TCM Prescription: Shui An Capsules



Prescription Description
Prescription IDTCMF5784
Pinyin NameShui An Jiao Nang
Chinese Name睡安胶囊
English NameShui An Capsules
Function Description不寐, 怔忡, 惊悸
IndicationsInducible palpitation disorder, Spontaneous palpitation disorder, Insomnia disorder, Insomnia
Disease ICD-11 Category SA10 [Inducible palpitation disorder (TM1), 惊悸 (TM1) ];
SA11 [Spontaneous palpitation disorder (TM1), 怔忡 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, MAOB, MET, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 12.2627
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.6781
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 10.6781
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR3C1, PPARA, PTAFR, RORC, SLC6A4, SRC, TRPV1, TYR 10.5211
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TRPV1 10.3291
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, NR3C1, PPARA, PTAFR, RORC, SLC6A4, SRC, TRPV1, TYR 9.73567
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 8.89208
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, MAOB, NR3C1, PTAFR, RORC, SLC6A4, SRC, TYR 8.77599
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 8.03971
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FUT7, GBA2, HMGCR, PDE5A, PIM1, PPARA, PTAFR, TYR, XDH 7.76753
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, MAOB, NR3C1, PPARA, PTAFR, SLC6A4, SRC, TRPV1 7.74242
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PTAFR, RORC, SLC6A4, SRC, TERT, TRPV1 7.74242
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MAOB, MMP2, NR3C1, PPARA, PTAFR, SLC6A4, SRC, TRPV1 7.4173
[BP] GO:0032501 multicellular organismal process ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TRPV1, TYR 7.4173
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, MAOB, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1, TYR 7.18147
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HMGCR, MAOB, PTAFR, TYR 7.03154
[BP] GO:0042127 regulation of cell proliferation ADORA3, ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PIM1, PTAFR, SLC6A4, SRC, TERT, XDH 6.99683
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.74992
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1 6.61446
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TYR, XDH 6.6041
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.47257
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KCNH2, KDR, MAOB, NR3C1, PTAFR, SLC6A2, SLC6A4, SRC, TRPV1 6.31054
[BP] GO:0010647 positive regulation of cell communication ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.27791
[BP] GO:0023056 positive regulation of signaling ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.25102
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.13588
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA 6.13371
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.08824
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, TERT 5.97678
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.95431
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.7952
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, SRC, TERT 5.65665
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.63419
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.60099
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.53203
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.39709
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.3848
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.34221
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.27812
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.27812
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 5.27812
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MMP12, MMP2, MMP9, NR3C1, PPARA, PTAFR, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 5.24902
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.21276
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TRPV1, XDH 5.1461
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 5.14341
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, RORC 5.13624
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 5.09379
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.0936
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.01965
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.99409
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 4.99409
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.91164
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.85464
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.81525
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.81525
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1 4.81038
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.78175
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2, TRPV1 4.77347
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRA2A, AKR1B1, ALOX12, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.76173
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CYP1A1, CYP1B1, HMGCR, KDR, MAOB, SLC6A4, SRC 4.66903
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.65571
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP2, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 4.65017
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 4.61806
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.60621
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.58254
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.5141
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 4.40325
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1 4.36819
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KCNH2, KDR, NR3C1, PTAFR, SRC, TRPV1 4.29238
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, NR3C1, PTAFR, SRC 4.28525
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.28525
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.25285
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.2464
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.24274
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, MAOB, NR3C1, PTAFR, SRC 4.23215
[BP] GO:0007165 signal transduction ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 4.18966
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.13885
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRA2A, ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, KCNH2, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PTAFR, SLC1A1, SLC6A4, SRC, TERT, TNKS2, TRPV1, XDH 4.1044
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, KCNH2, MET, SRC, TERT, TRPV1 4.09
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.07595
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, PPARA 3.9629
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PTAFR, SLC1A1, SRC, TERT, TRPV1 3.91715
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 3.90356
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, TERT 3.88401
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR 3.81715
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, KCNH2, MAOB, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TERT, TRPV1 3.77532
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.77003
[BP] GO:2000145 regulation of cell motility ADORA3, ADRA2A, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.70844
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.70008
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 3.69793
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTAFR, PTPN1, SRC, XDH 3.69199
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, KCNH2, MET, TRPV1 3.68617
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.64781
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTAFR, PTPN1, SRC, XDH 3.6467
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.6467
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.6467
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.59825
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, MAOB, NR3C1, PTAFR 3.56753
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.53191
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, GRM1, HMGCR, KDR, MET, PDE5A, PTPN1, SRC, XDH 3.53191
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PTAFR, PTPN1, SRC, XDH 3.52703
