TCM Prescription: Xue Zhi Ning Pills



Prescription Description
Prescription IDTCMF459
Pinyin NameXue Zhi Ning Wan 
Chinese Name血脂宁丸
English NameXue Zhi Ning Pills
Function Description高脂血症, 症见气短, 乏力, 头晕, 头痛, 胸闷, 腹胀, 食少纳呆等; 也可用于高脂血症及动脉粥样硬化引起的心脑血管疾病的辅助治疗
IndicationsHyperlipidemia
Disease ICD-11 Category 5C80.Z [Hyperlipoproteinaemia, unspecified, 高脂蛋白血症，未特指的 ];
Human Tissues Associated with IndicationBrain, Blood, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH825 Nelumbo nucifera 荷叶 TCMH825 ITSAI3109-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.90028
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 9.43376
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 9.23468
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 8.83506
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FUT7, GLO1, HMGCR, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.83506
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 8.36006
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.98549
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 7.98039
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 7.57774
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC 7.48912
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 7.41586
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.41586
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.99051
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TOP2A, TYR 6.97104
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 6.70879
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HTR1A, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 6.65684
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 6.37927
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP4, HMGCR, HSD17B2, HTR1A, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 6.3575
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.2932
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 6.24988
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, PTGS2, RORC, SRC, TYR 6.22558
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, EPHX2, HMGCR, KDR, SRC 6.22558
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 5.89049
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 5.81241
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 5.62795
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, DRD2, EPHX2, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.62795
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CYP1B1, DRD2, ESR1, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 5.43863
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.39558
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.3751
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGS1, PTGS2 5.35355
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.35355
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, DRD2, EPHX2, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.33424
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGS1, PTGS2 5.33424
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.33424
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, DRD2, ESR1, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 5.2379
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.1757
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGS1, PTGS2 5.15623
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 5.09766
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 4.99932
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD17B2 4.97221
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2, NQO2, PTGS1, RORC 4.92142
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TOP2A 4.85417
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.7464
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 4.71347
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, GLO1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.61282
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.51671
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, FABP3, HMGCR, KDR, PTGS2, SRC 4.50921
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 4.47495
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.4235
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA, PTGS1, PTGS2 4.38931
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 4.38918
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 4.36184
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.30196
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, HMGCR, HTR1A, TYR 4.21738
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TYR 4.21207
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 4.1914
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AURKB, AXL, BCL2, CDC25B, CYP1A1, CYP1A2, DRD2, ESR1, FLT3, FUT7, GLO1, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 4.18179
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CYP1B1, DRD2, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.18179
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGS1, PTGS2 4.14852
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CYP19A1, CYP1A1, HMGCR, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.05882
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 4.04438
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGS1, PTGS2 4.00507
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.93502
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.922
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.86759
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.8526
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.84986
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.84986
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.84986
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 3.84225
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD2, HMGCR, KDR, PIK3CB, PTGS2, SRC 3.78173
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, EPHX2, FABP3, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC 3.78173
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PPARA, PTGS1, PTGS2 3.7537
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.72323
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.68947
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD2, ESR1, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.66002
[BP] GO:0048511 rhythmic process AXL, BCL2, DRD2, ESR1, PPARA, RORC, SRC, TOP2A 3.58522
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD2, ESR1, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.56836
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HMGCR, HSD17B2, HTR1A 3.55668
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.55225
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.52633
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.52633
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.52633
[BP] GO:0006950 response to stress ACHE, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, HTR1A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A 3.51484
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD2, EPHX2, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.50802
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.50197
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.49106
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.45727
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, MET, PIK3CA, PIK3CB, SRC, XDH 3.411
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.37211
[BP] GO:0042325 regulation of phosphorylation BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.37211
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 3.35616
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.34822
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32698
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.32413
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, HTR1A, TYR 3.31544
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 3.29718
[BP] GO:0044092 negative regulation of molecular function AURKB, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.29718
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, DRD2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.27122
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, DRD2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.22733
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CYP1B1, DRD2, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.22037
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.212
[BP] GO:0032879 regulation of localization ACHE, APEX1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD2, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.20338
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CYP1A1, DRD2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, RORC, SRC, TOP2A 3.20154
[BP] GO:0001932 regulation of protein phosphorylation BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.19098
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.94691
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.94691
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DRD2, ESR1, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.92467
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.91938
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.91938
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.90576
[BP] GO:0030334 regulation of cell migration APEX1, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.90529
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.84773
[BP] GO:0009893 positive regulation of metabolic process AURKB, BCL2, CDC25B, DRD2, EPHX2, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.84229
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, BCL2, CDC25B, DRD2, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.83602
