TCM Prescription: Yu Ye Xiao Ke Infusion



Prescription Description
Prescription IDTCMF6435
Pinyin NameYu Ye Xiao Ke Chong Ji
Chinese Name玉液消渴冲剂
English NameYu Ye Xiao Ke Infusion
Function Description消渴
IndicationsWasting thirst disorder, Diabetes
Disease ICD-11 Category SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ];
5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2059 Radix pseudostellariae 太子参 TCMH2059
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, MET, TRPV1 8.00396
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, KDR, MAOB, MET, SRC, TRPV1, XDH 6.8518
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 6.13386
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 6.13386
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.91318
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, PDE5A, PIM1, XDH 5.78321
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 5.77404
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.43285
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 5.42936
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, SRC 5.40094
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.40094
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, MAOB, XDH 5.35836
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PIM1, SRC, TRPV1, XDH 5.06613
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1 5.04928
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, NR3C1, SRC, TRPV1 4.98635
[BP] GO:0009725 response to hormone AKR1B1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, SRC, TRPV1 4.96909
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.93694
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 4.92477
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, PDE5A, PIM1, SRC, XDH 4.7235
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PIM1, SRC, TRPV1, XDH 4.72316
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, PDE5A, SRC, XDH 4.71541
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, PDE5A, SRC, XDH 4.70041
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, SRC 4.67525
[BP] GO:0014070 response to organic cyclic compound CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, MAOB, NR3C1, SRC, TRPV1 4.65391
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 4.54207
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, PIM1, SRC, TRPV1, XDH 4.48238
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 4.42821
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, SRC 4.27691
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 4.27691
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 4.22643
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MAOB, NR3C1, SRC, TRPV1 4.22274
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MAOB, MMP12, PDE5A, SRC, XDH 4.17811
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, KDR, SRC 4.17811
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.06722
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 4.04596
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 4.03069
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 4.03069
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1 3.9718
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, IGF1R, MAOB, NR3C1, SRC, TRPV1 3.84561
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, NR3C1, SRC, TRPV1 3.84027
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, SRC 3.84027
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, PDE5A, SRC, XDH 3.76731
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.71159
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIM1, SRC, XDH 3.70396
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, PDE5A, SRC, XDH 3.7006
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TRPV1 3.58949
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MET 3.57987
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, SRC, TRPV1 3.50698
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 3.47418
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.45658
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, SRC, TRPV1 3.38163
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.37926
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, SRC 3.31339
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.26476
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, PIM1, SRC 3.22945
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, SRC, TRPV1 3.22656
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, SRC, TRPV1 3.16058
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 3.15425
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, MAOB 3.12178
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, MAOB 3.12041
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 3.09964
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, TRPV1 3.09964
[BP] GO:0044248 cellular catabolic process ACHE, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MAOB, PDE5A, SRC, XDH 3.09822
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 3.07456
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.07456
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3 3.07456
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, KDR, MAOB, NR3C1, SRC, TRPV1 3.0733
[BP] GO:1901575 None ACHE, ADORA1, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MAOB, PDE5A, XDH 3.06613
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, PDE5A, SRC, XDH 3.01063
[BP] GO:0009115 None AOX1, XDH 3.01063
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.01063
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.01063
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.01063
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, KDR, MAOB, PIM1, SRC 3.01063
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1 3.01063
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, SRC, TRPV1, XDH 2.97899
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, PIM1, SRC 2.97899
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.97151
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.97151
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, MAOB, PDE5A, XDH 2.93643
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.93454
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.93158
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, KDR, MET, PDE5A, SRC, XDH 2.89818
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, SRC, TRPV1, XDH 2.89453
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, SRC, TRPV1 2.81712
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 2.81712
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 2.78612
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, SRC, TRPV1, XDH 2.78612
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 2.74517
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, SRC, TRPV1 2.71573
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.65579
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, PIM1, SRC 2.63735
[BP] GO:0046110 None AOX1, XDH 2.63735
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.63735
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.6154
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, PDE5A, SRC, XDH 2.59627
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, KDR, MET, MMP12, PDE5A, PIM1, SRC, TRPV1, XDH 2.58478
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.56472
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MAOB 2.54829
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CYP1B1, ESRRB, HCAR2, KDR, MET, MMP12, PDE5A, PIM1, SRC, TRPV1 2.54774
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SRC, TRPV1 2.52958
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.51955
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, TRPV1 2.46455
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.42686
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.41668
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.41668
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1 2.41554
[BP] GO:0006145 None AOX1, XDH 2.4115
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.4115
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.4115
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4 2.4115
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.36659
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, TRPV1 2.35505
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.28522
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP12, PDE5A, SRC, XDH 2.2844
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, SRC 2.26835
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.25191
[BP] GO:1901654 None AKR1B1, CSNK2A1, MAOB, NR3C1, SRC 2.24178
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4 2.23859
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, MET, MMP12, PDE5A, SRC, XDH 2.23859
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.23859
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.23859
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 2.23859
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.23859
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, HSD11B1, KDR, MAOB, MET, PIM1, SRC 2.1811
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, IGF1R, MET, MMP12, PDE5A, PIM1, SRC, TRPV1 2.15788
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, SRC 2.09733
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MAOB 2.09131
[BP] GO:0046113 None AOX1, XDH 2.09131
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.09131
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.09131
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 2.0858
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5 2.07499
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3 2.04436
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1 2.04436
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, SRC 2.0317
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1 2.01622
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, KDR, MAOB, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 1.57596
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, PIM1, SRC, TRPV1 1.29069
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FLT3, HCAR2, HSD11B1, IGF1R, KDR, MAOB, MET, PIM1, SRC, TRPV1 1.04296
[CC] GO:0044228 host cell surface AXL 0.964798
[CC] GO:0005829 cytosol AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA7, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 0.952315
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PIM1, XDH 11.8507
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 9.72837
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.51894
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 8.02457
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, MAOB, XDH 6.13386
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, PDE5A, PIM1, SRC, XDH 5.90071
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1 5.85739
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.69073
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.51166
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.4561
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PDE5A, PIM1, TRPV1, XDH 5.10915
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.93694
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, TRPV1 4.90669
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PDE5A, PIM1, TRPV1, XDH 4.72316
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.56136
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, MAOB, SRC, XDH 4.39427
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 4.20705
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1 4.07531
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 4.00662
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.85108
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, SRC, TRPV1 3.84027
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.70791
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.57987
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.57987
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, TRPV1 3.56476
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1 3.47418
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, SRC, TRPV1, XDH 3.35129
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.24375
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 3.14698
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 3.12041
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, TRPV1 3.07154
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 3.04384
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 3.04384
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.01063
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.01063
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, TRPV1 2.97272
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, SRC, TRPV1, XDH 2.82666
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.71952
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, TRPV1 2.69746
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD11B1, HSD17B1, XDH 2.67985
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.63735
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.63735
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.63735
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 2.46455
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.46174
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.42686
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, SRC, TRPV1, XDH 2.42109
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, SRC, TRPV1, XDH 2.42109
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.4115
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.4115
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.4115
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.4115
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1 2.34375
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NR3C1 2.30717
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR3C1, PDE5A, PIM1, SRC, TRPV1, XDH 2.26068
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.23859
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.23859
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.23859
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.23859
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, PIM1, SRC 2.23859
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.16366
[MF] GO:0004064 arylesterase activity CA1, CA2 2.09131
[MF] GO:0043546 None AOX1, XDH 2.09131
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, KDR, NR3C1 2.02643


