TCM Prescription: Bu Xin Qi Oral Liquid



Prescription Description
Prescription IDTCMF610
Pinyin NameBu Xin Qi Kou Fu Ye 
Chinese Name补心气口服液
English NameBu Xin Qi Oral Liquid
Function Description胸痹心痛
IndicationsCoronary heart disease, Angina pectoris
Disease ICD-11 Category BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ];
BA40 [Angina pectoris, 心绞痛 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH2309 Allium macrostemon 薤白 TCMH2309 ITSAL4510-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, KDR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SRC, TERT, XDH 10.596
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, HMGCR, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.69647
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 8.87426
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 8.75661
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGS2, SRC, TYR 8.5176
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 8.09342
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, HMGCR, MIF, PIK3CA, PIM1, PPARA, PTAFR, PTGS1, PTGS2, TYR, XDH 7.85806
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, GSK3B, HCAR2, HMGCR, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 7.43026
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, GSK3B, HCAR2, HMGCR, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 7.42375
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 7.42305
[BP] GO:0010033 response to organic substance AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTAFR, PTGS2, SRC, TYR 7.42305
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 7.16085
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.16085
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.16085
[BP] GO:0042221 response to chemical AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGS2, SRC, TERT, TYR 6.98185
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.7464
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.7464
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HMGCR, HSD17B1, HSD17B2 6.73384
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.64489
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, HMGCR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.58444
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GSK3B, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 6.49634
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 6.40549
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGS1, PTGS2 6.40549
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GSK3B, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.23034
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SLC1A1, SRC, TERT, XDH 6.21118
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGS1, PTGS2 6.21118
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, PTAFR, PTGS1, PTGS2, SRC, TERT, XDH 6.21118
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC 6.19714
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.16355
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.76202
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 5.74971
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.71942
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, GRM3, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.48064
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, SRC, TERT 5.44223
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 5.36376
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.34391
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.33737
[BP] GO:0051716 cellular response to stimulus AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, IGF1R, KDR, MIF, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, PTPN1, SRC, TERT 5.28648
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT 5.28648
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.28008
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.2274
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 5.18335
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 5.13613
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 5.13613
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 5.12979
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 5.12979
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 5.10588
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGS1, PTGS2 5.1033
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.1033
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.1033
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.1033
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD17B2, IGF1R, KDR, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR 5.09263
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 5.09263
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTAFR, PTGS2, SRC, TYR 5.08606
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SRC 5.08599
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 4.95423
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.94313
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.92333
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, GRIK5, GRM5, GSK3B, IGF1R, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, SRC 4.88071
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, PTAFR, PTGS2, TERT 4.87992
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC, TERT 4.71001
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.66319
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, PIK3CA, PTAFR, PTGS2, SRC 4.65741
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.61743
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.53485
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.49517
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.44933
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, MIF, PIK3CB, PTGS2, SRC 4.36861
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 4.36319
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF, PTAFR 4.34896
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.32599
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, MIF, PIK3CA, PIK3CB, PTPN1, SRC 4.19094
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.18377
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, GSK3B, HCAR2, HMGCR, MIF, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT 4.15942
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.15171
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2 4.11188
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, ESR1, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 4.04647
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SRC, TERT 3.99836
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.98197
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.97758
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.91305
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTAFR, PTGS2, SRC 3.91305
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 3.91125
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, SRC, TYR 3.81826
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.80988
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, MIF, PIK3CB, PTPN1, SRC 3.78812
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SRC, TERT 3.74709
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 3.681
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, GSK3B, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.65353
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TYR 3.63285
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1 3.62973
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.62284
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 3.62284
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, SRC 3.59544
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, PTGS2, SRC, TERT, TYR 3.59544
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTAFR, PTGS2, SRC, TYR 3.55127
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 3.53706
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 3.47768
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 3.47609
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR 3.43384
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SRC, TERT 3.42785
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTPN1, SRC 3.42063
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SRC, TERT 3.41829
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.40218
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SRC, TYR 3.37535
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, ESR1, FLT3, GRM1, GRM5, GSK3B, MET, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TERT, XDH 3.37535
