TCM Prescription: Xiao Ke Pills



Prescription Description
Prescription IDTCMF6187
Pinyin NameXiao Ke Wan
Chinese Name消渴丸
English NameXiao Ke Pills
Function Description消渴
IndicationsWasting thirst disorder, Diabetes
Disease ICD-11 Category SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ];
5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH2538 Zea mays 玉米须 TCMH2538
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH680 NA 格列本脲 TCMH680
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, PPARA, PTGS2, TRPV1 10.2452
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, IDO1, MPO, PIM1, PPARA, PTGS2, XDH 8.54656
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, IDO1, MPO, PTGS2, XDH 6.6155
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, MPO, NR3C1, PPARA, PTGS2, SRC, TRPV1 6.59254
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 6.38497
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, KDR, MET, PPARA, PTGS2, SRC, TRPV1, XDH 6.29061
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 6.21011
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 6.20028
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, SRC, TRPV1, XDH 6.20028
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR6, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 6.12624
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IDO1, MPO, NR3C1, PTGS2, SRC 6.10266
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 6.05109
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, IDO1, IGF1R, MPO, NR3C1, PPARA, PTGS2, SRC, TRPV1 5.69639
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, SRC 5.66954
[BP] GO:0009725 response to hormone AKR1B1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PTGS2, SRC, TRPV1 5.66954
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR6, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 5.66954
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.66954
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.66462
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET, PPARA, PTGS2 5.64646
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, SRC, TRPV1, XDH 5.64152
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.57043
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.51401
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.48757
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, SRC 5.41913
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, SRC 5.41271
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, PTGS2, SRC 5.41271
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, MPO, NR3C1, PPARA, PTGS2, SRC, TRPV1 5.41271
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IDO1, IGF1R, KDR, MMP12, PIM1, PTGS2, SRC, XDH 5.21493
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 5.17369
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 5.01297
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 5.00515
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 4.93619
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 4.9072
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, NR3C1, PPARA, PTGS2, SRC, TRPV1 4.8083
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.70205
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, PTGS2 4.69772
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, KDR, PPARA, SRC 4.68921
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, SRC 4.63627
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, IDO1, MPO, PTGS2 4.61931
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.56323
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, IDO1, MMP12, MPO, SRC, XDH 4.56323
[BP] GO:0014070 response to organic cyclic compound CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, PTGS2, SRC, TRPV1 4.51424
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR6, KDR, MET, MMP12, PTGS2, SRC, XDH 4.46677
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, IDO1, IGF1R, KDR, MET, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, XDH 4.46128
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR6, KDR, MET, MMP12, PTGS2, SRC, XDH 4.46128
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 4.39269
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.38966
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2 4.34714
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.13068
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 4.12714
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 4.08225
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 4.07487
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 4.04149
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.99494
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 3.86701
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PTGS2, SRC, TRPV1 3.86231
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PTGS2, SRC, TRPV1 3.60191
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.43068
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2 3.42079
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 3.42079
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2 3.39835
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS2 3.39092
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 3.37092
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2 3.37092
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 3.35256
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TRPV1 3.34955
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 3.33749
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, HTR6, KDR, MET, PTGS2, SRC, XDH 3.33749
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HTR6, IGF1R, KDR, MET, MMP12, PTGS2, SRC, XDH 3.33234
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.31827
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HTR6, IGF1R, KDR, MET, PTGS2, SRC, XDH 3.31
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HTR6, IGF1R, KDR, MET, MMP12, PTGS2, SRC, XDH 3.26298
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, HTR6, IDO1, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, SRC, XDH 3.19303
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, IDO1, IGF1R, MET, MMP12, MPO, PIM1, PPARA, PTGS2, SRC, TRPV1 3.19282
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.19282
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO 3.1558
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, SRC, TRPV1 3.15571
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.13123
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGS2 3.10507
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, KDR, PIM1, PPARA, PTGS2, SRC 3.10507
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, MPO 3.09742
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.07906
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 3.07416
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 3.04571
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, HTR6, IDO1, KDR, MET, MMP12, PTGS2, SRC, XDH 3.04073
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 3.02847
[BP] GO:0009115 None AOX1, XDH 3.02847
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.02847
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.02847
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.02847
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.00626
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, KDR, MET, MPO, PIM1, PPARA, PTGS2, SRC 2.98042
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1 2.97429
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.94865
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, HTR6, KDR, MET, MMP12, PTGS2, SRC, XDH 2.94515
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, PTGS2, SRC, TRPV1 2.93745
[BP] GO:0044248 cellular catabolic process ACHE, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, IDO1, MPO, SRC, XDH 2.87943
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.8622
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.8622
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.83387
[BP] GO:1901575 None ACHE, ADORA1, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, IDO1, XDH 2.83387
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.78366
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, PTGS2, SRC 2.77315
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, SRC, TRPV1 2.77314
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 2.74186
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, PTGS2, SRC 2.70863
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, KDR, PTGS2, SRC, TRPV1 2.66879
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, MMP12, MPO, NR3C1, PPARA, PTGS2, SRC, TRPV1 2.64008
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.64008
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.64008
[BP] GO:0046110 None AOX1, XDH 2.64008
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.64008
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.62582
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, SRC, TRPV1, XDH 2.62378
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.59875
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, PTGS2, SRC 2.59248
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.5467
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, PTGS2, SRC 2.53737
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, SRC, TRPV1, XDH 2.50108
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.49721
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, ESR1, FABP4, IDO1, IGF1R, MET, MMP12, PPARA, PTGS2, SRC, XDH 2.49548
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, IDO1, PTGS2 2.47823
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, PTGS2 2.47823
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, PPARA, PTGS2, SRC, XDH 2.42857
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, SRC, TRPV1, XDH 2.42224
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.40505
[BP] GO:0006145 None AOX1, XDH 2.39873
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.39873
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.39873
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2 2.38993
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.37679
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, PIM1, PTGS2 2.373
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, PTGS2, SRC 2.35134
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, IDO1, PTGS2 2.35134
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, IDO1, PTGS2 2.3474
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS2 2.3474
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, PTGS2, SRC 2.3474
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.34184
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4 2.33563
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CYP1B1, ESRRB, IDO1, KDR, MET, MMP12, PIM1, PTGS2, SRC, TRPV1 2.32923
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PPARA, PTGS2, SRC, TRPV1 2.30881
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS2 2.30419
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MPO 2.26361
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, IDO1, KDR, MET, MMP12, PIM1, PTGS2, SRC, TRPV1, XDH 2.26286
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.25013
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, PTGS2 2.23166
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.23162
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.23162
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.23162
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.20182
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, NR3C1, PTGS2, SRC, TRPV1 2.19492
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, TRPV1 2.18814
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PTGS2, SRC, TRPV1 2.18044
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, PPARA 2.17266
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.17152
[BP] GO:0046113 None AOX1, XDH 2.08293
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.08293
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.08293
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MMP12, PPARA, PTGS2, SRC 2.07224
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 2.0539
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, IDO1, XDH 2.04816
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.04671
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1 2.01557
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, MPO, PPARA, PTGS2, SRC, TRPV1 2.00704
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, PTGS2 2.00506
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IDO1, KDR, MPO, NR3C1, PIM1, PTGS2, SRC, TRPV1, XDH 1.80285
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AOX1, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HTR6, IDO1, IGF1R, KDR, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, XDH 1.27022
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 0.99843
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, FLT3, HTR6, IGF1R, KDR, MET, TRPV1 0.992771
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CSNK2A1, ESR1, FLT3, HTR6, IGF1R, KDR, MET, PIM1, SRC, TRPV1 0.992771
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PIM1, PPARA, XDH 12.2687
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 10.0768
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.54656
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 7.88232
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, IDO1, MPO, PTGS2, XDH 7.80274
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO, PTGS2, SRC 7.34493
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO, PTGS2, SRC 7.10034
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, HSD11B1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PTGS2, SRC, XDH 6.31776
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, TRPV1, XDH 6.31776
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, IDO1, MPO, PTGS2, SRC, XDH 6.03221
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, TRPV1, XDH 5.96171
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1 5.94271
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.76007
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.64238
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 5.64152
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.64152
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.64152
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.57043
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 5.53749
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.00515
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.59719
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.46128
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.46128
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 4.22355
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 4.20852
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PPARA 4.07704
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 4.015
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR6, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 4.015
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.57488
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.51877
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR6, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.39835
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2 3.39092
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 3.3105
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR6, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.28382
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.21086
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 3.09742
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 3.06912
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.02847
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.02847
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR6, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.02015
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, PIM1, PPARA, SRC 2.64273
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 2.64008
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.64008
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.64008
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.64008
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.64008
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD11B1, HSD17B1, XDH 2.62386
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 2.61518
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.58171
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.39873
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.39873
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.39873
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1 2.2693
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NR3C1 2.26286
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.23162
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.23162
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.20182
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.13417
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08293
[MF] GO:0043546 None AOX1, XDH 2.08293
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.08293
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, PPARA, SRC 2.051
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TRPV1, XDH 2.04671
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MPO, PIM1, SRC, TRPV1, XDH 2.02437


