Prescription Description
| Prescription ID | TCMF4785 |
| Pinyin Name | Jia Wei Qing E Wan |
| Chinese Name | 加味青娥丸 |
| English Name | Jia Wei Qing E Pills |
| Function Description | 腰痛, 阳痿, 遗精, 腹痛 |
| Indications | Abdominal pain disorder, Involuntary ejaculation disorder, Impotence disorder, Lumbago disorder, Sexual dysfunction, Lumbago |
| Disease ICD-11 Category |
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛，未特指的 ]; |
| Human Tissues Associated with Indication | Intestine, Stomach, Uterus, Kidney, Bladder |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
| TCMH823 | Semen juglandis | 核桃仁 | TCMH823 | |
| TCMH31 | Morinda officinalis | 巴戟天 | TCMH31 | ITSAJ4459-14 |
| TCMH1740 | Cistanche deserticola | 肉苁蓉 | TCMH1740 | ITSAM2511-14 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
| TCMH1753 | Boswellia carterii | 乳香 | TCMH1753 | |
| TCMH1508 | Commiphora myrrha | 没药 | TCMH1508 | MH522406 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
| TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
| TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
| TCMT151 | PRKCA | Protein kinase C alpha | Kinase | P17252 |
| TCMT152 | PRKCB | Protein kinase C beta | Kinase | P05771 |
| TCMT153 | PRKCG | Protein kinase C gamma | Kinase | P05129 |
| TCMT154 | PRKCD | Protein kinase C delta | Kinase | Q05655 |
| TCMT155 | PRKCE | Protein kinase C epsilon | Kinase | Q02156 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
| TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
| TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
| TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
| TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
| TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
| TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
| TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
| TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
| TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
| TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
| TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
| TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
| TCMT336 | IDO1 | Indoleamine 2,3-dioxygenase | Oxidoreductase | P14902 |
| TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
| TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
| TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
| TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
| TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
| TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
| TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
| TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
| TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
| TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
| TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
| TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
| TCMT619 | HSP90AA1 | Heat shock protein HSP 90-alpha | Unclassified | P07900 |
| TCMT624 | HSP90AB1 | Heat shock protein HSP 90-beta | Unclassified | P08238 |
| TCMT637 | SIRT3 | NAD-dependent deacetylase sirtuin 3 | Hydrolase | Q9NTG7 |
| TCMT638 | SIRT2 | NAD-dependent deacetylase sirtuin 2 | Hydrolase | Q8IXJ6 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
| TCMT67 | PPARG | Peroxisome proliferator-activated receptor gamma | Nuclear receptor | P37231 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT783 | NR3C2 | Mineralocorticoid receptor | Nuclear receptor | P08235 |
| TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
| TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
| TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
| TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
| TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
| TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT904 | PGR | Progesterone receptor | Nuclear receptor | P06401 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
| TCMT1218 | Staphylococcus aureus |
| TCMT1219 | Enterococcus |
| TCMT1222 | Plasmodium falciparum D6 |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1231 | Human herpesvirus 1 strain KOS |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1246 | Escherichia coli |
| TCMT1248 | Hepatitis C virus |
| TCMT1249 | Dengue virus 2 |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1286 | Bacillus cereus |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1354 | Streptococcus mutans UA159 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1390 | Human herpesvirus 2 strain G |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1442 | Leishmania donovani |
| TCMT1443 | Leishmania amazonensis |
| TCMT1447 | Respiratory syncytial virus |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1449 | Influenza A virus |
| TCMT1450 | Plasmodium falciparum 3D7 |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1464 | Hepatitis B virus |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MMP2, NR3C1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR | 13.8553 |
| [BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR | 12.3207 |
| [BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, HSP90AB1, IDO1, IGF1R, MMP2, MMP9, NR3C1, PPARG, PRKCB, PRKCD, PRKCE, RORC, SRC, TYR | 11.5588 |
| [BP] GO:0008152 | metabolic process | ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR, XDH | 10.7714 |
| [BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR, XDH | 10.2323 |
| [BP] GO:0033993 | response to lipid | ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PPARG, PRKCE, RORC, SRC, TYR | 10.2323 |
| [BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 9.25674 |
| [BP] GO:0014070 | response to organic cyclic compound | ALPL, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PRKCE, PRKCG, RORC, SRC, TYR | 9.13261 |
| [BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, ALPL, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PRKCB, PRKCD, PRKCE, RORC, SRC | 8.51475 |
| [BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, ALPL, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARG, PRKCB, PRKCD, PRKCE, RORC, SRC | 8.33726 |
| [BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA6, CA7, CA9 | 8.11866 |
