GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
[BP] GO:0008152 |
metabolic process
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, TYR, XDH |
8.11991 |
[BP] GO:0044237 |
cellular metabolic process
|
ABCG2, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, TYR, XDH |
7.09803 |
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT |
7.09803 |
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
7.09366 |
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET |
7.04547 |
[BP] GO:0044281 |
small molecule metabolic process
|
ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, PIM1, TYR, XDH |
6.9141 |
[BP] GO:0042221 |
response to chemical
|
ABCG2, AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TERT, TYR |
6.88811 |
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, APEX1, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TYR |
6.68945 |
[BP] GO:0010033 |
response to organic substance
|
AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TYR |
6.57822 |
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, PTPRS, RORC, SRC, TERT, TOP2A, TYR |
6.5612 |
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH |
6.37095 |
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA7, CA9 |
6.11868 |
[BP] GO:0033993 |
response to lipid
|
AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR |
6.00672 |
[BP] GO:0014070 |
response to organic cyclic compound
|
APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC, TYR |
5.98497 |
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, SRC, TERT, XDH |
5.89999 |
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH |
5.8937 |
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 |
5.84313 |
[BP] GO:0070887 |
cellular response to chemical stimulus
|
AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TERT |
5.84313 |
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH |
5.75999 |
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
5.52116 |
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR |
5.34983 |
[BP] GO:0051716 |
cellular response to stimulus
|
AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TERT, TOP2A |
5.17589 |
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH |
5.17589 |
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH |
5.1694 |
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT |
5.12927 |
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
4.89451 |
[BP] GO:0071310 |
cellular response to organic substance
|
AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC |
4.86635 |
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
4.77057 |
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT |
4.65947 |
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC |
4.60638 |
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
4.60276 |
[BP] GO:0065008 |
regulation of biological quality
|
ABCG2, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, SRC, TERT, XDH |
4.51058 |
[BP] GO:0009719 |
response to endogenous stimulus
|
AKR1B1, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, NR3C1, SRC |
4.51058 |
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, TYR, XDH |
4.48976 |
[BP] GO:0071704 |
organic substance metabolic process
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, TYR, XDH |
4.46073 |
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT |
4.44477 |
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
AR, ESR1, NR3C1, NR3C2, PGR, RORC, SRC |
4.44477 |
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
AKR1B1, APEX1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC |
4.2237 |
[BP] GO:0050896 |
response to stimulus
|
ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TERT, TOP2A, TYR |
4.2237 |
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH |
4.22188 |
[BP] GO:0009725 |
response to hormone
|
AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, SRC |
3.9768 |
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 |
3.88921 |
[BP] GO:0019369 |
arachidonic acid metabolic process
|
ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 |
3.77259 |
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
AR, ESR1, NR3C1, NR3C2, PGR, RORC, SRC |
3.76683 |
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 |
3.74095 |
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, XDH |
3.69936 |
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH |
3.68902 |
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.68387 |
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC |
3.67908 |
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
AR, ESR1, NR3C1, PGR, PIM1, RORC, SRC |
3.67908 |
[BP] GO:0048513 |
animal organ development
|
ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PTPRS, SRC, TYR |
3.61466 |
[BP] GO:0042592 |
homeostatic process
|
ABCG2, ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT |
3.61466 |
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, AR, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT |
3.55625 |
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, XDH |
3.46273 |
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KCNA3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT |
3.44207 |
[BP] GO:0048869 |
cellular developmental process
|
ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PGR, PTPRS, RORC, SRC, TERT, TOP2A |
3.44207 |
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC |
3.40505 |
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT |
3.38705 |
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH |
3.37859 |
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH |
3.36271 |
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH |
3.31675 |
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH |
3.29574 |
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET |
3.20429 |