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.83602
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.83602
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, BCL2, CDC25B, DRD2, EPHX2, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.80932
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.78031
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.78031
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.77748
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.732
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.732
[BP] GO:0016311 None ALPI, ALPL, APEX1, BCL2, CDC25B, EPHX2, PTPN1 2.71546
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.70242
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.701
[BP] GO:2000145 regulation of cell motility APEX1, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.69817
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, DRD2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.67258
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, MMP2, MMP9, PTGS2, SRC, TOP2A 2.67196
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.66386
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.65318
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.65318
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, HMGCR, MMP2, PPARA, PTGS2, SRC, TYR 2.64631
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.63332
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.58934
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CDC25B, DRD2, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.58914
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD2, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.56763
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.56045
[BP] GO:0031401 positive regulation of protein modification process BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.55175
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MMP2, MMP9, PTGS2, RORC, TOP2A 2.55103
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.54144
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.53637
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53637
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.524
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, KDR, SRC 2.516
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, PTGS2, SRC, TYR 2.51089
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.50585
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 2.50585
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.50504
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.50504
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.49396
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.46028
[BP] GO:0040012 regulation of locomotion APEX1, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.44651
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.4429
[BP] GO:0051270 regulation of cellular component movement APEX1, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.43788
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, HMGCR, HTR1A, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.4348
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.42142
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.42142
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.3925
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.3925
[BP] GO:0080134 regulation of response to stress CYP19A1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 2.38769
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, PTGS2, SRC 2.35887
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, PIK3CB, PTGS2 2.35887
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD2, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.3558
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.35116
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35116
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.34756
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.33575
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CYP19A1, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.33069
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.33069
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, PTGS2 2.32348
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30594
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.30407
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.29679
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, PPARA, PTGS2, SRC 2.27027
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.26444
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD2, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTGS2 2.23934
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.22707
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.22528
[BP] GO:0045859 regulation of protein kinase activity CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.22196
[BP] GO:0032270 positive regulation of cellular protein metabolic process BCL2, CDC25B, DRD2, ESR1, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.21789
[BP] GO:0008217 None DRD2, EPHX2, PPARA, PTGS1, PTGS2 2.21751
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.20774
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DRD2, ESR1, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.19288
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC 2.187
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.187
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.16033
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.1565
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, PTGS2, SRC 2.1565
[BP] GO:0003018 None EPHX2, HMGCR, HTR1A, PTGS2, SRC 2.1565
[BP] GO:0031399 regulation of protein modification process BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.1565
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.1327
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.1327
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.12802
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.12723
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.12723
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, FLT3, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH 2.12186
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.12186
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.11598
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.10358
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.0968
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.0968
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.09519
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, EPHX2, ESR1, FABP3, PIK3CB 2.0871
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.06211
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.06069
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.06069
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2 2.04551
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.0402
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.0402
[BP] GO:0043549 regulation of kinase activity CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.0278
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CDC25B, DRD2, ESR1, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.02568
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00905
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.00073
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.2271
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00905
[CC] GO:0016020 membrane ACHE, ALOX5, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR 1.97657
[CC] GO:0005783 None APEX1, BCL2, CA4, CYP19A1, FLT3, HMGCR, KDR, PTGS2, PTPN1, XDH 1.74181
[CC] GO:0044425 membrane part ACHE, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, FUT7, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 1.73751
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH 12.629
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 12.2871
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FLT3, FUT7, GLO1, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 10.9317
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.5133
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, ESR1, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TOP2A, TYR, XDH 8.37878
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.41586
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 7.36392
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.79188
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TOP2A, TYR, XDH 6.62422
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.22558
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.89049
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A 5.14846
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.61234
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.4235
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.14852
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.89834
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, NQO2, PTGS1, PTGS2, SRC, XDH 3.72953
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.72953
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.72208
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.29718
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.22037
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.02805
[MF] GO:0042802 identical protein binding ACHE, BCL2, DRD2, EPHX2, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TOP2A, TYR, XDH 2.99967
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.94691
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.91938
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.91072
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, DRD2, EPHX2, FLT3, HMGCR, NQO2, PTGS2, TOP2A, TYR, XDH 2.81416