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.37454
[BP] GO:0043393 regulation of protein binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.33876
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, FLT3, GRM1, HMGCR, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 3.32845
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.31144
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31144
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, XDH 3.31144
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, HMGCR, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.29865
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.28235
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, ESR1, FLT3, GRM1, GRM5, GSK3B, MIF, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TERT, XDH 3.26883
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.26883
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, ESR1, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 3.25374
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, SRC, TYR 3.24896
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 3.22708
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 3.22708
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB 3.22592
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, XDH 3.21206
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 3.18688
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 3.16423
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.15092
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.15092
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, ESR1, FABP4, GSK3B, HMGCR, IGF1R, MET, MIF, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.15092
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.13385
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGS2, SRC 3.12216
[BP] GO:1901698 response to nitrogen compound AKR1B1, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SRC, TYR 3.12136
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.09808
[BP] GO:0006793 phosphorus metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, XDH 3.09185
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, MIF, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2 3.09185
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, GRM1, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 3.09185
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TYR, XDH 3.07798
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, HMGCR, MIF, PTAFR, PTGS1, PTGS2 3.06734
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CSNK2A1, CYP2D6, ESR1, FABP4, GRM3, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.04331
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.03562
[BP] GO:0001516 None MIF, PTGS1, PTGS2 3.03562
[BP] GO:0046457 None MIF, PTGS1, PTGS2 3.03562
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.03562
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, GSK3B, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT 2.97762
[BP] GO:0051098 regulation of binding AURKB, CYP2D6, GSK3B, MET, MMP9, PPARA, SRC, TERT 2.96926
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.96926
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.95397
[BP] GO:0043408 regulation of MAPK cascade ADORA1, FLT3, GRM1, HMGCR, IGF1R, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 2.95397
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.92317
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC 2.92184
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, PTAFR, PTGS2, SRC 2.86008
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.81643
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GRIK5, GSK3B, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, XDH 2.80783
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.79752
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.79623
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.78813
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 2.78203
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GRIK5, GSK3B, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, XDH 2.78203
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, MIF, PIK3CB, PTPN1, SRC 2.77823
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.74872
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.72135
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GRM3, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.72135
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 2.71814
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CYP1B1, ESR1, GRM1, GSK3B, HCAR2, HMGCR, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, SLC1A1, SRC, TERT, XDH 2.70846
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.70532
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.68992
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, MIF, PIK3CB, PTPN1, SRC 2.68004
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.65618
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.65357
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTAFR, PTGS2, SRC 2.62937
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.62503
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 2.61191
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ESR1, GSK3B, HMGCR, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.61191
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.61104
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, GRM5, GSK3B, IGF1R, MMP2, PTAFR, PTGS2, SRC 2.6092
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ESR1, GSK3B, HMGCR, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.6086
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, ESR1, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, PIK3CA, PIK3CB, PTAFR, SRC 2.60678
[BP] GO:0099566 None GRM1, GRM5 2.58692
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58692
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, XDH 2.57912
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.57298
[BP] GO:0010942 positive regulation of cell death CYP1B1, GRIK5, GSK3B, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, XDH 2.5721
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, GSK3B, HCAR2, MIF, PTAFR, PTGS2, SRC, TERT 2.5708
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, ESR1, GSK3B, HMGCR, IGF1R, MET, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.56712
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.56712
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.56712
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.51011
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.51011
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, HMGCR, PTAFR, TYR 2.50136
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.49876
[BP] GO:0048015 phosphatidylinositol-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.49876
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.49783
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.49369
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, ESR1, FLT3, GRM5, GSK3B, IGF1R, MMP2, PTAFR, PTGS2, SRC 2.48033
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.46358
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.4614
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.45045
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, HCAR2, HMGCR, KDR, MET, MIF, MMP9, PIM1, PTAFR, PTGS2, SLC1A1, SRC, TERT 2.43631
[BP] GO:0048017 inositol lipid-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.43009
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.4284
[BP] GO:2001234 negative regulation of apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC, TERT 2.4284
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, GRM5, GSK3B, IGF1R, MMP2, PTAFR, PTGS2, SRC 2.42166
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41354
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 2.36725
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35984
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.34638
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34638
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34638
[BP] GO:0030335 positive regulation of cell migration IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 2.33656
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT, XDH 2.32881
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.3245
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.3245
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 2.29005
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 2.28731
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.27723
[BP] GO:0006693 None MIF, PTGS1, PTGS2 2.27723
