TCM Prescription: Xiao Er Jin Shi Tablets



Prescription Description
Prescription IDTCMF5996
Pinyin NameXiao Er Jin Shi Pian
Chinese Name小儿进食片
English NameXiao Er Jin Shi Tablets
Function Description积滞, 厌食
IndicationsDyspepsia, Anorexia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
MG43.7 [Anorexia, 纳差 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1171 Aspongopus 九香虫 TCMH1171
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1237 Mycobacterium kansasii
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, POLB, PPARA, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.6517
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IDO1, IGF1R, INSR, MPO, POLB, PPARA, PTAFR, PTGS2, RORC, SRC, TEK, TYR 10.3764
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 10.1833
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, POLB, PPARA, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.6254
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.25086
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.25086
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, MPO, PTAFR, PTGS2, RORC, SRC, TYR 8.13576
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 8.01713
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.82415
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.71176
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.65109
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.55687
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.4289
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HMGCR, HSPA1A, IDO1, MPO, PIM1, PPARA, PTAFR, PTGS2, TBXAS1, TYR, XDH 7.42187
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.23401
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR6, INSR, KDR, MET, PTGS2, PTPN1, SRC, TEK, XDH 7.19247
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 7.16993
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.11362
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.94393
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.94393
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, NUAK1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.76732
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, NUAK1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.7361
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, PTGS2, TBXAS1 6.66259
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.58941
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK 6.51658
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.50543
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, PTAFR, PTGS2, SRC, TEK 6.48917
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 6.48872
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSPA1A, MPO, POLB, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TYR 6.4315
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MPO, NUAK1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR 6.40583
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.30231
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 6.24873
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.22973
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.98254
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTAFR, PTGS2, RORC, SRC, TEK, TYR 5.97518
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC 5.95232
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK 5.95232
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 5.93932
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 5.93003
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, POLA1, POLB, SMAD3, SRC 5.92537
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IDO1, IGF1R, INSR, MET, MMP12, MPO, PIM1, PPARA, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TYR 5.77207
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.73118
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.6491
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.6491
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 5.56488
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.39534
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, PTAFR, PTGS2, RORC, SMAD3, SRC 5.31346
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.31053
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.29127
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.26257
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, PTAFR, PTGS2, RORC, SMAD3, SRC 5.25429
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPN1, SMAD3, SRC, TEK 5.1695
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.15785
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.15785
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 5.11194
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC, TEK 4.9056
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 4.88126
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 4.86314
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, PTGS2, SRC 4.8273
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, NUAK1, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.69229
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 4.55137
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.48627
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGS2, TBXAS1 4.45834
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, INSR, MMP12, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC 4.43902
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4096
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.37748
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2 4.37748
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, POLB, PTAFR, PTGS2, SRC 4.37113
[BP] GO:0007193 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8 4.25469
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 4.25133
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, PIM1, PTAFR, PTGS2, TEK 4.21628
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 4.18315
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 4.17023
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 4.17023
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IDO1, IGF1R, MET, MMP12, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.15753
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 4.02544
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HMGCR, HSD17B2, INSR, KDR, MET, MPO, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.01258
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.98124
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK 3.96495
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.94274
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.9357
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 3.9294
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 3.90785
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, HMGCR, KDR, PTGS2, SRC 3.90389
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 3.90389
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HMGCR, HSPA1A, IDO1, KDR, MET, MMP12, PIM1, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK 3.887
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 3.887
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK 3.887
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.8223
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SMAD3, SRC, TEK 3.80809
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, PTGS2, SRC 3.79928
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.77634
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 3.75114
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.74727
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.73997
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTAFR, PTGS2, SRC 3.73997
[BP] GO:0003018 None ADORA1, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 3.73997
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.72996
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.72876
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 3.72846
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 3.72251
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.71782
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.70686
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HMGCR, HSD17B1, HSD17B2 3.69007
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.68581
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.68581
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 3.68581
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRM2, CYP1B1, EGFR, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, IDO1, INSR, KDR, MET, MMP12, PIM1, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 3.68187
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 3.67852
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.66589
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, EGFR, GPR35, GRM1, HCAR2, PTAFR, PTGS2, SLC1A1, SMAD3 3.63736
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.63736
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.63736
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.63666
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.63666
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.62715
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.62715
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, PIM1, PPARA, PTGS2, PTPN1, SRC 3.60435
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, PTAFR, PTGS2, SRC, TEK, TYR 3.60215
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.57702
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.57608
