Prescription ID | TCMF5626 |
Pinyin Name | Wu Zi Yan Zong Pian |
Chinese Name | 五子衍宗片 |
English Name | Wu Zi Yan Zong Tablets |
Function Description | 腰痛, 遗精, 早泄, 阳痿, 不育 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Male Infertility disorder, Lumbago disorder, Infertility, Sexual dysfunction, Lumbago, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SB0C [Male Infertility disorder (TM1), 不育 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; GA31 [Female infertility, 女性不孕症 ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Kidney, Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
TCMH241 | Plantago asiatica | 车前子 | TCMH241 | ITSAB3641-14 |
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH611 | Rubus idaeus | 覆盆子 | TCMH611 | ITSAE336-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT151 | PRKCA | Protein kinase C alpha | Kinase | P17252 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT237 | SLC5A1 | Sodium/glucose cotransporter 1 | Transporter | P13866 |
TCMT238 | SLC5A2 | Sodium/glucose cotransporter 2 | Transporter | P31639 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT847 | SLC5A4 | Low affinity sodium-glucose cotransporter | Transporter | Q9NY91 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Target ID | Target Name |
---|---|
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1212 | Verticillium dahliae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 8.78126 |
[BP] GO:0065008 | regulation of biological quality | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, SMAD3, SRC, TEK, TRPV1, XDH | 8.55385 |
[BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 | 8.45007 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 7.57464 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TRPV1, TYR | 7.26348 |
[BP] GO:0010647 | positive regulation of cell communication | AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 6.87157 |
[BP] GO:0023056 | positive regulation of signaling | AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 6.87157 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.87157 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 6.63614 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, HSPA1A, PIM1, PPARA, TYR, XDH | 6.63614 |
[BP] GO:0008152 | metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 6.48045 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 6.40638 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 6.40584 |
[BP] GO:0042127 | regulation of cell proliferation | AKR1B1, ALOX12, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH | 6.37887 |
[BP] GO:0010941 | regulation of cell death | AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 6.37887 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.37887 |
[BP] GO:0060548 | negative regulation of cell death | AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK | 6.29741 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 6.29741 |
[BP] GO:0043067 | regulation of programmed cell death | AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 6.24025 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 | 6.1216 |
[BP] GO:0043069 | negative regulation of programmed cell death | AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK | 6.0624 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.01 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.99258 |
[BP] GO:0032501 | multicellular organismal process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SLC5A1, SMAD3, SRC, TEK, TRPV1, TYR | 5.94495 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC | 5.90848 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 | 5.73435 |
[BP] GO:1902531 | regulation of intracellular signal transduction | AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH | 5.68548 |
[BP] GO:0042981 | regulation of apoptotic process | AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 5.65358 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK | 5.56608 |
[BP] GO:0032502 | developmental process | ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR | 5.53047 |
[BP] GO:0014070 | response to organic cyclic compound | APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TEK, TRPV1, TYR | 5.48001 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK, XDH | 5.4611 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 5.46076 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.44964 |
[BP] GO:0043066 | negative regulation of apoptotic process | AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK | 5.44652 |
[BP] GO:0032879 | regulation of localization | ACHE, ALOX12, ALOX15, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 | 5.42366 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.42366 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH | 5.42366 |
[BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.26467 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR | 5.26467 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH | 5.23502 |
[BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 | 5.20927 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 | 5.14929 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR | 5.14929 |
[BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.14929 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK | 5.12271 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 5.06374 |
[BP] GO:0009967 | positive regulation of signal transduction | AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 5.05068 |
[BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.04254 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK | 5.03391 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 | 5.02951 |
[BP] GO:0048856 | anatomical structure development | ACHE, AKR1B1, ALOX15, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR | 4.99334 |
[BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 4.91536 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 | 4.91536 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 4.91536 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 4.91536 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, MET, PPARA | 4.90547 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 4.85114 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR | 4.84538 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 | 4.82502 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 4.80785 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA | 4.76263 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH | 4.67974 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, TEK | 4.61215 |