[BP] GO:0006692 None MIF, PTGS1, PTGS2 2.27723
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, CSNK2A1, CYP2D6, ESR1, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, MET, MIF, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.25956
[BP] GO:2000147 positive regulation of cell motility IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 2.2492
[BP] GO:0050730 None ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.2489
[BP] GO:0007568 aging AURKB, CYP1A1, HMGCR, MIF, PTGS2, TERT 2.2489
[BP] GO:1904646 cellular response to amyloid-beta GRM5, GSK3B, IGF1R 2.23747
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 2.23747
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.20768
[BP] GO:0051246 regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 2.19572
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.19572
[BP] GO:0033032 regulation of myeloid cell apoptotic process HCAR2, MIF, PIK3CB 2.19572
[BP] GO:0051272 positive regulation of cellular component movement IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 2.17836
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.17575
[BP] GO:0008217 None ADORA1, PPARA, PTAFR, PTGS1, PTGS2 2.16344
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, MIF, PIK3CB, PTPN1, SRC 2.15822
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, PTAFR, PTGS2, SRC 2.15822
[BP] GO:0006636 unsaturated fatty acid biosynthetic process MIF, PTGS1, PTGS2 2.15822
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC 2.13002
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.12075
[BP] GO:1904645 response to amyloid-beta GRM5, GSK3B, IGF1R 2.12075
[BP] GO:0070542 None FABP3, PTAFR, PTGS2, SRC 2.1204
[BP] GO:1901570 None ALOX5, MIF, PTGS1, PTGS2 2.1204
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, GSK3B, MET, PPARA 2.10022
[BP] GO:0003018 None ADORA1, HMGCR, PTAFR, PTGS2, SRC 2.10022
[BP] GO:0040017 positive regulation of locomotion IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 2.09377
[BP] GO:0007188 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.08995
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.089
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, FABP4, HMGCR, KDR, MET, MIF, PPARA, PTGS2 2.07227
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC 2.07103
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.05423
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.05423
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.04931
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, GSK3B, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 2.03476
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, HMGCR, PTAFR, TYR 2.03476
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.03476
[BP] GO:0033029 regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.03476
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.03476
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.03476
[BP] GO:0080135 regulation of cellular response to stress GSK3B, HMGCR, IGF1R, MET, MIF, PTGS2, PTPN1, TERT, XDH 2.00643
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, SLC1A1, SRC, TERT 4.94588
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TYR 4.44933
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 4.36879
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.63285
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 3.31144
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, SRC 3.0537
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTGS2, SLC1A1, SRC 2.65202
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 2.6092
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.60197
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.55497
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.55497
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 2.27723
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GSK3B, HMGCR, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 2.2703
[CC] GO:0098794 None ADORA1, GRIA2, GRIA4, GRM3, GSK3B 2.13002
[CC] GO:0005783 None ADORA1, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, KDR, PTGS2, PTPN1, XDH 2.08434
[CC] GO:0043005 None ADORA1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 2.03558
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.03476
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.92829
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TYR, XDH 8.89273
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.40277
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, GSK3B, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 7.98534
[MF] GO:0043167 ion binding ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TYR, XDH 7.49366
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.58444
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.5445
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.76778
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.57754
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.44223
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.36376
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.23188
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.12979
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR 5.1033
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR 4.65874
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, GSK3B, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 4.61743
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.22526
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 4.00928
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR 3.98097
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 3.92868
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR 3.84949
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR 3.84949
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR 3.81613
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1 3.80988
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.63285
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.59785
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR 3.47119
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH 3.27102
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.27059
[MF] GO:0043169 cation binding ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, TERT, TYR, XDH 3.26883
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.25248
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.22708
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.22105
[MF] GO:0046872 metal ion binding ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, TERT, TYR, XDH 3.0242
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.97045
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.97045
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.96926
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.70652
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.68992
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, XDH 2.68965
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, TERT, TYR, XDH 2.67877
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.67877
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.6092
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.6092
[MF] GO:0099583 None GRM1, GRM5 2.58692
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.56712
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.55027
[MF] GO:0004971 None GRIA2, GRIA4 2.34638
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.31998
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, SLC1A1, SRC, XDH 2.12864
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.089
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2 2.03647
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03476


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.8729
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3965
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.1014
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.6133
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, PTAFR, GRM8, ADORA1, GRM1, GRIA4 6.6133
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.4461
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1 6.4461
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.408
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.4461
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.8105
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 4.5638
Focal adhesion_Homo sapiens_hsa04510 GSK3B, PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 4.5638
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 4.5638
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 4.3642
