Prescription Description
| Prescription ID | TCMF6069 |
| Pinyin Name | Yang Yin Jiang Tang Pian |
| Chinese Name | 养阴降糖片 |
| English Name | Yang Yin Jiang Tang Tablets |
| Function Description | 消渴 |
| Indications | Wasting thirst disorder, Diabetes |
| Disease ICD-11 Category |
SD71 [Wasting thirst disorder (TM1), 消渴 (TM1)
]; 5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ]; |
| Human Tissues Associated with Indication | Pancreas, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH677 | Pueraria lobata | 葛根 | TCMH677 | ITSAJ4206-14 |
| TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
| TCMH2343 | Scrophularia ningpoensis | 玄参 | TCMH2343 | ITSAO4295-14 |
| TCMH2551 | Polygonatum odoratum | 玉竹 | TCMH2551 | ITSAM921-14 |
| TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
| TCMH2624 | Anemarrhena asphodeloides | 知母 | TCMH2624 | GBVA3255-11, GBVU1201-13 |
| TCMH1513 | Paeonia moutan | 牡丹皮 | TCMH1513 | |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH921 | Polygonum cuspidatum | 虎杖 | TCMH921 | ITSAI2369-14 |
| TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT132 | BCHE | Butyrylcholinesterase | Hydrolase | P06276 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
Showing 1 to 10 of 98 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 59 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 3.49958 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.84233 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.42584 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.57506 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 4.83273 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, BCL2, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 2.27196 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC | 2.28919 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.73961 |
| [BP] GO:0006091 | generation of precursor metabolites and energy | AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH | 2.02928 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.27196 |
Showing 1 to 10 of 319 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.6521 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.3391 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.624 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.5993 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 3.8959 |
| Alcoholism_Homo sapiens_hsa05034 | MAOB | 0.3508 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.7742 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.1649 |
| Amphetamine addiction_Homo sapiens_hsa05031 | MAOB | 0.6356 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.7484 |
Showing 1 to 10 of 158 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples