TCM Prescription: Su He Xiang Pills



Prescription Description
Prescription IDTCMF546
Pinyin NameSu He Xiang Wan 
Chinese Name苏合香丸
English NameSu He Xiang Pills
Function Description中风不省人事, 癫狂
IndicationsStroke
Disease ICD-11 Category 8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2040 Liquidambar orientalis 苏合香 TCMH2040 GBVL2408-11, GBVL2411-11
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH1717 Moschus moschiferus 人工麝香 TCMH1717 GBMA2112-09
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH25 Styrax benzoin 安息香 TCMH25 CRCZ1380-16, CRCZ1353-16
TCMH1999 Bubalus bubalis 水牛角浓缩粉 TCMH1999 GBMA0080-06
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH158 Piper longum 荜茇 TCMH158 ITSAJ4247-14
TCMH827 Terminalia chebula 诃子肉 TCMH827
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 13.137
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 11.7006
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, PGR, PIM1, PPARA, RORC, SRC, THRA, THRB 11.5087
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, INSR, KDR, MET, MIF, NR1H4, PPARA, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, XDH 10.9226
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR1H4, NR3C1, PPARA, RORC, SRC, TEK, TYR 9.79996
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 9.47909
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 9.46031
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, NR3C1, PPARA, SMAD3, SRC, TEK 9.0969
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 8.95825
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 8.95825
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 8.16154
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, XDH 8.11685
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, NR3C1, PPARA, SRC, TEK 8.08377
[BP] GO:0010647 positive regulation of cell communication ADRA2A, ADRA2C, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 8.05499
[BP] GO:0023056 positive regulation of signaling ADRA2A, ADRA2C, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 8.03979
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, XDH 8.02628
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 8.02628
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.89014
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FUT7, GLO1, HSD17B3, HSPA1A, HTR2C, MIF, NR1H4, PIM1, PPARA, TBXAS1, TYR, XDH 7.70967
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, NR1H4, NR3C1, RORC, SRC, TYR 7.526
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, GRIK5, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 7.50562
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, GRIK5, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 7.49369
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, NR1H4 7.35639
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, GPER1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HTR2C, NR1H4 7.28121
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP9, NR1H4, NUAK1, PTPN1, SRC, TEK, XDH 7.20023
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NR3C1, RORC, SMAD3, SRC 7.07874
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.99354
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.99354
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, GRIK5, HSPA1A, IGF1R, KDR, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 6.97631
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AXL, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 6.965
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.94437
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 6.94437
[BP] GO:0042127 regulation of cell proliferation ADORA3, ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 6.93697
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, PPARA, SMAD3, SRC, TEK, THRA, TYR 6.93697
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 6.86879
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, MIF, NR1H4, PPARA, TBXAS1 6.81379
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, NR3C1, RORC, SRC, TEK, TYR 6.78964
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR1H4, NR3C1, RORC, SMAD3, SRC 6.75655
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 6.74036
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.61043
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR1H4, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 6.5782
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.54492
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.47499
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 6.34195
[BP] GO:0032501 multicellular organismal process ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, GPER1, GRM1, GRM5, GRM8, HSD17B2, HTR2C, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP1, TYR 6.30284
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.12087
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HTR2C, INSR, KDR, MIF, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 6.12087
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HTR2C, INSR, KDR, MIF, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 6.12087
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.07084
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRA2A, ADRA2C, APEX1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPER1, GPR35, GRIK5, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, THRA 6.00318
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HSPA1A, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 5.80622
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 5.80052
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CYP1B1, EGFR, ESR1, GPER1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC 5.78924
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.75293
[BP] GO:0007165 signal transduction ADORA3, ADRA2A, ADRA2C, AKR1B1, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB 5.71749
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ADRA2C, AR, EGFR, FLT3, GPER1, GRM1, HTR2C, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.65058
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK 5.63733
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR1H4, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, TOP1, TOP2A, TYR 5.63662
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 5.60714
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.56357
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ADRA2C, AR, DUSP3, EGFR, FLT3, GPER1, GRM1, HTR2C, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.33314
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.32521
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, INSR, MET, NR1H4, SMAD3, SRC 5.25467
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, INSR, MET, NR1H4, SMAD3 5.09616
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, NR1H4, SRC, TEK 5.03876
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK 5.01638
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HSPA1A, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.956
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.95345
[BP] GO:0030334 regulation of cell migration ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.91553
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, NR3C1, RORC, SRC 4.89507
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 4.88592
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, AR, EGFR, ESR1, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, NR3C1, SMAD3, SRC 4.88592
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 4.87955
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 4.83739
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESRRB, FLT3, GPER1, GRM1, GRM5, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.83739
