TCM Prescription: Xiao Ji Jian Er Tablets



Prescription Description
Prescription IDTCMF6110
Pinyin NameXiao Ji Jian Er Pian
Chinese Name消积健儿片
English NameXiao Ji Jian Er Tablets
Function Description积滞, 疳病, 虫积
IndicationsInfantile malnutrition disorder, Dyspepsia
Disease ICD-11 Category SE37 [Infantile malnutrition disorder (TM1), 疳病 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1938 Quisqualis indica 使君子 TCMH1938 GENG1719-16
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH905 Picrorhiza kurrooa 胡黄连 TCMH905 GBVX6435-15, GBVX5995-15
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1533 Saussurea lappa 木香 TCMH1533
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT661 FOLH1 Glutamate carboxypeptidase II Hydrolase Q04609
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1193 Staphylococcus
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1200 Bacillus thuringiensis
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1268 Nocardia farcinica
TCMT1269 Mycobacterium ulcerans
TCMT1270 Streptomyces coelicolor
TCMT1271 Shigella flexneri
TCMT1273 Pseudomonas putida
TCMT1275 Erwinia chrysanthemi
TCMT1278 Pseudomonas
TCMT1279 Staphylococcus aureus subsp. aureus
TCMT1280 Salmonella sp.
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1303 Bacillus
TCMT1305 Salmonella enteritidis
TCMT1311 Pseudomonas tolaasii
TCMT1312 Enterococcus durans
TCMT1318 Human T-lymphotropic virus 1
TCMT1325 Mycobacterium gordonae
TCMT1326 Shigella
TCMT1328 Enterococcus avium
TCMT1329 Bacillus fortis
TCMT1330 Salmonella enterica subsp. enterica serovar Paratyphi B
TCMT1331 Acinetobacter sp.
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1461 Salmonella enterica subsp. enterica serovar Gallinarum
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, MPO, POLB, PPARA, PTGS2, RORC, SRC, TEK, TYR 10.0694
[BP] GO:0010033 response to organic substance ADRB2, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MPO, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.0694
[BP] GO:0010647 positive regulation of cell communication ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.02725
[BP] GO:0023056 positive regulation of signaling ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.02725
[BP] GO:0042221 response to chemical ADRB2, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, MPO, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.95256
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 7.71766
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.66374
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.59723
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.46015
[BP] GO:0065008 regulation of biological quality ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 7.17784
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.02863
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.90547
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.89594
[BP] GO:1902531 regulation of intracellular signal transduction ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 6.86434
[BP] GO:0009967 positive regulation of signal transduction ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.86434
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.86434
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, PTGS2, PTPN1, SRC, TEK, XDH 6.86434
[BP] GO:0008152 metabolic process ACHE, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.86434
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.86434
[BP] GO:0009719 response to endogenous stimulus ADRB2, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 6.84832
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 6.68266
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.66496
[BP] GO:0032502 developmental process ACHE, ADRB1, ADRB2, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, MPO, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.47345
[BP] GO:0032501 multicellular organismal process ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.40354
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR 6.38323
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.35109
[BP] GO:0044237 cellular metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.32722
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.30071
[BP] GO:0048584 positive regulation of response to stimulus ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.21957
[BP] GO:0048518 positive regulation of biological process ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.21212
[BP] GO:0010646 regulation of cell communication ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.05834
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.05442
[BP] GO:0009628 response to abiotic stimulus ADRB1, ADRB2, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, MPO, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 6.01457
[BP] GO:0023051 regulation of signaling ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.95395
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 5.95346
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 5.92912
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, PTGS2, PTPN1, RORC, SMAD3, SRC 5.92912
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.74336
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC 5.71281
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS2, TBXAS1 5.64236
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTGS2, RORC, SRC, TEK, TYR 5.44967
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.4421
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.39392
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRB2, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.3036
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 5.20933
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.1757
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 5.16998
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, XDH 5.11414
[BP] GO:0042592 homeostatic process ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 4.90053
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PTGS2, RORC, SMAD3, SRC 4.88329
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, XDH 4.78801
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.78801
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.70539
[BP] GO:0019220 regulation of phosphate metabolic process ADRB1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.67766
[BP] GO:0051174 regulation of phosphorus metabolic process ADRB1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.62404
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.40494
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 4.39347
[BP] GO:0030334 regulation of cell migration ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.37406
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, MPO, PTGS2, SRC 4.37324
[BP] GO:0006950 response to stress ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.37194
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.34008
[BP] GO:0048583 regulation of response to stimulus ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.33956
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADRB2, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 4.29624
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.24641
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.21372
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 4.21372
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.21372
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.1206
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.11995
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.11912
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRB1, ADRB2, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.11912
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRB1, ADRB2, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.11912
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS2, TBXAS1 4.10643
[BP] GO:0009966 regulation of signal transduction ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.09255
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, MMP2, POLB, PPARA, PTGS2, SMAD3, SRC, TEK 4.05344
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.03381
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.02172
[BP] GO:0080134 regulation of response to stress CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.90733
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.88607
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.88607
[BP] GO:0003018 None ADRB1, ADRB2, CHRM1, EGFR, PTGS2, SRC, TEK 3.86
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.85418
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.84987
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH 3.81913
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.81913
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.80068
[BP] GO:0051270 regulation of cellular component movement ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.80068
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.80068
[BP] GO:0051049 regulation of transport ACHE, ADRB2, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC 3.75398
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.75398
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.74215
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.74215
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.71477
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9 3.67294
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.67229