| [BP] GO:0048522 | positive regulation of cellular process | ACHE, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 7.24492 |
| [BP] GO:0043401 | steroid hormone mediated signaling pathway | AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARG, RORC, SRC | 7.11469 |
| [BP] GO:0019748 | secondary metabolic process | AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 7.10446 |
| [BP] GO:0009725 | response to hormone | AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARG, PRKCD, PRKCE, SRC | 6.7883 |
| [BP] GO:0065008 | regulation of biological quality | ACHE, AKR1B1, ALOX15, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MET, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 6.75904 |
| [BP] GO:0043067 | regulation of programmed cell death | AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PRKCA, PRKCD, PRKCG, SRC, XDH | 6.75904 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PPARG | 6.73711 |
| [BP] GO:0044281 | small molecule metabolic process | AKR1B1, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARG, TYR, XDH | 6.67429 |
| [BP] GO:0048518 | positive regulation of biological process | ACHE, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 6.54449 |
| [BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARG, PRKCD, PRKCE, SRC | 6.3576 |
| [BP] GO:0009755 | hormone-mediated signaling pathway | AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARG, RORC, SRC | 6.32371 |
| [BP] GO:0010941 | regulation of cell death | AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PRKCA, PRKCD, PRKCG, SRC, XDH | 6.27057 |
| [BP] GO:0043069 | negative regulation of programmed cell death | AKR1B1, AR, AURKB, AXL, CSNK2A1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC | 6.2439 |
| [BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PRKCB, PRKCD, PRKCE, RORC, SRC | 6.24063 |
| [BP] GO:0030522 | intracellular receptor signaling pathway | AR, ESR1, ESR2, NR3C1, PGR, PIM1, PPARG, RORC, SRC | 6.1974 |
| [BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PPARG, PRKCB, PRKCD, PRKCE, RORC, SRC | 6.16499 |
| [BP] GO:0008202 | steroid metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1, HSD17B2 | 6.16187 |
| [BP] GO:0042981 | regulation of apoptotic process | AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HSP90AB1, IDO1, IGF1R, KDR, MMP9, PIM1, PPARG, PRKCA, PRKCD, PRKCG, SRC, XDH | 6.1373 |
| [BP] GO:0055114 | oxidation-reduction process | AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, IDO1, PPARG, TYR, XDH | 6.11183 |
| [BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 | 6.03214 |
| [BP] GO:0050896 | response to stimulus | ACHE, AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR | 5.93436 |
| [BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.93436 |
| [BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, AR, CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SRC | 5.92301 |
| [BP] GO:0044238 | primary metabolic process | ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR, XDH | 5.91514 |
| [BP] GO:0060548 | negative regulation of cell death | AKR1B1, AR, AURKB, AXL, CSNK2A1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC | 5.80318 |
| [BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, SRC | 5.78737 |
| [BP] GO:0010647 | positive regulation of cell communication | AKR1B1, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HSP90AB1, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 5.58984 |
| [BP] GO:0043066 | negative regulation of apoptotic process | AKR1B1, AR, AURKB, AXL, CSNK2A1, HSP90AB1, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, SRC | 5.57238 |
| [BP] GO:0023056 | positive regulation of signaling | AKR1B1, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HSP90AB1, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 5.57238 |
| [BP] GO:0019369 | arachidonic acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.55973 |
| [BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.51302 |
| [BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HSP90AB1, KDR, NR3C1, PPARG, PRKCD, PRKCE, PRKCG, SRC | 5.51018 |
| [BP] GO:0048513 | animal organ development | ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, PPARG, SRC, TYR | 5.39772 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARG, RORC | 5.36103 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.32624 |
| [BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 5.21791 |
| [BP] GO:0071704 | organic substance metabolic process | ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR, XDH | 5.18472 |
| [BP] GO:0030168 | platelet activation | AXL, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 5.17428 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 5.12062 |
| [BP] GO:0048584 | positive regulation of response to stimulus | AKR1B1, ALOX15, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, HSP90AA1, HSP90AB1, IDO1, KDR, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 5.10657 |
| [BP] GO:1901654 | None | AKR1B1, AR, CA9, CSNK2A1, NR3C1, PPARG, PRKCE, SRC | 5.04633 |
| [BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, PRKCD, SRC | 4.91434 |
| [BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, PRKCD, SRC | 4.86579 |
| [BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC | 4.7488 |
| [BP] GO:0032502 | developmental process | ACHE, AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARG, PRKCA, PRKCD, RORC, SRC, TYR | 4.70648 |
| [BP] GO:0030518 | intracellular steroid hormone receptor signaling pathway | AR, ESR1, ESR2, NR3C1, PGR, SRC | 4.70185 |
| [BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, HSP90AB1, KDR, NR3C1, PRKCD, PRKCE, SRC | 4.70185 |
| [BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 4.66409 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARG, RORC | 4.63351 |
| [BP] GO:1901655 | None | AKR1B1, AR, NR3C1, PPARG, PRKCE, SRC | 4.62505 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARG | 4.54691 |
| [BP] GO:0010817 | regulation of hormone levels | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2, PRKCA, PRKCE | 4.51239 |
| [BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, HSP90AA1, KDR, PRKCD, PRKCE, SRC | 4.47624 |
| [BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARG | 4.32857 |
