TCM Prescription: Pu Di Lan Xiao Yan Tablets



Prescription Description
Prescription IDTCMF4681
Pinyin NamePu Di Lan Xiao Yan Pian
Chinese Name蒲地蓝消炎片
English NamePu Di Lan Xiao Yan Tablets
Function Description疮疡, 喉痹, 痄腮
IndicationsPharyngitis, Mumps
Disease ICD-11 Category CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患,未特指的 ];
1D80 [Mumps, 腮腺炎 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH1205 Corydalis bungeana 苦地丁 TCMH1205 MH349108
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1260 Streptococcus agalactiae
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, FABP3, FUT7, GLO1, IDO1, PIM1, PPARA, PTGS2, XDH 9.55182
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 8.29098
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSD17B1, MET, PPARA, PTGS2 7.99527
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.72072
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, FLT3, GSK3B, KDR, MET, MMP12, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.35643
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, FLT3, GSK3B, KDR, MET, MMP12, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.35643
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.23977
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, HSD17B1, KDR, MET, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.18864
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.1868
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, SRC, TERT 7.1868
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, GSK3B, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, SRC 6.9422
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP2, PPARA, PTGS2, SRC 6.81256
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TOP2A, XDH 6.81256
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS2 6.80868
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, GSK3B, HSD17B1, IDO1, PTGS2, XDH 6.75586
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 6.62941
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS2 6.6283
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.44417
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT 6.44417
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS2 6.44417
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.44417
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2, TOP2A 6.35755
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.20609
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC, TERT 6.13627
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 5.99305
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.90308
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.80714
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MET, PPARA, PTGS2 5.59171
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.51723
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, IDO1, PPARA, PTGS2 5.50206
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 5.50206
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.44722
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT 5.43827
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS2 5.43502
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC, TERT 5.4205
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS2 5.33172
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS2 5.3177
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, KDR, MET, MMP12, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 5.3177
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.14964
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1 5.00439
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GSK3B, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.98163
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.96131
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 4.91809
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC, TERT, TOP2A 4.90065
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT 4.90065
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.85785
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 4.85785
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DHFR, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 4.82899
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.80037
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.69382
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2 4.66223
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.66223
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 4.65516
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FLT3, PTGS2, SRC 4.64512
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DHFR, DRD1, FABP3, KDR, PTGS2, SRC 4.58839
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.54259
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.50542
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.49332
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.45708
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, PTGS2, SRC 4.45532
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DHFR, DRD1, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 4.45532
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 4.42985
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, IDO1 4.29274
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 4.26012
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 4.22696
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2 4.22567
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2 4.14585
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 4.14585
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DHFR, DRD1, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 4.12436
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS2, SRC, TERT, TOP2A 4.12436
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, GSK3B, IDO1, MMP2, MMP9, PPARA, PTGS2, SRC, TERT, TOP2A 4.09855
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 3.9389
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.88423
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, KDR, PTGS2, SRC, TNKS, TNKS2 3.80591
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.79401
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DHFR, DRD1, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, TOP2A, XDH 3.75276
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, SRC 3.70757
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, PTGS2 3.63028
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, PTGS2, SRC 3.63028
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, GSK3B, IGF1R, MMP2, PTGS2, SRC 3.54493
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.54493
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.53732
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, PTGS2, SRC 3.44966
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, GSK3B, MMP12, PTGS2, SRC, TERT 3.4203
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1 3.39435
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 3.34426
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.33643
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.31922
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31922
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, GSK3B, IGF1R, MMP2, PTGS2, SRC 3.29583
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, PTGS2, TNKS, TNKS2 3.23669
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, FABP3, FABP4, FLT3, MET, SRC, TERT 3.22535
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.19699
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.18785
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, IDO1, PTGS2, SRC 3.12453
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, SRC, TNKS, TOP2A 3.10025
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.09005
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, GSK3B, MET, PPARA, TNKS 3.09005
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 3.08418
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, DRD1, FLT3, PTGS2, SRC 3.01419
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.00558
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, FABP4, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS2 2.99597
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FLT3, GSK3B, KDR, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC 2.97296
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD1, GSK3B, MMP12, MMP9, PPARA, PTGS2, SRC, TERT 2.91737
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.90811
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.90516
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.86786
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.84239
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, PTPRS 2.83912
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.83912
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.83912
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DHFR, DRD1, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.83912
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DRD1, GSK3B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 2.83912
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.81927
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DHFR, PPARA 2.79425
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.76539
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.7521
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.74662
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.73862
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.73862
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.73862
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, FLT3, KDR, MET, PTGS2, SRC, XDH 2.73684
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.7351
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DHFR, DRD1, FABP4, FLT3, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, XDH 2.7351
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.7351
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.71972
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.70657
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.70487
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CBR1, CYP1A1, DRD1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, MET, MMP2, MMP9, PTGS2, PTPRS, SRC, TERT, TOP2A 2.70487
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, KDR, SRC 2.69905
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, GSK3B, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.67994
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.67994
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.67994
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.66647
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, MMP2, PPARA, PTGS2, SRC, TERT 2.65951
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, FLT3, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.6577
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CSNK2A1, CYP2D6, DHFR, FABP4, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.61593
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.60602
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, PTGS2 2.60602
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, PTGS2 2.60602
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.57828
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.56218
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.56218
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.5537
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.5537
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.55014
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.54603
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.54603
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, XDH 2.54393
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, SRC 2.54262
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, KDR, SRC 2.54262
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.52972
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.52972
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.52865
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.52865
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.51972
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.51972
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, PTGS2 2.5036
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 2.50116
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.49264
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, KDR, MMP2, PTGS2, SRC 2.47473
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, PTGS2 2.47473
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.47473
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.47473
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.4506
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, DRD1, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.42388
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.42139
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.3934
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.38635
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.37488
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37488
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.37116
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.35923
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.34458
[BP] GO:0070213 None TNKS, TNKS2 2.32897
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32897
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32897
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, GSK3B, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.31604
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.28502
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.28502
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1B1, DHFR, GSK3B, MMP9, PTGS2, SRC, TERT, TOP2A 2.24596
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPRS, SRC 2.24596
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.24596
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.24596
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, CSNK2A1, CYP2D6, DHFR, FABP4, GSK3B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.23497
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.23497
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, GSK3B, IDO1, SRC, XDH 2.2263
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, PTGS2, SRC 2.20504
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.19364
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.1832
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.17578
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, GSK3B, IGF1R, MET, PTGS2, PTPRS, TERT, XDH 2.16747
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.13708
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.12723
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.12
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTGS2 2.10131
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, PPARA, PTPRS, SRC 2.09474
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.08789
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.08655
[BP] GO:0051099 positive regulation of binding APP, GSK3B, MET, MMP9, TERT 2.07894
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A 2.07772
[BP] GO:0032092 positive regulation of protein binding APP, GSK3B, MMP9, TERT 2.07197
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 2.06567
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, DRD1, GSK3B, SRC, TNKS 2.06567
[BP] GO:0030177 positive regulation of Wnt signaling pathway CSNK2A1, SRC, TERT, TNKS, TNKS2 2.06567
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.06567
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 2.06467
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.06467
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.0483
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CSNK2A1, DHFR, DRD1, FABP4, FLT3, GSK3B, IGF1R, MMP9, PTGS2, SRC, TERT, TNKS, XDH 2.00561
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.00561
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.00561
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.00513
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.00513
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.76401
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, KDR, MMP2, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.67994
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.51957
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MMP2, PIM1, PTPRS, SRC, TERT 1.95859
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.806
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 13.8536
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 13.463
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TNKS, XDH 10.8111
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.5133
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.23977
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, HSD17B1, IDO1, PTGS2, XDH 6.95665
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.77168
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, TERT, TNKS, TNKS2, TOP2A, XDH 6.4212
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.90312
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, IDO1, PTGS2, SRC 5.83767
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 5.83464
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, IDO1, PTGS2, SRC 5.61315
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.60382
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, TERT, TNKS, TNKS2, TOP2A, XDH 5.43502
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.41237
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 5.24832
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, HSD17B1, IDO1, PTGS2, SRC, XDH 4.62476
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.36505
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, TNKS 4.16908
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.75276
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.74037
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.69739
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.28035
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS2 3.09005
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, MET, PIM1, PTPRS, SRC, TOP2A, TUBB3, XDH 2.98172
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.94247
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.76981
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.76235
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.73862
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.70502
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, TUBB3, XDH 2.65203
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.5537
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.38635
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.25519
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, SRC 2.22753
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TERT 2.06878
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00561
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.00513
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6 2.00513
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS2 2.00513


