43321
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR5A, MAOA, MAP2K1, MAP3K7, PTGES, PTPN1, RELA, SIGMAR1, TNKS, TNKS2, TYR, XDH 4.21878
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, SIGMAR1 4.21878
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.53731
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, BCL2, CA12, CA14, CA2, CA4, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MAOA, PTGES, PTPN1, SIGMAR1, TYR 3.41306
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, CA4, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.21157
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, GBA2, HSD17B3, HTR5A, MAP2K1, PTPN1, SIGMAR1, XDH 2.87392
[CC] GO:0031233 None CA4, F10, F3 2.47547
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AR, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F3, GBA2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MAP2K1, MAP3K7, PTPN1 2.19467
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS, TYR, XDH 9.74547
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.10068
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, TNKS, TNKS2, TYR, XDH 7.98597
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.98597
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.65407
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 7.58911
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP3K7, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 7.43702
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.95493
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.87458
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.87458
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.86872
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.86872
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6 6.74064
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 6.5096
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.3212
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.82157
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, XDH 5.79734
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.29611
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 5.28036
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.25443
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.25443
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MAP2K1, MAP3K7, PPARA, SIGMAR1 5.16831
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.13186
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.01916
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.00936
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TYR 5.00062
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, CDK6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 5.00062
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.90494
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.87871
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 4.61107
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.46603
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.37925
[MF] GO:0008289 lipid binding AR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG 4.19042
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.11018
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, MAP2K1, MAP3K7, PTGES, PTPN1, TNKS, TNKS2, TYR, XDH 4.06906
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B2, HSD17B1, PTGES, XDH 4.00371
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TYR 3.84392
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS 3.4534
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6 3.24299
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP2D6 3.2069
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.16737
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6 3.09087
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.04704
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MAP3K7, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.95205
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.95205
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.92226
[MF] GO:0003845 None HSD11B1, HSD11B2 2.92226
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.84036
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.54948
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.511
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.47547
[MF] GO:0008144 drug binding ACHE, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, HTR2A, HTR2B, MAP2K1, MAP3K7, PPARA, SIGMAR1 2.46767
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.33628
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.33628
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30388
[MF] GO:0005497 None AR, SHBG 2.30388
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12545


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 12.5591
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 10.7435
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 8.4584
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 6.5786
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2003
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 6.4291
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, MAP2K1, ADORA1, HTR1A, CACNA1C, DRD1, DRD2, PPARA, RELA 6.4198
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A 5.6005
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.6005
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.5007
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 4.3789
Gap junction_Homo sapiens_hsa04540 MAP2K1, HTR2B, HTR2A, DRD1, DRD2 3.9241
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 4.0425
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1, DRD2, DRD3 3.2311
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 3.3298
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.6629
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, ESR1, ESR2, RELA 3.1037
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2311
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA1A 2.7908
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA 2.7908
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.4814
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.756
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.3987
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 2.1852
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, BCL2, RELA 2.1033
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.0953
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 2.1033
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 2.1032
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7908
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.8952
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, CYP1B1, CDC25B 1.8952
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 2.0386
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.7462
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, MAP3K7 2.035
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3, RELA 1.7462
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, ESR1, ESR2 1.7462
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.8952
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0953
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA 1.7328
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7314
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.7282
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MAP3K7, RELA 1.7022
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, BCL2, RELA 1.5164
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.7038
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.6247
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.4756
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C, ADRA1A 1.6247
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.52
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C, ADRA1A 1.4186
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, CDK6, BCL2, RELA 1.239
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2674
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, RELA 1.088
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HTR2B, HTR2A 1.0679
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B 1.0679
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, CACNA1C 1.1097
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0574
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1 0.927
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8536
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3727
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, ESR1 0.9462
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.3727
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.8551
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.8788
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, ADRA1A 0.927
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1097
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB 0.8536
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C 1.1715
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8536
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6 1.3012
HTLV-I infection_Homo sapiens_hsa05166 RELA 0.2437
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, RELA 1.3727
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.927
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8259
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.257
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6 1.2674
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8142
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1 0.2953
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2674
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.3251
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3012
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, CACNA1C 0.8142
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.3061
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.7567
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7778
Tuberculosis_Homo sapiens_hsa05152 BCL2, RELA 0.7486
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 RELA 0.3466
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, BCL2 0.6868
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3512
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, ESR1 0.6868
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.257
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3617
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, RELA 0.6868
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, RELA 0.7254
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, DRD2 0.6778
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3516
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2053
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2674
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3727
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.3251
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.422
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4126
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4295
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1 0.432
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4839
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5144
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5224
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5224
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5224
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5311
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5311
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA 0.5311
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.53
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5224
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5311
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1 0.5409
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5409
GABAergic synapse_Homo sapiens_hsa04727 CACNA1C 0.5409
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7462
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5397
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5433
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5043
Salmonella infection_Homo sapiens_hsa05132 RELA 0.542
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5409
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5524
Peroxisome_Homo sapiens_hsa04146 XDH 0.5493
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5493
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5637
Pertussis_Homo sapiens_hsa05133 RELA 0.5756
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5776
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1 0.5974
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5974
Bile secretion_Homo sapiens_hsa04976 CA2 0.5872
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5776
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1 0.5991
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.595
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 RELA 0.5974
Shigellosis_Homo sapiens_hsa05131 RELA 0.6017
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1 0.6164
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6017
Long-term depression_Homo sapiens_hsa04730 MAP2K1 0.6194
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.6017
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9024
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7303
Legionellosis_Homo sapiens_hsa05134 RELA 0.6503
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6692
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.668
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6735
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6778
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6868
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6868
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6868
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6868
Bladder cancer_Homo sapiens_hsa05219 MAP2K1 0.7242
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7328
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.765
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7265
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8216
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8336
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8066
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8216
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3002
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8216
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8401
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8336
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8551
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9598
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9462
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0369
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3012


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)