| [BP] GO:1902531 | regulation of intracellular signal transduction | AKR1B1, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 4.31123 |
| [BP] GO:0010646 | regulation of cell communication | ACHE, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 4.31059 |
| [BP] GO:0042127 | regulation of cell proliferation | AKR1B1, AR, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IDO1, IGF1R, KDR, MMP2, MMP9, PGR, PIM1, PPARG, PRKCA, SRC, XDH | 4.28791 |
| [BP] GO:1901568 | fatty acid derivative metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.28361 |
| [BP] GO:0051972 | regulation of telomerase activity | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC | 4.2809 |
| [BP] GO:0023051 | regulation of signaling | ACHE, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 4.22527 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.13561 |
| [BP] GO:0048856 | anatomical structure development | ACHE, AKR1B1, ALOX15, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, MMP9, PGR, PIM1, PPARG, RORC, SRC, TYR | 4.12013 |
| [BP] GO:0018105 | peptidyl-serine phosphorylation | AURKB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 4.12013 |
| [BP] GO:0016310 | phosphorylation | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 4.09776 |
| [BP] GO:0009967 | positive regulation of signal transduction | AKR1B1, ALOX15, AR, AXL, CSNK2A1, CYP1B1, FLT3, HSP90AB1, KDR, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 4.0578 |
| [BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC | 3.95836 |
| [BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.95836 |
| [BP] GO:0042592 | homeostatic process | AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, MET, PPARG, PRKCB, PRKCE, SRC | 3.957 |
| [BP] GO:0071396 | cellular response to lipid | AR, AXL, ESR1, FLT3, NR3C1, PPARG, PRKCE, RORC, SRC | 3.957 |
| [BP] GO:0048583 | regulation of response to stimulus | AKR1B1, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP2, MMP9, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 3.95487 |
| [BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, ALPL, AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 3.8762 |
| [BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.8762 |
| [BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.8762 |
| [BP] GO:0032787 | None | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARG | 3.8762 |
| [BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 | 3.86474 |
| [BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, RORC | 3.86101 |
| [BP] GO:0018209 | peptidyl-serine modification | AURKB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 3.85805 |
| [BP] GO:0048608 | reproductive structure development | AR, AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC | 3.8578 |
| [BP] GO:0010243 | response to organonitrogen compound | AKR1B1, FABP3, FLT3, HSP90AB1, IGF1R, MMP2, PPARG, PRKCD, PRKCE, PRKCG, SRC, TYR | 3.77797 |
| [BP] GO:0097237 | cellular response to toxic substance | AKR1B1, AXL, CYP1B1, KDR, PRKCD, PRKCE | 3.75799 |
| [BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, SRC | 3.75386 |
| [BP] GO:0016572 | histone phosphorylation | AURKB, PRKCA, PRKCB, PRKCD | 3.74965 |
| [BP] GO:0048511 | rhythmic process | AXL, CSNK2A1, ESR1, PGR, PPARG, PRKCG, RORC, SRC | 3.72022 |
| [BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARG, PRKCD, PRKCE, SRC | 3.70842 |
| [BP] GO:0048519 | negative regulation of biological process | ACHE, AKR1B1, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 3.70256 |
| [BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ALOX15, AR, AURKB, CSNK2A1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 3.6974 |
| [BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PRKCA, PRKCE, SRC | 3.67713 |
| [BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, ALPL, AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 3.64765 |
| [BP] GO:0080134 | regulation of response to stress | CYP19A1, ESR1, FABP4, HSP90AA1, HSP90AB1, IDO1, IGF1R, MET, MMP2, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, SRC, XDH | 3.63188 |
| [BP] GO:0008283 | cell proliferation | ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, PRKCD, SRC, TYR | 3.60357 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, FLT3, HSP90AA1, HSP90AB1, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC | 3.56424 |
| [BP] GO:0044255 | cellular lipid metabolic process | ACHE, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, MET, PPARG | 3.54229 |
| [BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, HSP90AA1, HSP90AB1, IGF1R, PRKCD, PRKCG, SRC | 3.50567 |
| [BP] GO:1902533 | positive regulation of intracellular signal transduction | AKR1B1, ALOX15, AR, AXL, CYP1B1, FLT3, KDR, MET, PRKCA, PRKCB, PRKCE, SRC, XDH | 3.48897 |
| [BP] GO:1901698 | response to nitrogen compound | AKR1B1, FABP3, FLT3, HSP90AB1, IGF1R, MMP2, PPARG, PRKCD, PRKCE, PRKCG, SRC, TYR | 3.48773 |
| [BP] GO:0010632 | regulation of epithelial cell migration | KDR, MET, MMP9, PPARG, PRKCA, PRKCE, SRC | 3.48773 |
| [BP] GO:0048523 | negative regulation of cellular process | ACHE, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 3.47543 |
| [BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARG | 3.47219 |
| [BP] GO:0009893 | positive regulation of metabolic process | ALOX15, AR, AURKB, CSNK2A1, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 3.46572 |
| [BP] GO:0031325 | positive regulation of cellular metabolic process | ALOX15, AR, AURKB, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 3.46572 |
| [BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, AR, ESR1, FLT3, IGF1R, MMP2, NR3C1, PPARG, PRKCD, PRKCE, SRC | 3.46572 |
| [BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.46423 |
| [BP] GO:0010604 | positive regulation of macromolecule metabolic process | ALOX15, AR, AURKB, CSNK2A1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 3.43483 |
| [BP] GO:0044092 | negative regulation of molecular function | AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARG, PRKCA, PRKCD, PRKCE, SRC | 3.42395 |
| [BP] GO:0051130 | positive regulation of cellular component organization | ALOX15, AR, AURKB, AXL, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PPARG, PRKCD, PRKCE, SRC | 3.40502 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PPARG, PRKCE, SRC | 3.4008 |
