TCM Prescription: Wei Chang Ling Capsules



Prescription Description
Prescription IDTCMF5586
Pinyin NameWei Chang Ling Jiao Nang
Chinese Name胃肠灵胶囊
English NameWei Chang Ling Capsules
Function Description腹痛, 腹泻
IndicationsAbdominal pain disorder, Dyspepsia, Enteritis, Diarrhea
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
ME05.1 [Diarrhoea, 腹泻 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2745 Stephania hernandifolia 钻地风 TCMH2745
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH789 Lonicera japonica 海螵蛸 TCMH789 ITSAI3881-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH907 Piper nigrum 胡椒 TCMH907 ITSAA3189-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT642 ADRA1D Alpha-1d adrenergic receptor GPCR P25100
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT650 ADRA1B Alpha-1b adrenergic receptor GPCR P35368
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.1823
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5579
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, KCNH2, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH 11.5624
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, PPARA, RORC, SRC, TYR 9.18422
[BP] GO:0010033 response to organic substance ADRA1A, ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, PPARA, RORC, SRC, TYR 8.86808
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, PPARA, RORC, SRC, TYR 8.72046
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR2C, KCNH2, KDR, SRC 8.63445
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, RORC, SRC, TYR 7.85138
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 7.5664
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, GLO1, HTR2C, PIM1, PPARA, TYR, XDH 7.46347
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 7.18877
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM2, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, KDR, MET, PIM1, PPARA, RORC, SRC, TNKS2, TOP2A, TYR 7.16704
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, F10, F2, F3, FLT3, HCAR2, HTR2C, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 7.12662
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, F10, F2, F3, FLT3, HCAR2, HTR2C, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 7.12222
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.01986
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 6.72136
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRB2, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC 6.65213
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.65009
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.5742
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.30548
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, PPARA, PTPN1, RORC, SRC, TOP2A, TYR 6.30548
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 6.00559
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.00559
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CHRNA7, CYP1B1, F10, F2, F3, FLT3, HTR2C, KDR, MET, PTPN1, SRC, XDH 5.95117
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CHRNA7, ESR1, F2, FABP3, FABP4, FLT3, HTR2C, KCNH2, MET, SRC 5.87293
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F2, F3, FABP4, HSD11B2, HSD17B2, HTR2C, IGF1R, KCNH2, MET, PIM1, PPARA, RORC, SRC, TNKS2, TYR 5.855
[BP] GO:0044237 cellular metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.77863
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3 5.63668
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C 5.60402
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, RORC, SRC, TYR 5.3968
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.2482
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 5.18266
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, F10, F2, F3, FLT3, HTR2C, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 5.10331
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, F2, HCAR2, HTR2C, KDR, SRC, TNKS, TNKS2 5.04817
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 4.94999
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CHRNA7, CNR2, CYP1A1, CYP1B1, KDR, SRC 4.92343
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, KDR, PIM1, PPARA, RORC, SRC, TYR 4.90209
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 4.86934
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.75751
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA1D, AKR1B1, BCL2, CDC25B, CDK6, CHRNA7, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FLT3, IGF1R, KDR, PIM1, SRC, XDH 4.61836
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.50101
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TOP2A, XDH 4.50101
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, F10, F2, F3, FLT3, HTR2C, IGF1R, KDR, MET, PTPN1, SRC, XDH 4.50101
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.47119
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR2 4.42236
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.30887
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, FABP3, HTR2C, KCNH2, PPARA 4.22847
[BP] GO:0001994 None ADRA1A, ADRA1B, ADRA1D 4.22847
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.22847
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2C, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.17901
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.08611
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA1B, ADRA1D, AKR1B1, BCL2, CA12, CA2, CA7, CHRNA7, ESR1, F2, FABP3, FABP4, HTR2C, KCNH2, MET 4.05987
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRB2, APEX1, AXL, BCL2, CA2, CA7, CDK6, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, F10, F2, F3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PPARA, PTPN1, SRC 3.99966
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, PIM1, PTPN1, SRC, TOP2A, XDH 3.97746
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, F2, FABP3, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 3.91406
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, F2, FABP3, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 3.91406
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.8769
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2C, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.8769
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CA2, CDK6, CHRM2, CHRNA3, CHRNA7, CYP1B1, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, HTR2C, KCNH2, KDR, MET, PIM1, SRC, TNKS2, XDH 3.87464
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.86558
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, F2, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 3.86323
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2C, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.86323
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESRRA, F10, F2, F3, FABP4, FLT3, HTR2C, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.86323
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, HTR2C, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.78804
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 3.78804
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2C, IGF1R, KDR, MET, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.76161
[BP] GO:0008283 cell proliferation ABCB1, ACHE, ADRA1B, ADRA1D, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 3.74593
[BP] GO:0071880 None ADRA1A, ADRA1B, ADRA1D, ADRB2 3.72961
[BP] GO:0007200 None ADRA1A, ADRA1B, ADRA1D, CHRM2, ESR1, HTR2C 3.71272
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.70951
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FLT3, HCAR2, HTR2C, PPARA, RORC, SRC 3.69168