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HSD11B1, HSD17B1, HSD17B2, HSD17B3, TBXAS1, TYR, XDH 4.76657
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CYP1A1, FABP3, FLT3, GPER1, HTR2C, NR1H4, PPARA, RORC, SRC, TEK, THRA 4.76657
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.66081
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, BACE1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.66081
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, BACE1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.66081
[BP] GO:2000145 regulation of cell motility ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.58545
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.56597
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.51749
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.46953
[BP] GO:0009966 regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, XDH 4.46953
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ADRA2C, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 4.46953
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ADRA2C, AR, CDC25B, EGFR, FLT3, GPER1, GRM1, GRM5, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.46953
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ADRA2C, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 4.45229
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.37145
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR 4.32787
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP1, TOP2A, XDH 4.2158
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, NR1H4, PPARA, SLC1A1 4.19959
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.19959
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.19168
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.18031
[BP] GO:0040012 regulation of locomotion ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.17823
[BP] GO:0051270 regulation of cellular component movement ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.16111
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 4.14196
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MMP2, MMP9, PGR, SRC, THRA, THRB, TOP2A 4.14072
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, GPER1, INSR, MET, SRC, TEK, XDH 4.14072
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.05077
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.04297
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PGR, PPARA, RORC, SRC, TOP1, TOP2A 4.03684
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GPER1, GRM1, GRM5, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.03648
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 4.03648
[BP] GO:0030335 positive regulation of cell migration ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.99595
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HTR2C, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.98092
[BP] GO:0051172 None ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 3.95693
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 3.94809
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.92328
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, NR1H4, SRC, TEK 3.89914
[BP] GO:0048583 regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPER1, GPR35, GRM1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, XDH 3.8981
[BP] GO:2000147 positive regulation of cell motility ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.85704
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 3.85139
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 3.84262
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 3.82596
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.81951
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TOP1, TOP2A, XDH 3.79275
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.74947
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, NR1H4, PPARA, SRC, TEK 3.72942
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK, TYR 3.71671
[BP] GO:0065009 regulation of molecular function ADORA3, ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPER1, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.71408
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP1, TOP2A, XDH 3.70575
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ADRA2C, AXL, CA2, CA7, CYP19A1, EGFR, GPER1, GPR35, GRIK5, GRM5, HSPA1A, HTR2C, INSR, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, THRA 3.70052
[BP] GO:0080134 regulation of response to stress ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.68943
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.67505
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.65124
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK 3.62631
[BP] GO:0040017 positive regulation of locomotion ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.62348
[BP] GO:0051254 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.61575
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.6021
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRA2A, ADRA2C, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, GPR35, GRM1, HSPA1A, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PIM1, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, XDH 3.59688
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ADRA2C, AR, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.59688
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.5738
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.5431
[BP] GO:0031399 regulation of protein modification process ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.53554
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.49754
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 3.49753
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, PGR, SRC 3.48957
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, MIF, PTPN1, SRC 3.4539
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESR1, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.43037
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, GPER1, INSR, NR3C1, SRC 3.428
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AR, AXL, CA2, CYP1B1, EGFR, ESRRB, GPER1, HSPA1A, KDR, MET, MIF, MMP12, MMP9, NR1H4, PIM1, SLC1A1, SMAD3, SRC, TEK 3.42155
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MIF, MMP9, NR1H4, PTPN1, SRC, XDH 3.41509
[BP] GO:0044057 None ADORA3, ADRA2A, ADRA2C, EGFR, GPER1, GPR35, GRM1, HTR2C, SLC1A1, SMAD3, THRA, THRB 3.40151
[BP] GO:0045893 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.40151
[BP] GO:1903508 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.40151
[BP] GO:1902680 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.39906
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.39873
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK, TYR 3.39775
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC 3.38975
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GPER1, GRM5, IGF1R, INSR, PPARA, SRC, TEK 3.38887
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.38887
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, GPER1, HTR2C, KDR, MIF, PTPN1, SRC, TEK 3.37376
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, GPER1, NR1H4, NR3C1, RORC, SRC 3.32004
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 3.31002
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.28198
[BP] GO:0043549 regulation of kinase activity ADRA2A, ADRA2C, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.243
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.23499
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA, TBXAS1 3.22889
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, NR1H4, PPARA, SLC1A1 3.22233
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ADRA2C, AR, CDC25B, EGFR, FLT3, GPER1, GRM1, GRM5, HTR2C, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.20224