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.67229
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRB1, ADRB2, AXL, BCL2, CA2, CHRM1, CHRM2, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.65425
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 3.65302
[BP] GO:0044238 primary metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.65159
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.65159
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.65159
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.61352
[BP] GO:0071704 organic substance metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.59096
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.57399
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.54382
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.54382
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.53692
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.53692
[BP] GO:0050873 None ADRB1, ADRB2, FABP4, PTGS2 3.526
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.52207
[BP] GO:0065009 regulation of molecular function ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.51671
[BP] GO:0051050 positive regulation of transport ACHE, ADRB2, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC 3.51006
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.46942
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.45636
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRB2, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.4361
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 3.43529
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.42715
[BP] GO:0023057 negative regulation of signaling ACHE, ADRB2, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.42715
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.41759
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.38395
[BP] GO:0007165 signal transduction ADORA3, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.36656
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.36354
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.36354
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.35686
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.35169
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.33033
[BP] GO:0048585 negative regulation of response to stimulus ADRB2, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.31398
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.3082
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, PTGS2, SRC 3.29588
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29588
[BP] GO:0042325 regulation of phosphorylation ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.25582
[BP] GO:0010638 positive regulation of organelle organization ADRB2, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.25582
[BP] GO:0003013 None ADRB1, ADRB2, CHRM1, EGFR, PTGS2, SRC, TEK 3.23685
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.23685
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.214
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, PTGS2, RORC, SRC 3.20603
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 3.19503
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.19503
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.16693
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.14374
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.12334
[BP] GO:0044057 None ADORA3, ADRB1, ADRB2, CHRM1, CHRM2, EGFR, GPR35, HCAR2, PTGS2, SMAD3 3.11291
[BP] GO:0001932 regulation of protein phosphorylation ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 3.11291
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP1, MMP12, MPO, POLA1, SMAD3, SRC 3.09137
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.08022
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 3.08022
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO 3.05985
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.02875
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.00064
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.99069
[BP] GO:0031399 regulation of protein modification process ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 2.98113
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97972
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.97462
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.97462
[BP] GO:0001934 positive regulation of protein phosphorylation ADRB2, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 2.97462
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.97462
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.95284
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC 2.95284
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, ADRB2, AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.94865
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 2.94339
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.91798
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.91691
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.91691
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.91004
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.87369
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.84582
[BP] GO:0051098 regulation of binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.80801
[BP] GO:0042327 positive regulation of phosphorylation ADRB2, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 2.80473
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC 2.80068
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.75763
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, FLT3, PTGS2, RORC, SRC 2.7461
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.7441
[BP] GO:0043408 regulation of MAPK cascade ADRB2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.73231
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.73231
[BP] GO:0019538 protein metabolic process ACHE, ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK 2.72309
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.72309
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.72309
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.72309
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.72309
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.72309
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.71943
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.71059
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.68947
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, PTGS2, SRC 2.67734
[BP] GO:0009968 negative regulation of signal transduction ADRB2, BCL2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.67563
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, PTGS2, SRC 2.67533
[BP] GO:0035556 intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, POLB, PTPN1, SRC, TEK 2.66865
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.66675
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SRC 2.66272
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2, TBXAS1 2.65988
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.64352
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.6262
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.61666
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.61393
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.59078
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.59078
[BP] GO:0007187 None ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, HTR6 2.59004
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56347
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56211
[BP] GO:0002025 None ADRB1, ADRB2 2.56211
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.532
[BP] GO:0009894 regulation of catabolic process ADRB2, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.52157
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.51551
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.51551
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.51551
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.51444
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.51444
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 2.51263
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC 2.49997
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 2.49735
[BP] GO:0043410 positive regulation of MAPK cascade ADRB2, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.48577
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.46602
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 2.46532
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, CHRM1, EGFR, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.46513
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.46513
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.46513
[BP] GO:0044267 cellular protein metabolic process ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK 2.46513
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.42754
[BP] GO:0050806 positive regulation of synaptic transmission ADRB2, CA2, CA7, EGFR, PTGS2 2.42754
[BP] GO:0040008 regulation of growth ADRB1, ADRB2, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, MPO, PIM1, SMAD3 2.42754
[BP] GO:0051247 positive regulation of protein metabolic process ADRB2, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.42754
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.4236
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.41528
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 2.41217