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.78187
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.73573
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B2, XDH 2.35887
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.23679
[MF] GO:0032403 protein complex binding ACHE, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.20972
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.19167
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.13943
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.13583
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0968
[MF] GO:0019902 phosphatase binding BCL2, HMGCR, MET, PPARA, PTPN1 2.07365
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00905
[MF] GO:0004035 alkaline phosphatase activity ALPI, ALPL 2.00905
[MF] GO:0016301 kinase activity AURKB, AXL, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.00466


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7029
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.3229
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.7685
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.5442
Metabolic pathways_Homo sapiens_hsa01100 EPHX2, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 5.5442
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.1752
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 5.0608
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.9821
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.7755
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.7755
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, DRD2, MET, IGF1R 4.7208
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.0416
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.0851
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.9147
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, PIK3CA, HTR1A, PIK3CB, DRD2, PPARA 3.8371
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.5924
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2912
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.8303
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2, PTGS2, PTGS1 3.7097
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.5484
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.5995
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.5637
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.5589
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5924
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.5484
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.3138
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.4755
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.1657
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.357
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.4216
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 3.1094
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.0252
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 3.0278
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR1A, PTGS2, PTGS1 3.0074
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.8908
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.9112
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.9555
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.9555
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.9555
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.8952
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.5764
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.5764
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3843
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 2.1513
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.631
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.1941
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.6655
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.6411
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.3175
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.2377
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9076
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.6211
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.9838
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.1094
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 1.9838
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.8456
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.5204
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.8941
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.8941
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.8477
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.8413
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.7867
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.8044
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.5761
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.5242
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.5123
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3007
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4115
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1A, DRD2 1.2375
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4224
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2813
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.4097
Alcoholism_Homo sapiens_hsa05034 DRD2 0.4097
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.4804
Tight junction_Homo sapiens_hsa04530 SRC 0.4851
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.7298
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0862
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB 1.1219
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1234
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, PIK3CB 0.9863
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1365
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5173
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5173
Axon guidance_Homo sapiens_hsa04360 MET 0.5116
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.967
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2 0.5089
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9582
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2956
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3807
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.3206
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3727
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.3063
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3239
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.3063
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3354
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5874
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5874
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5979
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5874
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5972
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.3727
Gap junction_Homo sapiens_hsa04540 SRC, DRD2 1.4029
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6155
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6207
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6207
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.6368
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5351
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5725
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5351
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5809
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.4454
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5476
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.6486
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.5476
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6803
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6782
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.5879
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.5725
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6934
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6955
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6944
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6568
Shigellosis_Homo sapiens_hsa05131 SRC 0.7158
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7373
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.7158
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.7506
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.8044
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8413
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.9226
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7991
Malaria_Homo sapiens_hsa05144 MET 0.8119
Cocaine addiction_Homo sapiens_hsa05030 DRD2 0.8119
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8216
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8265
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.1106
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0627
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8801
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9838
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.967
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.9314
Base excision repair_Homo sapiens_hsa03410 APEX1 0.9523
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9863
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3091
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0201
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9763
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0084
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 1.0862
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.6655
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4216


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)