[BP] GO:0010646 | regulation of cell communication | ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 4.58958 |
[BP] GO:0040012 | regulation of locomotion | ALOX12, APP, CHRM1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 4.58438 |
[BP] GO:0030334 | regulation of cell migration | ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 4.52074 |
[BP] GO:0044238 | primary metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 4.51548 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR | 4.50862 |
[BP] GO:0023051 | regulation of signaling | ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 4.49739 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.39035 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH | 4.37707 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | ALOX15, APP, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK | 4.30379 |
[BP] GO:2000145 | regulation of cell motility | ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 4.22671 |
[BP] GO:0043408 | regulation of MAPK cascade | ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH | 4.1003 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 4.06466 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 4.05683 |
[BP] GO:0080134 | regulation of response to stress | ALOX12, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 4.01345 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK | 4.00172 |
[BP] GO:0048584 | positive regulation of response to stimulus | AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 4.00172 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ALOX15, APP, EGFR, FLT3, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH | 3.92208 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.9121 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 | 3.9121 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 3.9121 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 3.90109 |
[BP] GO:0051270 | regulation of cellular component movement | ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 3.87933 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR | 3.87933 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.87104 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR | 3.87056 |
[BP] GO:0051049 | regulation of transport | ACHE, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, PPARA, PRKCA, PTPN1, SMAD3, SRC, TRPV1 | 3.86702 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 3.84141 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 | 3.84141 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.84141 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.84141 |
[BP] GO:0042592 | homeostatic process | AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TRPV1 | 3.82244 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AXL, CA2, CHRM3, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, PRKCA, SMAD3, SRC, TEK, TRPV1 | 3.79192 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.77941 |
[BP] GO:0071363 | cellular response to growth factor stimulus | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 3.73041 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 3.70387 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.6834 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.67571 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 | 3.66397 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 3.6159 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 3.6159 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.6016 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 | 3.59969 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR | 3.59021 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APP, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 | 3.58542 |
[BP] GO:0019216 | regulation of lipid metabolic process | CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK | 3.47728 |
[BP] GO:0050896 | response to stimulus | ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 3.46235 |
[BP] GO:0045787 | positive regulation of cell cycle | APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, SRC | 3.41182 |
[BP] GO:0009628 | response to abiotic stimulus | AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR | 3.40115 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.38874 |
[BP] GO:0070848 | response to growth factor | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 3.37885 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 3.37885 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PRKCA, SRC, TEK | 3.37885 |
[BP] GO:0044092 | negative regulation of molecular function | APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC | 3.36706 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.36706 |
[BP] GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ALOX15, APP, EGFR, KDR, PRKCA, SRC, TEK | 3.36416 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 | 3.36209 |
[BP] GO:0042325 | regulation of phosphorylation | ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, TEK, XDH | 3.33917 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, SRC, TEK | 3.33917 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.30649 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, SRC, TEK, XDH | 3.18358 |
[BP] GO:0001932 | regulation of protein phosphorylation | ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH | 3.17297 |
[BP] GO:0048583 | regulation of response to stimulus | AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 3.11942 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A | 3.08267 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA | 3.06624 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3 | 3.04665 |
[BP] GO:0031399 | regulation of protein modification process | ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH | 3.04561 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 3.01471 |
[BP] GO:0010038 | response to metal ion | ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 3.01471 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH | 3.01471 |
[BP] GO:0030155 | regulation of cell adhesion | ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, SMAD3, SRC, TEK | 3.00232 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 2.98959 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.97512 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, INSR, SMAD3, TRPV1 | 2.97444 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.97444 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, SRC, TEK | 2.96337 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 | 2.93489 |