| [BP] GO:0022414 | reproductive process | AKR1B1, ALPL, AR, AXL, CYP19A1, CYP1A1, ESR1, HSD17B2, HSP90AB1, IDO1, MMP2, MMP9, PGR, PPARG, SRC | 3.38723 |
| [BP] GO:0060736 | prostate gland growth | AR, CYP19A1, ESR1 | 3.34864 |
| [BP] GO:0019752 | carboxylic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARG, TYR | 3.33694 |
| [BP] GO:0032879 | regulation of localization | ACHE, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 3.32744 |
| [BP] GO:0032870 | cellular response to hormone stimulus | AR, ESR1, FLT3, NR3C1, PPARG, PRKCD, PRKCE, SRC | 3.22217 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AR, AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, PGR, PPARG, SRC | 3.15892 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 3.13482 |
| [BP] GO:0032230 | positive regulation of synaptic transmission, GABAergic | CA2, CA7, PRKCE | 3.13482 |
| [BP] GO:0032501 | multicellular organismal process | AKR1B1, ALOX15, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PRKCD, PRKCG, RORC, SRC, TYR | 3.13365 |
| [BP] GO:0009056 | catabolic process | ACHE, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, HSP90AA1, IDO1, MMP1, MMP2, MMP9, SRC, XDH | 3.11977 |
| [BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, PRKCD, SRC | 3.11211 |
| [BP] GO:0019216 | regulation of lipid metabolic process | CYP1A1, FABP3, FLT3, PPARG, PRKCD, PRKCE, RORC, SRC | 3.05944 |
| [BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 3.04339 |
| [BP] GO:0035408 | None | PRKCA, PRKCB | 3.03486 |
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC | 2.98011 |
| [BP] GO:0007165 | signal transduction | AKR1B1, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC | 2.96561 |
| [BP] GO:0043436 | oxoacid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARG, TYR | 2.95599 |
| [BP] GO:2000278 | regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC | 2.90027 |
| [BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.89354 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARG, TYR | 2.89354 |
| [BP] GO:0051052 | regulation of DNA metabolic process | AURKB, HSP90AA1, HSP90AB1, IGF1R, PPARG, PRKCD, PRKCG, SRC | 2.89354 |
| [BP] GO:0009966 | regulation of signal transduction | AKR1B1, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, SRC, XDH | 2.88 |
| [BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, AXL, CYP1B1, PRKCD, SRC | 2.8563 |
| [BP] GO:0043254 | regulation of protein complex assembly | ALOX15, ESR1, HSP90AA1, MET, MMP1, PRKCD, PRKCE, SRC | 2.85412 |
| [BP] GO:0002682 | regulation of immune system process | ALOX15, AXL, CA2, CYP19A1, ESR1, HSP90AA1, HSP90AB1, IDO1, MMP2, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, SRC | 2.85195 |
| [BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, SRC | 2.78888 |
| [BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC | 2.75599 |
| [BP] GO:0009628 | response to abiotic stimulus | AKR1B1, AURKB, CA2, CYP1A1, HSP90AA1, HSP90AB1, MMP2, PPARG, PRKCB, PRKCE, SRC, TYR | 2.74855 |
| [BP] GO:0009892 | negative regulation of metabolic process | AR, AURKB, CSNK2A1, ESR1, ESR2, FABP4, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.69935 |
| [BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2 | 2.66799 |
| [BP] GO:0009891 | positive regulation of biosynthetic process | AR, AURKB, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NR3C1, PGR, PPARG, PRKCD, RORC, SRC | 2.63114 |
| [BP] GO:0043393 | regulation of protein binding | AURKB, HSP90AB1, MET, MMP9, PRKCD, SRC | 2.63114 |
| [BP] GO:0060748 | None | AR, PGR | 2.62922 |
| [BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.62922 |
| [BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, AXL, CYP1B1, PRKCD | 2.58946 |
| [BP] GO:0043408 | regulation of MAPK cascade | ALOX15, AR, FLT3, IGF1R, KDR, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.57884 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 | 2.56997 |
| [BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, AR, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA | 2.55181 |
| [BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, SRC | 2.52027 |
| [BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.52027 |
| [BP] GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | HSP90AA1, HSP90AB1, PRKCD, PRKCE, SRC | 2.51854 |
| [BP] GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | HSP90AA1, HSP90AB1, PRKCD, PRKCE, SRC | 2.51854 |
| [BP] GO:0048545 | response to steroid hormone | ALPL, AR, CA2, FLT3, NR3C1, SRC | 2.5 |
| [BP] GO:0002431 | Fc receptor mediated stimulatory signaling pathway | HSP90AA1, HSP90AB1, PRKCD, PRKCE, SRC | 2.49443 |
| [BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.47587 |
| [BP] GO:0038094 | Fc-gamma receptor signaling pathway | HSP90AA1, HSP90AB1, PRKCD, PRKCE, SRC | 2.46939 |
| [BP] GO:0051128 | regulation of cellular component organization | ALOX15, AR, AURKB, AXL, CSNK2A1, ESR1, ESR2, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP9, PPARG, PRKCD, PRKCE, PRKCG, SRC | 2.46939 |
| [BP] GO:0031334 | positive regulation of protein complex assembly | ALOX15, ESR1, MET, MMP1, PRKCE, SRC | 2.44956 |
| [BP] GO:0035902 | response to immobilization stress | CYP1A1, CYP1A2, PPARG | 2.42997 |
| [BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.42997 |
| [BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, HSP90AA1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TYR, XDH | 2.41779 |
| [BP] GO:0010562 | positive regulation of phosphorus metabolic process | ALOX15, AR, FABP3, FLT3, HSP90AB1, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.4112 |
| [BP] GO:0045937 | positive regulation of phosphate metabolic process | ALOX15, AR, FABP3, FLT3, HSP90AB1, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.4112 |
| [BP] GO:0051098 | regulation of binding | AURKB, HSP90AB1, MET, MMP9, PPARG, PRKCD, SRC | 2.38798 |
| [BP] GO:1905323 | None | HSP90AA1, HSP90AB1 | 2.38798 |
| [BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.38798 |
| [BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.38798 |
| [BP] GO:0030334 | regulation of cell migration | CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, SRC | 2.36684 |