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7459
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.3657
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.6586
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH, IDO1 4.1231
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.2811
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 3.8019
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1231
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.1267
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.6684
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1231
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, ALOX15, PTGS2 3.7627
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 3.5764
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.3394
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET 2.9133
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.427
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.7744
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3707
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.4564
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0206
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8483
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.8483
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1 1.9702
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6133
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.2595
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3304
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, PPARA 1.2517
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1337
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3159
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2517
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2595
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2517
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2517
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.2517
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.2517
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.1337
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.1321
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0669
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0254
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1321
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2517
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2071
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1 1.0046
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1321
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0254
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA 1.0254
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1239
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.0028
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0028
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9974
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, DRD1 0.9562
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8125
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.9337
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9401
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.961
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8248
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9104
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.9248
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.9248
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.8914
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6885
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9274
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.87
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8425
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.8425
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9702
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.7418
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7734
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7867
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.6256
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3556
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3662
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4029
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.397
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4029
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4029
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4029
Alcoholism_Homo sapiens_hsa05034 DRD1 0.4029
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4583
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.431
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4365
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4365
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B 0.4624
Platelet activation_Homo sapiens_hsa04611 SRC 0.4968
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4748
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.4968
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4968
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4968
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5396
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5156
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5396
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.4968
Melanogenesis_Homo sapiens_hsa04916 GSK3B 0.5396
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5396
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4968
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5363
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5396
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5396
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5363
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5396
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5514
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5516
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5396
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5516
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5519
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5514
Peroxisome_Homo sapiens_hsa04146 XDH 0.5613
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6026
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6017
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6026
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6101
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6256
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6242
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6282
Glioma_Homo sapiens_hsa05214 IGF1R 0.6256
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6229
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6256
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6256
Shigellosis_Homo sapiens_hsa05131 SRC 0.6256
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6704
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6582
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6582
Malaria_Homo sapiens_hsa05144 MET 0.684
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.684
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6811
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6988
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7115
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7867
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7418
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8213
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8013
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.87
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8608
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9337
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0157
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1934


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)