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 10.0491
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.7247
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.4403
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 6.2208
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, CYP3A4, CYP19A1, HSD11B1, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, XDH 4.7426
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.9821
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.8083
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.8167
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4 3.7645
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.6895
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 3.2264
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12 3.1292
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.6409
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.4998
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.4776
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.2392
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.2041
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.1933
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 2.1933
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9551
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1 1.8874
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.6434
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.6008
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.4421
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6008
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.6008
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5656
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.5054
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2779
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.5054
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.5054
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7249
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET 1.1603
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1 1.9226
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4421
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 1.0606
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.5054
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4 1.5054
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.158
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.155
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MET, IGF1R 0.9329
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.9863
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 1.0606
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0606
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.9296
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2041
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1 0.8771
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.6282
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.6282
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4427
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1 0.6183
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.6282
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6282
Platelet activation_Homo sapiens_hsa04611 SRC 0.5683
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.431
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5916
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4418
Alcoholism_Homo sapiens_hsa05034 MAOB 0.4729
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4729
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4657
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.6251
Hepatitis B_Homo sapiens_hsa05161 SRC 0.5342
Gap junction_Homo sapiens_hsa04540 SRC 0.6282
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6282
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.5093
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5683
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5518
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.54
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.628
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6282
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.6156
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6592
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5683
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5556
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.573
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4657
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6282
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.5626
Peroxisome_Homo sapiens_hsa04146 XDH 0.6282
Axon guidance_Homo sapiens_hsa04360 MET 0.5638
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.628
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6931
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.628
Glioma_Homo sapiens_hsa05214 IGF1R 0.6931
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.628
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6996
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6931
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6931
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6931
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6996
Shigellosis_Homo sapiens_hsa05131 SRC 0.6931
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7622
Malaria_Homo sapiens_hsa05144 MET 0.7622
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7622
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7622
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7607
Bladder cancer_Homo sapiens_hsa05219 SRC 0.8069
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.8097
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8986
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8459
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8794
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9045
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9263
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9496
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.0606
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3969
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4421


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)