TCM Prescription: Shao Shang Fu Kang Oral Liquid



Prescription Description
Prescription IDTCMF5837
Pinyin NameShao Shang Fu Kang Ye
Chinese Name烧伤肤康液
English NameShao Shang Fu Kang Oral Liquid
Function Description水火烫伤, 痱子, 湿疹
IndicationsEczema, Miliaria
Disease ICD-11 Category EA8Z [Dermatitis or eczema, unspecified, 皮炎或湿疹，未特指 ];
EE02 [Miliaria, 痱 ];
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH462 Sanguisorba officinalis 地榆 TCMH462 GENG545-14, GBVT2403-13
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH1714 Lonicera japonica 忍冬藤 TCMH1714 ITSAI3881-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, TYR, XDH 10.9714
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TYR 10.9714
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SRC, TYR 10.0001
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SRC, TYR 10.0001
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 9.78734
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC, TYR 9.43057
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, TYR, XDH 9.09299
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCHE, BCL2, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, PTGS1, PTGS2, SRC, XDH 8.09338
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TYR 8.08124
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC, SRC 7.96059
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC 7.93522
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 7.73092
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.29276
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.27369
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.17469
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, XDH 7.16944
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC, SRC 7.0529
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PTGS2, SRC 6.96362
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, RORC, SRC 6.91252
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.82253
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.73905
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 6.68607
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SRC, XDH 6.58654
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC 6.58654
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SRC, TYR 6.46491
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 6.33878
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F10, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 6.2598
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, TYR, XDH 6.15115
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.15115
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.13397
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 6.10119
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.09653
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 6.08932
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1, RORC 5.92733
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, TYR, XDH 5.91507
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 5.83109
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 5.72236
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SRC, XDH 5.70464
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.65864
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PTGS1, PTGS2, RORC, SRC, TYR 5.61073
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.61073
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 5.49194
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 5.36201
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 5.34446
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.3148
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.30955
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PIK3CA, SRC, TYR 5.29965
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 5.29352
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 5.2531
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.2531
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.23594
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.22503
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PGR, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 5.20432
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.17114
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCHE, BCL2, CA2, FLT3, NR3C1, PTGS2, SRC 5.09481
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 5.08346
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.98892
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC 4.80124
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.69976
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.67028
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.65654
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.63321
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.51881
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.51881
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 4.49597
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.49062
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.39636
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.39127
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC 4.3479
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.27914
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, RORC, SRC, XDH 4.24361
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 4.15291
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.15291
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC 4.14139
[BP] GO:0042493 response to drug AKR1B1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, DRD1, FABP3, KDR, NR3C1, PTGS2, SRC 4.06969
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 3.97416
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 3.97406
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, RORC, SRC, XDH 3.9571
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, FLT3, NR3C1, PTGS2, SRC 3.93752
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.93752
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, RORC, SRC, XDH 3.92828
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, TYR 3.90648
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, RORC, SRC, XDH 3.90648
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PGR, PTGS2, SRC 3.90203
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 3.88808
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, BCHE, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1 3.87214
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.85575
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 3.82241
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.77385
[BP] GO:0009820 alkaloid metabolic process BCHE, CYP1A2, CYP3A4 3.72079
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PTGS2, RORC, SRC, XDH 3.68457
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.66634
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, DRD1, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.66634
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, DRD1, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.66634
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.62248
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, DRD1, PTGS2 3.53145
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.47332
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, KDR, PIK3CB, PTGS2, SRC 3.45195
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, PTGS2 3.43981
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.4288
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PTGS2, SRC 3.4288
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCHE, BCL2, CBR1, CYP1A1, DRD1, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC 3.42624
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CYP19A1, ESR1, ESRRB, HSD17B2, PGR, PTGS2, SRC 3.41829
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.37184
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, PTGS2, SRC 3.36171
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.31453
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.29273
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27443
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 3.22536
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 3.22535
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, KDR, SRC 3.22535
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.21699
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, TYR, XDH 3.21009
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, KDR, SRC 3.19144
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BCHE, CA2, CA7, DRD1, PTGS2 3.18811
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BCHE, CA2, CA7, DRD1, PTGS2 3.18811
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.16886
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.16886
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, FLT3, NR3C1, PTGS2 3.1612
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PTGS2, RORC, SRC, XDH 3.12639
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.10064
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, TYR 3.08949
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.06613
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.03067
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PTGS2, RORC, SRC 3.00628
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.00628
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, ESR1, PGR, PTGS2, SRC 2.98515
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCHE, BCL2, DRD1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, XDH 2.9816
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCHE, BCL2, DRD1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, XDH 2.97053
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96926
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC 2.96882
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, SRC, TYR, XDH 2.94322
[BP] GO:0009115 None AOX1, XDH 2.91912
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.91912
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, ESRRB, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.89243
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89033
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.87616
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.84426
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, DRD1, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.84042
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.72177
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72177
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, RORC, SRC 2.68462
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.68276
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, DRD1, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.68276
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, DRD1, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.66692
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, DRD1, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.64199
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.63521
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.6078
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.6078
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 2.60207
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.59954
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.59954
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, BCHE, DRD1, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC, TYR 2.59954
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, BCHE, CSNK2A1, DRD1 2.59836
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PTGS2, RORC, SRC 2.57484
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.54946
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.52436
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.51842
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.51842
[BP] GO:0060748 None AR, PGR 2.51842
[BP] GO:0046110 None AOX1, XDH 2.51842
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51842
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PGR, RORC, SRC 2.50569
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.45937
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, MET, PIK3CA 2.45382
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.42701
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.42701
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 2.39043
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.36864
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC 2.35946
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.35747
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.35626
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.35626
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.35626
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, BCHE, DRD1, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC, TYR 2.35626
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PTGS2, RORC, SRC, XDH 2.34953
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.34498
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.34498
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.32965
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32965
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.32846
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.3214
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.31812
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, ESR1, F3, FABP4, FLT3, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.30989
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.30839
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.28669
[BP] GO:0006145 None AOX1, XDH 2.28669
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28669
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, SRC 2.28239
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, MMP2, PTGS2, SRC, TYR 2.27326
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TYR 2.27323
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.24974
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCHE, BCL2, CYP1B1, FABP3, PTGS2, XDH 2.24974
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.1987
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.1987
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR, XDH 2.1987
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, PIK3CB, PTGS2 2.1804
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.15334
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, SRC 2.14439
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.13358
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.11114
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, PGR, SRC 2.09954
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.09954
[BP] GO:0010641 None F3, SRC 2.09954
[BP] GO:0007598 None F10, F3 2.09954
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.09513
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.0778
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.07662
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, TYR 2.06235
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCHE, BCL2, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, KDR, MMP2, MMP9, PTGS2, RORC 2.04851
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.04499
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, PIK3CA, TYR 2.04499
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, ESR1, F3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.02468
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.01012
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.01012
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.01012
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 2.01012
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, NR3C1, RORC, SRC 2.01012
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.01012
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.01012
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE 3.55143
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TYR, XDH 2.98093
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F10, FLT3, HSD17B2, NR3C2, PTGS1, PTGS2 2.96603
[CC] GO:0031233 None CA4, F10, F3 2.47839
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TYR 2.47839
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, HSD17B2, NR3C2, PTGS1, PTGS2 2.0075
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, RORC, TYR, XDH 18.1141
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, TYR, XDH 14.2308
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.9714
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2989
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 9.43057
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PTGS1, PTGS2, RORC, TYR, XDH 9.32907
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, RORC 9.30585
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TYR, XDH 8.94674
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PTGS1, PTGS2, RORC, TYR, XDH 7.49257
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.25263
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, RORC 6.91252
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, RORC 6.91252
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC 6.85954
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.62085
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.80302
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.60223
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.49313
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.36663
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.26781
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TYR 5.07374
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.07308
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.98303
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 4.46878
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 4.26706
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1 4.20066
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.17956
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.95195
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC 3.80557
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 3.80557
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.68457
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 3.63464
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.59045
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCHE, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PGR, PTGS2, TYR, XDH 3.55143
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.52537
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.41
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 3.28357
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.16886
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.1612
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.91912
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91912
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.91912
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.87616
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, XDH 2.84042
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.60207
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.51842
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.51842
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.51342
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.50513
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.45582
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.43821
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, RORC, SRC, XDH 2.42701
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28669
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28669
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28669
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.22806
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09954
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09954
[MF] GO:0004252 None F10, F3, MMP1, MMP12, MMP2, MMP9 2.00243