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.56307
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, MPO, PTGS2, SRC, TYR 3.51834
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 3.51504
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.4813
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, IDO1, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.46228
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC 3.45281
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MPO, PTGS2, SRC 3.45099
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 3.45023
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.4391
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK 3.40525
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.40225
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.40225
[BP] GO:0007187 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8, HTR6 3.38891
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, FLT3, PTAFR, PTGS2, RORC, SRC 3.38891
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.38049
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTAFR, PTGS2, SMAD3, SRC 3.36751
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.36668
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK 3.32987
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 3.30871
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, EGFR, HMGCR, IDO1, MMP12, MPO, PTAFR, PTGS2, SMAD3, SRC, TYR 3.30721
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, PTAFR, PTGS2, SRC, TEK, TYR 3.30406
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.29492
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, PTAFR, PTGS2, SMAD3, SRC 3.27009
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26139
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 3.26139
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.23118
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 3.19673
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTAFR, PTGS2, SMAD3, SRC 3.19587
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTAFR, PTGS2, SRC 3.18103
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 3.16586
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 3.15096
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, PTAFR, PTGS2 3.13554
[BP] GO:0003013 None ADORA1, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 3.11714
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.11414
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.09462
[BP] GO:0007268 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.09462
[BP] GO:0098916 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.09462
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.09296
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PTGS2, SLC1A1, TEK 3.08774
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.08774
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 3.07416
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.06838
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 3.06838
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.06838
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.06286
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 3.05426
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTAFR, PTGS2 3.05236
[BP] GO:0099536 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.04871
[BP] GO:0099537 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.04871
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO, NUAK1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK 3.04149
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.04116
[BP] GO:0042391 None ADORA1, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.02607
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 3.02529
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.02529
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, PTAFR, PTGS2, RORC, SRC 3.02233
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, MPO, PTGS2, SRC, TYR 2.9908
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HMGCR, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SRC, XDH 2.9744
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96781
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.93526
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.93526
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, HMGCR, PTAFR, TYR 2.92623
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO 2.90664
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.90329
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.86953
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.86293
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.85765
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, HMGCR, MPO, POLB, PTGS2 2.85765
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTAFR, PTGS2, SRC 2.85765
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MPO, POLA1, PTAFR, SMAD3, SRC 2.84184
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.83413
[BP] GO:0007188 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8 2.82367
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.81358
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK 2.8051
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.79839
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.77945
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.76513
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, HMGCR, IDO1, MPO, PTAFR, PTGS2 2.76257
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.75489
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.75426
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 2.72888
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.72498
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.72216
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.67886
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.67509
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.67428
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.66586
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.6617
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.6617
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.6617
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.6617
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 2.65214
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.63759
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.62548
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, SRC 2.59838
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.59409
[BP] GO:0010676 None INSR, PPARA, PTAFR, SRC 2.59409
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.57622
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.55831
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.55831
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.55831
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.55831
[BP] GO:0099566 None GRM1, GRM5 2.55831
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55831
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.55831
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.55304
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.55304
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.55304
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.55304
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP12, MPO, SRC, XDH 2.55304
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.55304
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, PTGS2, SRC 2.5327
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2, TBXAS1 2.53205
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.51453
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.49015
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, IDO1, PTGS2, SMAD3, SRC, XDH 2.49015
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.48833
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 2.48085
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.47997
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.47997
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, IDO1, PTGS2, SMAD3, SRC, XDH 2.46305
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.45877
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.44906
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.44107
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.44107
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.44107
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MMP12, PTAFR, SRC 2.43821
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, POLB, PTAFR, PTPN1, SRC, TEK 2.43307
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.41822
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.40871
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC 2.4038
[BP] GO:0007267 None ADORA1, CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1, TEK 2.4038
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.40182
[BP] GO:1903522 None ADORA1, ADORA3, CHRM2, EGFR, PTAFR, PTGS2, SLC1A1 2.39763
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.39387
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.38894
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.3688
[BP] GO:0010675 None INSR, PPARA, PTAFR, RORC, SRC 2.3688
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, PTAFR, PTGS2, SRC 2.36111
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, IDO1, MMP12, PTAFR, PTGS2, SMAD3, SRC 2.36111
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PTAFR, PTGS2, SRC, TEK, TYR 2.35919
