TCM Prescription: Jin Qi Jiang Tang Tablet



Prescription Description
Prescription IDTCMF649
Pinyin NameJin Qi Jiang Tang Pian 
Chinese Name金芪降糖片
English NameJin Qi Jiang Tang Tablet
Function Description轻, 中度型非胰岛素依赖型糖尿病
IndicationsType 2 diabetes
Disease ICD-11 Category 5A11 [Type 2 diabetes mellitus, 2åž‹ç³–å°¿ç—… ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET 7.35068
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, SRC, TYR, XDH 6.45611
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TYR 6.26447
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2 6.24311
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TYR 5.83463
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH 5.65412
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, KDR, MET, MMP12, MMP9, SRC, XDH 5.6424
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, KDR, MET, MMP12, MMP9, SRC, XDH 5.6424
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.56344
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, PIM1, TYR, XDH 5.46516
[BP] GO:0042221 response to chemical AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TYR 5.23159
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.21278
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 5.18783
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 5.18783
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FLT3, NR3C1, RORC, SRC, TYR 5.18783
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.17695
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, SRC, XDH 5.17695
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.09077
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, RORC, SRC, XDH 5.06257
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC 4.93121
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, SRC, TYR, XDH 4.75467
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, RORC, SRC, TYR, XDH 4.75467
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, RORC, SRC, XDH 4.57369
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC 4.46772
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7 4.46273
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.33896
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SRC, TYR 4.33896
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, SRC, TYR, XDH 4.33676
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, DRD1, FLT3, NR3C1, RORC, SRC 4.29809
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC 4.28595
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, RORC, SRC, TYR 4.24046
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 4.18863
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIM1, SRC, XDH 4.15121
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 4.0856
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET 4.07936
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, IGF1R, MMP2, NR3C1, SRC 3.99081
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.96087
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.96087
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.92519
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.90497
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, TYR 3.8326
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIM1, SRC, XDH 3.81279
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.7627
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 3.72618
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FLT3, HSD17B2, KDR, MMP9, PGR, PIM1, RORC, SRC, TYR 3.71414
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.68224
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.67341
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MMP9, PIM1, SRC, XDH 3.58936
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MMP12, MMP9, SRC, XDH 3.56259
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.44126
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, XDH 3.41305
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.40186
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7 3.39775
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, KDR, MET, SRC, XDH 3.36219
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, XDH 3.36219
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH 3.36219
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, RORC, SRC, TYR 3.33783
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, SRC, TYR 3.30117
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 3.2643
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 3.23517
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC 3.233
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP12, MMP9, SRC 3.23283
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1 3.15353
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.14884
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, RORC, SRC 3.14145
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, SRC 3.14045
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.11804
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, SRC, XDH 3.08898
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, SRC 3.08008
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.03152
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.02448
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 3.02448
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.98876
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.98801
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.97237
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.86556
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.86556
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.86217
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.83993
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.83303
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.83303
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, KDR, SRC 2.79474
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, FABP3, FABP4, FLT3, MET, SRC 2.77454
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1 2.77454
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.75442
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.71692
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.70375
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.68088
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.57669
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.5684
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.56452
[BP] GO:0060748 None AR, PGR 2.56452
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56452
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, MET, PIM1, SRC, TYR 2.55099
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.53451
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, SRC 2.53148
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.47612
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, RORC, SRC, XDH 2.45569
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.42859
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, FLT3, IGF1R, MMP2, NR3C1, SRC 2.42514
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.403
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.38276
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.33704
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.33704
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31869
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31869
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.31388
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.29504
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, RORC 2.29478
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, PGR, SRC 2.28866
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2 2.27499
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, XDH 2.27499
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, KDR, SRC 2.27499
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.27258
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.27258
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, FABP3, KDR, NR3C1, SRC 2.22519
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CYP19A1, CYP1A1, DRD1, HSD17B2, MMP2, MMP9, PGR, SRC 2.19035
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, RORC, SRC, XDH 2.18728
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CYP1A1, DRD1, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PGR, RORC, SRC 2.18728
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.18699
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SRC, XDH 2.17846
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.16041
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.1571
[BP] GO:0010641 None F3, SRC 2.15397
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, FABP3, FLT3, IGF1R, MMP2, SRC, TYR 2.14268
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.13737
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, SRC 2.13196
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, SRC 2.12794
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3 2.10962
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.10696
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SRC, XDH 2.09889
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1 2.09889
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TYR, XDH 2.08632
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1 2.08632
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1 2.08632
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.02375
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.02375
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, DRD1, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SRC, XDH 2.0175
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, MMP2, SRC, TYR 2.00139
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, SRC 2.00139
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.00139
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC 2.00139
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, SRC, TYR, XDH 1.87416
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.83632
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, MMP2, NR3C2, PGR, PIM1, SRC, TYR 1.77661
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, F3, FLT3, IGF1R, KDR, MET 1.46418
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, HSD17B2, NR3C2 1.33679
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, TYR, XDH 12.5466
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, SRC, TYR, XDH 8.3747
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TYR, XDH 6.36945
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7 6.26447
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, NR3C1, NR3C2, PGR, RORC 5.65412
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.56344
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.35335
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 5.18575
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, RORC 4.75467
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, TYR, XDH 4.64433
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.42456
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.33896
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.33896
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7 4.09342
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, RORC 3.97379
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC 3.91173
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.90521
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.75187
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, TYR, XDH 3.72673
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.63759
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.60678
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.58936
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7 3.58936
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.53289
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.49707
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.37667
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 3.37244
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 3.36219
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 3.07961
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 2.85206
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.79837
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 2.72837
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.60541
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.56452
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.55288
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 2.45613
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.31869
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.31869
[MF] GO:0017171 serine hydrolase activity ACHE, F3, MMP1, MMP12, MMP2, MMP9 2.18699
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15397
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.13737
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7 2.08632
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.08498
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.07409
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, SRC 2.0484


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7298
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.558
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA14 7.9838
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.7642
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 4.4674
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.0795
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.6084
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.4674
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 3.5151
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.5445
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0334
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4397
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.118
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2763
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0993
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 2.0698
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3956
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0725
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9176
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.9176
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, NR3C1 1.8462
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.7545
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.4045
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5792
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5786
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5488
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5634
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4959
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4958
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4947
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2868
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.5482
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.3522
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0993
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3522
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.4955
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.3014
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9776
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.9867
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4277
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.731
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.3522
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 1.052
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3522
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4947
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.2119
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 1.0445
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1743
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1789
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9485
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0664
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9412
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8928
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1 0.8536
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5894
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5542
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5542
Platelet activation_Homo sapiens_hsa04611 SRC 0.5327
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.5122
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5854
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5824
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4816
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4557
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5797
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5732
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4275
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5148
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5894
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5406
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4557
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4156
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5312
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5187
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5894
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5122
Alcoholism_Homo sapiens_hsa05034 DRD1 0.4557
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4816
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4557
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4263
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5894
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6321
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4637
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5122
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.655
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5894
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4504
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5406
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5854
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.5256
Axon guidance_Homo sapiens_hsa04360 MET 0.527
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6271
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5854
Glioma_Homo sapiens_hsa05214 IGF1R 0.655
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5854
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4504
Peroxisome_Homo sapiens_hsa04146 XDH 0.5933
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.655
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.607
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.655
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.655
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.655
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.655
Shigellosis_Homo sapiens_hsa05131 SRC 0.655
Malaria_Homo sapiens_hsa05144 MET 0.7305
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.7305
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.8108
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8489
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8851
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8911
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9359
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9278
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2994


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)