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.41217
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.4046
[BP] GO:0097746 None ADRB1, ADRB2, CHRM1, EGFR, PTGS2 2.39086
[BP] GO:0035296 None ADRB1, ADRB2, CHRM1, EGFR, PTGS2 2.39086
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.3773
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, MPO, RORC, SMAD3, SRC 2.37448
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ADRB2, ALPL, AXL, BCL2, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK 2.37448
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.37448
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37448
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.37448
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.37448
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.36665
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.3577
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35133
[BP] GO:0006940 None ADRB2, CHRM1, CHRM2, PTGS2 2.35133
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.34478
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.34297
[BP] GO:0009893 positive regulation of metabolic process ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.33856
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33856
[BP] GO:0051894 None KDR, SMAD3, TEK 2.33192
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.33149
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.32845
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, EGFR, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 2.30928
[BP] GO:0031325 positive regulation of cellular metabolic process ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.30746
[BP] GO:0050880 None ADRB1, ADRB2, CHRM1, EGFR, PTGS2 2.29577
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.29499
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.28711
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.28589
[BP] GO:0035150 None ADRB1, ADRB2, CHRM1, EGFR, PTGS2 2.28589
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.28242
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.2739
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.24789
[BP] GO:1903393 None KDR, SMAD3, TEK 2.24789
[BP] GO:0006464 cellular protein modification process ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK 2.23694
[BP] GO:0036211 protein modification process ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK 2.23694
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.2354
[BP] GO:0043549 regulation of kinase activity ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.23191
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.21531
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.21309
[BP] GO:0033554 cellular response to stress AKR1B1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, POLA1, POLB, PTGS2, PTPN1, SRC 2.21172
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.21172
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.21172
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PTGS2 2.20579
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.20372
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRB2, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.20372
[BP] GO:0051338 regulation of transferase activity ADRB2, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.20302
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.20279
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.16937
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, MPO, POLB, PTGS2 2.16412
[BP] GO:0045926 negative regulation of growth ADRB1, ADRB2, BCL2, HSPA1A, MPO, SMAD3 2.15513
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.14613
[BP] GO:0044093 positive regulation of molecular function ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.13768
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.13768
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.12709
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.12218
[BP] GO:0031401 positive regulation of protein modification process ADRB2, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 2.11519
[BP] GO:0008217 None ADRB1, ADRB2, PPARA, PTGS2, SMAD3 2.10098
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09927
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.09215
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, EGFR, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC, TYR 2.06443
[BP] GO:1901890 None KDR, SMAD3, TEK 2.06233
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06233
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.05623
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.04049
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.04049
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.04049
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.04049
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.0321
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.03117
[BP] GO:0007188 None ADRB1, ADRB2, CHRM1, CHRM2, CHRM4 2.0272
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.0272
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.01712
[BP] GO:0043085 positive regulation of catalytic activity ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.01606
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, EGFR, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.01235
[CC] GO:0098590 plasma membrane region ADRB2, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, EGFR, INSR, MET, PTGS2, SRC, TEK 2.84582
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRB1, ADRB2, AXL, CA4, CHRM1, CHRM2, CHRM4, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, TEK 2.83721
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRB1, ADRB2, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 2.82898
[CC] GO:0044459 plasma membrane part ADORA3, ADRB1, ADRB2, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DUSP3, EGFR, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, PTGS2, SRC, TEK 2.71546
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, TEK 2.51551
[CC] GO:0016020 membrane ACHE, ADORA3, ADRB1, ADRB2, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR6, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TEK, TYR 2.23483
[CC] GO:0044425 membrane part ACHE, ADORA3, ADRB1, ADRB2, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR6, IGF1R, INSR, KDR, MET, PTGS2, PTPN1, SRC, TBXAS1, TEK, TYR 2.2099
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0272
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PTGS2, PTPN1, SRC, TBXAS1, TEK, TYR, XDH 10.02
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.02
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 9.30423
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 8.06966
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.43174
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.88061
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.84832
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.62792
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.4684
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.38999
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.52517
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 5.4421
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 5.36968
[MF] GO:0008227 None ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, HTR6 4.97644
[MF] GO:0038023 signaling receptor activity ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.8483
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MPO, POLA1, PTGS2, SRC, TBXAS1, XDH 4.84063
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 4.51513
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.37826
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.37324
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 4.22199
[MF] GO:0004871 signal transducer activity ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 4.18262
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 4.18262
[MF] GO:0004872 receptor activity ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.15891
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.11912
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 4.11912
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 4.11912
[MF] GO:0060089 molecular transducer activity ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.00948
[MF] GO:0044877 macromolecular complex binding ACHE, ADRB2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.00195
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.88607
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.88607
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1, TYR 3.86
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80068
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.80068
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.68342
[MF] GO:0032403 protein complex binding ACHE, ADRB2, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.65159
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63581
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.41759
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.35982
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR6 3.08077
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.01057
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.83877
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.80028
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.62456
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.61393