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, ADRA2C, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 3.20224
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, GPER1, NR3C1, SRC 3.18691
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, GPER1, INSR, MIF, SRC 3.18691
[BP] GO:0007188 None ADRA2A, ADRA2C, GPER1, GRM1, GRM3, GRM5, GRM8 3.17896
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic EGFR, GRM1, GRM3, GRM5, GRM8 3.17051
[BP] GO:0044093 positive regulation of molecular function ADRA2A, ADRA2C, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.16805
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.15846
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, TYR 3.15846
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.15846
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.15846
[BP] GO:0071073 None FABP3, HTR2C, NR1H4 3.15846
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.1503
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, NR1H4, SRC, TEK, TOP1, TOP2A 3.1136
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.08654
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, EGFR, ESR1, FABP3, GPER1, GPR35, GRM1, GRM5, HTR2C, NR1H4, SMAD3 3.07707
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, CA2, CA7, EGFR, GPER1, HTR2C, KDR, MIF, NR1H4, SRC 3.07051
[BP] GO:0050730 None ADRA2A, ADRA2C, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 3.05397
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.04943
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AR, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 3.04867
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.0315
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0315
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, THRA, THRB 3.0315
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, GPER1, HSPA1A, MMP12, MMP2, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK 3.01687
[BP] GO:0051338 regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.01687
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC 3.00754
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, SRC 3.00721
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 2.99473
[BP] GO:0031348 negative regulation of defense response CYP19A1, GPER1, MMP12, NR1H4, PPARA, SMAD3, TEK 2.97742
[BP] GO:0009890 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.96664
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 2.96408
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK, THRA 2.96408
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADRA2A, ADRA2C, FLT3, GRM5, MIF, PTPN1, SRC 2.95145
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, XDH 2.94848
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, GPER1, NR1H4, PPARA, SMAD3, TEK 2.94746
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, THRA, TYR 2.94416
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.94195
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 2.93835
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.92754
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.92754
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 2.9122
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.90248
[BP] GO:0090087 None ACHE, ADRA2A, ADRA2C, CA2, EGFR, GPER1, HTR2C, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.89679
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.88953
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 2.88289
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, HSD17B3, NR1H4, TYR 2.86616
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.84741
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, RORC, SRC 2.84602
[BP] GO:0007187 None ADRA2A, ADRA2C, GPER1, GRM1, GRM3, GRM5, GRM8 2.82302
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC 2.81629
[BP] GO:1903507 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.81185
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, GRIK5, INSR, SLC1A1, SMAD3 2.81009
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.81009
[BP] GO:1902679 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.81009
[BP] GO:0008050 None THRA, THRB 2.81009
[BP] GO:0009115 None AOX1, XDH 2.81009
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.78295
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, NR1H4, SRC 2.76516
[BP] GO:0045742 None ADRA2A, ADRA2C, GPER1, MMP9 2.76396
[BP] GO:0007267 None ADRA2C, AR, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PGR, SLC1A1, TEK 2.7495
[BP] GO:0007193 None ADRA2A, GRM1, GRM3, GRM5, GRM8 2.7495
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.73799
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, HSPA1A 2.73648
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HTR2C, KDR, NR3C1, SRC, TOP1 2.73578
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, EGFR, FLT3, GRM1, INSR, MIF, PTPN1, SRC 2.73031
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.73031
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, XDH 2.69042
[BP] GO:1901186 None ADRA2A, ADRA2C, GPER1, MMP9 2.6897
[BP] GO:0045944 None AR, EGFR, ESR1, ESRRA, ESRRB, GPER1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, SMAD3, THRA, THRB, TOP2A 2.68708
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, SRC 2.67111
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade EGFR, GPER1, HTR2C, KDR, MIF, SRC, TEK 2.66259
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65366
[BP] GO:0010629 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, KDR, MIF, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, XDH 2.64097
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.63847
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.62797
[BP] GO:0002791 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, HTR2C, MIF, MMP12, NR1H4, SRC 2.59821
[BP] GO:0031327 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.59682
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF 2.57901
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.55259
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC 2.55259
[BP] GO:0061098 None ADRA2A, ADRA2C, GRM5, PTPN1 2.54166
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GPER1, GRM5, IGF1R, INSR, SRC 2.52907
[BP] GO:0042058 None ADRA2A, ADRA2C, EGFR, GPER1, MMP9 2.52679
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, GRM3, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.52331
[BP] GO:0006357 None AR, AURKB, CA9, EGFR, ESR1, ESR2, ESRRA, ESRRB, GLO1, GPER1, HSPA1A, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, THRB, TOP2A 2.52035
[BP] GO:0051253 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.51097
[BP] GO:0045892 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.51097
[BP] GO:0071071 None FABP3, HTR2C, NR1H4 2.49753
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49753
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, FABP4, GPER1, KDR, MET, MIF, MMP12, NR1H4, PPARA, SMAD3, TEK 2.49753
[BP] GO:0010628 positive regulation of gene expression AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.48228
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, ADRA2C, AURKB, CDC25B, EGFR, ESR1, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, XDH 2.44373
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, ADRA2C, CYP19A1, EGFR, GPER1, GRIK5, HTR2C, MIF, MMP12, NR1H4, SRC 2.44309
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, TBXAS1 2.42858
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, NR1H4, PPARA, TBXAS1 2.41918
[BP] GO:0099566 None GRM1, GRM5 2.41547
[BP] GO:0060748 None AR, PGR 2.41547
[BP] GO:0046110 None AOX1, XDH 2.41547
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41547
