Prescription ID | TCMF5835 |
Pinyin Name | Xia Ling Ke Li |
Chinese Name | 遐龄颗粒 |
English Name | Xia Ling Granules |
Function Description | 不寐, 健忘, 阳痿, 早泄 |
Indications | Premature ejaculation disorder, Impotence disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Sexual dysfunction, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1768 | Panax notoginseng | 三七 | TCMH1768 | ITSAO2360-14 |
TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH1848 | Crataegus pinnatifida | 山楂 | TCMH1848 | ITSAH1684-14 |
TCMH967 | Polygonatum sibiricum | 黄精 | TCMH967 | ITSAH4762-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH1181 | Chrysanthemum morifolium | 菊花 | TCMH1181 | KX675020 |
TCMH848 | Sesamum indicum | 黑芝麻 | TCMH848 | GENG619-14, GBVT1400-13 |
TCMH269 | Fructus broussonetiae | 楮实子 | TCMH269 | |
TCMH1796 | Morus alba | 桑葚清膏 | TCMH1796 | ITSAL1073-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT22 | ALPI | Intestinal alkaline phosphatase | Hydrolase | P09923 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT244 | HRH1 | Histamine H1 receptor | GPCR | P35367 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT307 | KCNH2 | HERG | Ion channel | Q12809 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT596 | SLC6A15 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Transporter | Q9H2J7 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT807 | SLC22A12 | Solute carrier family 22 member 12 | Transporter | Q96S37 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
TCMT884 | PHF8 | Histone lysine demethylase PHF8 | Oxidoreductase | Q9UPP1 |
TCMT965 | KDM7A | Lysine-specific demethylase 7 | Oxidoreductase | Q6ZMT4 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1189 | Pseudomonas fluorescens |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1296 | Influenza A virus H3N2 |
TCMT1319 | Corynebacterium xerosis |
TCMT1321 | Staphylococcus hominis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 10.1827 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 8.20007 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HRH1, HSD17B1, HSD17B2, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH | 8.1287 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR | 8.1287 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.7299 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 7.66941 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP2A, TYR | 7.66941 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HRH1, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR | 7.41565 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GLO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 7.33755 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 7.19586 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH | 7.02954 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH | 6.91825 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HRH1, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR | 6.86004 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.80375 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 6.68193 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR | 6.62039 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HRH1, PTGS2, RORC, SRC, TYR | 6.59207 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 6.47811 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HRH1, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 6.47811 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 6.41755 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 6.41755 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH | 6.40997 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 6.40911 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.36154 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.36005 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD17B1, HSD17B2 | 6.30553 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH | 6.25512 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HRH1, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR | 6.24453 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.08687 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 5.99029 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.90001 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH | 5.8846 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 5.8846 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HRH1, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC | 5.8596 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HRH1, IGF1R, MMP2, PPARA, PTGS2, SRC | 5.72637 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 | 5.46403 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 5.45086 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HRH1, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TOP2A | 5.24492 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH | 5.1859 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 5.16631 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, HRH1, PTGS2, RORC, SRC | 4.93324 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.92193 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, ESR1, FLT3, FUT7, GLO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 4.86984 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH | 4.85208 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 4.82767 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC | 4.79351 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HRH1, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR | 4.78141 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 4.77616 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 4.75294 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 4.69774 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR | 4.68537 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 4.65966 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.55653 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC, TNKS | 4.55653 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 4.47349 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GLO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 4.46435 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC | 4.41422 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.34671 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.30031 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.1975 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.18441 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 4.18441 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC | 4.15401 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 4.14795 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 | 4.14795 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS | 4.14795 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 4.11835 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS | 4.08405 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 4.02651 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PHF8, PIK3CA, PPARA, SRC, TYR | 3.99493 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GLO1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 3.97789 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC | 3.96325 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CDK6, CYP1B1, KCNH2, KDR, PTGS2, SRC | 3.90675 |
[BP] GO:0007200 | None | CHRM1, CHRM2, CHRM3, CHRM5, ESR1, HRH1 | 3.89509 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SRC | 3.89126 |
[BP] GO:0032787 | None | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 | 3.80283 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.80283 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 3.77709 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.68594 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 3.682 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 3.65952 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.65114 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.65114 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 | 3.65114 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HRH1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 3.65078 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, PTGS2, SRC | 3.61527 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.5864 |