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9562
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.8395
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.6596
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.1352
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, PTGS2, CYP3A4, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, XDH, IDO1 5.9638
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.1352
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.9547
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, ALOX15, ALOX12, PTGS2 4.0907
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2 3.808
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.7719
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.5896
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 3.0921
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, ADORA3, ADORA1, TRPV1, NR3C1 2.5505
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.5791
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.6609
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.4252
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.4643
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.4962
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.2164
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 2.3822
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.1844
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.1771
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.4962
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 2.1771
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9119
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MET 1.7162
Pathways in cancer_Homo sapiens_hsa05200 FLT3, PTGS2, MET, IGF1R 1.3912
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, PPARA 1.4337
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.3532
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.542
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4337
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4337
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4255
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1986
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4255
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.971
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3834
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0905
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2615
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7084
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0874
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9739
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.919
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.919
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9809
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8854
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.205
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5834
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1 0.5784
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5834
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5834
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5834
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5834
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5784
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5784
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.42
Gap junction_Homo sapiens_hsa04540 SRC 0.5834
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4482
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6085
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5834
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5611
Platelet activation_Homo sapiens_hsa04611 SRC 0.5375
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6 0.4482
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4082
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.5611
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5834
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.636
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5784
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4188
Hepatitis B_Homo sapiens_hsa05161 SRC 0.5028
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6085
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4427
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5611
Peroxisome_Homo sapiens_hsa04146 XDH 0.5834
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4482
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4947
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5834
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5756
Glioma_Homo sapiens_hsa05214 IGF1R 0.636
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5204
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5088
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5245
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5375
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5784
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5375
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5245
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4427
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5784
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5426
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5784
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6185
Phagosome_Homo sapiens_hsa04145 MPO 0.4917
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6417
Axon guidance_Homo sapiens_hsa04360 MET 0.5328
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.636
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.636
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6417
Shigellosis_Homo sapiens_hsa05131 SRC 0.636
Malaria_Homo sapiens_hsa05144 MET 0.7106
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7135
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.712
Bladder cancer_Homo sapiens_hsa05219 SRC 0.7627
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8136
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8465
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.8136
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8407
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8353
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8094
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8523
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8814
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8742
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3488
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3834


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)