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PTAFR, PTPN1, SRC, XDH 3.52703
[BP] GO:0032845 None ADRA2A, BCL2, HMGCR, SRC, TNKS, TNKS2, TRPV1 3.48123
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.47769
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.40703
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, GRM1, HMGCR, HSD11B2, MMP2, PPARA, PTAFR, SLC6A4, SRC, TERT, TRPV1, TYR 3.40452
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TNKS2, TYR 3.40452
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40452
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.40452
[BP] GO:0030334 regulation of cell migration ADORA3, ADRA2A, ALOX12, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.38743
[BP] GO:0040012 regulation of locomotion ADORA3, ADRA2A, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.37236
[BP] GO:0051270 regulation of cellular component movement ADORA3, ADRA2A, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.35751
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.3146
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.30513
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.27783
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 3.26625
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 3.26625
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 3.26625
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.25196
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.23708
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.2306
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.19889
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 3.16246
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 3.1528
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, TERT 3.0999
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1, TRPV1 3.00621
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KCNH2, KDR, MET, PDE5A, PIM1, PTAFR, PTPN1, SRC, TNKS, XDH 2.9811
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.95665
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PDE5A, PTPN1, SRC, XDH 2.94363
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, PIM1, PPARA, TYR 2.93876
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, MAOB, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.92252
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.90463
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, SLC6A4, SRC, TRPV1, TYR 2.89905
[BP] GO:0048583 regulation of response to stimulus ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.89198
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 2.8832
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR 2.84818
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC, TRPV1, TYR 2.84121
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 2.79705
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, TERT 2.78215
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.78215
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 2.77137
[BP] GO:0071396 cellular response to lipid AXL, CDK6, ESR1, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC 2.76993
[BP] GO:0007193 None ADRA2A, GRM1, GRM3, GRM5, GRM8 2.76818
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.75338
[BP] GO:0060078 None GRIA2, GRIA4, GRIK5, GRM5, TRPV1 2.74897
[BP] GO:0009115 None AOX1, XDH 2.74516
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.74516
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.74516
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.74516
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KCNH2, KDR, MET, PDE5A, PIM1, PTAFR, PTPN1, SRC, TNKS, XDH 2.73496
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 2.73412
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.70961
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.68512
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PTAFR, SLC6A4, SRC, TRPV1 2.66251
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.66232
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.66232
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.66169
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.6208
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.61625
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 2.60512
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.5983
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 2.5983
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.57585
[BP] GO:1901698 response to nitrogen compound AKR1B1, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC, TRPV1, TYR 2.56563
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.56442
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, PIM1, PPARA, TYR 2.55633
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.54332
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.54207
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PDE5A, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 2.51614
[BP] GO:0046165 None AKR1B1, CES1, CYP3A4, HMGCR, PTAFR 2.50788
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, AXL, BCL2, CA2, CYP19A1, HCAR2, KCNH2, MMP12, PTAFR, SLC6A4, SRC, TERT, TRPV1 2.49339
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, PIM1, PPARA, TYR 2.48547
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46993
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.46993
[BP] GO:0042391 None BCL2, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 2.45978
[BP] GO:0065009 regulation of molecular function ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 2.45352
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HMGCR, HSD11B2, SLC6A4, SRC, TRPV1, TYR 2.42349
[BP] GO:0051046 None ACHE, ADRA2A, CYP19A1, GRIK5, HCAR2, HMGCR, MAOB, MMP12, PTAFR, SLC6A4, SRC, TRPV1 2.41248
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.40369
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.40369
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.40369
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ALOX15, FLT3, GRM1, HMGCR, KDR, PDE5A, PTPN1, SRC, XDH 2.40369
[BP] GO:0099566 None GRM1, GRM5 2.36784
[BP] GO:0046110 None AOX1, XDH 2.36784
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36784
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PIM1, PPARA, RORC, SRC, TYR 2.3607
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, SLC6A4, SRC 2.35728
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.35589
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.34281
[BP] GO:0045934 None ADRA2A, AURKB, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 2.32675
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, MAOB 2.31789
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.29601
[BP] GO:0044093 positive regulation of molecular function ADRA2A, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MET, MMP9, PDE5A, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 2.29601
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.29601
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.27025
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.26962
[BP] GO:0080134 regulation of response to stress ADRA2A, ALOX12, CDK6, CYP19A1, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.22571
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.22314
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1, TRPV1 2.22314
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, FLT3, GRM1, HMGCR, IGF1R, PDE5A, PTPN1, SRC 2.22011
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PTAFR, PTPN1, SRC, XDH 2.21205
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.19864
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.19833
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.1942
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.1942
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, HSD11B2, IGF1R, PPARA, SRC, TRPV1 2.1583
[BP] GO:1901654 None AKR1B1, CSNK2A1, MAOB, NR3C1, PTAFR, SRC 2.1583
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.14644
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.13516
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.13516
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTAFR, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 2.13516