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.35919
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34911
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.3476
[BP] GO:0097746 None ADORA1, EGFR, HMGCR, PTAFR, PTGS2 2.33317
[BP] GO:0035296 None ADORA1, EGFR, HMGCR, PTAFR, PTGS2 2.33317
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33317
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 2.33296
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PTGS2, SRC, TEK 2.32023
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.30691
[BP] GO:0006940 None ADORA1, CHRM2, PTAFR, PTGS2 2.30691
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 2.30691
[BP] GO:0051894 None KDR, SMAD3, TEK 2.30657
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, PTAFR, PTGS2 2.27783
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.2716
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.26103
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, IDO1, PTGS2, SMAD3, SRC, XDH 2.25381
[BP] GO:0045913 None INSR, PPARA, PTAFR, SRC 2.24409
[BP] GO:0051246 regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.24301
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.23912
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.23094
[BP] GO:0050880 None ADORA1, EGFR, HMGCR, PTAFR, PTGS2 2.23093
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.22548
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.22449
[BP] GO:1903393 None KDR, SMAD3, TEK 2.22449
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3 2.22449
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.22449
[BP] GO:0035150 None ADORA1, EGFR, HMGCR, PTAFR, PTGS2 2.22449
[BP] GO:0007610 None BCL2, EGFR, GRM1, GRM5, HMGCR, IDO1, INSR, PPARA, PTGS2 2.22449
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.21728
[BP] GO:0031644 None ADORA1, GPR35, GRM1, PTAFR 2.214
[BP] GO:1903524 None EGFR, PTAFR, PTGS2, SLC1A1 2.214
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.21236
[BP] GO:0090087 None ACHE, ADORA1, CA2, EGFR, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.21236
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MPO, PTAFR, RORC, SMAD3, SRC 2.21236
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.18919
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.18919
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, PTAFR, PTGS2, SRC 2.17787
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.17608
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, INSR, PTAFR, SRC 2.17467
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, MMP12, PTAFR, SRC 2.17467
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, FLT3, GRM5, IGF1R, INSR, PTAFR, PTGS2, SMAD3, SRC 2.17115
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.17115
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, PTGS2 2.16857
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.15375
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PTGS2 2.12323
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.11194
[BP] GO:0023052 None ADORA1, CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1, TEK 2.1061
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.10187
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, XDH 2.08326
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 2.08326
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, PTPN1, SRC 2.08044
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.07509
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.07509
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.04523
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.04318
[BP] GO:1901890 None KDR, SMAD3, TEK 2.03746
[BP] GO:0008217 None ADORA1, PPARA, PTAFR, PTGS2, SMAD3 2.03706
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.03594
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.03594
[BP] GO:0070542 None FABP3, PTAFR, PTGS2, SRC 2.03095
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02243
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.00445
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK 6.54256
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM2, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, SLC1A1, SRC, TEK 5.25429
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, TEK 4.7424
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PIM1, PTAFR, PTPN1, SLC1A1, SMAD3, SRC, TEK 4.37846
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, TEK 4.37186
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HTR6, IGF1R, INSR, KDR, MET, PTAFR, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TYR 4.29616
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HTR6, IGF1R, INSR, KDR, MET, PIM1, PTAFR, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR 3.74811
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.49482
[CC] GO:0097060 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.13554
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.85765
[CC] GO:0044456 None ACHE, ADORA1, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.67428
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.48085
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 2.36971
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.36496
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.36496
[CC] GO:0043005 None ADORA1, CA2, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 2.2716
[CC] GO:0005783 None ADORA1, BCL2, CA4, CYP19A1, FLT3, GRIK5, HMGCR, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.26103
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR6, PTGS2, SRC, TEK 2.11479
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02243
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82419
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.05068
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, PTAFR, RORC, TEK 7.69634
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.31885
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PTGS2, PTPN1, SRC, TBXAS1, TEK, TYR, XDH 7.23401
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PTAFR, TEK 7.05219
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PTAFR, TEK 7.05219
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.94912
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, PTAFR, RORC, TEK 6.94393
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, PTAFR, RORC, SMAD3, TEK 6.87812
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.87222
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, PTAFR, RORC, TEK 6.7361
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.7361
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 6.7361
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.51639
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.4315
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.30231
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 5.95772
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, IDO1, MPO, POLA1, PTGS2, SRC, TBXAS1, XDH 5.50043
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.39534
[MF] GO:0030594 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR6 4.59194
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 4.34231
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.27768
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.17023
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.77634
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1, TYR 3.73997
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7325
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.68581
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.64688
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.63736
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58707
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.47786
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.38891
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 3.16586
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.13441
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH 3.088
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TYR, XDH 3.0493
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.95852
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SLC1A1, SRC, TEK, XDH 2.88981
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 2.83382
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TYR, XDH 2.82704
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.8051
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, GRM5, HMGCR, HSPA1A, MET, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK 2.5805
[MF] GO:0099583 None GRM1, GRM5 2.55831
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.55304
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.55304
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.55304
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.40699
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.39645
[MF] GO:0004971 None GRIA2, GRIA4 2.33317
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, GRM5, POLA1, PTAFR, PTPN1, SMAD3, SRC 2.26103
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.26103
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.25482
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.22449
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP12, PPARA, PTPN1, RORC, SMAD3 2.214
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.18917
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, PTAFR, SLC1A1, SRC, TEK, XDH 2.17115
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16865