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.7655
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3042
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.6341
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.3982
Pathways in cancer_Homo sapiens_hsa05200 AR, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 6.2131
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.2827
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.2827
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.7044
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 5.0166
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.51
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7932
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.5078
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.5078
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.5078
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, BCL2, PIK3CB, IGF1R 4.1669
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.6061
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.5174
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1752
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6354
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1669
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.6061
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.3311
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.5575
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.4011
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.4824
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 3.2152
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.5158
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.3477
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, IGF1R 2.978
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.3057
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1698
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.8091
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8119
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.9083
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.6684
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.8063
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.6459
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.7102
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.754
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.754
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.754
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.5035
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.3862
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.3064
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2039
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.0695
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB, DRD1 2.0781
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.4772
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.5082
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4873
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB, NR3C2 2.978
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.0695
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.181
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.1011
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.467
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7575
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.1066
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.4288
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.8677
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.8447
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7642
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.755
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.7338
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.4288
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.8416
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, NR3C1 1.6934
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6857
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4645
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3888
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.3455
Purine metabolism_Homo sapiens_hsa00230 XDH 0.371
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3633
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3814
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3694
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3694
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3814
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4349
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4349
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1696
Axon guidance_Homo sapiens_hsa04360 MET 0.4651
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.4626
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6661
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 0.9851
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.0356
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0589
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0128
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0498
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0356
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8861
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8948
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 1.0572
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5461
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2132
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB 1.1985
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5455
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2372
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5591
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2227
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3021
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5583
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2406
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2227
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2893
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2522
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5763
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3021
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5786
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5786
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5774
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.3198
Peroxisome_Homo sapiens_hsa04146 XDH 0.5943
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4847
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4516
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4516
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6373
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4935
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6353
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3923
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4645
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4645
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4847
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5666
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6661
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6726
Shigellosis_Homo sapiens_hsa05131 SRC 0.6726
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6726
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.694
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6128
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.575
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6688
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7555
Malaria_Homo sapiens_hsa05144 MET 0.768
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7185
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.768
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.755
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7742
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7693
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7426
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0345
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.9165
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8993
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9863
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 2.0566
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9337
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2039
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9539
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.988
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9439
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9801
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2132
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3064
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4847


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)