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, GPER1, NR1H4, PPARA, SMAD3, TEK 2.39864
[BP] GO:0023052 None ADRA2C, AR, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PGR, SLC1A1, TEK 2.3662
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.35637
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, GPER1, NR3C1, SRC 2.34857
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 2.34857
[BP] GO:0003018 None ADRA2A, ADRA2C, EGFR, GPER1, SRC, TEK 2.34857
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.34094
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.32073
[BP] GO:1901184 None ADRA2A, ADRA2C, EGFR, GPER1, MMP9 2.28347
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, MIF, PTPN1, SRC 2.27205
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.26518
[BP] GO:1900542 None ADRA2A, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA 2.26125
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, HSD17B3, TYR 2.2548
[BP] GO:0050714 None ACHE, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.25311
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.25311
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.25311
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.25311
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.25311
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, NR1H4, SRC 2.21828
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.21828
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.21828
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.21828
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, THRA, THRB, TOP1, TOP2A, XDH 2.20917
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AR, AXL, CDC25B, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A 2.20667
[BP] GO:0006140 None ADRA2A, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA 2.19819
[BP] GO:0051046 None ACHE, ADRA2A, ADRA2C, CYP19A1, EGFR, GPER1, GRIK5, HTR2C, MIF, MMP12, NR1H4, SRC 2.19473
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.18965
[BP] GO:0035625 None ADRA2A, ADRA2C 2.17082
[BP] GO:0032811 None ADRA2A, ADRA2C 2.17082
[BP] GO:0006145 None AOX1, XDH 2.17082
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.17082
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17082
[BP] GO:0050678 None AR, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 2.16905
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, MIF, NR1H4, PIM1, PPARA, TBXAS1, TYR 2.16905
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ADRA2C, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPER1, GRM1, GRM5, HSPA1A, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.16372
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.16372
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.15249
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15103
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.15103
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 2.14134
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, INSR, PPARA, RORC, SRC 2.12918
[BP] GO:0007154 None ADRA2C, AR, AXL, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PGR, SLC1A1, TEK 2.12918
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, SMAD3 2.10492
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.10452
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10063
[BP] GO:0051094 positive regulation of developmental process ADRA2C, AR, AXL, CA2, CYP1B1, ESRRB, GPER1, HTR2C, INSR, KDR, NR1H4, PIM1, SMAD3, SRC, TEK, THRA 2.09233
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, THRA, TYR 2.08548
[BP] GO:0002793 None ACHE, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.08448
[BP] GO:0071384 None EGFR, FLT3, GPER1, NR3C1 2.08289
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.07593
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.07515
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.05897
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.05897
[BP] GO:0051894 None KDR, SMAD3, TEK 2.05778
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05778
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, NR1H4, SMAD3 2.05778
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.02524
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AR, AXL, CYP1A1, EGFR, ESR1, PGR, SRC, THRA, THRB 2.02524
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRA2A, EGFR, FLT3, GRM1, INSR, MIF, PTPN1, SRC 2.01816
[BP] GO:0046883 regulation of hormone secretion ADRA2A, ADRA2C, CYP19A1, EGFR, GPER1, HTR2C, NR1H4 2.01782
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.01616
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, AR, CSNK2A1, EGFR, GPER1, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.00056
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GLO1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 2.00056
[BP] GO:0035624 None ADRA2A, ADRA2C 2.00056
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.00056
[BP] GO:0060509 None THRA, THRB 2.00056
[BP] GO:0014060 None ADRA2A, ADRA2C 2.00056
[BP] GO:0030263 None GPER1, TOP2A 2.00056
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.00056
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.00056
[CC] GO:0098590 plasma membrane region ADRA2A, CA2, CA4, CA9, EGFR, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 4.27488
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.2158
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRA2A, ADRA2C, AXL, BACE1, CA4, F10, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.18139
[CC] GO:0043235 receptor complex ADRA2A, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 3.62631
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRA2A, ADRA2C, ALPL, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 3.6021
[CC] GO:0044459 plasma membrane part ADORA3, ADRA2A, ADRA2C, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, F10, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 3.4539
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRA2A, ADRA2C, AXL, BACE1, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.42058
[CC] GO:0009330 None TOP1, TOP2A 2.81009
[CC] GO:0016020 membrane ACHE, ADORA3, ADRA2A, ADRA2C, ALOX5, ALPL, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HSD17B3, HTR2C, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR 2.76396
[CC] GO:0097060 None GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.51097
[CC] GO:0044432 endoplasmic reticulum part BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, GPER1, GRIA2, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTPN1, TBXAS1 2.43369
[CC] GO:0043227 membrane-bounded organelle ACHE, ADRA2C, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, BACE1, CA1, CA2, CA4, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM5, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SHBG, SLC1A1, SMAD3, SRC, THRA, THRB, TOP1, TOP2A, TYR, XDH 2.41547
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AR, AURKB, CDC25B, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, MIF, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP1, TOP2A 2.10492
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.00056
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, THRA, THRB, TYR, XDH 19.9878
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 16.2357
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC, SHBG 13.9541
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, PGR, PPARA, RORC, THRA, THRB 13.9541
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, PGR, PPARA, RORC, THRA, THRB 13.9541
[MF] GO:0038023 signaling receptor activity ADORA3, ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 13.0596
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3, THRA, THRB 12.5718
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.7333