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, MMP9, PGR, PIM1, PTPRS, RORC, SRC, TYR |
3.20429 |
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
3.17394 |
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, FLT3, KDR, MET, PTPN1, SRC, XDH |
3.16845 |
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT |
3.16348 |
[BP] GO:0030518 |
intracellular steroid hormone receptor signaling pathway
|
AR, ESR1, NR3C1, PGR, SRC |
3.1592 |
[BP] GO:0010038 |
response to metal ion
|
ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT |
3.11899 |
[BP] GO:0060736 |
prostate gland growth
|
AR, CYP19A1, ESR1 |
3.07127 |
[BP] GO:1901989 |
None
|
APEX1, APP, CDC25B, CYP1A1, TERT |
3.01907 |
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH |
2.97134 |
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 |
2.93412 |
[BP] GO:0042493 |
response to drug
|
ABCG2, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, SRC |
2.8678 |
[BP] GO:0006367 |
transcription initiation from RNA polymerase II promoter
|
AR, ESR1, NR3C1, NR3C2, PGR, RORC |
2.86673 |
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.86673 |
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT |
2.86673 |
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT |
2.85627 |
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
2.8045 |
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.78408 |
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SRC, TYR |
2.74826 |
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 |
2.70842 |
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC |
2.69774 |
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC |
2.67265 |
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 |
2.65697 |
[BP] GO:1901654 |
None
|
AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC |
2.65697 |
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.63899 |
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
2.63118 |
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ALOX15, APP, AR, FLT3, KDR, PTPN1, SRC, XDH |
2.62137 |
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
2.60515 |
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ALOX15, APP, AR, AURKB, CDC25B, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
2.60508 |
[BP] GO:0008283 |
cell proliferation
|
ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR |
2.59935 |
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1, SRC |
2.59935 |
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, FLT3, IGF1R, KDR, MET, SRC |
2.58624 |
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, SRC |
2.58608 |
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
2.58608 |
[BP] GO:0048511 |
rhythmic process
|
AXL, CSNK2A1, ESR1, PGR, RORC, SRC, TOP2A |
2.57051 |
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, FLT3, IGF1R, KDR, MET, SRC |
2.56094 |
[BP] GO:0009987 |
cellular process
|
ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNA3, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, TYR, XDH |
2.55282 |
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC |
2.5104 |
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTPN1, SRC |
2.51035 |
[BP] GO:0022414 |
reproductive process
|
AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, MMP2, MMP9, PGR, SRC, TOP2A |
2.49495 |
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, XDH |
2.49495 |
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3 |
2.4862 |
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
AKR1B1, APEX1, APP, AR, ESR1, FLT3, IGF1R, MMP2, NR3C1, SRC |
2.4862 |
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, TYR |
2.47045 |
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 |
2.44693 |
[BP] GO:0097237 |
cellular response to toxic substance
|
AKR1B1, APEX1, AXL, CYP1B1, KDR |
2.43837 |
[BP] GO:0060748 |
None
|
AR, PGR |
2.4309 |
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.4309 |
[BP] GO:0006352 |
DNA-templated transcription, initiation
|
AR, ESR1, NR3C1, NR3C2, PGR, RORC |
2.41694 |
[BP] GO:0043393 |
regulation of protein binding
|
APP, AURKB, MET, MMP9, SRC, TERT |
2.41694 |
[BP] GO:0030198 |
extracellular matrix organization
|
APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 |
2.40601 |
[BP] GO:0043062 |
extracellular structure organization
|
APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 |
2.40004 |
[BP] GO:0070301 |
cellular response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1 |
2.39163 |
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, HSD17B1, HSD17B2 |
2.39163 |
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.38195 |
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ALOX15, APP, AR, FLT3, IGF1R, KDR, PTPN1, SRC, XDH |
2.347 |
[BP] GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation
|
MMP2, MMP9, TERT |
2.33082 |
[BP] GO:0030574 |
collagen catabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.30359 |
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, XDH |
2.30359 |
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.28235 |
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.22803 |
[BP] GO:0042180 |
None
|
AKR1B1, AKR1B10, CYP19A1, GLO1 |
2.21129 |
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, APP, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PTPN1, PTPRS, SRC, TERT, XDH |
2.21117 |
[BP] GO:1901992 |
positive regulation of mitotic cell cycle phase transition
|
APEX1, APP, CYP1A1, TERT |
2.19487 |
[BP] GO:0032847 |
regulation of cellular pH reduction
|
CA2, CA7 |
2.19405 |
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.19405 |
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, AR, ESR1, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH |
2.17523 |
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, SRC |
2.17184 |