| [BP] GO:1903725 | regulation of phospholipid metabolic process | FABP3, FLT3, PRKCD, SRC | 2.36684 |
| [BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, HSP90AA1, KDR, SRC | 2.36684 |
| [BP] GO:0048878 | chemical homeostasis | AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PPARG, PRKCB, PRKCE | 2.34818 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ALOX15, AR, FLT3, HSP90AB1, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.34393 |
| [BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | AR, AURKB, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, MET, NR3C1, PGR, PPARG, PRKCD, PRKCG, RORC, SRC | 2.34393 |
| [BP] GO:0009410 | None | HSP90AB1, NR3C1, PPARG, PRKCE, PRKCG | 2.33052 |
| [BP] GO:0071383 | None | AR, FLT3, NR3C1, SRC | 2.33045 |
| [BP] GO:0032101 | regulation of response to external stimulus | CYP19A1, ESR1, FABP4, IDO1, KDR, MET, PPARG, PRKCA, PRKCD, PRKCG | 2.3282 |
| [BP] GO:0044089 | positive regulation of cellular component biogenesis | ALOX15, ESR1, KDR, MET, MMP1, PRKCA, PRKCE, SRC | 2.31764 |
| [BP] GO:0031347 | regulation of defense response | CYP19A1, ESR1, FABP4, HSP90AB1, IDO1, MMP2, PPARG, PRKCD, PRKCE, SRC | 2.31764 |
| [BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 | 2.31764 |
| [BP] GO:0031324 | negative regulation of cellular metabolic process | AR, AURKB, CSNK2A1, ESR1, ESR2, FABP4, HSP90AB1, IGF1R, MET, MMP9, NR3C1, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.30687 |
| [BP] GO:0031100 | animal organ regeneration | AXL, CSNK2A1, FLT3, PPARG | 2.30187 |
| [BP] GO:0051240 | positive regulation of multicellular organismal process | AR, AXL, CA2, CYP1B1, IDO1, KDR, MET, MMP9, PIM1, PPARG, PRKCA, PRKCB, PRKCE, SRC | 2.30187 |
| [BP] GO:0044093 | positive regulation of molecular function | AR, AURKB, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, MET, MMP9, PPARG, PRKCB, PRKCD, PRKCE, SRC, XDH | 2.30116 |
| [BP] GO:0018107 | peptidyl-threonine phosphorylation | CSNK2A1, PRKCA, PRKCB, PRKCD | 2.26249 |
| [BP] GO:0010605 | negative regulation of macromolecule metabolic process | AR, AURKB, CSNK2A1, ESR1, ESR2, FABP4, HSP90AB1, IGF1R, KDR, MMP9, NR3C1, PGR, PPARG, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.24753 |
| [BP] GO:0031399 | regulation of protein modification process | ALOX15, AR, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PRKCA, PRKCD, PRKCE, PRKCG, SRC, XDH | 2.23407 |
| [BP] GO:0070542 | None | FABP3, PPARG, PRKCE, SRC | 2.22593 |
| [BP] GO:0032800 | receptor biosynthetic process | ACHE, PPARG | 2.21534 |
| [BP] GO:0031328 | positive regulation of cellular biosynthetic process | AR, AURKB, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, MET, NR3C1, PGR, PPARG, PRKCD, RORC, SRC | 2.21534 |
| [BP] GO:0042327 | positive regulation of phosphorylation | ALOX15, AR, FLT3, HSP90AB1, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.2097 |
| [BP] GO:0006950 | response to stress | ACHE, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSP90AA1, HSP90AB1, IDO1, MMP2, MMP9, PPARG, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.20459 |
| [BP] GO:0035265 | organ growth | AR, CYP19A1, ESR1 | 2.20266 |
| [BP] GO:0043410 | positive regulation of MAPK cascade | ALOX15, AR, FLT3, KDR, PRKCA, PRKCE, SRC, XDH | 2.19669 |
| [BP] GO:0033273 | response to vitamin | ALPL, CYP1A1, PPARG, TYR | 2.19669 |
| [BP] GO:2000145 | regulation of cell motility | CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, SRC | 2.19029 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ALOX15, AR, FABP4, FLT3, HSP90AB1, IGF1R, KDR, MMP9, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.18016 |
| [BP] GO:0022900 | electron transport chain | AKR1B1, CYP19A1, CYP1A2, IDO1, XDH | 2.16523 |
| [BP] GO:0051172 | None | AR, AURKB, CSNK2A1, ESR1, ESR2, FABP4, HSP90AB1, IGF1R, MMP9, NR3C1, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.15499 |
| [BP] GO:0002684 | positive regulation of immune system process | AXL, CA2, HSP90AA1, HSP90AB1, IDO1, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, SRC | 2.15156 |
| [BP] GO:0018210 | peptidyl-threonine modification | CSNK2A1, PRKCA, PRKCB, PRKCD | 2.14661 |
| [BP] GO:0032228 | regulation of synaptic transmission, GABAergic | CA2, CA7, PRKCE | 2.13439 |
| [BP] GO:0051090 | regulation of DNA binding transcription factor activity | AR, CYP1B1, ESR1, ESR2, PIM1, PPARG, PRKCB | 2.12943 |
| [BP] GO:0045321 | leukocyte activation | ALOX5, AXL, FLT3, HSP90AA1, HSP90AB1, MMP9, PRKCB, PRKCD, PRKCE, RORC | 2.12636 |
| [BP] GO:0050776 | regulation of immune response | ALOX15, ESR1, HSP90AA1, HSP90AB1, IDO1, MMP2, PPARG, PRKCB, PRKCD, PRKCE, SRC | 2.09991 |
| [BP] GO:2000377 | regulation of reactive oxygen species metabolic process | CYP1B1, HSP90AA1, HSP90AB1, PRKCD, XDH | 2.09313 |
| [BP] GO:0051247 | positive regulation of protein metabolic process | ALOX15, AR, CSNK2A1, ESR1, FLT3, HSP90AB1, KDR, MMP9, PPARG, PRKCA, PRKCD, PRKCE, SRC, XDH | 2.09313 |
| [BP] GO:2001300 | lipoxin metabolic process | ALOX15, ALOX5 | 2.07403 |
| [BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | HSP90AA1, HSP90AB1, PRKCD, XDH | 2.06671 |
| [BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 | 2.06671 |
| [BP] GO:0032496 | response to lipopolysaccharide | ALPL, AXL, CYP1A1, CYP1A2, IDO1, SRC | 2.06058 |
| [BP] GO:0043279 | None | HSP90AB1, PPARG, PRKCE, PRKCG | 2.0537 |
| [BP] GO:0009058 | None | ACHE, AKR1B1, ALOX15, ALOX5, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IDO1, NR3C1, NR3C2, PGR, PPARG, PRKCB, RORC, TYR | 2.04825 |
| [BP] GO:0051049 | regulation of transport | ACHE, ALOX15, AXL, CA2, CA7, CYP19A1, HSP90AB1, MMP9, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.04825 |
| [BP] GO:0001890 | placenta development | HSD17B2, HSP90AB1, PPARG | 2.0401 |
| [BP] GO:0002009 | morphogenesis of an epithelium | AR, CA2, CA9, ESR1, MET, SRC | 2.0268 |
| [BP] GO:0051973 | positive regulation of telomerase activity | AURKB, HSP90AA1, HSP90AB1 | 2.00745 |
| [BP] GO:0044087 | regulation of cellular component biogenesis | ALOX15, ESR1, HSP90AA1, KDR, MET, MMP1, PRKCA, PRKCD, PRKCE, SRC | 2.00322 |
| [BP] GO:0019222 | regulation of metabolic process | ACHE, ALOX15, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.00025 |