[MF] GO:0004939 None ADRB1, ADRB2 2.56211
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.50479
[MF] GO:0019899 enzyme binding ADRB1, ADRB2, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, HSPA1A, MET, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.45175
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, INSR, KDR, SMAD3 2.41528
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.3882
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.32296
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.24789
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.24789
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.21172
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16861
[MF] GO:0051380 None ADRB1, ADRB2 2.16861
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.13768
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06233
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0272


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.5198
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5198
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.4188
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 5.4752
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0021
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 5.0528
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3558
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 4.7986
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.7734
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADRB1, ADRB2, PTGS2 4.7986
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.4153
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CHRM1, GPR35, ADORA3, CHRM4, ADRB1, ADRB2 4.4876
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, ADRB1, ADRB2, PPARA 4.4377
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3667
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.3685
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8891
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, CHRM1, ADRB1, ADRB2, EGFR 3.7778
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.719
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.8303
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.54
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2984
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1646
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.8041
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3566
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.8401
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 2.5283
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.1194
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3833
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.2889
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3391
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADRB1, ADRB2 2.1357
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3064
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.3328
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2751
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2272
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2691
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 2.0029
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9859
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.2043
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 2.0061
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6033
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8055
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9694
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, PTGS2 1.782
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5547
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7373
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.4267
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, ADRB2 1.4946
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.222
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0918
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0138
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1603
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9516
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1184
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.9586
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8918
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.1629
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9654
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRB2 1.1489
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9508
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9031
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3613
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8864
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1465
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8811
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2274
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8811
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9508
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8864
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8758
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4237
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8611
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3702
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8374
Renin secretion_Homo sapiens_hsa04924 ADRB1, ADRB2 1.3613
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3561
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8072
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7967
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4032
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3613
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7095
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7967
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3613
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.35
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5967
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3495
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3649
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4044
Phagosome_Homo sapiens_hsa04145 MPO 0.4044
Apoptosis_Homo sapiens_hsa04210 BCL2 0.431
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4431
Axon guidance_Homo sapiens_hsa04360 MET 0.4588
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4671
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4728
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4756
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5226
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5226
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5151
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5226
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5226
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5253
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5148
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5248
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5226
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5436
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5436
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5542
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1 0.5421
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5429
Peroxisome_Homo sapiens_hsa04146 XDH 0.5552
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5936
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5936
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5936
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5919
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5948
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5804
Bile secretion_Homo sapiens_hsa04976 CA2 0.5936
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6062
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5967
Shigellosis_Homo sapiens_hsa05131 SRC 0.6084
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6358
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6592
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6623
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6805
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8755
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6842
Malaria_Homo sapiens_hsa05144 MET 0.6962
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7003
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.83
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7577
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7095
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7716
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0524
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7983
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7983
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8611
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8251
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7983
Base excision repair_Homo sapiens_hsa03410 POLB 0.8072
DNA replication_Homo sapiens_hsa03030 POLA1 0.7967
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.838
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8633
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8339
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8611
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.045
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2288


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)