[BP] GO:0007165 | signal transduction | AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 | 2.93489 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.93489 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.93489 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.93489 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, INSR, SMAD3, TRPV1, XDH | 2.93241 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.91376 |
[BP] GO:0042327 | positive regulation of phosphorylation | ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH | 2.85254 |
[BP] GO:0051239 | regulation of multicellular organismal process | ALOX12, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIM1, PRKCA, SMAD3, SRC, TEK, TRPV1, XDH | 2.84033 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 2.84033 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 2.83921 |
[BP] GO:0009966 | regulation of signal transduction | AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 2.83241 |
[BP] GO:0051130 | positive regulation of cellular component organization | ALOX15, APP, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK | 2.75933 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH | 2.74798 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5 | 2.74348 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.73136 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.73136 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.73136 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.73136 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.73136 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 2.72131 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TYR, XDH | 2.7167 |
[BP] GO:0072593 | reactive oxygen species metabolic process | ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.7167 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK | 2.70759 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.70526 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.70524 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 | 2.70524 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 2.69075 |
[BP] GO:1901654 | None | AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC | 2.65706 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.64891 |
[BP] GO:0009611 | response to wounding | ACHE, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 | 2.64891 |
[BP] GO:0044089 | positive regulation of cellular component biogenesis | ALOX15, HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK | 2.64891 |
[BP] GO:0010638 | positive regulation of organelle organization | ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 2.63097 |
[BP] GO:0016042 | lipid catabolic process | AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 2.63024 |
[BP] GO:0065009 | regulation of molecular function | APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 2.63024 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.59459 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.59459 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.56183 |
[BP] GO:0007166 | cell surface receptor signaling pathway | APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 | 2.55938 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.55831 |
[BP] GO:0001503 | ossification | ALOX15, EGFR, MMP2, MMP9, TEK | 2.53294 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC | 2.53294 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.52492 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, INSR, SMAD3, TRPV1 | 2.52492 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 | 2.48648 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ALOX15, APP, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 2.47465 |
[BP] GO:0044057 | None | CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, PRKCA, SMAD3, TRPV1 | 2.46444 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.45586 |
[BP] GO:0009056 | catabolic process | ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH | 2.40481 |
[BP] GO:0035428 | None | SLC5A1, SLC5A2, SLC5A4 | 2.40348 |
[BP] GO:1904659 | None | SLC5A1, SLC5A2, SLC5A4 | 2.40348 |
[BP] GO:1905950 | None | SLC5A1, SLC5A2, SLC5A4 | 2.40348 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, SRC, TEK | 2.40334 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, EGFR, FLT3, HSPA1A, MMP9, PRKCA, RORC, SMAD3, SRC, TRPV1 | 2.40334 |
[BP] GO:0051050 | positive regulation of transport | ACHE, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 | 2.38755 |
[BP] GO:0009893 | positive regulation of metabolic process | ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.38161 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, MET, MMP9, PPARA, SRC | 2.38161 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, FABP3, PPARA, SLC5A1, SLC5A2, SLC5A4, TRPV1 | 2.36013 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.35549 |
[BP] GO:0048585 | negative regulation of response to stimulus | ALOX12, ALOX15, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 2.34256 |
[BP] GO:0022600 | None | CHRM1, CHRM3, CHRM5, SLC5A1 | 2.33673 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ALOX15, APP, AURKB, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.32046 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.32046 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.32046 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.32046 |
[BP] GO:0061900 | None | APP, EGFR, TRPV1 | 2.32046 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.32046 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 | 2.2973 |
[BP] GO:0010632 | regulation of epithelial cell migration | KDR, MET, MMP9, PRKCA, SRC, TEK | 2.2973 |
[BP] GO:0032872 | regulation of stress-activated MAPK cascade | APP, DUSP3, EGFR, IGF1R, PTPN1, XDH | 2.2973 |
[BP] GO:0070302 | regulation of stress-activated protein kinase signaling cascade | APP, DUSP3, EGFR, IGF1R, PTPN1, XDH | 2.28769 |
[BP] GO:0050790 | regulation of catalytic activity | APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 2.27196 |
[BP] GO:0051726 | regulation of cell cycle | APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, SRC | 2.26311 |
[BP] GO:0043549 | regulation of kinase activity | APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK | 2.25192 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.24572 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ALOX15, APP, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH | 2.23715 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.23715 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.23715 |