[MF] GO:0004872 receptor activity ADORA3, ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 11.6621
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, TYR, XDH 11.6009
[MF] GO:0060089 molecular transducer activity ADORA3, ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 11.3789
[MF] GO:0004871 signal transducer activity ADORA3, ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK, THRA, THRB 11.3789
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NR3C1, SHBG, THRA, THRB 9.79996
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR2C, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, THRA, THRB, TOP2A, TYR, XDH 8.04331
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.79553
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.526
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, THRA, THRB, TOP2A, TYR, XDH 7.28121
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 7.27175
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.20023
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, GPER1, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 7.20023
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.87332
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.11756
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HSD11B1, HSD17B1, HSD17B2, HSD17B3, TBXAS1, TYR, XDH 6.00016
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 5.57192
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 4.98493
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.91846
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.67586
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRA2A, ADRA2C, AXL, EGFR, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, TEK 4.62025
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRA2A, ADRA2C, AXL, EGFR, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2C, IGF1R, INSR, KDR, MET, TEK 4.62025
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.60679
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 4.46953
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.37145
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, THRA 4.22015
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 4.18031
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, THRA 4.14196
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.8981
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.76385
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.64444
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.63693
[MF] GO:0019899 enzyme binding ADRA2A, AR, AURKB, BACE1, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, GRM5, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PTPN1, SMAD3, SRC, TEK, THRB, TOP2A 3.56731
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.45794
[MF] GO:0004887 None NR1H4, THRA, THRB 3.45205
[MF] GO:0043565 None APEX1, AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TOP1 3.39191
[MF] GO:0003690 None APEX1, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 3.37654
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.20039
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.19134
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.15846
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.15846
[MF] GO:0000981 None AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, THRB 3.1564
[MF] GO:0097159 organic cyclic compound binding ADRA2A, ADRA2C, AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SHBG, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, XDH 3.14752
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.10688
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR2C 3.04943
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.0315
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HSD17B1, SRC, TBXAS1, XDH 3.0188
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3 2.88084
[MF] GO:0000976 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.86855
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81009
[MF] GO:0044212 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.76516
[MF] GO:0001067 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.76396
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.6897
[MF] GO:1990837 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, TOP1 2.6897
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PGR, SMAD3, TOP2A, TYR, XDH 2.68002
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.56356
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.51097
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.43268
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41547
[MF] GO:0004938 None ADRA2A, ADRA2C 2.41547
[MF] GO:0099583 None GRM1, GRM5 2.41547
[MF] GO:0008134 transcription factor binding APEX1, AR, ESR1, ESRRB, FLT3, NR1H4, PIM1, PPARA, SMAD3, SRC, THRA 2.36821
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 2.35261
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.29918
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.29918
[MF] GO:0003682 None APEX1, AR, EGFR, ESR1, GPER1, SMAD3, THRA, THRB, TOP1, TOP2A 2.28389
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 2.22805
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, TOP1 2.18689
[MF] GO:0001012 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3 2.17082
[MF] GO:0000977 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3 2.17082
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17082
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17082
[MF] GO:0004971 None GRIA2, GRIA4 2.17082
[MF] GO:0005497 None AR, SHBG 2.17082
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17082
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.15103
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, DAO, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SLC1A1, SRC, TEK, TOP1, TOP2A, XDH 2.10452
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.08289
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.05815
[MF] GO:1901363 heterocyclic compound binding AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TOP2A, XDH 2.01782
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.01616
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.00056
[MF] GO:0043559 insulin binding IGF1R, INSR 2.00056


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, THRB, THRA, GPR35, GRIK5, HTR2C, NR3C1, ADRA2C, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, GRIA4 10.1234
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.4759
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7844
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 9.7757
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.8492
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.5488
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.1144
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.3064
Metabolic pathways_Homo sapiens_hsa01100 HSD17B3, AKR1B1, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.0998
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7525
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.4048
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.6362
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.2854
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.4048
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.4628
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.4628
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9333
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2C, GRM1, EGFR 3.4048
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.5201
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.6955
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.8453
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7678