[BP] GO:0070988 | demethylation | APEX1, CYP1A1, CYP1A2, CYP2D6, PHF8 | 3.44751 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.44364 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC | 3.42714 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 3.42714 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.41127 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.40955 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.40185 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 3.40032 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 3.38027 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH | 3.37955 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TNKS | 3.32949 |
[BP] GO:0006940 | None | ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 | 3.28733 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A | 3.23012 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, FABP3, FLT3, HRH1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.1467 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, FABP3, FLT3, HRH1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.1467 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, FABP3, FLT3, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 3.14253 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, HRH1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.14249 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.1263 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, HCAR2, HRH1, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SRC, TNKS2, XDH | 3.10548 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, HRH1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.10548 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.10548 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.09763 |
[BP] GO:0044267 | cellular protein metabolic process | ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PHF8, PIK3CA, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A | 3.04397 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP2A | 3.03586 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 | 3.03224 |
[BP] GO:1903522 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, HRH1, KCNH2, PTGS2 | 3.03067 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 3.02261 |
[BP] GO:0007193 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 | 3.02178 |
[BP] GO:0006464 | cellular protein modification process | ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KCNH2, KDR, MET, PHF8, PIK3CA, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A | 3.02178 |
[BP] GO:0036211 | protein modification process | ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KCNH2, KDR, MET, PHF8, PIK3CA, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A | 3.02178 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.01656 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC | 3.01081 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.96978 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.89987 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 | 2.88716 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC | 2.87782 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, APP, FABP3, FLT3, HRH1, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR | 2.8479 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.83047 |
[BP] GO:0043412 | macromolecule modification | ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KCNH2, KDR, MET, PHF8, PIK3CA, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A | 2.78261 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA | 2.75849 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.74085 |
[BP] GO:0010038 | response to metal ion | APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.74085 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.7304 |
[BP] GO:0003018 | None | ADORA1, CHRM1, CHRM3, HRH1, PTGS2, SRC | 2.69447 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB | 2.63098 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 2.63051 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.62625 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, MMP9, PTGS2, PTPN1, SRC | 2.6215 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.6215 |
[BP] GO:2000811 | negative regulation of anoikis | BCL2, PIK3CA, SRC | 2.58472 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.58472 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, APP, FABP3, FLT3, HRH1, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR | 2.56303 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, HCAR2, KCNH2, MMP12, PTGS2, SRC | 2.55966 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.5526 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.51806 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.51332 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC | 2.50218 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PIK3CB, SRC | 2.47313 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.45539 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.44508 |
[BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.42605 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.41533 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 2.40706 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HRH1, MMP2, PPARA, PTGS2, SRC, TYR | 2.40435 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.40435 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.38881 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.38098 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH | 2.35877 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.35877 |
[BP] GO:2001251 | None | PHF8, SRC, TNKS, TNKS2, TOP2A | 2.35445 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.33914 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HRH1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A | 2.33627 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, HCAR2, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC | 2.33627 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.32824 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTGS2, RORC, SRC, TOP2A | 2.29709 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.29364 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.28576 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.28576 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, MMP2, MMP9, PTGS2, SRC, TOP2A | 2.28576 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TNKS, TNKS2 | 2.27748 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.25274 |
[BP] GO:0019229 | None | CHRM1, CHRM3, HRH1, PTGS2 | 2.25274 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.24672 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.23423 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.23423 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.22912 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.22233 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, PTGS2 | 2.21583 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APEX1, APP, HRH1, IGF1R, MMP2, PTGS2, SRC | 2.20467 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.19981 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, HRH1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.19711 |
[BP] GO:2000209 | regulation of anoikis | BCL2, PIK3CA, SRC | 2.19711 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.19711 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC | 2.19526 |
[BP] GO:0097746 | None | ADORA1, CHRM1, CHRM3, HRH1, PTGS2 | 2.18861 |
[BP] GO:0035296 | None | ADORA1, CHRM1, CHRM3, HRH1, PTGS2 | 2.18861 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.18861 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.18861 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.18861 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.18861 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, SRC, TNKS, TNKS2 | 2.18419 |
[BP] GO:0044057 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, HCAR2, HRH1, KCNH2, PTGS2 | 2.1803 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 2.1803 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.1803 |
[BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALPI, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.16787 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.16682 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.16682 |