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH |
2.17184 |
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH |
2.17184 |
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, AR, ESR1, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH |
2.17184 |
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
2.16311 |
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ALOX15, AR, CYP19A1, ESR1, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH |
2.16311 |
[BP] GO:0044243 |
multicellular organismal catabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.15186 |
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, APP, CDC25B, CYP1A1, TERT |
2.15186 |
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC |
2.14508 |
[BP] GO:0071383 |
None
|
AR, FLT3, NR3C1, SRC |
2.13403 |
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH |
2.13403 |
[BP] GO:0032787 |
None
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1 |
2.13403 |
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ALOX15, APP, AR, CDC25B, FLT3, KDR, MMP9, PTPN1, SRC, XDH |
2.11353 |
[BP] GO:0071248 |
cellular response to metal ion
|
ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 |
2.11025 |
[BP] GO:0071396 |
cellular response to lipid
|
AR, AXL, ESR1, FLT3, NR3C1, RORC, SRC |
2.1032 |
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, MMP2, MMP9, TERT |
2.1032 |
[BP] GO:0065007 |
biological regulation
|
ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KCNA3, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, XDH |
2.09755 |
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TERT, TOP2A, XDH |
2.06633 |
[BP] GO:0006082 |
organic acid metabolic process
|
ABCG2, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, TYR |
2.05303 |
[BP] GO:0022617 |
extracellular matrix disassembly
|
MMP1, MMP12, MMP2, MMP9 |
2.04931 |
[BP] GO:1901655 |
None
|
AKR1B1, AR, NR3C1, SRC |
2.0166 |
[BP] GO:0032963 |
collagen metabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.0166 |
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, APP, AURKB, CDC25B, CYP1A1, SRC, TERT |
2.0166 |
[BP] GO:0035265 |
organ growth
|
AR, CYP19A1, ESR1 |
2.0166 |
[CC] GO:0044444 |
cytoplasmic part
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, SRC, TERT, TOP2A, TYR, XDH |
3.20429 |
[CC] GO:0005886 |
plasma membrane
|
ABCG2, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, IGF1R, KCNA3, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SRC, TERT |
2.38168 |
[CC] GO:0016020 |
membrane
|
ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GLO1, HSD17B2, IGF1R, KCNA3, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, PTPRS, SRC, TERT, TYR |
2.03527 |
[CC] GO:0097443 |
sorting endosome
|
KDR, PTPN1 |
1.90833 |
[CC] GO:0005641 |
nuclear envelope lumen
|
ALOX5, APP |
1.69346 |
[MF] GO:0046914 |
transition metal ion binding
|
ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TYR, XDH |
16.0258 |
[MF] GO:0043167 |
ion binding
|
ABCG2, ACHE, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, RORC, SRC, TERT, TOP2A, TYR, XDH |
10.5527 |
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
10.3294 |
[MF] GO:0003824 |
catalytic activity
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TOP2A, TYR, XDH |
9.49602 |
[MF] GO:0008270 |
zinc ion binding
|
AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, RORC |
7.76424 |
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
7.09366 |
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TERT, TOP2A, TYR, XDH |
6.5954 |
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.5954 |
[MF] GO:0046872 |
metal ion binding
|
ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TERT, TOP2A, TYR, XDH |
6.22892 |
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 |
5.75999 |
[MF] GO:0005496 |
steroid binding
|
AR, ESR1, HSD17B1, NR3C1, NR3C2, PGR, RORC |
5.48909 |
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH |
5.1694 |
[MF] GO:0003707 |
steroid hormone receptor activity
|
AR, ESR1, NR3C1, NR3C2, PGR, RORC |
5.03377 |
[MF] GO:0005506 |
iron ion binding
|
ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH |
3.87759 |
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
3.74095 |
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
3.57061 |
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, FLT3, IGF1R, KDR, MET |
3.55625 |
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH |
3.20429 |
[MF] GO:0008289 |
lipid binding
|
ALOX15, AR, AXL, ESR1, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC |
3.16845 |
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, FLT3, IGF1R, KDR, MET |
3.13665 |
[MF] GO:0042562 |
hormone binding
|
ACHE, AR, HSD17B1, IGF1R, NR3C1 |
2.99838 |
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR |
2.80077 |
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
2.77403 |
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
AR, ESR1, PGR, RORC |
2.65697 |
[MF] GO:0004879 |
nuclear receptor activity
|
AR, ESR1, PGR, RORC |
2.65697 |
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, FLT3, IGF1R, KDR, MET, SRC |
2.63118 |
[MF] GO:0008144 |
drug binding
|
ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP2A |
2.55488 |
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC |
2.52723 |
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 |
2.44957 |
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC |
2.3396 |
[MF] GO:0042802 |
identical protein binding
|
ABCG2, ACHE, APP, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PGR, TERT, TOP2A, TYR, XDH |
2.30968 |
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC |
2.20841 |
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PTPN1, SRC |
2.06633 |
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR |
2.03527 |
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC |
2.00182 |