[BP] GO:0070213 None TNKS, TNKS2 2.13516
[BP] GO:0006145 None AOX1, XDH 2.13516
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13516
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic GRM1, GRM3, GRM5, GRM8 2.13291
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, CYP19A1, GRIK5, HCAR2, HMGCR, MAOB, MMP12, PTAFR, SLC6A4, SRC 2.12713
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2C19, CYP3A4, MAOB 2.11698
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.11698
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTAFR, SLC6A4, SRC 2.11698
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.11162
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0995
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.08466
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.04947
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.04212
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PTAFR, PTPN1, SRC, XDH 2.03973
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.03639
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, GBA2, MAOB, PDE5A, SRC, XDH 2.02541
[BP] GO:0003008 None ADRA2A, AKR1B1, BCL2, CYP1B1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, KCNH2, PDE5A, PTAFR, SLC6A4, SRC, TRPV1, TYR 2.02232
[BP] GO:0006066 None AKR1B1, AKR1B10, CES1, CYP1B1, CYP3A4, HMGCR, PTAFR 2.02039
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.01915
[BP] GO:0010675 None ESRRB, PPARA, PTAFR, RORC, SRC 2.01574
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, HMGCR, SLC6A4, TRPV1, TYR 2.01245
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.00632
[CC] GO:0016020 membrane ACHE, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR 4.35986
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRA2A, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CSNK2A1, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 3.70844
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRA2A, AXL, CA4, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.14442
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.14442
[CC] GO:0044425 membrane part ACHE, ADORA3, ADRA2A, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1, TYR 3.02776
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.76818
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.63107
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, MAOB, MMP2, MMP9, NR3C1, PDE5A, PIM1, PTAFR, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 2.46201
[CC] GO:0098590 plasma membrane region ADRA2A, CA2, CA4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 2.43351
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.39634
[CC] GO:0044459 plasma membrane part ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1 2.38144
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.17072
[CC] GO:0044456 None ACHE, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC, TRPV1 2.06653
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 13.9576
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 9.13684
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 7.9553
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TYR, XDH 7.82716
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.7544
[MF] GO:0038023 signaling receptor activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 7.72426
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.66792
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH 7.3093
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 7.18147
[MF] GO:0060089 molecular transducer activity ADORA3, ADRA2A, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 7.16374
[MF] GO:0004872 receptor activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.75073
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.20175
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.06926
[MF] GO:0004871 signal transducer activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.00051
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 5.97288
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, TNKS 5.78105
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.71129
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.69826
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 5.03949
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.99409
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.85464
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.85464
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.77347
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B2, HSD17B1, MAOB, SRC, XDH 4.70279
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.61806
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 4.53409
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.94235
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 3.91049
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, SRC 3.75891
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, SRC 3.58182
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP9, SLC6A4, TERT, TRPV1, TYR, XDH 3.57989
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRA2A, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR, TRPV1 3.43453
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRA2A, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR, TRPV1 3.43453
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 3.30833
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.2306
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.14447
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.14442
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.14442
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.12673
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 3.05088
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP3A4 2.87802
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, KCNH2, MET, NR3C1, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TNKS2 2.79342
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC, TRPV1 2.76818
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74516
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.74516
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74516
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.71651
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.51614
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.4032
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.39901
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.36784
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.36784
[MF] GO:0005330 None SLC6A2, SLC6A4 2.36784
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.36784
[MF] GO:0099583 None GRM1, GRM5 2.36784
[MF] GO:0047374 None CES1, CES2 2.36784
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.29601
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.29601
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.24811
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.23329
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.17677
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, HMGCR, KCNH2, MAOB, SLC6A4, TERT, TYR, XDH 2.16213
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.16213
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.13516
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.13516
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.13516
[MF] GO:0004971 None GRIA2, GRIA4 2.13516
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.13516
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.10753


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.699
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.4275
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP2C19, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 7.3639
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, PTAFR, GRM8, TRPV1, NR3C1, GRM1, ADRA2A, GRIA4 7.4275
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.5519
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.3927
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9706
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.3597
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 4.7908