[BP] GO:0003013 | None | ADORA1, CHRM1, CHRM3, HRH1, PTGS2, SRC | 2.16458 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, CA2, CA7, HRH1, PTGS2 | 2.14629 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, CA2, CA7, HRH1, PTGS2 | 2.14629 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, KDR, SRC | 2.13678 |
[BP] GO:0040014 | regulation of multicellular organism growth | APP, BCL2, PIK3CA, TNKS2 | 2.12918 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, TNKS, TOP2A | 2.12918 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR | 2.11497 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC, XDH | 2.11284 |
[BP] GO:0030198 | extracellular matrix organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.09945 |
[BP] GO:0050880 | None | ADORA1, CHRM1, CHRM3, HRH1, PTGS2 | 2.09601 |
[BP] GO:0043062 | extracellular structure organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.09405 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1 | 2.09268 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, TNKS2 | 2.09242 |
[BP] GO:1904353 | regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.08934 |
[BP] GO:0035150 | None | ADORA1, CHRM1, CHRM3, HRH1, PTGS2 | 2.08886 |
[BP] GO:0050794 | regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.07549 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA | 2.06107 |
[BP] GO:0030154 | cell differentiation | ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MMP2, MMP9, PTGS2, RORC, TOP2A | 2.05359 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH | 2.05233 |
[BP] GO:1904357 | None | SRC, TNKS, TNKS2 | 2.05233 |
[BP] GO:0009891 | positive regulation of biosynthetic process | APP, AURKB, ESR1, FABP3, HRH1, IGF1R, KDR, MET, MMP12, PHF8, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, TOP2A | 2.05044 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, FLT3, PTGS2, SRC | 2.05044 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APEX1, APP, HRH1, IGF1R, MMP2, PTGS2, SRC | 2.04466 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, SRC | 2.04328 |
[BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, HCAR2, HRH1, PIK3CA, PIK3CB, SRC | 2.0415 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APEX1, APP, ESR1, FLT3, HRH1, IGF1R, MMP2, PTGS2, SRC | 2.03749 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.03364 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, APP, CDK6, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH | 2.03054 |
[BP] GO:0044243 | multicellular organismal catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.02779 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH | 2.025 |
[BP] GO:0033032 | regulation of myeloid cell apoptotic process | BCL2, HCAR2, PIK3CB | 2.02153 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.01987 |
[BP] GO:0006954 | inflammatory response | ADORA1, ADORA3, AXL, HRH1, PIK3CA, PIK3CB, PTGS1, PTGS2 | 2.01176 |
[BP] GO:0043271 | negative regulation of ion transport | ADORA1, BCL2, KCNH2, MMP9, PTGS2 | 2.00275 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FLT3, FUT7, GLO1, HCAR2, HRH1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR | 3.67239 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GLO1, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC | 3.02133 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HRH1, HSD17B1, HSD17B2, KCNH2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 2.19711 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FLT3, FUT7, HCAR2, HRH1, HSD17B2, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR | 2.13305 |
[CC] GO:0005783 | None | ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, KDR, PTGS2, PTPN1, XDH | 2.12918 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH | 14.3572 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 14.3572 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 10.0879 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.9211 |
[MF] GO:0008270 | zinc ion binding | ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PPARA, PTPN1, RORC, TNKS | 7.41722 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH | 7.31772 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH | 6.89852 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.72328 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.36154 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.3147 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A | 6.14591 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH | 6.14591 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PHF8, PTGS1, PTGS2, TYR | 5.83725 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 5.24492 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC | 5.24492 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 | 5.24492 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC | 5.01462 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 4.99711 |
[MF] GO:0005506 | iron ion binding | ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PHF8, XDH | 4.60957 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5, HRH1 | 4.2627 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.02527 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 3.96 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 3.77709 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 3.69503 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5, HRH1 | 3.51897 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC | 3.39875 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.37955 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 3.36074 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, PPARA, RORC | 3.27155 |
[MF] GO:0004629 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 3.24646 |
[MF] GO:0042578 | None | ADORA1, ALPI, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, PTPN1 | 3.12983 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, PPARA, RORC | 3.04555 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.02261 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 3.02178 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH | 2.9715 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 2.9591 |
[MF] GO:0016788 | None | ACHE, ADORA1, ALPI, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, PTPN1 | 2.8828 |
[MF] GO:0042562 | hormone binding | ACHE, CHRM3, HSD17B1, IGF1R, NQO2 | 2.8219 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.80834 |
[MF] GO:0008081 | None | ADORA1, APEX1, CHRM1, CHRM3, CHRM5 | 2.69732 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, PPARA, RORC | 2.69732 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC | 2.46223 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.39429 |
[MF] GO:0030594 | None | CHRM1, CHRM2, CHRM3, CHRM5, HRH1 | 2.38098 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.3809 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.37956 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, FLT3, HCAR2, HRH1, IGF1R, KCNH2, KDR, MET, PPARA, RORC | 2.25274 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 | 2.24057 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC | 2.13678 |
[MF] GO:0042802 | identical protein binding | ACHE, APP, BCL2, CSNK2A1, ESR1, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, TOP2A, TYR, XDH | 2.05233 |
[MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.05233 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 9.422 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.0028 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB | 6.7528 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.0262 |
Pathways in cancer_Homo sapiens_hsa05200 | CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R | 5.769 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.0091 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 5.9948 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 4.9219 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, CDK6, CHRM1, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R | 4.5637 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 | 4.7752 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH | 4.5184 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.5637 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA | 4.3441 |