[BP] GO:0050801 ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA12, CA2, CA7, CHRNA7, ESR1, F2, FABP3, HTR2C, KCNH2 3.66243
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, F2, HTR2C, KDR, SRC 3.65092
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, SRC 3.65092
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, ADRB2, CA2, CA7, CHRNA3, CHRNA7, CNR2 3.45285
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, ADRB2, CA2, CA7, CHRNA3, CHRNA7, CNR2 3.45285
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, F2, FABP4, FLT3, HTR2C, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.45285
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, F2, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 3.45256
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.45254
[BP] GO:0071875 None ADRA1A, ADRA1B, ADRA1D, ADRB2 3.45254
[BP] GO:0042391 None ADORA1, ADRA1A, ADRB2, BCL2, CHRNA3, CHRNA7, CNR2, KCNH2, KDR, SRC 3.36601
[BP] GO:0006937 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3 3.35473
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA1B, ADRB2, CHRNA7, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 3.27841
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.26789
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.24965
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3, HCAR2, HTR2C, KCNH2 3.22839
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, F2, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.19418
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, F2, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.14813
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA12, CA2, CA7, CHRNA7, ESR1, F2, HTR2C, KCNH2 3.143
[BP] GO:0008284 positive regulation of cell proliferation ADRA1D, AKR1B1, BCL2, CDC25B, CDK6, CHRNA7, CSNK2A1, ESR1, F2, F3, FLT3, IGF1R, KDR, PIM1 3.14272
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.11083
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CNR2 3.04067
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APEX1, CHRNA7, FABP3, HSD11B2, IGF1R, PPARA, SRC 3.01558
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.01558
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.01558
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.01487
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, ADRB2, CA2, CA7, CHRNA7 3.01487
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, RORC, SRC 2.99904
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2C, PPARA, SRC 2.98341
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.94121
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.92942
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.92513
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 2.90806
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, RORC, SRC 2.89636
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.89342
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 2.8438
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, APEX1, CHRNA3, CHRNA7, CNR2, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC, TYR 2.8438
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, F2, FABP4, FLT3, HTR2C, IGF1R, KDR, PTPN1, SRC, XDH 2.8438
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 2.83668
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KCNH2, KDR, SRC 2.83396
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP2A 2.81459
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.75999
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA1B, ADRB2, CHRNA7, FLT3, HTR2C, IGF1R, KDR, PTPN1, SRC, XDH 2.73759
[BP] GO:0097756 None ADORA1, ADRA1A, ADRA1B, ADRA1D 2.72541
[BP] GO:0009115 None AOX1, XDH 2.71997
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.71997
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.71997
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, ESR1, ESR2, F2, F3, FLT3, MET, PTPN1, SRC, TNKS, XDH 2.69073
[BP] GO:0032845 None ADORA1, BCL2, HTR2C, SRC, TNKS, TNKS2 2.66152
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, PIM1, PTPN1, SRC 2.63259
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.63259
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.60067
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, F2, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.59218
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, SRC 2.59211
[BP] GO:0055080 cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, ESR1, F2, HTR2C, KCNH2 2.58855
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, ESR1, F2, F3, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 2.58368
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, F2, HCAR2, TNKS, TNKS2 2.56766
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, AURKB, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 2.56047
[BP] GO:0090257 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, CHRNA3 2.55317
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, APEX1, CHRNA7, CNR2, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC, TYR 2.55317
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 2.55317
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 2.54279
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, SRC 2.52884
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2 2.51548
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 2.49886
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49544
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD17B1, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.49124
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F2, F3, FLT3, HTR2C, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 2.47083
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.47083
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, HSD11B2 2.47083
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.43086
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, F2, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 2.42734
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, BCL2, CDC25B, CHRNA3, CHRNA7, ESR1, F2, F3, FLT3, HTR2C, KDR, PTPN1, SRC, XDH 2.37911
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CA2, CHRNA7, CYP1B1, ESRRB, F2, F3, HCAR2, KDR, MET, PIM1, SRC 2.37059
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.36407
[BP] GO:0046110 None AOX1, XDH 2.34805
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34805
[BP] GO:1905144 None CHRNA3, CHRNA7 2.34805
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.33135
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, CHRNA3, CHRNA7, F2, FLT3, PTPN1, SRC, TNKS 2.32392
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.31385
[BP] GO:0030003 cellular cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, ESR1, F2, HTR2C 2.31064
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31009
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.30557
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC 2.29917
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, HSD11B2, PPARA, SRC 2.27792
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, SRC 2.27102
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MET, PPARA 2.27102
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, F2, PPARA 2.25154
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F2, F3, FABP4, FLT3, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 2.24754
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, ESR1, F2, F3, FLT3, PTPN1, SRC, TNKS, XDH 2.24669
[BP] GO:0006873 cellular ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CA2, CA7, CHRNA7, ESR1, F2, HTR2C 2.24667
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, HSD11B2, PPARA, SRC 2.21699