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.5369
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.9559
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, PIK3CB, PPARA 3.8196
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.7091
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.5865
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 3.7091
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 3.4876
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7091
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2038
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.5071
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.4612
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4876
Prostate cancer_Homo sapiens_hsa05215 GSK3B, PIK3CA, PIK3CB, IGF1R 3.1684
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.4302
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.9952
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, PIK3CA, SRC, PIK3CB 3.1929
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.0202
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.3368
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8658
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.2785
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.7428
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, PTGS2, PTGS1 2.8477
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.7428
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.7086
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.757
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.7731
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.7428
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.6602
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, PIK3CA, PIK3CB 2.633
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, PPARA 2.6602
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, PIK3CA, PIK3CB 2.6156
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.5782
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, PIK3CA, PIK3CB, IGF1R 2.6068
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, PIK3CB, PPARA 2.555
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.4896
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.4154
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, PIK3CA, PIK3CB 2.7428
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3034
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, PIK3CB 2.1625
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, PIK3CA, SRC, PIK3CB 2.2703
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.6158
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9952
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.5782
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, PIK3CA, PIK3CB 2.6068
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.5735
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.16
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, PIK3CA, PIK3CB 2.4651
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.1985
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 2.1077
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 2.0383
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8681
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, PIK3CA, TERT, PIK3CB 1.8687
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.5698
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.6068
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, PIK3CA, PIK3CB 2.1057
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.2886
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.5698
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 2.2703
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, PIK3CA, PIK3CB 1.967
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.9813
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.6874
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GSK3B, GRIA4 1.8962
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2745
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.5661
Influenza A_Homo sapiens_hsa05164 GSK3B, PIK3CA, PIK3CB 1.5882
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3576
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3686
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3793
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3785
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.3921
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4211
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.4133
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.4573
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4953
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2231
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5648
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.0825
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0843
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5819
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 1.0475
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0994
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5809
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 1.0753
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1129
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5952
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5964
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5964
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 1.1535
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5964
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.1388
Taste transduction_Homo sapiens_hsa04742 GRM1 0.6121
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5964
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2645
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5964
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3404
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.2988
Peroxisome_Homo sapiens_hsa04146 XDH 0.6121
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3495
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2756
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2988
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2948
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3068
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.3275
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.3404
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6523
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6501
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6655
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5148
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6944
Shigellosis_Homo sapiens_hsa05131 SRC 0.6914
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5552
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5661
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.5583
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5331
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.6258
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.5331
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.5693
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.5552
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.5478
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.7442
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.7481
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6733
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6349
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.7752
Malaria_Homo sapiens_hsa05144 MET 0.7846
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7799
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7981
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8033
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.7747
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7867
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8359
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.93
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.914
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.1077
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.9996
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0644
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9897
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9813
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2886
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0161
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 1.0843
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.1746
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3368


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)