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.15375
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.11194
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, GRM5, POLA1, PTAFR, PTPN1, SMAD3, SRC 2.04212
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03746
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02243


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.2733
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GPR35, GRIK5, PTAFR, GRM1, GRM3, HTR6, GRM5, ADORA3, GRM8, ADORA1, GRIA4 9.4526
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2733
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2938
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.8739
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 4.991
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9863
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, HTR6, ADORA1, PPARA, GRIA4 4.051
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.9352
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.6338
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.8661
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5805
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.5805
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.8661
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, GRM5, PTAFR, GRM1, EGFR 3.5203
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.5805
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.3058
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MET, EGFR, CDC25B 3.3058
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.4685
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0997
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.1853
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, BCL2, PTGS2, MET, EGFR, IGF1R 2.6661
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, GRM1, EGFR, HSPA1A 2.6722
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.4641
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1, EGFR 2.8505
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.9504
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2179
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2235
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1864
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.2121
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1615
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.156
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 1.9027
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1213
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1505
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1 1.7647
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8874
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6801
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0985
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1448
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6925
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8444
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, PTGS2 1.6786
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5156
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.6343
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6231
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4748
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.6094
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.4568
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.3802
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.338
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1763
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.1309
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9097
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8542
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0678
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8781
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8655
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1091
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9027
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1329
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.848
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0893
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8419
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8419
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.848
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0866
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8156
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.1361
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7986
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7706
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3237
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2018
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7533
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3202
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3278
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.667
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3826
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7493
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3273
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5591
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3427
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.338
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3178
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3815
Phagosome_Homo sapiens_hsa04145 MPO 0.3815
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3891
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.312
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4049
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4171
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2713
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3237
Axon guidance_Homo sapiens_hsa04360 MET 0.4327
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3688
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4411
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3237
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4467
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4496
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.4717
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.486
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4935
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4935
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4935
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4951
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4856
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5002
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4996
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.513
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5139
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5139
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4773
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5242
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5139
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.523
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4595
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5139
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5139
Peroxisome_Homo sapiens_hsa04146 XDH 0.5242
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5591
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5591
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5591
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5574
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5458
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5608
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6094
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5763
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5627
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5809
Shigellosis_Homo sapiens_hsa05131 SRC 0.5786
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7744
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6144
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6295
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6295
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6295
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6472
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7395
Malaria_Homo sapiens_hsa05144 MET 0.667
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6674
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6772
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6803
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9598
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.743
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7706
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7706
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8327
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7986
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7706
Base excision repair_Homo sapiens_hsa03410 POLB 0.7773
DNA replication_Homo sapiens_hsa03030 POLA1 0.7632
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8125
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8389
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.803
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8327
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8735
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0426
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0997


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)