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.2152
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2005
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 1.9983
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 1.9983
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, SRC, ESR1 1.9987
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 1.8216
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8668
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.9326
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.8425
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADRA2C, ADRA2A 1.64
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8374
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8321
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8216
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, HTR2C, GRM1, EGFR 1.5865
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8216
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.5201
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 1.8268
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.5986
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5907
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, CYP3A4 1.8216
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5865
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.5224
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.5493
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4499
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.3342
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1989
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1989
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.1989
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1705
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, PPARA, GRIA4 0.9389
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7469
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.169
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9401
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2C 0.8831
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR2C 0.794
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9038
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.745
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.766
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.766
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9014
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2243
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7106
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.745
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.7263
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.238
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.244
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9263
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2525
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2585
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.719
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2522
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2525
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2439
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.2585
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7104
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.1989
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.67
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2823
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7104
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6513
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7042
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0128
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5357
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6513
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3209
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5067
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9706
Axon guidance_Homo sapiens_hsa04360 MET 0.3352
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1989
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1382
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3 0.3508
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1696
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3738
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3738
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1322
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3898
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3966
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1264
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3966
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3966
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4052
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4047
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4094
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4191
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4191
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4298
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4289
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1382
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.183
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4184
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4177
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4627
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4443
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.1631
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.2835
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4501
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4612
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4747
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4931
Shigellosis_Homo sapiens_hsa05131 SRC 0.4951
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5067
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.4403
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3276
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.537
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5402
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4274
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.558
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5896
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5616
Malaria_Homo sapiens_hsa05144 MET 0.5693
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.5654
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.5986
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5735
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5737
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5735
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.563
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4904
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7652
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.67
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6332
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6332
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7258
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7042
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6851
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7106
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7268
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7104
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7258
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8668
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9263
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8453
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1989


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)