[BP] GO:0051338 | regulation of transferase activity | APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK | 2.22207 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR | 2.21703 |
[BP] GO:0071383 | None | EGFR, FLT3, NR3C1, SRC | 2.16511 |
[BP] GO:0034219 | None | SLC5A1, SLC5A2, SLC5A4 | 2.14905 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.14313 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.14313 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.14313 |
[BP] GO:0031401 | positive regulation of protein modification process | ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH | 2.14061 |
[BP] GO:0065007 | biological regulation | ACHE, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.13752 |
[BP] GO:0007193 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.13706 |
[BP] GO:0031100 | animal organ regeneration | AXL, CSNK2A1, EGFR, FLT3 | 2.13706 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9 | 2.13706 |
[BP] GO:0046903 | None | ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSPA1A, MMP9, TRPV1, XDH | 2.13584 |
[BP] GO:0043405 | regulation of MAP kinase activity | DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC | 2.13312 |
[BP] GO:0042060 | None | ALOX15, EGFR, PPARA, SMAD3 | 2.12188 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC | 2.11496 |
[BP] GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | FLT3, SRC, TEK | 2.08598 |
[BP] GO:0042743 | hydrogen peroxide metabolic process | CYP1A1, CYP1A2, EGFR | 2.08598 |
[BP] GO:0048732 | gland development | CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR | 2.07271 |
[BP] GO:1901890 | None | KDR, SMAD3, TEK | 2.05125 |
[BP] GO:0071276 | cellular response to cadmium ion | CYP1A2, EGFR, MMP9 | 2.05125 |
[BP] GO:0006691 | None | ALOX12, ALOX15, ALOX5 | 2.05125 |
[BP] GO:0032844 | regulation of homeostatic process | AURKB, CA2, CA7, EGFR, HCAR2, KDR, SRC, TRPV1 | 2.05125 |
[BP] GO:1901655 | None | AKR1B1, EGFR, NR3C1, SRC | 2.05125 |
[BP] GO:0045766 | positive regulation of angiogenesis | ALOX12, CYP1B1, KDR, PRKCA, TEK | 2.04488 |
[BP] GO:1903426 | None | EGFR, INSR, SMAD3, TRPV1 | 2.03568 |
[BP] GO:1901888 | regulation of cell junction assembly | KDR, SMAD3, SRC, TEK | 2.03568 |
[BP] GO:0003018 | None | CHRM1, CHRM3, EGFR, SRC, TEK | 2.03568 |
[BP] GO:0009894 | regulation of catabolic process | CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PTPN1, SMAD3 | 2.02749 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH | 2.01796 |
[BP] GO:1990535 | None | APP, INSR | 2.01512 |
[BP] GO:0002933 | lipid hydroxylation | CYP1A1, CYP3A4 | 2.01512 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP3A4 | 2.01512 |
[CC] GO:0005886 | plasma membrane | ACHE, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 | 4.19379 |
[CC] GO:0031226 | intrinsic component of plasma membrane | APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 | 4.00172 |
[CC] GO:0044459 | plasma membrane part | ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 | 3.7579 |
[CC] GO:0005887 | integral component of plasma membrane | APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 | 3.66397 |
[CC] GO:0098590 | plasma membrane region | CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, INSR, MET, SRC, TEK, TRPV1 | 2.89756 |
[CC] GO:0016020 | membrane | ACHE, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR | 2.84033 |
[CC] GO:0045202 | None | ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR | 2.71056 |
[CC] GO:0016323 | basolateral plasma membrane | CA2, CA4, CA9, CHRM3, EGFR, TEK | 2.56858 |
[CC] GO:0044425 | membrane part | ACHE, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1, TYR | 2.25974 |
[CC] GO:0030054 | cell junction | ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HCAR2, HSPA1A, KDR, TEK, TRPV1 | 2.14313 |
[CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 2.01512 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH | 13.0809 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.76993 |
[MF] GO:0003824 | catalytic activity | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, TYR, XDH | 9.51149 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 8.39533 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, SRC, TEK, TRPV1 | 7.95615 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.34351 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.6506 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.37887 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.37887 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH | 6.22508 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH | 5.90848 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 5.64682 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.51452 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 5.40953 |
[MF] GO:0042562 | hormone binding | ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 | 5.38424 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK | 5.24391 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 5.17646 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3 | 5.02827 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH | 4.78129 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK | 4.45862 |
[MF] GO:0038023 | signaling receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 | 4.36868 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH | 4.22671 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.19452 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 4.15266 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK | 4.04881 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR | 3.92208 |
[MF] GO:0005412 | None | SLC5A1, SLC5A2, SLC5A4 | 3.9121 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH | 3.80693 |
[MF] GO:0004871 | signal transducer activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 | 3.77941 |
[MF] GO:0004872 | receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 | 3.73613 |
[MF] GO:0060089 | molecular transducer activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 | 3.57899 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.51791 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 | 3.47728 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.41874 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.41874 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK | 3.3752 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC | 3.33917 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC | 3.1624 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.07664 |
[MF] GO:0099600 | transmembrane receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 | 3.04059 |
[MF] GO:0004888 | transmembrane signaling receptor activity | AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 | 3.04059 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.93489 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR | 2.93241 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.88057 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 2.85968 |
[MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.77068 |
[MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.74348 |
[MF] GO:0043168 | anion binding | ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH | 2.69356 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK | 2.57027 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.55831 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.55831 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.55831 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.52492 |
[MF] GO:0032403 | protein complex binding | ACHE, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC | 2.45586 |
[MF] GO:0005355 | None | SLC5A1, SLC5A2, SLC5A4 | 2.45586 |
[MF] GO:0036094 | small molecule binding | AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH | 2.41235 |
[MF] GO:0015149 | None | SLC5A1, SLC5A2, SLC5A4 | 2.40348 |
[MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 | 2.34953 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.32046 |
[MF] GO:0051425 | None | APP, INSR | 2.32046 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.32046 |
[MF] GO:0015145 | None | SLC5A1, SLC5A2, SLC5A4 | 2.32046 |
[MF] GO:0019838 | growth factor binding | EGFR, IGF1R, INSR, KDR, TEK | 2.32046 |
[MF] GO:0000166 | nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH | 2.26311 |
[MF] GO:1901265 | nucleoside phosphate binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1, XDH | 2.26193 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5 | 2.23715 |
[MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.19436 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.19436 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5 | 2.19436 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.14313 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.14313 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.12388 |
[MF] GO:0043548 | phosphatidylinositol 3-kinase binding | AXL, IGF1R, INSR | 2.12388 |
[MF] GO:0004629 | None | CHRM1, CHRM3, CHRM5 | 2.08598 |
[MF] GO:0005158 | None | IGF1R, PTPN1, SRC | 2.05125 |
[MF] GO:0035639 | purine ribonucleoside triphosphate binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.02913 |
[MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.01966 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH | 2.01512 |
[MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.01512 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 9.6977 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.2438 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 9.3295 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.5756 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, PRKCA, MMP9, MET, EGFR, IGF1R | 5.3959 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 5.5074 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R | 5.3188 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 5.3959 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, CHRM1, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R | 4.808 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, CHRM5, PRKCA | 4.7655 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 5.3959 |
Pathways in cancer_Homo sapiens_hsa05200 | SMAD3, FLT3, MMP1, MMP2, PRKCA, MMP9, MET, EGFR, IGF1R | 4.3448 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 4.3097 |
Ras signaling pathway_Homo sapiens_hsa04014 | INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R | 4.1495 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.8351 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, EGFR, HSPA1A | 3.8431 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, CHRM1, CHRM5, PRKCA, EGFR | 3.7685 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, CHRM3, CHRM1, GPR35, CHRM5, TRPV1, NR3C1 | 3.7219 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | INSR, PRKCA, TEK, EGFR, IGF1R | 3.8139 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B | 3.5741 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5, ALOX15, PRKCA, ALOX12 | 3.7082 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, PRKCA, MET, EGFR, IGF1R | 3.5741 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR | 3.4722 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15, ALOX12 | 3.5605 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, PRKCA, EGFR | 2.9948 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC, PRKCA, ALOX12, TRPV1 | 2.8861 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PIM1, PRKCA | 2.8649 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.4135 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, INSR, EGFR, IGF1R | 2.4263 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, PRKCA, EGFR, CDC25B, HSPA1A | 2.3288 |
Hepatitis B_Homo sapiens_hsa05161 | SMAD3, SRC, PRKCA, MMP9 | 2.3386 |
Glioma_Homo sapiens_hsa05214 | PRKCA, EGFR, IGF1R | 2.3386 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR, PRKCA | 2.3748 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | INSR, IGF1R, HSPA1A | 2.3386 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.0905 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, CHRM1, PPARA | 1.9706 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET, EGFR | 2.3288 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, CYP3A4 | 2.3386 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2, PRKCA | 2.2466 |
Melanoma_Homo sapiens_hsa05218 | MET, EGFR, IGF1R | 2.2882 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 2.3212 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC, PRKCA, EGFR | 2.0747 |
Bile secretion_Homo sapiens_hsa04976 | CA2, SLC5A1, CYP3A4 | 2.2882 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, INSR, PPARA | 1.852 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8748 |
Gap junction_Homo sapiens_hsa04540 | SRC, PRKCA, EGFR | 2.07 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.6087 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2, PRKCA | 1.9722 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, PRKCA, MMP9 | 1.7729 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1, PRKCA | 1.5909 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | INSR, PRKCA, EGFR | 1.5817 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC, PRKCA, EGFR | 1.4925 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC, PRKCA | 1.6087 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.2504 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 1.1261 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, HSPA1A | 0.9154 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | INSR, PPARA | 0.8582 |
Prostate cancer_Homo sapiens_hsa05215 | EGFR, IGF1R | 1.1853 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, PRKCA | 1.0031 |
Melanogenesis_Homo sapiens_hsa04916 | PRKCA, TYR | 1.1158 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA, EGFR | 0.927 |
AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.9755 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, HSPA1A | 0.6807 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, IGF1R | 0.8928 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, INSR | 0.9041 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PRKCA, EGFR | 1.1135 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | INSR, IGF1R | 1.1534 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, HSPA1A | 1.0031 |
Influenza A_Homo sapiens_hsa05164 | PRKCA, HSPA1A | 0.7744 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3, PRKCA | 1.2041 |
Cell cycle_Homo sapiens_hsa04110 | SMAD3, CDC25B | 0.9755 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC, PRKCA | 1.1853 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3, PRKCA | 1.1853 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3 | 0.2569 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 1.1822 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.267 |
Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.3227 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3496 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.36 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSPA1A | 0.3705 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.3592 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.349 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3705 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIM1 | 0.3842 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | INSR | 0.3705 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3921 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PRKCA | 0.4004 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.4293 |
Pancreatic cancer_Homo sapiens_hsa05212 | SMAD3, EGFR | 1.3903 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PRKCA | 0.4293 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.4499 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PRKCA | 0.4525 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4417 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4499 |
Dopaminergic synapse_Homo sapiens_hsa04728 | PRKCA | 0.4393 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.4744 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, INSR | 1.4925 |
Glutamatergic synapse_Homo sapiens_hsa04724 | PRKCA | 0.4646 |
Vascular smooth muscle contraction_Homo sapiens_hsa04270 | PRKCA | 0.4525 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PRKCA, EGFR | 1.4925 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP1A2, CYP3A4 | 1.3603 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3 | 0.4917 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4992 |
Long-term depression_Homo sapiens_hsa04730 | PRKCA, IGF1R | 1.4557 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PRKCA | 0.5099 |
Amoebiasis_Homo sapiens_hsa05146 | PRKCA | 0.4992 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PRKCA | 0.5005 |
Morphine addiction_Homo sapiens_hsa05032 | PRKCA | 0.511 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4847 |
Circadian entrainment_Homo sapiens_hsa04713 | PRKCA | 0.5088 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5088 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.3964 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PRKCA | 0.4992 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.5099 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5167 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3 | 0.5317 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.5308 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.516 |
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCA | 0.5337 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5317 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4629 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | SMAD3 | 0.5664 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC | 0.568 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5494 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PRKCA | 0.5787 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5712 |
Long-term potentiation_Homo sapiens_hsa04720 | PRKCA | 0.5825 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5825 |
Thyroid hormone synthesis_Homo sapiens_hsa04918 | PRKCA | 0.5696 |
Amphetamine addiction_Homo sapiens_hsa05031 | PRKCA | 0.5807 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PRKCA | 0.604 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5825 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3 | 0.5952 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP3A4, XDH | 1.6087 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.6345 |
Endometrial cancer_Homo sapiens_hsa05213 | EGFR | 0.6486 |
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | PRKCA | 0.6345 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR, PRKCA | 1.7366 |
Vibrio cholerae infection_Homo sapiens_hsa05110 | PRKCA | 0.6521 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6596 |
Mineral absorption_Homo sapiens_hsa04978 | SLC5A1 | 0.6521 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | INSR | 0.6635 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | PRKCA | 0.6676 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | SLC5A1 | 0.6807 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9187 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.7744 |
African trypanosomiasis_Homo sapiens_hsa05143 | PRKCA | 0.7744 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7883 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8719 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.7744 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.8582 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0925 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8193 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8582 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.2516 |