Melanoma_Homo sapiens_hsa05218 | CDK6, PIK3CA, PIK3CB, MET, IGF1R | 4.3441 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R | 4.3441 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB | 4.2045 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 | 4.1412 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 | 4.3441 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.3441 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 3.8268 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 | 4.1321 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 | 4.1854 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, CHRM3, HRH1, CHRM1, ADORA3, CHRM5, ADORA1 | 3.631 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, CYP2D6, ALOX5, PTGS2, PTGS1 | 3.631 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.4304 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB | 3.5364 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.631 |
Glioma_Homo sapiens_hsa05214 | CDK6, PIK3CA, PIK3CB, IGF1R | 3.4531 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.1321 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, PTGS2, PTGS1 | 3.5187 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.3352 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.4304 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, HRH1, CHRM1, CHRM5 | 2.8814 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, BCL2, PIK3CB, IGF1R | 3.0161 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | HRH1, PIK3CA, SRC, PIK3CB | 2.8904 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 2.8904 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.2253 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.394 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, BCL2, PIK3CB, IGF1R | 2.83 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.7423 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 2.7471 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.522 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.6119 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.6568 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, BCL2, PIK3CB | 2.6568 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.6568 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1, PIK3CA, PIK3CB | 2.4716 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, BCL2, PIM1, PIK3CB | 2.2881 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.2881 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.2082 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, BCL2, PIK3CB | 1.9614 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.1124 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6, PIK3CA, SRC, PIK3CB | 1.9454 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6, PIK3CA, PIK3CB | 2.2881 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.1124 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6, PIK3CA, PIK3CB | 2.5535 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.6511 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PIK3CB, IGF1R | 2.0332 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6, PIK3CA, PIK3CB | 2.4052 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.4277 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, BCL2, PIK3CB | 1.7838 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2, PTGS2 | 2.0394 |
Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, BCL2, PIK3CB | 2.4594 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.4052 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.751 |
FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, IGF1R | 1.6859 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, BCL2, PIK3CB | 1.6484 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.6859 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.6511 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.6371 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8904 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.5819 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.5998 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2386 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3306 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3435 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2 | 0.3537 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.3823 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3537 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.0548 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4057 |
HTLV-I infection_Homo sapiens_hsa05166 | PIK3CA, PIK3CB | 0.5988 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4412 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.9462 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4494 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, PIK3CB | 0.9281 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 0.9638 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB | 0.8133 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.8049 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 0.9767 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, CDC25B | 1.0197 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.1316 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.1563 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5171 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5171 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.1421 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.203 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.2156 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.1596 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.1421 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.171 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PTGS2 | 0.5171 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5306 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2 | 1.1826 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.5435 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5445 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5456 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5456 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3 | 0.5527 |
Gap junction_Homo sapiens_hsa04540 | SRC | 0.5456 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3 | 0.5456 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3 | 0.5468 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5456 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5527 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.5948 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.601 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.3823 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.5989 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.4203 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.6031 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2 | 1.3759 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.3951 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6229 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6229 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.6229 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.6438 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.4203 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2 | 1.4134 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.5074 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1 | 1.4471 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.5161 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.6045 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.7044 |
Malaria_Homo sapiens_hsa05144 | MET | 0.7169 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.73 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.6859 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.6511 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.7349 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.7838 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.7878 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9727 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8312 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8732 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.8514 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.8931 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8431 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.937 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.9281 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8831 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1665 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9187 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL, ALPI | 2.522 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.306 |