| [CC] GO:0044444 | cytoplasmic part | ACHE, AKR1B1, ALOX15, ALOX5, AR, AURKB, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IDO1, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TYR, XDH | 3.82036 |
| [CC] GO:0005829 | cytosol | AKR1B1, ALOX15, ALOX5, AR, AURKB, CA1, CA2, CA7, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IDO1, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TYR, XDH | 2.96234 |
| [CC] GO:0016020 | membrane | ACHE, ALOX15, ALOX5, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, NR3C2, PGR, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TYR | 2.95684 |
| [CC] GO:0048471 | perinuclear region of cytoplasm | ACHE, AKR1B1, CA4, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR | 2.92037 |
| [CC] GO:0005886 | plasma membrane | ACHE, ALOX15, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.0268 |
| [MF] GO:0046914 | transition metal ion binding | ALOX15, ALOX5, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCG, RORC, TYR, XDH | 21.6704 |
| [MF] GO:0043167 | ion binding | ACHE, ALOX15, ALOX5, ALPL, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TYR, XDH | 17.4988 |
| [MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 13.126 |
| [MF] GO:0008270 | zinc ion binding | AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARG, PRKCA, PRKCB, PRKCG, RORC | 11.3641 |
| [MF] GO:0043169 | cation binding | ACHE, ALOX15, ALOX5, ALPL, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, IDO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, TYR, XDH | 11.0192 |
| [MF] GO:0046872 | metal ion binding | ALOX15, ALOX5, ALPL, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, IDO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, TYR, XDH | 10.4954 |
| [MF] GO:0003824 | catalytic activity | ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TYR, XDH | 9.58877 |
| [MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 8.51425 |
| [MF] GO:0003707 | steroid hormone receptor activity | AR, ESR1, ESR2, NR3C1, NR3C2, PGR, PPARG, RORC | 8.30588 |
| [MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 7.48281 |
| [MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 7.32345 |
| [MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.14437 |
| [MF] GO:0005496 | steroid binding | AR, ESR1, ESR2, HSD17B1, NR3C1, NR3C2, PGR, RORC | 7.10446 |
| [MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 6.82813 |
| [MF] GO:0005506 | iron ion binding | ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH | 6.4532 |
| [MF] GO:0004697 | None | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG | 6.43832 |
| [MF] GO:0016491 | oxidoreductase activity | AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, IDO1, TYR, XDH | 6.31284 |
| [MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 5.98034 |
| [MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, SRC | 5.98034 |
| [MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, SRC | 5.77991 |
| [MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | AR, ESR1, ESR2, PGR, PPARG, RORC | 5.77991 |
| [MF] GO:0004879 | nuclear receptor activity | AR, ESR1, ESR2, PGR, PPARG, RORC | 5.77991 |
| [MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.77991 |
| [MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 5.56809 |
| [MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 5.56341 |
| [MF] GO:0008289 | lipid binding | ALOX15, AR, AXL, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARG, RORC | 5.0483 |
| [MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, PRKCD, SRC | 4.9954 |
| [MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 4.94539 |
| [MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 4.72986 |
| [MF] GO:0004698 | None | PRKCA, PRKCB, PRKCG | 4.69034 |
| [MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 4.43969 |
| [MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 4.28361 |
| [MF] GO:0030235 | nitric-oxide synthase regulator activity | ESR1, HSP90AA1, HSP90AB1 | 3.8762 |
| [MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, SRC, XDH | 3.85787 |
| [MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.84701 |
| [MF] GO:0036094 | small molecule binding | AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 3.77815 |
| [MF] GO:0043168 | anion binding | ALOX15, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 3.6348 |
| [MF] GO:0005524 | ATP binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 3.59534 |
| [MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 3.48297 |
| [MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6 | 3.46572 |
| [MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 3.46572 |
| [MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.42395 |
| [MF] GO:0009931 | None | PRKCA, PRKCB, PRKCG | 3.34864 |
| [MF] GO:0042562 | hormone binding | ACHE, AR, HSD17B1, IGF1R, NR3C1 | 3.2899 |
| [MF] GO:0010857 | None | PRKCA, PRKCB, PRKCG | 3.23509 |
| [MF] GO:0035258 | None | ESR1, FLT3, PPARG, PRKCB, SRC | 3.22217 |
| [MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 3.03486 |
| [MF] GO:0008389 | None | CYP2A13, CYP2A6 | 3.03486 |
| [MF] GO:0035403 | None | PRKCA, PRKCB | 3.03486 |
| [MF] GO:0000166 | nucleotide binding | AURKB, AXL, CSNK2A1, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 2.98078 |
| [MF] GO:1901265 | nucleoside phosphate binding | AURKB, AXL, CSNK2A1, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, XDH | 2.98027 |
| [MF] GO:1901363 | heterocyclic compound binding | AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.93427 |
| [MF] GO:0097159 | organic cyclic compound binding | AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IDO1, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, XDH | 2.89354 |
| [MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, IDO1, XDH | 2.8563 |
| [MF] GO:0035173 | histone kinase activity | AURKB, PRKCA, PRKCB | 2.82979 |
| [MF] GO:0019899 | enzyme binding | AR, AURKB, CYP1A1, CYP1A2, CYP2A6, ESR1, ESR2, HSP90AA1, HSP90AB1, MET, NR3C1, PGR, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, SRC | 2.78888 |
| [MF] GO:0035639 | purine ribonucleoside triphosphate binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.63043 |
| [MF] GO:0004699 | None | PRKCD, PRKCE | 2.62922 |