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12, CYP2C19, SLC6A4 4.1351
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.806
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4, CYP2C19 4.011
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9281
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9281
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.1351
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.9488
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7178
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.9488
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, CYP2C19 3.0551
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.5433
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.9983
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.401
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9488
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.401
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.181
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9215
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.9226
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0492
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, GRIA4 1.9408
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.945
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB 2.2735
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9215
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9165
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6635
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.5983
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PPARA, GRIA4 1.5546
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.4872
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.6546
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.4437
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9215
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.6949
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2358
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, GRIA4 1.3431
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1713
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, PDE5A, ADRA2A 1.127
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.0648
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8781
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9385
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9281
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8976
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9151
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.136
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8719
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9582
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8395
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1715
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2017
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8474
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9183
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7956
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.127
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0279
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8111
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8111
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8111
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.8041
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1821
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7962
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7575
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7627
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1225
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7962
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1923
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1924
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7428
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.6156
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7486
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5539
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6124
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2358
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5502
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2622
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2687
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2898
Alcoholism_Homo sapiens_hsa05034 MAOB 0.2754
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2752
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2684
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3076
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3221
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3188
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3339
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3339
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3324
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3444
Platelet activation_Homo sapiens_hsa04611 SRC 0.364
Axon guidance_Homo sapiens_hsa04360 MET 0.3565
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3659
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.364
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3925
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4193
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4191
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4311
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4307
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4433
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4304
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4433
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4433
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4515
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4433
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4433
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4433
Peroxisome_Homo sapiens_hsa04146 XDH 0.4515
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4844
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4624
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.449
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4831
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4963
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.498
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.511
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.511
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.511
Shigellosis_Homo sapiens_hsa05131 SRC 0.511
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.631
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.511
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.515
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.5502
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5502
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5502
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5181
Malaria_Homo sapiens_hsa05144 MET 0.5772
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.5737
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5974
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5849
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.581
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5849
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6366
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8248
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.631
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7249
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7428
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7627
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7335
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7575
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.7854
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.8617
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8002
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8474
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9151
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9488
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1777


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)