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.20556
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRB2, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR2, CSNK2A1, ESR1, F2, F3, FABP4, FLT3, IGF1R, PTPN1, SRC, TNKS, XDH 2.18865
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.17899
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.1724
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA 2.17051
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, PIM1, PTPN1, SRC 2.16428
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15665
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.15207
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.15207
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, PTPN1, RORC, SRC, TOP2A 2.13378
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.13066
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 2.12808
[BP] GO:0070213 None TNKS, TNKS2 2.12396
[BP] GO:0006145 None AOX1, XDH 2.12396
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12396
[BP] GO:0095500 None CHRM2, CHRNA3, CHRNA7 2.1213
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1213
[BP] GO:1903831 None CHRM2, CHRNA3, CHRNA7 2.1213
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, ESR1, F2, HTR2C 2.11603
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.11437
[BP] GO:0009891 positive regulation of biosynthetic process ADRB2, AURKB, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2C, IGF1R, KDR, MET, PPARA, RORC, SRC, TNKS, TNKS2, TOP2A 2.10934
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, CHRNA3, CHRNA7, F2, FABP4, FLT3, IGF1R, PTPN1, SRC, TNKS 2.10704
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, CHRM2, KCNH2 2.08821
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.0778
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRB2, BCL2, CDK6, CNR2, CYP19A1, ESR1, ESR2, F2, IGF1R, MET, PPARA, PTPN1, SRC, XDH 2.0778
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.0778
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2 2.0611
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2 2.0611
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, HSD11B2, PPARA, SRC 2.04238
[BP] GO:0055074 calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, ESR1, F2, HTR2C 2.04209
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, BCL2, CHRNA7, ESR1, F2, HTR2C 2.00798
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.00798
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, SRC 2.00798
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, BCL2, MET, PPARA, SRC 2.00798
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR2, CSNK2A1, ESR1, F10, F2, F3, FLT3, GBA2, GLO1, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC 3.86217
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR 3.29691
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR2, F10, F2, F3, FLT3, HTR2C, IGF1R, KCNH2, KDR, MET, SRC 2.99775
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR2C, IGF1R, KCNH2, KDR, MET, PTPN1, SRC, TYR 2.66795
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CA4, CHRM2, CNR2, F10, F3, FLT3, HTR2C, IGF1R, KDR, MET 2.56475
[CC] GO:0044853 plasma membrane raft ADRA1A, ADRA1B, CHRNA3, CHRNA7, SRC 2.55317
[CC] GO:0031233 None CA4, F10, F3 2.25526
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, ADRA1B, ADRB2, CA2, CA4, CA9, CHRM2, CHRNA3, CHRNA7, MET, SRC 2.22133
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.5943
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 12.6028
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5579
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4801
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 9.38708
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.09809
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, F2, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.03493
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PPARA, RORC 8.67781
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CDK6, CHRM2, CHRNA3, CHRNA7, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PPARA, RORC 8.05687
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PPARA, RORC 7.59276
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, PPARA, PTPN1, RORC, TNKS 7.12222
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR2C, IGF1R, KCNH2, KDR, MET, PPARA, RORC 6.82696
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, HTR2C, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 6.51448
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.9342
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.9342
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.88757
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.79797
[MF] GO:0004937 None ADRA1A, ADRA1B, ADRA1D 4.72191
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.63458
[MF] GO:0008227 None ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRM2, HTR2C 4.60943
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.52515
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 4.47501
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 4.27851
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.27851
[MF] GO:0004935 None ADRA1A, ADRA1B, ADRA1D, ADRB2 4.05415
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR2, F3, FLT3, HCAR2, HTR2C, IGF1R, KDR, MET 3.86558
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRM2, CHRNA3, CHRNA7, CNR2, F3, FLT3, HCAR2, HTR2C, IGF1R, KDR, MET 3.86558
[MF] GO:0004936 None ADRA1A, ADRA1B, ADRA1D 3.6685
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50614
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.36601
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.32223
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.26789
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.20977
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.15786
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.04017
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.78246
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.71997
[MF] GO:0003845 None HSD11B1, HSD11B2 2.71997
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, HSD17B1, IGF1R 2.66042
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.56475
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.54279
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.48352
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.47706
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.43086
[MF] GO:0015464 None CHRM2, CHRNA3, CHRNA7 2.36407
[MF] GO:0042165 neurotransmitter binding ACHE, CHRNA3, CHRNA7, HTR2C 2.34024
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.27102
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.23279
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRB2, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, PIM1, PPARA, PTPN1, SRC 2.18865
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.15077
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12396
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.00798


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.013
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.6741
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRNA3, CNR2, ADORA3, CHRNA7, ADORA1, HTR2C, ADRA1D, ADRB2, F2, ADRA1B, ADRA1A 7.8871
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7615
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRNA7, HTR2C, ADRA1D, ADRB2, ADRA1B, ADRA1A 3.9855
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8044
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.3827
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.6657
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1D, ADRB2, ADRA1B, ADRA1A 3.3827
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRNA3, CHRNA7, BCL2 3.2116
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CHRNA7, CYP1A2, CYP1A1, CYP1B1 3.6657
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, PIM1, CYP1B1, MET, CDC25B 2.9678
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1D, ADRB2, ADRA1B, ADRA1A 2.7562
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.8719
Salivary secretion_Homo sapiens_hsa04970 ADRA1D, ADRB2, ADRA1B, ADRA1A 2.5977
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA1, ADRB2, PPARA 2.2311
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.2311
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.2311
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KDR, BCL2, MET, IGF1R 2.0375
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB2 2.1367
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB2, MET, IGF1R 1.901
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9187
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9187
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.9905
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.6031
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 1.9355
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.608
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.8374
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.551
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, BCL2, MET, IGF1R 1.2974
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1D, ADRA1B, ADRA1A 1.4694
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4694
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2 1.2634
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2053
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.1429
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2 0.994
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2175
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9626
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1935
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1712
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2053
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.156
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9978
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB2 1.1742
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2C 0.9626
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9626
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0088
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1532
Gap junction_Homo sapiens_hsa04540 SRC, HTR2C 0.9987
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8542
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0779
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8996
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9363
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.1504
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9788
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1429
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR2C 0.8857
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8661
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8661
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7852
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.8477
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6153
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.777
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7809
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8477
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6645
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.551
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6169
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6164
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2192
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3047
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3169
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3262
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3047
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3559
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3445
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3742
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3742
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3728
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3845
Platelet activation_Homo sapiens_hsa04611 SRC 0.4008
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3845
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4021
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4008
Axon guidance_Homo sapiens_hsa04360 MET 0.3933
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6031
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5421
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4595
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4595
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4796
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4708
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.479
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4707
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.479
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4707
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4796
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4796
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4794
Peroxisome_Homo sapiens_hsa04146 XDH 0.4896
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5297
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5287
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5417
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8283
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.556
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.556
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.556
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.543
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5622
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5585
Shigellosis_Homo sapiens_hsa05131 SRC 0.556
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.556
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5847
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5585
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6164
Malaria_Homo sapiens_hsa05144 MET 0.6187
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6256
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6221
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6256
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6645
Bladder cancer_Homo sapiens_hsa05219 SRC 0.6605
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6256
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6371
Nicotine addiction_Homo sapiens_hsa05033 CHRNA7 0.6645
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6645
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7426
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7224
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.759
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.759
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7809
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7506
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.777
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8801
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8841
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9626
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1825


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)