| [MF] GO:0042802 | identical protein binding | ACHE, CSNK2A1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PGR, PPARG, TYR, XDH | 2.56763 |
| [MF] GO:0032555 | purine ribonucleotide binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.52249 |
| [MF] GO:0017076 | purine nucleotide binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.49971 |
| [MF] GO:0032553 | ribonucleotide binding | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.49443 |
| [MF] GO:0004674 | protein serine/threonine kinase activity | AURKB, CSNK2A1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG | 2.47903 |
| [MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, HSD11B1, HSD17B1, HSD17B2, XDH | 2.44361 |
| [MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC | 2.40196 |
| [MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.38798 |
| [MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX15, ALOX5, IDO1 | 2.34806 |
| [MF] GO:0005504 | None | FABP3, FABP4, PPARG | 2.31764 |
| [MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.31764 |
| [MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX15, ALOX5, IDO1 | 2.31764 |
| [MF] GO:0035257 | None | ESR1, FLT3, PPARG, PRKCB, SRC | 2.31764 |
| [MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.23478 |
| [MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.21534 |
| [MF] GO:0038023 | signaling receptor activity | AR, AXL, ESR1, ESR2, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARG, RORC | 2.19631 |
| [MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.13439 |
| [MF] GO:0050543 | None | FABP3, PPARG | 2.07403 |
| [MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.07403 |
| [MF] GO:0051427 | hormone receptor binding | ESR1, FLT3, PPARG, PRKCB, SRC | 2.06671 |
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 | 14.2579 |
| Pathways in cancer_Homo sapiens_hsa05200 | PRKCG, HSP90AA1, HSP90AB1, PRKCB, FLT3, MMP1, MMP2, PRKCA, MMP9, IGF1R, AR, PPARG, MET | 8.6411 |
| Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.523 |
| Proteoglycans in cancer_Homo sapiens_hsa05205 | PRKCG, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, IGF1R | 8.2744 |
| Estrogen signaling pathway_Homo sapiens_hsa04915 | HSP90AA1, HSP90AB1, SRC, MMP2, PRKCD, MMP9, ESR1, ESR2 | 8.2613 |
| Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 8.2734 |
| Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 6.0612 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PRKCB, MMP2, PRKCE, PRKCD, PIM1, PRKCA | 5.4486 |
| Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA | 5.4887 |
| Tight junction_Homo sapiens_hsa04530 | PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA | 5.8471 |
| Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 5.8471 |
| VEGF signaling pathway_Homo sapiens_hsa04370 | PRKCG, PRKCB, SRC, KDR, PRKCA | 5.1657 |
| Focal adhesion_Homo sapiens_hsa04510 | PRKCG, PRKCB, SRC, KDR, PRKCA, MET, IGF1R | 4.9382 |
| MicroRNAs in cancer_Homo sapiens_hsa05206 | PRKCG, PRKCB, PRKCE, PIM1, CYP1B1, PRKCA, MMP9, MET | 4.934 |
| Rap1 signaling pathway_Homo sapiens_hsa04015 | PRKCG, PRKCB, SRC, KDR, PRKCA, MET, IGF1R | 4.8697 |
| Metabolic pathways_Homo sapiens_hsa01100 | ALOX15, AKR1B1, TYR, CYP19A1, HSD11B1, CYP2A6, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 | 4.5685 |
| GnRH signaling pathway_Homo sapiens_hsa04912 | PRKCB, SRC, MMP2, PRKCD, PRKCA | 4.5277 |
| Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA | 4.5006 |
| Serotonergic synapse_Homo sapiens_hsa04726 | PRKCG, PRKCB, ALOX5, ALOX15, PRKCA | 4.1418 |
| Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PRKCG, PRKCB, SRC, PRKCA, ESR1 | 4.0651 |
| Ras signaling pathway_Homo sapiens_hsa04014 | PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R | 3.8265 |
| Vascular smooth muscle contraction_Homo sapiens_hsa04270 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA | 4.0456 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCG, PRKCB, PRKCA, IDO1 | 4.7129 |
| Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PRKCG, PRKCB, MMP2, PRKCA, MMP9 | 4.0651 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PRKCG, PRKCB, PRKCA, NR3C2 | 4.5685 |
| Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1, IDO1 | 4.5459 |
| Hepatitis B_Homo sapiens_hsa05161 | PRKCG, PRKCB, SRC, PRKCA, MMP9 | 3.7185 |
| Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.5277 |
| Glioma_Homo sapiens_hsa05214 | PRKCG, PRKCB, PRKCA, IGF1R | 3.8739 |
| Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | PRKCG, PRKCB, PRKCA, ESR1 | 4.3407 |
| Long-term depression_Homo sapiens_hsa04730 | PRKCG, PRKCB, PRKCA, IGF1R | 3.9974 |
| Gastric acid secretion_Homo sapiens_hsa04971 | PRKCG, PRKCB, CA2, PRKCA | 3.7185 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCG, PRKCB, PRKCE, PRKCA | 3.5766 |
| ErbB signaling pathway_Homo sapiens_hsa04012 | PRKCG, PRKCB, SRC, PRKCA | 3.4708 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.7185 |
| Prostate cancer_Homo sapiens_hsa05215 | AR, HSP90AA1, HSP90AB1, IGF1R | 3.4627 |
| Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, PPARG, MMP9, MET, IGF1R | 3.3716 |
| PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | HSP90AA1, HSP90AB1, KDR, PRKCA, MET, IGF1R | 3.0418 |
| PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARG | 3.7994 |
| GABAergic synapse_Homo sapiens_hsa04727 | PRKCG, PRKCB, SRC, PRKCA | 3.4708 |
| Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | HSP90AA1, HSP90AB1, PGR, IGF1R | 3.3318 |
| Cholinergic synapse_Homo sapiens_hsa04725 | PRKCG, ACHE, PRKCB, PRKCA | 3.1527 |
| Melanogenesis_Homo sapiens_hsa04916 | PRKCG, PRKCB, PRKCA, TYR | 3.3079 |
| Gap junction_Homo sapiens_hsa04540 | PRKCG, PRKCB, SRC, PRKCA | 3.4708 |
| HIF-1 signaling pathway_Homo sapiens_hsa04066 | PRKCG, PRKCB, PRKCA, IGF1R | 3.2681 |
| Pancreatic secretion_Homo sapiens_hsa04972 | PRKCG, PRKCB, CA2, PRKCA | 3.3563 |
| Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PRKCG, PRKCB, PRKCE, PRKCA | 3.0418 |
| Wnt signaling pathway_Homo sapiens_hsa04310 | PRKCG, CSNK2A1, PRKCB, PRKCA | 2.7913 |
| Oxytocin signaling pathway_Homo sapiens_hsa04921 | PRKCG, PRKCB, SRC, PRKCA | 2.6505 |
| Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.9893 |
| Circadian entrainment_Homo sapiens_hsa04713 | PRKCG, PRKCB, PRKCA | 2.3086 |
| Insulin secretion_Homo sapiens_hsa04911 | PRKCG, PRKCB, PRKCA | 2.4178 |
| mTOR signaling pathway_Homo sapiens_hsa04150 | PRKCG, PRKCB, PRKCA | 2.7932 |
| Choline metabolism in cancer_Homo sapiens_hsa05231 | PRKCG, PRKCB, PRKCA | 2.26 |
| Morphine addiction_Homo sapiens_hsa05032 | PRKCG, PRKCB, PRKCA | 2.3549 |
| Salivary secretion_Homo sapiens_hsa04970 | PRKCG, PRKCB, PRKCA | 2.3753 |
| Amoebiasis_Homo sapiens_hsa05146 | PRKCG, PRKCB, PRKCA | 2.26 |
| Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PRKCG, PRKCB, PRKCA | 2.277 |
| Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 2.6187 |
| Insulin resistance_Homo sapiens_hsa04931 | PRKCB, PRKCE, PRKCD | 2.1793 |
| Glutamatergic synapse_Homo sapiens_hsa04724 | PRKCG, PRKCB, PRKCA | 2.1308 |
| Amphetamine addiction_Homo sapiens_hsa05031 | PRKCG, PRKCB, PRKCA | 2.6861 |
| Non-small cell lung cancer_Homo sapiens_hsa05223 | PRKCG, PRKCB, PRKCA | 2.8726 |
| Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PRKCG, PRKCB, PRKCA | 2.26 |
| Long-term potentiation_Homo sapiens_hsa04720 | PRKCG, PRKCB, PRKCA | 2.6972 |
| Oocyte meiosis_Homo sapiens_hsa04114 | AR, PGR, IGF1R | 2.0446 |
| Dopaminergic synapse_Homo sapiens_hsa04728 | PRKCG, PRKCB, PRKCA | 1.9931 |
| Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PRKCG, PRKCB, PRKCA | 1.9504 |
| Calcium signaling pathway_Homo sapiens_hsa04020 | PRKCG, PRKCB, PRKCA | 1.6444 |
| Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.7082 |
| Thyroid hormone synthesis_Homo sapiens_hsa04918 | PRKCG, PRKCB, PRKCA | 2.6286 |
| Chemokine signaling pathway_Homo sapiens_hsa04062 | PRKCB, SRC, PRKCD | 1.6087 |
| MAPK signaling pathway_Homo sapiens_hsa04010 | PRKCG, PRKCB, PRKCA | 1.3012 |
| Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.2639 |
| Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | NR3C1 | 0.2761 |
| Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSP90AA1, HSP90AB1 | 0.9458 |
| Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.3649 |
| Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC | 0.3524 |
| Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.3632 |
| Huntington's disease_Homo sapiens_hsa05016 | PPARG | 0.3768 |
| Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3982 |
| Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3877 |
| Influenza A_Homo sapiens_hsa05164 | PRKCB, PRKCA | 0.9329 |
| Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.3975 |
| Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIM1 | 0.4289 |
| cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PRKCE | 0.4129 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PRKCA | 0.4486 |
| Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | IGF1R | 0.4566 |
| Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PRKCA | 0.4549 |
| Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.4686 |
| FoxO signaling pathway_Homo sapiens_hsa04068 | IGF1R | 0.4733 |
| Osteoclast differentiation_Homo sapiens_hsa04380 | PPARG | 0.4733 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PPARG, IGF1R | 1.1685 |
| Platelet activation_Homo sapiens_hsa04611 | SRC | 0.4944 |
| Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PRKCD | 0.497 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.4832 |
| TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.5222 |
| Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5 | 0.4996 |
| Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PPARG, IGF1R | 1.3688 |
| Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.574 |
| Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5911 |
| NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PRKCB | 1.3724 |
| Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5923 |
| Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5918 |
| Peroxisome_Homo sapiens_hsa04146 | XDH | 0.6112 |
| B cell receptor signaling pathway_Homo sapiens_hsa04662 | PRKCB | 0.6576 |
| Leishmaniasis_Homo sapiens_hsa05140 | PRKCB | 0.6576 |
| Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PRKCA | 0.6743 |
| Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.5099 |
| Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.6609 |
| Melanoma_Homo sapiens_hsa05218 | MET, IGF1R | 1.5768 |
| Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.6821 |
| Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET | 1.6087 |
| Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | IGF1R | 0.6842 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSP90AA1, HSP90AB1 | 1.5154 |
| Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6842 |
| Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.6842 |
| Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4 | 0.7279 |
| Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.6019 |
| Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2 | 1.5952 |
| Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B1 | 0.7109 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.7208 |
| Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | PRKCA | 0.731 |
| Vibrio cholerae infection_Homo sapiens_hsa05110 | PRKCA | 0.7575 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15 | 1.6566 |
| NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | HSP90AA1, HSP90AB1 | 1.7208 |
| Malaria_Homo sapiens_hsa05144 | MET | 0.7696 |
| Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PRKCB | 0.8 |
| Type II diabetes mellitus_Homo sapiens_hsa04930 | PRKCE, PRKCD | 1.8536 |
| Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.8834 |
| Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.5829 |
| Thyroid cancer_Homo sapiens_hsa05216 | PPARG | 0.9462 |
| Galactose metabolism_Homo sapiens_hsa00052 | AKR1B1 | 0.9458 |
| Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8948 |
| Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B1 | 0.8874 |
| Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B1 | 0.9278 |
| Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.9458 |
| Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9714 |
| Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2 | 2.234 |
| Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.3797 |
| Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.2398 |
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples